强脊灸加电针合PT对脑瘫患儿粗大功能的疗效研究

目的观察强脊灸加电针合PT在改善小儿脑瘫粗大功能方面的有效作用。方法对参与研究的1~8岁80例患儿抽签法随机分为试验组(42例)和对照组(38例),两组均给予PT训练,试验组在PT训练基础上辨证选取头电针和体针以及督脉艾灸治疗。根据粗大运动功能量表于治疗前后进行评估并进行统计学分析。结果治疗6个月后试验组、对照组总有效率分别为92.9%、78.9%,试验组优于对照组(P<0.05)。结论在常规康复治疗的基础上加用强脊灸和电针与单纯常规PT治疗相比,更有助于提高脑瘫患儿运动功能。

Research Progress on Molecular Mechanism of Moxibustion in the Treatment of Ankylosing Spondylitis

As an important part of traditional Chinese medicine (TCM) nursing technology, moxibustion plays a unique role in improving the symptoms of ankylosing spondylitis (AS). The research on the mechanism of moxibustion intervention in AS mainly focuses on anti-inflammatory effects, immune regulation, bone metabolism regulation, intestinal flora regulation, and so on. Molecular medicine is of great significance to further clarify the mechanism of moxibustion intervention in AS. However, there are still some problems in the research on the molecular mechanism of moxibustion intervention in AS: the existing biomedical research methods only explore from a specific field and lack the exploration of moxibustion-targeted molecules based on biomedical network. In the future, the molecular network effect of moxibustion on AS can be discussed comprehensively and systematically with the help of omics technology and the construction of biological information interaction network between omics. The effect of moxibustion on upstream osteogenic transcription factors and related signaling pathways such as WNT, β-catenin, and BMP/Smads is not yet clear. Future research can focus on the relevant signal targets of bone reconstruction and clarify the mechanism of moxibustion against the new bone formation. In addition, there is a lack of research on the molecular mechanism of moxibustion in the treatment of AS from the perspective of metabolites. It is necessary to further explore the mechanism of moxibustion in the treatment of AS with the help of metabonomics technology.

MULTI-CENTER RANDOMIZED CONTROLLED TRIALS OF COMBINED TREATMENT OF VERTEBRAL ARTERY TYPE CERVICAL SPONDYLOSIS WITH ACUPUNCTURE AND MASSAGE

Objective.To evaluate the clinical value of synthetical therapy of acupuncture and massage for treating vertebral artery type cervical spondylosis （VACS）. Methods： In the present study, triple-center, single-blind, randomized and control methods were adopted. Qualified subjects were randomly assigned to three groups： acupuncture-massage （acu-mas） group, acupuncture group, and massage group （60 subjects in each group）. Bilateral Fengchi （风池 GB 20）, Jiaji （夹脊 EX-B 2, C4-7） and Baihui （百会 GV 20） ware punctured in combination with massage at the neck-shoulder and back region. The treatment was conducted once daily, 14 times altogether. Results. After treatment, of the 60 cases in each of acu-mas, acupuncture and massage groups, 28, 11 and 13 were cured, 13, 20 and 17 markedly effective, 12, 14 and 16 effective, and 7, 15 and 14 ineffective, with the total effective rates being 88.3%, 75.0% and 76.7% respectively. The therapeutic effect of acu-mas group was significantly superior to that of simple acupuncture and massage groups （P〈 0.05）. The scores of clinical symptoms and signs in 3 groups all declined significantly after treatment （ P〈 0.01 ）, and the score of symptoms of acu-mas was markedly lower than those of acupuncture and massage groups （P〈 0.05）. No significant differences were found among 3 groups in the score of clinical signs and between acupuncture and massage groups in the score of clinical symptoms （P〉0.05）. The time for producing therapeutic effects in acu-mas group was significantly shorter than those of acupuncture and massage groups （P〈0.01, 0.05）, meanng a faster of aou-mas group in producing clinical effect. No adverse events ware found in all the 3 groups. Conclusion： Acupuncture and massage are effective and safe in the treatment of VACS, and the therapeutic effect of acupuncture combined with massage is superior to that of simple acupuncture and simple massage therapy.

Moxibustion on Governor Vessel for ankylosing spondylitis due to kidney yang deficiency:a clinical controlled study

Objective： To observe the clinical effect of moxibustion on Governor Vessel for ankylosing spondylitis（AS） due to kidney yang deficiency.Methods： A total of 60 patients of AS due to kidney yang deficiency were randomly divided into a treatment group and a control group by random digital table, 30 cases in each group. Both of the two groups were treated by oral administration of Sulfasalazine tablets. Additionally, the treatment group was given moxibustion on Governor Vessel, and the control group was given sham moxibustion. The treatment was given once every other day, 4 weeks constituted one course, 2 courses in total. Before treatment, after 1-course and 2-course treatments, the quantified scores of traditional Chinese medicine（TCM） syndromes and the symptoms scores recommended by AS International Society [including Bath ankylosing spondylitis disease activity index（BASDAI）, visual analogue scale（VAS）, Bath ankylosing spondylitis functional index（BASFI） and Bath ankylosing spondylitis metrology index（BASMI）] were respectively observed and recorded, and the change of safety item was monitored. Results： After 1-course and 2-course treatments, the quantified scores of TCM syndromes were obviously improved than those before treatment in the two groups（P〈0.05）, and the score was improved better in the treatment group than that in the control group（P〈0.05）. In comparison within the group, there were no statistical differences between the scores after 1-course treatment and 2-course treatment in the two groups（P〈0.05）. After 1-course treatment, the items of the symptoms scores were improved than those before treatment in the two groups（P〉0.05）. After 2-course treatment, the therapeutic effect was more remarkable in the treatment group, with a statistical difference between the two groups（P〈0.05）. During treatment, no obvious abnormality in all safety items was noticed in the two groups. Conclusion： Moxibustion on Governor Vessel can effectively relieve the clinical symptoms of AS patients, without obvious adverse reaction.

Clinical Observation on Long Snake Moxibustion for Ankylosing Spondylitis

Objective： To observe the clinical effect of long snake moxibustion for ankylosing spondylitis （AS）. Methods： A total of 58 AS cases were randomized into a long snake moxibustion group and a Western medication group, 29 in each group. The cases in the former group received long snake moxibustion and Western medication, whereas cases in the latter group received Western medication alone. Results： The total effective rate in the long snake moxibustion group was 93.1%, versus 62.1% in the Western medication group, showing a statistical significance （P〈0.01）; after the treatment, the scores of Bath Ankylosing Spondylitis Disease Activity Index （BASDAI） and Bath Ankylosing Spondylitis Function Index （BASFI） were improved in both groups; however, the improvements of BASDAI and BASFI results in the long snake moxibustion group were more significant than those in the Western medication group （P〈0.05）. Conclusion： Long snake moxibustion and Western medication can significantly improve the clinical effect on AS, coupled with a remarkable effect in enhancing the patients＇ functions.