04062 Remicade在美国获准用于治疗关节强硬性脊椎炎

Centocor公司的抗TNF药物Remicade(infliximab)(Ⅰ)，已经在美国获得批准用于治疗附加适应症关节强硬性脊椎炎。但是，它的标签也被更新以警告有发生肺炎和肝脏毒性的危险。

NICE关于关节强硬性脊椎炎治疗指导原则的最终决定

英国NICE（国家卫生和临床优选机构）在它的最终指导原则中明确，Abbott公司的Humira（adalimumab）和Wyeth公司的Enbrel（etanercept）在英格兰和威尔士可用于治疗严重活动期关节强硬性脊椎炎，但对Schering—Plough公司的Remicade（infliximab）亮了红灯。

幼年型强直性脊柱炎

幼年型强直性脊柱炎是一独立的结缔组织病，因缺乏特异性诊断标准，常被误诊。近年来，随着基因诊断学的发展和临床观察的深入，关于此病的概念、流行病学特点、病因及实验室诊断，都取得了可喜的进展。本文重点对此进行综述。

基于强酸性氧化离子水技术的大米黄曲霉毒素降解机理的研究

针对连续煮饭机开发的需要 ,对污染了黄曲霉毒素B1的大米用强酸性氧化离子水进行降解、脱毒试验 ,经强酸性氧化离子水洗涤后的大米能有效地降解黄曲霉毒素B1,同时经过对强酸性氧化离子水洗涤后的大米进行氧化还原处理后 ,大米的构质不会受到太大的影响。在试验的基础上 ,对强酸性氧化离子水降解黄曲霉毒素B1的机理进行了初步的探讨。

强直性脊柱炎的早期诊断及康复

强直性脊柱炎(AS)早期病人48例,男45例,女3例,发病年龄11～35岁。主要临床表现为腰骶部疼痛、僵硬30例,四肢关节受累19例,腰及臀部疼痛9例,腰椎压痛35例,“4”字试验阳性40例,血沉增快25例,X 线检查异常者44例。女性及儿童 AS 病人骶髂关节 X 线改变出现较晚,早期容易误诊。对本病的早期诊断进行了探讨。本病治疗的关键在早期发现,在药物及物理治疗的基础上,功能锻炼及日常生活中保护良好姿势对预防或减轻畸形具有重要意义。

谈对中医治疗强直性脊柱炎的研究

文章对中医治疗强直性脊柱炎进行了全面的论述。

强直性脊柱炎

9940545 强直性脊柱炎:非HLA-B*27保护性作用的证据/van der Linden S∥Ann Rheum Dis.-1998,57(4).-263264 医科情 9940546 强直性脊柱炎患者肺炎克雷伯杆菌固氮酶原酶抗体[信]/Ahmadi K∥Ann Rheum Dis.-1998,57(7).-441

2003年风湿病的治疗药物

肌肉骨骼系统药物用于肌肉骨骼系统疾病和结缔组织疾患。本文介绍其 2 0 0 3年度最新统计的资料。在开发中的新药总计有 86个 ,其中 6 9个药物用来治疗类风湿性关节炎、5个用于青少年类风湿性关节炎、12个用于骨关节炎、4个用于牛皮癣关节炎、3个用于关节强硬性脊椎炎、6个用于全身性红斑狼疮、2个用于硬皮病、1个用于Sj¨ogren综合征和 1个用于急性痛风关节炎。本文扼要介绍以上 8种肌肉骨骼系统疾病的重点新药的研制者、靶标、适应证和药物研究的发展阶段。

预算管理模式形成中的行为因素探析

从管理学原理的角度分析比较了强硬性预算模式和参与性预算模式的管理学理论基础和行为特征,指出了参与性预算的优越性,强调并分析了预算管理过程中的人的行为因素。

Effect of minor B addition on microstructure and properties of AlCoCrFeNi multi-compenent alloy

The influences of slight amount of B element on the microstructure and properties of AlCoCrFeNiBx high entropy alloys（x = 0,0.01,…,0.09 and 0.1,mole fraction） were investigated.The AlCoCrFeNi high entropy alloy exhibits equiaxed grain structures with obvious composition segregation.However,with the addition of B element,the alloys exhibit dendrite structures.Inside the dendrites,spinodal decomposition structure can be clearly observed.With the addition of B element,the crystal structures change from（B2 ＋ BCC） to（B2 ＋ BCC ＋ FCC） structures,and the hardness firstly increases from HV 486.7 to HV 502.4,then declines to HV 460.7（x ≥ 0.02）.The compressive fracture strength firstly shows a trend of increasing,and then declining（x ≥ 0.08）.The coercive forces and the specific saturation magnetizations of the alloys decrease as B addition contents increase,the decreasing coercive forces show a better soft magnetic behavior.

Anisotropic and temperature-dependent growth mechanism of S-phase precipitates in Al-Cu-Mg alloy in relation with GPB zones

By employing atomic-resolution imaging and first principles energy calculations, the growth behavior of S-phase precipitates in a high strength A1-Cu-Mg alloy was investigated. It is demonstrated that the nucleation and growth of the S-phase precipitate are rather anisotropic and temperature-dependent companying with low dimensional phase transformation. There are actually two types of Guinier-Preston （GP） zones that determine the formation mechanism of S-phase at high aging temperatures higher than 180 ℃. One is the precursors of the S-phase itself, the other is the structural units or the precursors of the well-known Guinier-Preston-Bagaryatsky （GPB） zones. At high temperatures the later GPB zone units may form around S-phase precipitate and cease its growth in the width direction, leading to the formation of rod-like S-phase crystals; whereas at low temperatures the S-phase precipitates develop without the interference with GPB zones, resulting in S-phase orecioitates with lath-like momhology.

酸性水的制备与应用

综述了新型功能水一强硬性水的性质、制备和应用 ,对 ,制备强酸性水的电解条件进行了研究 。

Experiments and modeling of double-peak precipitation hardening and strengthening mechanisms in Al-Zn-Mg alloy

The aim of the present work is to develop a model for simulating double-peak precipitation hardening kinetics in Al-Zn-Mg alloy with the simultaneous formation of different types of precipitates at elevated temperatures based on the modified Langer-Schwartz approach. The double aging peaks are present in the long time age-hardening curves of Al-Zn-Mg alloys. The physically-based model, while taking explicitly into account nucleation, growth, coarsening of the new phase precipitations and two strengthening mechanisms associated with particle-dislocation interaction （shearing and bypassing）, was used for the analysis of precipitates evolution and precipitation hardening during aging of Al-Zn-Mg alloy. Model predictions were compared with the measurements of Al-Zn-Mg alloy. The systematic and quantitative results show that the predicted hardness profiles of double peaks via adding a shape dependent parameter in the growth equation for growth and coarsening generally agree well with the measured ones. Two strengthening mechanisms associated with particle-dislocation interaction （shearing and bypassing） were considered operating simultaneously in view of the particle size-distribution. The transition from shearing to bypassing strengthening mechanism was found to occur at rather early stage of the particle growth. The bypassing was found to be the prevailing strengthening mechanism in the investigated alloys.

现代养生保健秘方:笑

“现代医学一向被指控为过分科技化与专注于疾病本身,然而它亦开始对情感与欢笑的治疗角色作出探究。”“笑之诊所”负责人罗伯特·浩登强调,笑是治病良药。他认为笑不但调节心率、平衡血压,而且拥有舒缓绷紧肌肉的功效。 一副灿烂的笑容,一个看似简单的面部运动,除了可以提高大脑所需的氧气和营养素,还能够改变情绪。“当我们感受压力时,我们体内自主神经系统的交感神经部分便会活动,这时。

现代保健秘方——笑

笑被誉为祛病解愁的灵丹妙药,已经不是什么新鲜事了。500多份科学研究报告表明,笑对人的生理和心理均有很大裨益,更是一种现代保健秘方。3年前,第一所“笑之诊所”在英国伯明翰诞生。

golimumab在它的第一个市场获准

Centocor（J＆J）和Schering—Plough公司的全人源化抗一TNF治疗药Simponi（golimumab）在它的第一个市场加拿大获准。它是一种一月皮下注射一次的产品，用于与甲氨蝶呤联用治疗中到重度类风湿关节炎（RA）；单独或与甲氨蝶呤联用治疗活动期牛皮癣性关节炎（APA）和用于活动期关节强硬性脊椎炎。预计会在今年下半年上市。这个产品将由西安杨森公司在中国推出。

Preparation and mechanical properties of in situ Al_2O_3/Al composites by adding NH_4AlO(OH)HCO_3

Aluminium matrix composite reinforced by Al2O3 particles was produced by adding NH4AlO（OH）HCO3 into molten aluminum.The mechanical properties and wear behavior of the as-fabricated composites were studied.The results show that during stirring γ-Al2O3 particles were formed via decomposition reaction of NH4AlO（OH）HCO3,and the distribution of Al2O3 particles is more uniform in the matrix aluminum than directly added Al2O3 into molten aluminum.The density and the hardness values of the as-fabricated composites increase with increasing the particle volume fraction,while the tensile strength of the composites decreases with increasing the volume fraction of the Al2O3 particles.The wear rate of the composites decreases with increasing the volume fraction of the particle and loading.The in situ formed Al2O3/Al composite by adding NH4AlO（OH）HCO3 shows more superior mechanical and wear behaviors than that prepared by directly adding Al2O3 particles.

Microstructure and mechanical properties of Ti−Nb−Fe−Zr alloys with high strength and low elastic modulus

Zr was added to Ti−Nb−Fe alloys to develop low elastic modulus and high strengthβ-Ti alloys for biomedical applications.Ingots of Ti−12Nb−2Fe−(2,4,6,8,10)Zr(at.%)were prepared by arc melting and then subjected to homogenization,cold rolling,and solution treatments.The phases and microstructures of the alloys were analyzed by optical microscopy,X-ray diffraction,and transmission electron microscopy.The mechanical properties were measured by tensile tests.The results indicate that Zr and Fe cause a remarkable solid-solution strengthening effect on the alloys;thus,all the alloys show yield and ultimate tensile strengths higher than 510 MPa and 730 MPa,respectively.Zr plays a weak role in the deformation mechanism.Further,twinning occurs in all the deformed alloys and is beneficial to both strength and plasticity.Ti−12Nb−2Fe−(8,10)Zr alloys with metastableβphases show low elastic modulus,high tensile strength,and good plasticity and are suitable candidate materials for biomedical implants.

Ductility and hardness of chloride cleaned AA6011/SiC_p composites

Theductility and hardness of AA6011/SiCp composites using NaCl, SnCl2, NH4Cl and PdCl2 as wetting reagents were investigated. SiCp was cleaned with the wetting reagents, and used as reinforcement in AA6011 alloy using the stir casting method. Ductility and hardness responses of the composites were measured using standard methods. Microstructural features were examined using scanning electron microscopy and the phases were determined with the help of an X-ray diffractometer. The results show that for all wetting agents, the increase in cleaning time leads to initial increase in ductility to a certain value, but a decrease afterwards with further increase in cleaning time. The best combination of hardness （BHN 57.88） and ductility （11.91%） was shown under conditions of 40 g/L SnCl2and cleaning time of 60 min. A minor formation of Al4C3was noted in diffraction patterns, indicating that the formation of deleterious precipitate was hindered by the cleaning process.

Microstructure, hardness evolution and thermal stability of binary Al-7Mg alloy processed by ECAP with intermediate annealing

A binary Al-7Mg alloy was processed by equal channel angular pressing （ECAP） at room temperature via route Bc, combined with intermediate annealing. After 6 passes, a high hardness of HV218 is achieved. Transmission electron microscopy （TEM） observations demonstrate that ECAP leads to a significant grain refinement and ultrafine grains down to 100-200 nm are developed after 5 or 6 passes. X-ray diffraction （XRD） analysis indicates that the major part of Mg atoms are in solid solution in the deformed material, and the possible strengthening effect of Mg solute atom clusters or precipitates is neglected. The high hardness of the 6 pass-treated materials comes mainly from grain boundary strengthening, which contributes about 41% to the total strength, while dislocations and Mg solid solution contribute about 24% and 35% to the remaining strength, respectively. Also, the thermal stability of this severely deformed material was investigated by hardness measurements. The material is relatively stable when annealed at a temperature lower than 250 ℃, while annealing at 300 ℃ leads to a rapid softening of the material.