Objective：To investigate the effect of Fufang Danshen pill on bone marrow stem mobilization during myocardial scathe. Methods：Rat models with expansionary myocardial disease were established by Pituitrin and Furazol...Objective：To investigate the effect of Fufang Danshen pill on bone marrow stem mobilization during myocardial scathe. Methods：Rat models with expansionary myocardial disease were established by Pituitrin and Furazolidone. Experimental rats were divided into the contrast group, the myocardial scathe group （MS group）, the myocardial scathe and Fufang Dansben pill group （ MS ＋ FD group） and the myocardial scathe and fluvastatin group （ MS ＋ FT group）. The ratio of CD34^＋ cells was examined at the 1^st, 3^nl and 6^th weekend. Index of heart structure and function including LVESD, LVEDD. LYEF, LVEDP and dp/dtmax were evaluated at the 6^th weekend. The HW/BW index was calculated. Results：In the MS group, the index of HW/BW, LVESD, LVEDD and LVEDP were obviously increased （P 〈 0.01 ） and index of dp/ dtmax and LVEF were obviously decreased （P 〈 0.05 ）. The ratio of CD34^＋ cells was significantly improved at the 1^at weekend and then reduced slowly with no difference from that of the contrast group at the 6th weekend. Compared the MS ＋ FD group and the MS ＋ FT group with the MS group, the index of HW/BW, LYESD, LYEDD and LYEDP of were signifi cantly decreased （ P 〈 0.05 ） and index of dp/dtmax and LVEF were increased （P 〈 0.01 ）. The ratio of CD34^＋ cells was significantly higher at the 1^st, 3^nl and 6^th weekend, but had no statistic meaning at 3^nl and 6^th weekend （P 〉 0.05 ）. Conclusion：Pituitrin and Furazolidone can be used to establish rat models with expansionary myocardial disease. There has bone marrow stem mobilization during the early period of myocardial scathe. Fufang Danshen pill has effect on improving bone marrow stem mobilization, lightening the expansionary degree of heart and protecting the heart function. The effect of Fufang Danshen pill is as same as that of fluvastatin.展开更多
Bleeding from esophageal varices (EVs) is a catastrophic complication of chronic liver disease. Many years ago, surgical procedures such as esophageal transection or distal splenorenal shunting were the only treatment...Bleeding from esophageal varices (EVs) is a catastrophic complication of chronic liver disease. Many years ago, surgical procedures such as esophageal transection or distal splenorenal shunting were the only treatments for EVs. In the 1970s, interventional radiology procedures such as transportal obliteration, left gastric artery embolization, and partial splenic artery embolization were introduced, improving the survival of patients with bleeding EVs. In the 1980s, endoscopic treatment, endoscopic injection sclerotherapy (EIS), and endoscopic variceal ligation (EVL), further contributed to improved survival. We combined IVR with endoscopic treatment or EIS with EVL. Most patients with EVs treated endoscopically required follow- up treatment for recurrent varices. Proper management of recurrent EVs can significantly improve patients’ quality of life. Recently, we have performed EVL at 2-mo (bimonthly) intervals for the management of EVs. Longer intervals between treatment sessions resulted in a higher rate of total eradication and lower rates of recurrence and additional treatment.展开更多
A dynamically positioned vessel, by the International Maritime Organization （IMO） and the certifying class societies （DNV, ABS, LR, etc.）, is defined as a vessel that maintains its position and heading （fixed loc...A dynamically positioned vessel, by the International Maritime Organization （IMO） and the certifying class societies （DNV, ABS, LR, etc.）, is defined as a vessel that maintains its position and heading （fixed location or pre-determined track） exclu- sively by means of active thrusters. The development of control technology promotes the upgrading of dynamic positioning （DP） systems. Today there are two different DP systems solutions available on the market： DP system based on PID regulator and that based on model-based control. Both systems have limited disturbance rejection capability due to their design principle. In this paper, a new DP system solution is proposed based on Active Dis^n＇bance Rejection Control （ADRC） technology. This technology is com- posed of Tracking-Differentiator （TD）, Extended State Observer （ESO） and Nonlinear Feedback Combination. On one hand, both TD and ESO can act as filters and can be used in place of conventional filters; on the other hand, the total disturbance of the system can be estimated and compensated by ESO, which therefore enhances the system＇s disturbance rejection capability. This technology＇s advantages over other methods lie in two aspects： 1） This method itself can not only achieve control objectives but also filter noisy measurements without other specialized filters; 2） This method offers a new useful approach to suppress the ocean disturbance. The simulation results demonstrate the effectiveness of the proposed method.展开更多
The active reflector of FAST （ five-hundred-meter aperture spherical radio telescope） is suppor- ted by a ring beam and a cable-net structure, in which nodes are actively controlled to form series of real-time parab...The active reflector of FAST （ five-hundred-meter aperture spherical radio telescope） is suppor- ted by a ring beam and a cable-net structure, in which nodes are actively controlled to form series of real-time paraboloids. To ensure the security and stability of the supporting structure, tension must be monitored for some typical cables. Considering the stringent requirements in accuracy and long- term stability, magnetic flux sensor, vibrating wire strain gauge and fiber bragg grating strain gauge are screened for the cable tension monitoring of the supporting cable-net. Specifically, receivers of radio telescopes have strict restriction on electro magnetic interference （EMI） or radio frequency in- terference （RFI）. These three types of sensors are evaluated from the view of EMIfRFI. Firstly, these fundamentals are theoretically analyzed. Secondly, typical sensor signals are collected in the time and analyzed in the frequency domain, which shows the characteristic in the frequency domain. Finally, typical sensors are tested in an anechoic chamber to get the EMI levels. Theoretical analysis shows that Fiber Bragg Grating strain gauge itself will not lead to EMI/RFI. According to GJB151 A, frequency domain analysis and test results show that for the vibrating wire strain gauge and magnetic flux sensor themselves, testable EMIfRF1 levels are typically below the background noise of the ane- choic chamber. FAST finally choses these three sensors as the monitoring sensors of its cable ten- sion. The proposed study is also a reference to the monitoring equipment selection of other radio tele- scopes and large structures.展开更多
文摘Objective：To investigate the effect of Fufang Danshen pill on bone marrow stem mobilization during myocardial scathe. Methods：Rat models with expansionary myocardial disease were established by Pituitrin and Furazolidone. Experimental rats were divided into the contrast group, the myocardial scathe group （MS group）, the myocardial scathe and Fufang Dansben pill group （ MS ＋ FD group） and the myocardial scathe and fluvastatin group （ MS ＋ FT group）. The ratio of CD34^＋ cells was examined at the 1^st, 3^nl and 6^th weekend. Index of heart structure and function including LVESD, LVEDD. LYEF, LVEDP and dp/dtmax were evaluated at the 6^th weekend. The HW/BW index was calculated. Results：In the MS group, the index of HW/BW, LVESD, LVEDD and LVEDP were obviously increased （P 〈 0.01 ） and index of dp/ dtmax and LVEF were obviously decreased （P 〈 0.05 ）. The ratio of CD34^＋ cells was significantly improved at the 1^at weekend and then reduced slowly with no difference from that of the contrast group at the 6th weekend. Compared the MS ＋ FD group and the MS ＋ FT group with the MS group, the index of HW/BW, LYESD, LYEDD and LYEDP of were signifi cantly decreased （ P 〈 0.05 ） and index of dp/dtmax and LVEF were increased （P 〈 0.01 ）. The ratio of CD34^＋ cells was significantly higher at the 1^st, 3^nl and 6^th weekend, but had no statistic meaning at 3^nl and 6^th weekend （P 〉 0.05 ）. Conclusion：Pituitrin and Furazolidone can be used to establish rat models with expansionary myocardial disease. There has bone marrow stem mobilization during the early period of myocardial scathe. Fufang Danshen pill has effect on improving bone marrow stem mobilization, lightening the expansionary degree of heart and protecting the heart function. The effect of Fufang Danshen pill is as same as that of fluvastatin.
文摘Bleeding from esophageal varices (EVs) is a catastrophic complication of chronic liver disease. Many years ago, surgical procedures such as esophageal transection or distal splenorenal shunting were the only treatments for EVs. In the 1970s, interventional radiology procedures such as transportal obliteration, left gastric artery embolization, and partial splenic artery embolization were introduced, improving the survival of patients with bleeding EVs. In the 1980s, endoscopic treatment, endoscopic injection sclerotherapy (EIS), and endoscopic variceal ligation (EVL), further contributed to improved survival. We combined IVR with endoscopic treatment or EIS with EVL. Most patients with EVs treated endoscopically required follow- up treatment for recurrent varices. Proper management of recurrent EVs can significantly improve patients’ quality of life. Recently, we have performed EVL at 2-mo (bimonthly) intervals for the management of EVs. Longer intervals between treatment sessions resulted in a higher rate of total eradication and lower rates of recurrence and additional treatment.
基金The support of the National Nature Science Foundation of China(Nos.61074053 and 61374114)the Applied Basic Research Program of Ministry of Transport of China(No.2011-329-225-390)are gratefully acknowledged
文摘A dynamically positioned vessel, by the International Maritime Organization （IMO） and the certifying class societies （DNV, ABS, LR, etc.）, is defined as a vessel that maintains its position and heading （fixed location or pre-determined track） exclu- sively by means of active thrusters. The development of control technology promotes the upgrading of dynamic positioning （DP） systems. Today there are two different DP systems solutions available on the market： DP system based on PID regulator and that based on model-based control. Both systems have limited disturbance rejection capability due to their design principle. In this paper, a new DP system solution is proposed based on Active Dis^n＇bance Rejection Control （ADRC） technology. This technology is com- posed of Tracking-Differentiator （TD）, Extended State Observer （ESO） and Nonlinear Feedback Combination. On one hand, both TD and ESO can act as filters and can be used in place of conventional filters; on the other hand, the total disturbance of the system can be estimated and compensated by ESO, which therefore enhances the system＇s disturbance rejection capability. This technology＇s advantages over other methods lie in two aspects： 1） This method itself can not only achieve control objectives but also filter noisy measurements without other specialized filters; 2） This method offers a new useful approach to suppress the ocean disturbance. The simulation results demonstrate the effectiveness of the proposed method.
基金Supported by the National Natural Science Foundation of China(No.11173035,11273036,11303059)
文摘The active reflector of FAST （ five-hundred-meter aperture spherical radio telescope） is suppor- ted by a ring beam and a cable-net structure, in which nodes are actively controlled to form series of real-time paraboloids. To ensure the security and stability of the supporting structure, tension must be monitored for some typical cables. Considering the stringent requirements in accuracy and long- term stability, magnetic flux sensor, vibrating wire strain gauge and fiber bragg grating strain gauge are screened for the cable tension monitoring of the supporting cable-net. Specifically, receivers of radio telescopes have strict restriction on electro magnetic interference （EMI） or radio frequency in- terference （RFI）. These three types of sensors are evaluated from the view of EMIfRFI. Firstly, these fundamentals are theoretically analyzed. Secondly, typical sensor signals are collected in the time and analyzed in the frequency domain, which shows the characteristic in the frequency domain. Finally, typical sensors are tested in an anechoic chamber to get the EMI levels. Theoretical analysis shows that Fiber Bragg Grating strain gauge itself will not lead to EMI/RFI. According to GJB151 A, frequency domain analysis and test results show that for the vibrating wire strain gauge and magnetic flux sensor themselves, testable EMIfRF1 levels are typically below the background noise of the ane- choic chamber. FAST finally choses these three sensors as the monitoring sensors of its cable ten- sion. The proposed study is also a reference to the monitoring equipment selection of other radio tele- scopes and large structures.
