To determine how the auto-antibodies (Abs) profiles overlap in chronic hepatitis C infection (CHC) and autoimmune hepatitis (AIH) and correlate to liver disease.METHODSLevels of antinuclear Ab, smooth muscle antibody ...To determine how the auto-antibodies (Abs) profiles overlap in chronic hepatitis C infection (CHC) and autoimmune hepatitis (AIH) and correlate to liver disease.METHODSLevels of antinuclear Ab, smooth muscle antibody (SMA) and liver/kidney microsomal-1 (LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune assays.RESULTSWe found that AIH patients had more severe liver disease as determined by elevation of total IgG, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies (auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total IgG. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1<sup>+</sup> Ab CHC cases showed best overlap with AIH.CONCLUSIONAuto-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other.展开更多
Background:Traditional vertical and side-alternating whole body vibrations(WBV) can effectively improve muscle power performance but have a limited efficacy for enhancing change-of-direction(COD) ability.Novel dual-pl...Background:Traditional vertical and side-alternating whole body vibrations(WBV) can effectively improve muscle power performance but have a limited efficacy for enhancing change-of-direction(COD) ability.Novel dual-plate WBV uniquely providing various directions of movements with higher and distinctive frequencies for each leg may cause better acute effect on muscle power and stretch-shortening cycle efficacy contributing to COD ability.Therefore,the purpose of this study was to investigate the acute effect of dual-or single-frequency WBV on squat jumps(SJs),countermovement jumps(CMJs),eccentric utilization ratios(EURs),and COD ability in rugby players.Methods:Fourteen male rugby players were recruited and performed a 4 min partial squat with 3 types of WBV protocols on a dual-plate WBV machine,including 1 dual-frequency WBV protocol(DFW) with the dominant leg receiving 35 Hz and the non-dominant leg receiving 45 Hz,and2 single-frequency WBV protocols(SFWs) with 35 Hz or 45 Hz provided to both legs(SFW35Hz and SFW45Hz) on 3 different days.Results:The results showed that all the vibration protocols significantly improved SJ and CMJ performances(SJ:p = 0.008;CMJ:p < 0.001),but did not significantly change EURs(p > 0.05).In addition,only the DFW significantly improved COD ability(p = 0.001 for the pre–post comparison).Conclusion:A 4 min dual-frequency WBV session improved both vertical jumping and COD ability in rugby players,suggesting that this could be a potential warm-up protocol for athletes.展开更多
As a popular meshfree particle method,the smoothed particle hydrodynamics(SPH) has suffered from not being able to di-rectly implement the solid boundary conditions.This influences the SPH approximation accuracy and h...As a popular meshfree particle method,the smoothed particle hydrodynamics(SPH) has suffered from not being able to di-rectly implement the solid boundary conditions.This influences the SPH approximation accuracy and hinders its further de-velopment and application to engineering and scientific problems.In this paper,a coupled dynamic solid boundary treatment(SBT) algorithm has been proposed,after investigating the features of existing SPH SBT algorithms.The novelty of the cou-pled dynamic SBT algorithm includes a new repulsive force between approaching fluid and solid particles,and a new numeri-cal approximation scheme for estimating field functions of virtual solid particles.The new SBT algorithm has been examined with three numerical examples including a typical dam-break flow,a dam-break flow with a sharp-edged obstacle,and a water entry problem.It is demonstrated that SPH with this coupled dynamic boundary algorithm can lead to accurate results with smooth pressure field,and that the new SBT algorithm is also suitable for complex and even moving solid boundaries.展开更多
文摘To determine how the auto-antibodies (Abs) profiles overlap in chronic hepatitis C infection (CHC) and autoimmune hepatitis (AIH) and correlate to liver disease.METHODSLevels of antinuclear Ab, smooth muscle antibody (SMA) and liver/kidney microsomal-1 (LKM-1) Ab and markers of liver damage were determined in the sera of 50 patients with CHC infection, 20 AIH patients and 20 healthy controls using enzyme linked immunosorbent assay and other immune assays.RESULTSWe found that AIH patients had more severe liver disease as determined by elevation of total IgG, alkaline phosphatase, total serum bilirubin and serum transaminases and significantly higher prevalence of the three non-organ-specific autoantibodies (auto-Abs) than CHC patients. Antinuclear Ab, SMA and LKM-1 Ab were also present in 36% of CHC patients and related to disease severity. CHC cases positive for auto-Abs were directly comparable to AIH in respect of most markers of liver damage and total IgG. These cases had longer disease duration compared with auto-Ab negative cases, but there was no difference in gender, age or viral load. KLM-1<sup>+</sup> Ab CHC cases showed best overlap with AIH.CONCLUSIONAuto-Ab levels in CHC may be important markers of disease severity and positive cases have a disease similar to AIH. Auto-Abs might have a pathogenic role as indicated by elevated markers of liver damage. Future studies will unravel any novel associations between these two diseases, whether genetic or other.
文摘Background:Traditional vertical and side-alternating whole body vibrations(WBV) can effectively improve muscle power performance but have a limited efficacy for enhancing change-of-direction(COD) ability.Novel dual-plate WBV uniquely providing various directions of movements with higher and distinctive frequencies for each leg may cause better acute effect on muscle power and stretch-shortening cycle efficacy contributing to COD ability.Therefore,the purpose of this study was to investigate the acute effect of dual-or single-frequency WBV on squat jumps(SJs),countermovement jumps(CMJs),eccentric utilization ratios(EURs),and COD ability in rugby players.Methods:Fourteen male rugby players were recruited and performed a 4 min partial squat with 3 types of WBV protocols on a dual-plate WBV machine,including 1 dual-frequency WBV protocol(DFW) with the dominant leg receiving 35 Hz and the non-dominant leg receiving 45 Hz,and2 single-frequency WBV protocols(SFWs) with 35 Hz or 45 Hz provided to both legs(SFW35Hz and SFW45Hz) on 3 different days.Results:The results showed that all the vibration protocols significantly improved SJ and CMJ performances(SJ:p = 0.008;CMJ:p < 0.001),but did not significantly change EURs(p > 0.05).In addition,only the DFW significantly improved COD ability(p = 0.001 for the pre–post comparison).Conclusion:A 4 min dual-frequency WBV session improved both vertical jumping and COD ability in rugby players,suggesting that this could be a potential warm-up protocol for athletes.
基金supported by the National Natural Science Foundation of China (Grant Nos. 10942004, 11172306)the National Defense Innovation Funds of the Chinese Academy of Sciences (Grant No. Y175031XML)
文摘As a popular meshfree particle method,the smoothed particle hydrodynamics(SPH) has suffered from not being able to di-rectly implement the solid boundary conditions.This influences the SPH approximation accuracy and hinders its further de-velopment and application to engineering and scientific problems.In this paper,a coupled dynamic solid boundary treatment(SBT) algorithm has been proposed,after investigating the features of existing SPH SBT algorithms.The novelty of the cou-pled dynamic SBT algorithm includes a new repulsive force between approaching fluid and solid particles,and a new numeri-cal approximation scheme for estimating field functions of virtual solid particles.The new SBT algorithm has been examined with three numerical examples including a typical dam-break flow,a dam-break flow with a sharp-edged obstacle,and a water entry problem.It is demonstrated that SPH with this coupled dynamic boundary algorithm can lead to accurate results with smooth pressure field,and that the new SBT algorithm is also suitable for complex and even moving solid boundaries.
