目的:探讨前列腺癌(prostate cancer,PCa)患者血清白介素-6(IL-6)、性激素和前列腺特异性抗原(prostate specific antigen,PSA)的水平及其临床评价。方法:采用化学发光免疫分析法测定了178例前列腺疾病[其中68例PCa,43例前列腺增生(BPH)...目的:探讨前列腺癌(prostate cancer,PCa)患者血清白介素-6(IL-6)、性激素和前列腺特异性抗原(prostate specific antigen,PSA)的水平及其临床评价。方法:采用化学发光免疫分析法测定了178例前列腺疾病[其中68例PCa,43例前列腺增生(BPH),31例BPH+急性尿潴留(AUR)和36例急性前列腺炎(AP)]患者和60例正常对照组血清IL-6、T、FSH和LH以及PSA的水平,并同时进行比较性分析。结果:在178例前列腺疾病中,68例PCa患者血清IL-6水平较43例BPH、31例BPH+AUR、36例AP患者和60例正常对照组均明显增高(P<0.01、<0.05、<0.05和<0.01)。在性激素分析中,68例PCa患者血清T水平较60例正常对照组明显降低(P<0.01),其他各组均正常(P均>0.05);68例PCa患者血清FSH水平较60例正常对照组明显增高(P<0.01),43例BPH和36例AP患者均正常(P均>0.05),而31例BPH+AUR患者稍增高(P<0.05);68例PCa患者血清LH较60例正常对照组明显增高(P<0.05),而31例AP患者明显降低,有待进一步探讨。在PSA测定中,68例PCa患者血清PSA较其他前列腺疾病组和60例正常对照组非常明显增高(P均<0.01),在68例PCa患者中,37例骨转移患者的血清IL-6和PSA水平较31例未转移患者明显增高(P分别为<0.01和<0.05),性激素之间无明显差异(P均>0.05)。结论:PCa患者血清IL-6、FSH、LH和PSA水平明显增高和血清T明显降低是诊断和鉴别前列腺良恶性疾病的有价值的临床指标,而PCa患者骨转移的典型特点是血清IL-6和PSA水平的增高,但与血清性激素水平无关。展开更多
Adamantiades-Behcet's disease (ABD) is a chronic,relapsing,systemic vasculitis of unknown etiology.It is more prevalent in populations along the ancient Silk Road from Eastern Asia to the Mediterranean Basin,and m...Adamantiades-Behcet's disease (ABD) is a chronic,relapsing,systemic vasculitis of unknown etiology.It is more prevalent in populations along the ancient Silk Road from Eastern Asia to the Mediterranean Basin,and most frequently affects young adults between the second and fourth decades of life.ABD-complicated gastroenteropathy is a significant cause of morbidity and mortality,with abdominal pain as the most common symptom.The ileocecal region is affected predominantly,with ulcerations that may lead to penetration and/or perforation,whereas other parts of the gastrointestinal system including the esophagus and stomach can also be affected.Endoscopy is useful to locate the site and extent of the lesions,and tissue biopsy is often warranted to examine the histopathology that is often suggestive of underlying vasculitis of small veins/venules or,alternatively in some cases,nonspecific inflammation.Bowel wall thickening is the most common finding on computed tomography scan.Treatment is largely empirical since well-controlled studies are difficult to conduct due to the heterogeneity of the disease,and the unpredictable course with exacerbation and remission.Corticosteroids with or without other immunosuppressive drugs,such as cyclophosphamide,azathioprine,sulfasalazine,tumor necrosis factor α antagonist or thalidomide should be applied before surgery,except in emergency.展开更多
Northern blot analysis of glutathione S-transferase (GST) Yb1 mRNA in different tissues of male and female rats revealed that its tissue-specific transcription patterns were highly sex hormone related. Although the GS...Northern blot analysis of glutathione S-transferase (GST) Yb1 mRNA in different tissues of male and female rats revealed that its tissue-specific transcription patterns were highly sex hormone related. Although the GST Yb1 mRNA could be detected in most of the tissues examined at various levels, the highest abundance was observed in the ventral prostate, uterus and liver, which were the main target tissue for androgen, estrogen and glucocorticoid respectively The effect of androgen on the transcription of GST Yb1 was also tissue-specific. Since androgen withdrawal by castration caused the up-regulation of GST Yb1 mRNA in the ventral prostate but down-regulation in the liver and no effect in the brain, evaluation of this system for studying the regulation mechanisms of gene expression by which androgen exerts its differential effects has been discussed.展开更多
文摘目的:探讨前列腺癌(prostate cancer,PCa)患者血清白介素-6(IL-6)、性激素和前列腺特异性抗原(prostate specific antigen,PSA)的水平及其临床评价。方法:采用化学发光免疫分析法测定了178例前列腺疾病[其中68例PCa,43例前列腺增生(BPH),31例BPH+急性尿潴留(AUR)和36例急性前列腺炎(AP)]患者和60例正常对照组血清IL-6、T、FSH和LH以及PSA的水平,并同时进行比较性分析。结果:在178例前列腺疾病中,68例PCa患者血清IL-6水平较43例BPH、31例BPH+AUR、36例AP患者和60例正常对照组均明显增高(P<0.01、<0.05、<0.05和<0.01)。在性激素分析中,68例PCa患者血清T水平较60例正常对照组明显降低(P<0.01),其他各组均正常(P均>0.05);68例PCa患者血清FSH水平较60例正常对照组明显增高(P<0.01),43例BPH和36例AP患者均正常(P均>0.05),而31例BPH+AUR患者稍增高(P<0.05);68例PCa患者血清LH较60例正常对照组明显增高(P<0.05),而31例AP患者明显降低,有待进一步探讨。在PSA测定中,68例PCa患者血清PSA较其他前列腺疾病组和60例正常对照组非常明显增高(P均<0.01),在68例PCa患者中,37例骨转移患者的血清IL-6和PSA水平较31例未转移患者明显增高(P分别为<0.01和<0.05),性激素之间无明显差异(P均>0.05)。结论:PCa患者血清IL-6、FSH、LH和PSA水平明显增高和血清T明显降低是诊断和鉴别前列腺良恶性疾病的有价值的临床指标,而PCa患者骨转移的典型特点是血清IL-6和PSA水平的增高,但与血清性激素水平无关。
文摘Adamantiades-Behcet's disease (ABD) is a chronic,relapsing,systemic vasculitis of unknown etiology.It is more prevalent in populations along the ancient Silk Road from Eastern Asia to the Mediterranean Basin,and most frequently affects young adults between the second and fourth decades of life.ABD-complicated gastroenteropathy is a significant cause of morbidity and mortality,with abdominal pain as the most common symptom.The ileocecal region is affected predominantly,with ulcerations that may lead to penetration and/or perforation,whereas other parts of the gastrointestinal system including the esophagus and stomach can also be affected.Endoscopy is useful to locate the site and extent of the lesions,and tissue biopsy is often warranted to examine the histopathology that is often suggestive of underlying vasculitis of small veins/venules or,alternatively in some cases,nonspecific inflammation.Bowel wall thickening is the most common finding on computed tomography scan.Treatment is largely empirical since well-controlled studies are difficult to conduct due to the heterogeneity of the disease,and the unpredictable course with exacerbation and remission.Corticosteroids with or without other immunosuppressive drugs,such as cyclophosphamide,azathioprine,sulfasalazine,tumor necrosis factor α antagonist or thalidomide should be applied before surgery,except in emergency.
文摘Northern blot analysis of glutathione S-transferase (GST) Yb1 mRNA in different tissues of male and female rats revealed that its tissue-specific transcription patterns were highly sex hormone related. Although the GST Yb1 mRNA could be detected in most of the tissues examined at various levels, the highest abundance was observed in the ventral prostate, uterus and liver, which were the main target tissue for androgen, estrogen and glucocorticoid respectively The effect of androgen on the transcription of GST Yb1 was also tissue-specific. Since androgen withdrawal by castration caused the up-regulation of GST Yb1 mRNA in the ventral prostate but down-regulation in the liver and no effect in the brain, evaluation of this system for studying the regulation mechanisms of gene expression by which androgen exerts its differential effects has been discussed.
