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免疫调控关键分子miR-146b-5p在肿瘤进程中异质性作用 被引量:1
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作者 余思茗 白璐 +1 位作者 王立军 黄小义 《国际免疫学杂志》 CAS 2020年第6期691-696,共6页
MicroRNA(miRNA)通过抑制靶基因的表达而促进或抑制细胞的生理进程,对细胞生长、分化、运动和凋亡加以调控。miR-146b-5p(miR-146b)是miR-146家族成员之一,是固有免疫和适应性免疫中的关键调控因子,在肿瘤的发生发展中同样发挥至关重要... MicroRNA(miRNA)通过抑制靶基因的表达而促进或抑制细胞的生理进程,对细胞生长、分化、运动和凋亡加以调控。miR-146b-5p(miR-146b)是miR-146家族成员之一,是固有免疫和适应性免疫中的关键调控因子,在肿瘤的发生发展中同样发挥至关重要的作用。miR-146b在不同肿瘤的进程中发挥促癌或者抑癌等截然不同的作用,甚至在相同肿瘤中也可表现出明显的异质性作用,文章将对miR-146b在恶性肿瘤中作用的研究进展进行综述和讨论,为探究miR-146b对恶行肿瘤的确切作用提供新的研究思路,同时也为进一步研究miRNAs对肿瘤的调控机制提供理论基础。 展开更多
关键词 MICRORNA 肿瘤 靶基因 异质性作用
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ON THE DIFFERENCES OF THE NATURES OF AUPOINTS AND CHINESE HERBAL MEDICINES
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作者 李艳芬 庄礼兴 《World Journal of Acupuncture-Moxibustion》 2007年第1期41-45,共5页
The acupoints and Chinese herbal medicines are quite different in their natures. In the present paper, the authors expound the differences of the natures between the acupoints and Chinese herbal medicines from a) sub... The acupoints and Chinese herbal medicines are quite different in their natures. In the present paper, the authors expound the differences of the natures between the acupoints and Chinese herbal medicines from a) substance carriers, b) the underlying mechanism in actions, and c) individual characteristics, etc.. 展开更多
关键词 The nature of acupoints The nature of Chinese herbs Efficacy Differences
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人类白细胞抗原限制性遗传异质性药物毒副作用研究进展
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作者 王佳宁 王晓钰 +2 位作者 施婷婷 陈麟鑫 梅虎 《中国药学杂志》 CAS CSCD 北大核心 2021年第1期1-7,共7页
基因关联研究结果显示,遗传异质性药物毒副作用(idiosyncratic adverse drug reactions,IADRs)与人类白细胞抗原(human leukocyte antigen,HLA)基因家族密切相关。笔者现就近二十年来IADRs与HLA基因关联研究进展及p-i机制、肽库改变模型... 基因关联研究结果显示,遗传异质性药物毒副作用(idiosyncratic adverse drug reactions,IADRs)与人类白细胞抗原(human leukocyte antigen,HLA)基因家族密切相关。笔者现就近二十年来IADRs与HLA基因关联研究进展及p-i机制、肽库改变模型、TCR库改变模型机制进行综述,以期为个性化精准医疗及药物安全评价提供理论参考依据。 展开更多
关键词 遗传异质性药物毒副作用 人类白细胞抗原 机制
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Heterogeneity in supraglacial debris thickness and its role in glacier mass changes of the Mount Gongga 被引量:13
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作者 ZHANG Yong HIRABAYASHI Yukiko +2 位作者 FUJITA Koji LIU Shi Yin LIU Qiao 《Science China Earth Sciences》 SCIE EI CAS CSCD 2016年第1期170-184,共15页
In the Tibetan Plateau, many glaciers have extensive covers of supraglacial debris in their ablation zones, which affects glacier response to climate change by altering ice melting and spatial patterns of mass loss. I... In the Tibetan Plateau, many glaciers have extensive covers of supraglacial debris in their ablation zones, which affects glacier response to climate change by altering ice melting and spatial patterns of mass loss. Insufficient debris thickness data make it difficult to analyze regional debris-cover effects. Maritime glaciers of the Mount Gongga have been characterized by a substantial reduction in glacier area and ice mass in recent decades. The thermal property of the debris layer estimated from remotely sensed data reveals that debris-covered glaciers are dominant in this region, on which the proportion of debris cover to total glacier area varies from 1.74% to 53.0%. Using a physically-based debris-cover effect assessment model, we found that although the presence of supraglacial debris has a significant insulating effect on heavily debris-covered glaciers, il accelerates ice melting on -10.2% of total ablation zone and produces rapid wastage of -25% of the debris-covered glaciers, leading to the similar mass losses between the debris-covered and debris-free glaciers. Widespread debris cover also facilitates the development of active terminus regions. Regional differences in debris-cover effects are apparent, highlighting the im- portance of debris cover for understanding glacier mass changes in the Tibetan Plateau and other mountain ranges around the world. 展开更多
关键词 Debris-cover effect Ice melting Maritime glacier Glacier status Mount Gongga
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Achieving highly stable Sn-based anode by a stiff encapsulation heterostructure 被引量:2
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作者 Ruizhe Li Jijian Xu +2 位作者 Zhuoran Lv Wujie Dong Fuqiang Huang 《Science China Materials》 SCIE EI CAS CSCD 2022年第3期695-703,共9页
Rationally designed heterostructures provide attractive prospects for energy storage electrodes by combining different active materials with distinct electrochemical properties.Herein,through a phase separation strate... Rationally designed heterostructures provide attractive prospects for energy storage electrodes by combining different active materials with distinct electrochemical properties.Herein,through a phase separation strategy,a heterostructure of SnO_(2) encapsulated by amorphous Nb_(2)O_(5) is spontaneously synthesized.Insertion-type anode Nb_(2)O_(5) outer shell,playing as reaction containers and fast ionic pathways,physically inhibits the Sn atoms’migration and enhances the reaction kinetics.Moreover,strong chemical interactions are found at the SnO_(2)/Nb_(2)O_(5) interfaces,which ensure the solid encapsulation of the SnO_(2) cores even after 500 cycles.When used for lithium-ion batteries,this heterostructured anode exhibits high cycling stability with a capacity of 626 mAhg^(-1) after 1000 cycles at 2Ag^(-1)(85% capacity retention)and good rate performance with the capacity of 340 mAhg^(-1) at 8Ag^(-1). 展开更多
关键词 HETEROSTRUCTURE ENCAPSULATION SnO2/Nb2O5 interface chemical interaction atom migration
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Symmetry energy at subsaturation densities and the neutron skin thickness of ^(208)Pb 被引量:2
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作者 FAN XiaoHua DONG JianMin ZUO Wei 《Science China(Physics,Mechanics & Astronomy)》 SCIE EI CAS CSCD 2015年第6期81-85,共5页
The mass-dependent symmetry energy coefficients asym(A) has been extracted by analysing the heavy nuclear mass differences reducing the uncertainties as far as possible in our previous work. Taking advantage of the ... The mass-dependent symmetry energy coefficients asym(A) has been extracted by analysing the heavy nuclear mass differences reducing the uncertainties as far as possible in our previous work. Taking advantage of the obtained symmetry energy coefficient asym(A) and the density profiles obtained by switching off the Coulomb interaction in ^208Pb, we calculated the slope parameter L0.11 of the symmetry energy at the density of 0.11 fm^-3. The calculated L0.11 ranges from 40.5 MeV to 60.3 MeV. The slope parameter L0.11 of the symmetry energy at the density of 0.11 fm^-3 is also calculated directly with Skyrme interactions for nuclear matter and is found to have a fine linear relation with the neutron skin thickness of ^208spb, which is the difference of the neutron and proton rms radii of the nucleus. With the linear relation the neutron skin thickness ARnp of ^208spb is predicted to be 0.15-0.21 fm. 展开更多
关键词 nuclear matter symmetry energy neutron skin
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