免疫缺陷、着丝粒不稳定和面部异常(immunodefificiency with centromeric instability and facial anomalies,ICF)综合征是一种罕见的常染色体隐性遗传疾病,以轻重不同程度的免疫缺陷为特征,伴有面部异常和染色体着丝粒区不稳定,涉及...免疫缺陷、着丝粒不稳定和面部异常(immunodefificiency with centromeric instability and facial anomalies,ICF)综合征是一种罕见的常染色体隐性遗传疾病,以轻重不同程度的免疫缺陷为特征,伴有面部异常和染色体着丝粒区不稳定,涉及的主要染色体为1、9和16号染色体。面部异常可包括圆脸、鼻梁扁平、上翘的鼻子、大舌和耳位偏低。大多数ICF患者有运动及语言发育迟缓,不同程度智力低下。其免疫学特征为:大多数患者患有低丙种球蛋白血症或无丙种球蛋白血症。展开更多
Although many functional magnetic resonance imaging(f MRI) studies have investigated the neurophysiology of attention deficit hyperactivity disorder(ADHD),the existing studies have not yielded consistent findings.This...Although many functional magnetic resonance imaging(f MRI) studies have investigated the neurophysiology of attention deficit hyperactivity disorder(ADHD),the existing studies have not yielded consistent findings.This may be related to the different properties of different frequency bands. To investigate the frequency-specific regional homogeneity(Re Ho) of spontaneous neural activities in ADHD, the current study used resting-state f MRI to explore the Re Ho properties of five frequency bands, slow-5(0.01–0.027 Hz), slow-4(0.027–0.073 Hz),slow-3(0.073–0.198 Hz), slow-2(0.198–0.25 Hz) and the extra-low frequency(0–0.01 Hz), in 30 drug-naive boys with ADHD and 30 healthy controls. Compared with controls, the ADHD group showed decreased Re Ho in the default mode network(DMN) including the medial prefrontal cortex and precuneus, middle frontal gyrus and angular gyrus. ADHD patients also showed increased Re Ho in the posterior cerebellum. Significant interactions between frequency band and group were observed predominantly in the dorsolateral prefrontal and parietal cortices, orbital frontal cortex, supplementary motor area,inferior occipital gyrus, thalamus and anterior cerebellum.In particular, we found that the between-group difference in the extra-low frequency band(0–0.01 Hz) seemed to be greater than that in the other frequency bands for most brain regions. The findings suggest that ADHD children display widespread abnormalities in regional brain activity,particularly in the DMN and attention network, and these abnormalities show frequency specificity.展开更多
文摘免疫缺陷、着丝粒不稳定和面部异常(immunodefificiency with centromeric instability and facial anomalies,ICF)综合征是一种罕见的常染色体隐性遗传疾病,以轻重不同程度的免疫缺陷为特征,伴有面部异常和染色体着丝粒区不稳定,涉及的主要染色体为1、9和16号染色体。面部异常可包括圆脸、鼻梁扁平、上翘的鼻子、大舌和耳位偏低。大多数ICF患者有运动及语言发育迟缓,不同程度智力低下。其免疫学特征为:大多数患者患有低丙种球蛋白血症或无丙种球蛋白血症。
基金supported by the National Basic Research Development Program of China(2014CB846104)the National Natural Science Foundation of China(81371496+3 种基金3097080281101014)the Program for New Century Excellent Talents in University(NCET-11-0013)supported by the‘‘Qian Jiang Distinguished Professor’’Program
文摘Although many functional magnetic resonance imaging(f MRI) studies have investigated the neurophysiology of attention deficit hyperactivity disorder(ADHD),the existing studies have not yielded consistent findings.This may be related to the different properties of different frequency bands. To investigate the frequency-specific regional homogeneity(Re Ho) of spontaneous neural activities in ADHD, the current study used resting-state f MRI to explore the Re Ho properties of five frequency bands, slow-5(0.01–0.027 Hz), slow-4(0.027–0.073 Hz),slow-3(0.073–0.198 Hz), slow-2(0.198–0.25 Hz) and the extra-low frequency(0–0.01 Hz), in 30 drug-naive boys with ADHD and 30 healthy controls. Compared with controls, the ADHD group showed decreased Re Ho in the default mode network(DMN) including the medial prefrontal cortex and precuneus, middle frontal gyrus and angular gyrus. ADHD patients also showed increased Re Ho in the posterior cerebellum. Significant interactions between frequency band and group were observed predominantly in the dorsolateral prefrontal and parietal cortices, orbital frontal cortex, supplementary motor area,inferior occipital gyrus, thalamus and anterior cerebellum.In particular, we found that the between-group difference in the extra-low frequency band(0–0.01 Hz) seemed to be greater than that in the other frequency bands for most brain regions. The findings suggest that ADHD children display widespread abnormalities in regional brain activity,particularly in the DMN and attention network, and these abnormalities show frequency specificity.
