Copper(Ⅱ)-ferron(7-iodo-8-hydroxyquinoline-5-sulfonate) one-dimensional coordination polymer Na 2 n [Cu(Ferron) 2] n ·6 n H 2O was synthesized and investigated by X-ray diffraction method. The polymer exhibits a...Copper(Ⅱ)-ferron(7-iodo-8-hydroxyquinoline-5-sulfonate) one-dimensional coordination polymer Na 2 n [Cu(Ferron) 2] n ·6 n H 2O was synthesized and investigated by X-ray diffraction method. The polymer exhibits a linear structure by the bis-iodine-axial coordination to the octahedral Cu(Ⅱ) center,which is stabilized by the iodine-aromatic ring(edge and face) and iodine-iodine interactions between the polymer lines,forming a special layer structure. The complex belongs to a triclinic system,space group P 1, a =0.648 4(19) nm, b =0.654 5(19) nm, c =1.911(6) nm, α=85.42(5)°,β=85.78(5)°,γ=72.99(4)°,V =0.772(4) nm 3 and Z=1 .展开更多
目的:探讨血必净注射液对脓毒症早期肺组织损伤的影响及其可能作用机制,为临床脓毒症时急性肺损伤的治疗提供新思路。方法:选用健康雄性S-D大鼠30只,随机分3组,即假手术组(Sham组)、盐水组(NS组)和血必净组(XBJ组)。应用盲肠结扎穿孔法(...目的:探讨血必净注射液对脓毒症早期肺组织损伤的影响及其可能作用机制,为临床脓毒症时急性肺损伤的治疗提供新思路。方法:选用健康雄性S-D大鼠30只,随机分3组,即假手术组(Sham组)、盐水组(NS组)和血必净组(XBJ组)。应用盲肠结扎穿孔法(CLP)建立脓毒症大鼠模型,术后6 h处死动物,通过HE染色光镜观察组织形态学改变及透射电镜观察肺组织超微结构,测定各组肺组织湿干重比,采用RT-PCR检测肺组织内皮素-1(ET-1)、诱导型一氧化氮合酶(iNOS)、基质金属蛋白酶-9(MMP-9)、组织金属蛋白酶抑制物-1(TIMP-1)mRNA的表达。结果:XBJ组肺泡及肺间质水肿和内皮细胞超微结构改变均较NS组明显减轻。术后6 h,NS组大鼠肺组织湿干重比(W/D)显著高于Sham组(5.37±0.12 vs 4.33±0.06,P<0.01),XBJ组肺组织W/D较NS组显著降低(4.67±0.09 vs 5.37±0.12,P<0.05)。此外,XBJ组大鼠肺组织ET-1(0.511±0.111 vs 0.705±0.122,P<0.01)、iNOS(0.456±0.075 vs 0.548±0.098,P<0.05),MMP-9(0.617±0.079 vs 0.732±0.131,P<0.05)、TIMP-1(0.438±0.043vs 0.515±0.049,P<0.01)mRNA的表达均较NS组明显降低,而NS组大鼠肺组织ET-1(0.705±0.122 vs 0.400±0.033,P<0.01)、iNOS(0.548±0.098 vs 0.334±0.027,P<0.01)、MMP-9(0.732±0.131 vs 0.352±0.061,P<0.01)、TIMP-1mRNA(0.515±0.049 vs 0.365±0.068,P<0.01)水平均较Sham组明显升高。结论:血必净治疗对脓毒症大鼠的肺组织损伤有一定的保护作用,可能与其降低肺组织ET-1、iNOS、MMP-9、TIMP-1的表达有关。展开更多
文摘Copper(Ⅱ)-ferron(7-iodo-8-hydroxyquinoline-5-sulfonate) one-dimensional coordination polymer Na 2 n [Cu(Ferron) 2] n ·6 n H 2O was synthesized and investigated by X-ray diffraction method. The polymer exhibits a linear structure by the bis-iodine-axial coordination to the octahedral Cu(Ⅱ) center,which is stabilized by the iodine-aromatic ring(edge and face) and iodine-iodine interactions between the polymer lines,forming a special layer structure. The complex belongs to a triclinic system,space group P 1, a =0.648 4(19) nm, b =0.654 5(19) nm, c =1.911(6) nm, α=85.42(5)°,β=85.78(5)°,γ=72.99(4)°,V =0.772(4) nm 3 and Z=1 .
文摘目的:探讨血必净注射液对脓毒症早期肺组织损伤的影响及其可能作用机制,为临床脓毒症时急性肺损伤的治疗提供新思路。方法:选用健康雄性S-D大鼠30只,随机分3组,即假手术组(Sham组)、盐水组(NS组)和血必净组(XBJ组)。应用盲肠结扎穿孔法(CLP)建立脓毒症大鼠模型,术后6 h处死动物,通过HE染色光镜观察组织形态学改变及透射电镜观察肺组织超微结构,测定各组肺组织湿干重比,采用RT-PCR检测肺组织内皮素-1(ET-1)、诱导型一氧化氮合酶(iNOS)、基质金属蛋白酶-9(MMP-9)、组织金属蛋白酶抑制物-1(TIMP-1)mRNA的表达。结果:XBJ组肺泡及肺间质水肿和内皮细胞超微结构改变均较NS组明显减轻。术后6 h,NS组大鼠肺组织湿干重比(W/D)显著高于Sham组(5.37±0.12 vs 4.33±0.06,P<0.01),XBJ组肺组织W/D较NS组显著降低(4.67±0.09 vs 5.37±0.12,P<0.05)。此外,XBJ组大鼠肺组织ET-1(0.511±0.111 vs 0.705±0.122,P<0.01)、iNOS(0.456±0.075 vs 0.548±0.098,P<0.05),MMP-9(0.617±0.079 vs 0.732±0.131,P<0.05)、TIMP-1(0.438±0.043vs 0.515±0.049,P<0.01)mRNA的表达均较NS组明显降低,而NS组大鼠肺组织ET-1(0.705±0.122 vs 0.400±0.033,P<0.01)、iNOS(0.548±0.098 vs 0.334±0.027,P<0.01)、MMP-9(0.732±0.131 vs 0.352±0.061,P<0.01)、TIMP-1mRNA(0.515±0.049 vs 0.365±0.068,P<0.01)水平均较Sham组明显升高。结论:血必净治疗对脓毒症大鼠的肺组织损伤有一定的保护作用,可能与其降低肺组织ET-1、iNOS、MMP-9、TIMP-1的表达有关。
