过去2000a中国东部干湿分异的百年际变化

分析了101～1900 AD间中国东部每200 a的干湿分异及其变化状况,讨论了它们与冷暖变化的对应关系.结果显示:2～11世纪,我国东部干湿分异为东西分异,西(西北)干东(东南)湿;12～15世纪,东西分异与南北分异并存,但仍以东西分异为主;而16～19世纪则为南北分异,北干南湿.冷暖变化与区域干湿变化的对应关系是:在暖的时期,干湿分界线偏西,最西达大同-太原-西安-汉中一线;在相对较冷的时期,干湿分界线摆向东南,达济南-菏泽-南阳一线,摆动最大幅度达5个经度以上;而在最冷的两个时段,东西分界线被南北分界线所取代.冷的时期,华北地区偏干,长江中下游及其以南地区偏湿;暖的时期,华北地区湿润,华东地区,特别是长江下游及其以南地区偏干.

滋阴除湿汤联合海普林软膏治疗异位性皮炎的研究

目的观察滋阴除湿法联合海普林软膏治疗儿童异位性皮炎(AD)的疗效。方法治疗组50例给予滋阴除湿汤口服及海普林软膏外涂,对照组50例给予西替利嗪糖浆口服及氢化可的松软膏外涂,两周后观察疗效。结果治疗组总有效率为86%,对照组为66%,两组间疗效有显著性差异(P<0.05)。结论滋阴除湿汤联合海普林治疗AD疗效确切。

对艾滋病中医病因的认识

目的:探讨艾滋病的中医病因和命名。方法:分析艾滋病病因、致病特点。结果:艾滋病符合湿邪治病的特点。结论:艾滋病病因为外邪,宜命名为异湿。

丙型肝炎中医病因探析

"异湿"既涵括了湿邪的属性,又涵括了异气的特性,是湿邪致病理论与疫病理论的有机结合,是"皆相染易"之异气的具体化、明确化,是中医异气学说的具体运用和发展。异湿是丙肝的唯一始动因素,是丙肝发生、发展、演变的根本原因,是复杂病机的症结所在。统一异湿命名,对丙肝病程的整体把握、治疗方案的统一规范和预后的判断有重要意义。

Fabrication of Silicon Crystal-Facet-Dependent Nanostructures by Electron-Beam Lithography

Silicon crystal-facet-dependent nanostructures have been successfully fabricated on a （100）-oriented silicon-oninsulator wafer using electron-beam lithography and the silicon anisotropic wet etching technique. This technique takes advantage of the large difference in etching properties for different crystallographic planes in alkaline solution. The minimum size of the trapezoidal top for those Si nanostructures can be reduced to less than 10nm. Scanning electron microscopy （SEM） and atomic force microscopy （AFM） observations indicate that the etched nanostructures have controllable shapes and smooth surfaces.

乙型肝炎病毒中医病因性质及命名辨析

乙型肝炎病毒致病隐匿,缠绵难愈,表现复杂,病位广泛,易犯脾土,与湿邪致病特征相符,宜命名为"异湿"。"异湿"之名,既体现出湿邪的特征,又体现出"皆相染易"之性,具体明确,针对性强。确认异湿是乙肝的唯一始动因素,是中医异气理论的发展和具体运用,对乙肝的辨治有重要意义。

An Evaluation of the Acetowhitening Test for Genital Condyloma Acuminata

Objective: To study the sensitivity and the specific-ity of the condyloma acuminata acetowhitening test.Methods: We placed gauzes soaked with 5% aceticacid onto the lesions for 3 to 5 minutes, then removedthe gauzes and observed the result of acetowhitening. Results: 165 of 211(78.2%) patients tested positive.159 patients had condyloma acuminata and 134 of themhad a positive acetowhitening test (84.3%). Of the 26patients with candida balanitis, 25 cases were positivewith a positive rate of 96.2%.Conclusions: The high sensitivity and specificity ofthe condyloma acuminata acetowhitening test justifythe use of this test in the clinical setting. However, thecondyloma acuminata acetowhitening test has someshortcomings and these must be considered duringdiagnosis.

Heterogeneity of Physico-Chemical Properties in Structured Soils and Its Consequences

Structured soils are characterized by the presence of inter- and intra-aggregate pore systems and aggregates, which show varying chemical, physical, and biological properties depending on the aggregate type and land use system. How far these aspects also affect the ion exchange processes and to what extent the interaction between the carbon distribution and kind of organic substances affect the internal soil strength as well as hydraulic properties like wettability are still under discussion. Thus, the objective of this research was to clarify the effect of soil aggregation on physical and chemical properties of structured soils at two scales: homogenized material and single aggregates. Data obtained by sequentially peeling off soil aggregates layers revealed gradients in the chemical composition from the aggregate surface to the aggregate core. In aggregates from long term untreated forest soils we found lower amounts of carbon in the external layer, while in arable soils the differentiation was not pronounced. However, soil aggregates originating from these sites exhibited a higher concentration of microbial activity in the outer aggregate layer and declined towards the interior. Furthermore, soil depth and the vegetation type affected the wettability. Aggregate strength depended on water suction and differences in tillage treatments.

Influence of nitrogen hetero-substitution on the electrochemical performance of coal-based activated carbons measured in non-aqueous electrolyte

Nitrogen-containing carbons were prepared by modification of activated carbons.The modified carbons were used as electrode materials with improved electrochemical performance.Precursor anthracite was activated by KOH(KOH:anthracite= 1:1), modified by melamine or urea and then treated at 1173 K to obtain the modified carbons.The porous structure, the chemical composition and the electrochemical characteristics of the carbons were investigated by nitrogen sorption, XPS and electrochemical methods respectively.Electrochemical experiments were performed in an organic electrolytic solution of 1 M(C2H5)4NBF4/PC.The samples modified by the different methods showed differences in chemical composition that introduced varying degrees of electrochemical performance enhancement.The presence of nitrogen enhanced the electron donor properties and the surface wettability of the activated carbons:this ensured a sufficient utilization of the exposed surface for charge storage.

Review of copper and copper alloys as immune and antibacterial element

This review discussed the relationship among copper,human,and bacteria.Copper plays an important role in human immunity.Copper can boost human immune defense reactions at recommended intake level.The content mainly focused on copper antibacterial activity and copper antibacterial mechanisms.Conclusions stated that copper antibacterial activity is affected by copper homeostasis mechanisms in bacteria,adhesion,humidity,strain specificity,and manufacturing methods of antibacterial agents.For the preparation of particle antibacterial agents and surface antibacterial agents,this review discussed several manufacturing methods,such as sol−gel,cold spray,and biosynthesis belonging to chemical synthesis,physical synthesis,and biological synthesis,respectively.Sol−gel method contributes to the preparation of particle agents and surface agents.Cold spray technique is utilized in synthesis of surface copper agent.Biosynthesis is a novel technology which can be applied in nanoparticle agent preparation.

Optimization of Wickerhamomyces anomalus Fermentation Conditions for Pectinase Production Based on Wet Processing of Arabica Coffee in Yunnan Province

In order to improve the pectin-degrading efficiency in wet processing of Arabica coffee in Yunnan, Box-Behnken design and single factor experiment were used to optimize the fermentation conditions of five pectinolytic Wickerhamomyces anomalus strains from the fermentation broth of Arabica coffee in Baoshan, Yunnan during wet processing with pectase activity as an indicator. The results showed that the five strains all synthesized pectin lyase(PL), polygalacturonase(PG), and pectin methylesterase(PM).Among them, strain CAP5 had strong ability to produce PG and PL,while strain CAP4 secreted a large amount of PM. Under optimized conditions, the activity of PG, PL, and PM of the five strains came in at 250.17~411.20 U/mL, 12.98~16.55 U/mL, and 208.52~322.83 U/mL,respectively. The four factors of nitrogen source concentration,fermentation time, Mn2+ concentration, and pH value were optimized and the optimal pectinase-producing fermentation conditions for five strains were as follows: peptone 2.2 g/L, fermentation time 30 h, Mn2+ 1.5 mmol/L, and pH 4.3. After fermentation under the optimized conditions, the maximum PG activity of CAP5 amounted to 411.20 U/mL, 114.03% higher than that before optimization.Meanwhile, the PG activity of strains CAP3, CAP4, CAP8, and CAP10 increased by 86.74%, 114.55%, 65.79%, and 66.07%,respectively, and the activity of PL and PM of the five strains rose 150.35%~218.56% and 341.07%~418.52%, respectively. These findings suggested that W. anomalus strains could be used as coffee starter and had great potential for the lysis of pectin.

Geographical Variation in Oligochaete Density and Biomass in Subtropical Mangrove Wetlands of China

Oligochaetes play an important role in nutrient cycling and energy flow in benthic food webs as well as in mangrove wetlands. However, they have not been as extensively studied as other macrofaunal groups such as polychaetes, gastropods, bivalves, and crustaceans. Under the assumption that oligochaete density and biomass obey specific geographical distribution patterns in subtropical mangrove wetlands of China, we investigated these two parameters in the Luoyang Estuary of Quanzhou Bay, Zhangjiang Estuary and Gaoqiao mangrove wetlands. A geographical gradient in oligochaete density was present in Aegiceras corniculatum and Kandelia obovata habitats, whereby it decreased from lower latitudes to higher latitudes. Further, ANOVA tests on oligochaete distribution revealed that both oligochaete density and biomass were significantly influenced by region, season and region × season at the A. corniculatum and K. obovata habitats. The annual average oligochaete density and biomass at the A. corniculatum habitat were higher than that at the K. obovata habitat, in both the Luoyang and Zhangjiang estuaries. There were significant correlations between oligochaete density and biomass and sediment particle size parameters, confirming that sand, silt, and clay contents were the key environmental factors affecting oligochaete distribution.

Isolation and characteristics of autoreactive T cells specific to aggrecan G1 domain from rheumatoid arthritis patients

Our previous work showed that the cartilage proteoglycan aggrecan could induce an erosive polyarthritis and spondylitis in BALB/c mice and the GI globular domain of the aggrecan (GI) contained the arthritogenic region. To elucidate whether autoreactive T cells to G1 are expressed in rheumatoid arthritis patients, we analyzed the frequency of human G1-specific T cells in the peripheral blood of five rheumatoid arthritis patients and tried to establish G1-reactive T cell lines from these rheumatoid arthritis patients. The results showed that the G1-specific T cells in PBL were detectable at the range of 4.97 ±0.5 ×10-6 in peripheral blood lymphocytes. We have also generated 15 G1-specific T lymphocyte lines from these pateints with a standard split-well method. All these cells expressed fine specificity to human recombinant G1, but not to unrelated antigen. All the 15 lines expressed a panT cell marker and 13 of them selectively used the αβ T cell receptor. Two of them used rye T cell receptor. The 13 of these T cell lines was CD4 positive. One line expressed CD8. One line expressed both CD4 and CD8. Moreover, 14 out of 15 lines expressed the Th-1 cytokine profile, characterized by interferon-γpositivity and IL-4 negativity. No Th-2 type cell line was generated. These data provide strong evidence in favor of the presence of autoreactive T cells in the rheumatoid arthritis pateints. What is the mechanism(s) that these autoreactive T cells attack self-target and whether these G1-specific, Th-1 type T cell lines can induce arthritis in immune deficiency mice are currently under investigation.

Comparison of plasma NSE, protein S-100b and EEG changes in traditional arrested-heart procedures and on-pump beating-heart procedures

Objective: To assess the cerebral injury in on-pump beating-heart procedures under mild hypothermia in comparison with traditional on-pump arrested-heart procedures under moderate hypothermia. Methods: Forty patients, 20 with congenital heart disease (CHD) and 20 of rheumatic heart disease (RHD) , were divided into 2 groups: Control group (group A, n =20) including 10 patients suffering from CHD as group Al and the left 10 from RHD as group A2; and experiment group (group B, n =20) which consisting of group B1 (10 with CHD) and group B2 (10 of RHD). The patients in group A underwent traditional arrested-heart procedures, and those in group B were operated on with beating-heart procedures. Arterial blood samples were collected at preoperation (time A) , 20 min after cardiopul-monary bypass (CPB) starting (time B) , 1 h after CPB (time C) and 24 h postoperation (time D) respectively. Plasma contents of neuron-specific enolase (NSE) and protein S-100b were measured with sensitive ELISA. All the patients received echoencephalography (EEG) before and 1 week after operation. Results: The plasma contents of protein S-lOOb were increased very significantly at time B, C and D in comparison with those at time A (P<0.01) , and that of patients in group Al was significantly higher than that in group B at time B (P < 0. 05 ). There was no significant difference at other time points. At time B, the plasma contents of NSE were significantly higher in group A than in group B, and in group Al and Bl than in group A2 and B2. What's more, at time B, the former fell back to their pre-operative levels, but the latter remained still higher levels than the preoperative ones ( P < 0.01). No significant difference was found in the abnormality rates of postoperative EEG between 2 groups. Conclusion: The perioperative plasma contents of NSE and protein S-100b are not significantly higher in group B than in group A. On-pump beating-heart procedures do not make more serious cerebral dysfunction than the traditional arrested-heart procedures.

Soil moisture drought detection and multi-temporal variability across China

Soil moisture droughts can trigger abnormal changes of material and energy cycles in the soil-vegetation-atmosphere system,leading to important effects on local ecosystem,weather,and climate.Drought detection and understanding benefit disaster alleviation,as well as weather and climate predictions based on the understanding the land-atmosphere interactions.We thus simulated soil moisture using land surface model CLM3.5 driven with observed climate in China,and corrected wet bias in soil moisture simulations via introducing soil porosity parameter into soil water parameterization scheme.Then we defined soil moisture drought to quantify spatiotemporal variability of droughts.Over the period from 1951 to 2008,40%of months(to the sum of 12×58)underwent droughts,with the average area of 54.6%of total land area of China's Mainland.The annual monthly drought numbers presented a significant decrease in arid regions,but a significant increase in semi-arid and semi-humid regions,a decrease in humid regions but not significant.The Mainland as a whole experienced an increasing drought trend,with77.3%of areal ratio of decrease to increase.The monthly droughts in winter were the strongest but the weakest in summer,impacting 54.3%and 8.4%total area of the Mainland,respectively.The drought lasting three months or more occurred mainly in the semi-arid and semi-humid regions,with probability>51.7%,even>77.6%,whereas those lasting 6 and 12 months or more impacted mainly across arid and semi-arid regions.

Effect of vegetation type, wetting intensity, and nitrogen supply on external carbon stimulated heterotrophic respiration and microbial biomass carbon in forest soils

By using packed soil-core incubation experiments, we have studied stimulating effects of addition of external carbon （C） （glu- cose, 6.4 g C m 2） on heterotrophic respiration and microbial biomass C of a mature broadleaf and Korean pine mixed forest （BKPF） and an adjacent white birch forest （WBF） soil under different wetting intensities （55% and 80% WFPS, water-filled pore space） and nitrogen （N） supply （NH4C1 and KNO3, 4.5 g N m-e） conditions. The results showed that for the control, the cumulative carbon dioxide （CO2） flux from WBF soil during the 15-day incubation ranged from 5.44 to 5.82 g CO2-C m-2, which was significantly larger than that from BKPF soil （2.86 to 3.36 g CO2-C m 2）. With increasing wetting intensity, the cumulative CO2 flux from the control was decreased for the WBF soil, whereas an increase in the CO2 flux was observed in the BKPF soil （P 〈 0.05）. The addition of NH4C1 or KNO3 alone significantly reduced the cumulative CO2 fluxes by 9.2%-21.6 % from the two soils, especially from WBF soil at low wetting intensity. The addition of glucose alone significantly increased soil heterotrophic respiration, microbial biomass C （MBC）, and microbial metabolic quotient. The glucose-induced cumulative CO2 fluxes and soil MBC during the incubation ranged from 8.7 to 11.7 g CO2-C m-2 and from 7.4 to 23.9 g C m-2, which are larger than the dose of added C. Hence, the addition of external carbon can increase the decomposition of soil native organic C. The glucose-induced average and maximum rates of CO2 fluxes during the incubation were significantly in- fluenced by wetting intensity （WI） and vegetation type （VT）, and by WIxVT, NH4ClxVT and WIxVTxNH4C1 （P〈0.05）. The addition of NH4C1, instead of KNO3, significantly decreased the glucose-induced MBC of WBF soil （P〈0.05）, whereas adding NH4C1 and KNO3 both significantly increased the glucose-induced MBC of BKPF soil at high moisture （P〈0.05）. According to the differences in soil labile C pools, MBC and CO2 fluxes in the presence and absence of glucose, it can be concluded that the stimulating effects of glucose on soil heterotrophic respiration and MBC under temperate forests were dependent on vegetation type, soil moisture, and amount and type of the N added.