目的探究强志组方治疗多发性抽动症(TS)复合恐惧行为的作用机制。方法腹腔注射亚氨基二丙腈(IDPN)建立TS大鼠模型后,进一步声电刺激建立TS复合恐惧大鼠模型,给予不同药物灌胃治疗后,采用旷场试验、行为学检测大鼠行为变化,高效液相法(HP...目的探究强志组方治疗多发性抽动症(TS)复合恐惧行为的作用机制。方法腹腔注射亚氨基二丙腈(IDPN)建立TS大鼠模型后,进一步声电刺激建立TS复合恐惧大鼠模型,给予不同药物灌胃治疗后,采用旷场试验、行为学检测大鼠行为变化,高效液相法(HPLC)检测脑组织中多巴胺(DA)的含量,免疫组织化学法检测酪氨酸羟化酶(TH)的含量,RT-PCR检测TH m RNA的表达。结果与正常对照组相比,模型对照组刻板行为、运动行为增加,冻结时间延长,脑组织中DA、TH、TH m RNA含量无明显变化;与模型对照组相比,强志组方组刻板行为、运动行为减少,冻结时间缩短,脑组织中DA、TH、TH m RNA含量减少。结论强志组方可改善模型大鼠抽动复合恐惧行为,其作用机制可能是通过下调TH m RNA表达,降低TH含量,减少DA合成实现的。展开更多
Moving object detection in video surveillance is an important step. This paper addresses an automatic object detection algorithm based on spatio-temporal compensation for video surveillance. Temporal difference of the...Moving object detection in video surveillance is an important step. This paper addresses an automatic object detection algorithm based on spatio-temporal compensation for video surveillance. Temporal difference of the pairs of two frames with a k-frame distance is utilized to obtain coarse object masks. Usually, object regions in these coarse masks have discontinuous boundaries and some holes. Region growing with the distance constraint is proposed to compensate these coarse object regions in spatial domain, followed by filling holes. The added distance constraint can prevent object regions from growing infinitely. The proposed filling holes method is simple and effective. To solve the temporarily stopping problem of moving objects, temporal compensation is proposed to compensate the object mask by utilizing temporal coherence of moving objects in temporal domain. The proposed detection algorithm can extract moving objects as completely as possible. Experimental results have successfully demonstrated the validity of the proposed algorithm.展开更多
OBJECTIVE:To analyze the distinctive pathological characteristics in the spectrums of spontaneous infrared radiation at the Taiyuan(LU 9) acupoint in patients with asthma.METHODS:A highly sensitive infrared spectrum d...OBJECTIVE:To analyze the distinctive pathological characteristics in the spectrums of spontaneous infrared radiation at the Taiyuan(LU 9) acupoint in patients with asthma.METHODS:A highly sensitive infrared spectrum detecting device was used to detect the spectrums of spontaneous infrared radiation at Taiyuan(LU 9) in 37 asthma patients and 34 healthy volunteers.RESULTS:Asthma patients had significantly lower infrared intensity than that of the healthy volunteers(P>0.01).Asthma patients had significantly lower overall infrared radiation intensity at the left Taiyuan(LU 9) than that of healthy volunteers(P>0.05),but there was no significant difference between healthy volunteers and asthma patients at the right Taiyuan(LU 9)(P>0.05).The infrared radiation intensity of 17 wavelength spots at the left Taiyuan(LU 9) and 4 wavelength spots at the right Taiyuan(LU 9) in asthma patients were significantly lower than those of healthy volunteers(P>0.05).At 2 μm,the infrared radiation intensity of asthma patients was significantly stronger than that of healthy volunteers(P>0.05).At 19 wavelength spots in the healthy volunteers and at 4 wavelength spots in the asthma patients,the left Taiyuan(LU 9) showed a significantly stronger intensity than that of the right Taiyuan(LU 9)(P>0.05).By Pearson's χ2 test,healthy volunteers had more wavelength spots that were significantly different between the left and right Taiyuan(LU 9) than the asthma patients(P>0.01).CONCLUSION:Changes in the infrared spectrum at the Taiyuan(LU 9) acupoint in asthma patients may reflect distinct pathological changes.Certain acupuncture points may be related to specific organs.展开更多
文摘目的探究强志组方治疗多发性抽动症(TS)复合恐惧行为的作用机制。方法腹腔注射亚氨基二丙腈(IDPN)建立TS大鼠模型后,进一步声电刺激建立TS复合恐惧大鼠模型,给予不同药物灌胃治疗后,采用旷场试验、行为学检测大鼠行为变化,高效液相法(HPLC)检测脑组织中多巴胺(DA)的含量,免疫组织化学法检测酪氨酸羟化酶(TH)的含量,RT-PCR检测TH m RNA的表达。结果与正常对照组相比,模型对照组刻板行为、运动行为增加,冻结时间延长,脑组织中DA、TH、TH m RNA含量无明显变化;与模型对照组相比,强志组方组刻板行为、运动行为减少,冻结时间缩短,脑组织中DA、TH、TH m RNA含量减少。结论强志组方可改善模型大鼠抽动复合恐惧行为,其作用机制可能是通过下调TH m RNA表达,降低TH含量,减少DA合成实现的。
基金National Natural Science Foundation of China (No.60502034)
文摘Moving object detection in video surveillance is an important step. This paper addresses an automatic object detection algorithm based on spatio-temporal compensation for video surveillance. Temporal difference of the pairs of two frames with a k-frame distance is utilized to obtain coarse object masks. Usually, object regions in these coarse masks have discontinuous boundaries and some holes. Region growing with the distance constraint is proposed to compensate these coarse object regions in spatial domain, followed by filling holes. The added distance constraint can prevent object regions from growing infinitely. The proposed filling holes method is simple and effective. To solve the temporarily stopping problem of moving objects, temporal compensation is proposed to compensate the object mask by utilizing temporal coherence of moving objects in temporal domain. The proposed detection algorithm can extract moving objects as completely as possible. Experimental results have successfully demonstrated the validity of the proposed algorithm.
基金Supported by the National Basic Research Program of China(2009CB522901)Key Project of State Administration of Traditional Chinese Medicine of ChinaShanghai Municipal Science Foundation(11DZ1973300,11ZR1436700, 10QA1406400)
文摘OBJECTIVE:To analyze the distinctive pathological characteristics in the spectrums of spontaneous infrared radiation at the Taiyuan(LU 9) acupoint in patients with asthma.METHODS:A highly sensitive infrared spectrum detecting device was used to detect the spectrums of spontaneous infrared radiation at Taiyuan(LU 9) in 37 asthma patients and 34 healthy volunteers.RESULTS:Asthma patients had significantly lower infrared intensity than that of the healthy volunteers(P>0.01).Asthma patients had significantly lower overall infrared radiation intensity at the left Taiyuan(LU 9) than that of healthy volunteers(P>0.05),but there was no significant difference between healthy volunteers and asthma patients at the right Taiyuan(LU 9)(P>0.05).The infrared radiation intensity of 17 wavelength spots at the left Taiyuan(LU 9) and 4 wavelength spots at the right Taiyuan(LU 9) in asthma patients were significantly lower than those of healthy volunteers(P>0.05).At 2 μm,the infrared radiation intensity of asthma patients was significantly stronger than that of healthy volunteers(P>0.05).At 19 wavelength spots in the healthy volunteers and at 4 wavelength spots in the asthma patients,the left Taiyuan(LU 9) showed a significantly stronger intensity than that of the right Taiyuan(LU 9)(P>0.05).By Pearson's χ2 test,healthy volunteers had more wavelength spots that were significantly different between the left and right Taiyuan(LU 9) than the asthma patients(P>0.01).CONCLUSION:Changes in the infrared spectrum at the Taiyuan(LU 9) acupoint in asthma patients may reflect distinct pathological changes.Certain acupuncture points may be related to specific organs.
