Energetic near-inertial internal waves (NlWs) were observed on the continental slope of the northern South China Sea in September 2008. Characteristics of the observed near-inertial waves were examined based on curr...Energetic near-inertial internal waves (NlWs) were observed on the continental slope of the northern South China Sea in September 2008. Characteristics of the observed near-inertial waves were examined based on current data recorded by a moored acoustic Doppler current profiler. Results of a simple slab model indicated that the NIWs were generated by the surface winds of Typhoon Hagupit. Following Hagupit's passage, the wave field was dominated by baroclinic NIWs. The near-inertial currents were surface-intensified with a maximum of 0.52 m/s but still reached 0.1 m/s at the depth of 210 m. Moreover, the near-inertial currents were clockwise-polarized and slightly elliptical. A depth-leading phase of the near- inertial currents was evident, which indicated downward energy propagation. However, the rotary vertical wavenumber spectra suggested that upward energy propagation also existed, which was consistent previous theoretical study. The frequency of the NIWs, modified by the positive background vorticity, was 0.714 2 cycles per day, which was 0.02f0 higher than the local inertial frequency (f0). The near-inertial kinetic energy evolved exponentially and had an e-folding timescale of about 3 days. The vertical phase and group velocity were estimated to be 10 and 2.1 m/h, respectively, corresponding to a vertical wavelength of 340 m. The NlWs were dominated by the second mode with a variance contribution of 〉50%, followed by the third mode, while the first mode was insignificant.展开更多
An experiment was conducted during Kharif seasons of 2009 and 2010 on sandy loam soil of West Bengal, India to evaluate the productivity and economic viability of maize + legume intercropping systems in additive as w...An experiment was conducted during Kharif seasons of 2009 and 2010 on sandy loam soil of West Bengal, India to evaluate the productivity and economic viability of maize + legume intercropping systems in additive as well as in replacement series with different row proportions. Maize (Zea rnays L.) cv. "Vijay" (composite), green gram (Vigna radiata L.) cv. "Samrat", black gram (Vigna mungo L.) cv. "Sarada", soybean (Glycine max L. Merril) cv. "PK 327" and peanut (Arachis hypogaea L.) cv. "JL 24", were tested in monoculture as well as in intercropping situations with 1:1 (additive series) and 1:2 ratios (replacement series). The result indicated that intercropped legumes improved the yield components of maize and offered some bonus yield. The highest maize grain yield (2,916.28 kg/ha) and maize equivalent yield (4,831.45 kg/ha) were recorded with maize + green gram (1:1) and maize + peanut (1:I), respectively. The values of all the competition functions were always greater than unity and maize + black gram (1:2) recorded the highest values of land equivalent ratio (1.433), area time equivalent ratio (1.374) and land equivalent coefficient (0.421). Maximum monetary advantage (Rs. 10,579.13) was found with maize + green gam (l:1). Maize + peanut (1:2) combination recorded the highest relative net return (2.01), net return (Rs. 28,523.08), benefit-cost ratio (2.76) ad per day return (Rs. 259.30).展开更多
A numerical model is presented to investigate the performance of homogeneous charge compression ignition(HCCI) engines fueled with ethanol. Two approaches are studied. On one hand, two-step reaction mechanisms with Ar...A numerical model is presented to investigate the performance of homogeneous charge compression ignition(HCCI) engines fueled with ethanol. Two approaches are studied. On one hand, two-step reaction mechanisms with Arrhenius reaction rates are implemented in combustion chemistry modeling. On the other hand, a reduced mechanism containing important reactions of ethanol involving heat release rate and reaction rates compatible with experimental data is employed. Since controls of combustion phenomenon and ignition timing are the main issues of these engines, the effects of inlet temperature and equivalence ratio as the controlling factors on the operating parameters such as ignition timing, burn duration, in-cylinder temperature and pressure of HCCI engines are explored. The results show that the maximum predicted pressures for thermodynamic model are about 71.3×10~5 Pa and 79.79×10~5 Pa, and for chemical kinetic model, they are about 71.48×10~5 Pa and 78.123×10~5 Pa, fairly comparable with corresponding experimental values of 72×10~5 Pa and 78.7×10~5 Pa. It is observed that increasing the initial temperature advances the ignition timing, decreases the burn duration and increases the peak temperature and pressure. Moreover, the maximum temperature and pressure are associated with richer mixtures.展开更多
The seismoacoustic analysis method has broad potential applications to source parameter estimation for near-surface explosion events such as industrial explosions and terrorist attacks.In this study,current models wer...The seismoacoustic analysis method has broad potential applications to source parameter estimation for near-surface explosion events such as industrial explosions and terrorist attacks.In this study,current models were improved by modifying the acoustic model and adopting the Bayesian Markov-chain-Monte-Carlo inversion method.The source parameters of near-surface small-yield chemical explosions were analyzed via the improved seismoacoustic analysis model and by the estimation accuracy of seismoacoustic joint inversion.Estimation and analysis results showed that the improved seismoacoustic analysis model considered ground shock coupling and the impact of explosion products ejecting from the surface so that the improved acoustic impulse relation was more consistent with the measured data than the Ford impulse relation.It is suitable for deep-burial,shallow-burial,and near-surface aerial explosions.Furthermore,trade-off relationships were declined through the application of the improved model to source parameter inversion for near-surface small-yield chemical explosions,and source parameter estimation accuracy was improved.展开更多
Inhalation of 222Rn progeny in the domestic environment contributes the greatest fraction of the natural radiation exposure to the public. The ultrafine activity of these progeny amounts up to about l 0 percent of the...Inhalation of 222Rn progeny in the domestic environment contributes the greatest fraction of the natural radiation exposure to the public. The ultrafine activity of these progeny amounts up to about l 0 percent of the total activity (attached and ultrafine), but is considered to yield about 50 percent of the total radiation dose. Therefore, measurements of ultrafine fraction are essential for the estimation of radiation dose. The current study presents measured data on the total equilibrium equivalent concentration (EEC) and ultrafine equilibrium equivalent concentration (EECUn), ultrafine fraction (fb), attached and unattached activity size distributions of radon progeny in the low ventilated rooms at Minia University, Minia city, Egypt. A screen diffusion battery was used for collection the ultrafine fraction and measuring the total activity concentration of radon progeny. The attached activity size distribution of 214pb is determined by using a low pressure cascade impactor. The EEC of radon progeny varied between 1.3 and 18.9 Bq/m3 with a mean value of 5.2 ± 0.48 Bq/m2. The mean activity thermodynamic diameter (AMTD) ofultrafine of radon progeny was determined to be 1.26 nm with relative mean geometric standard deviations (GSD) of 1.3. The ultrafine fraction of radon progeny, fb, has a range 0.01 to 0.21 with an average of 0.08 ± 0.03. A relative mean GSD of 2.7 was determined for attached 2Lapb at a mean active median aerodynamic diameter (AMD) of 350 nm. Based on the above experimental results, the deposition fractions have been evaluated in each air way generation through the human lung by applying a lung deposition model. The bronchial deposition efficiencies of particles in the size range of attached radon progeny were found to be lower than those of ultrafine progeny. The effect of radon progeny deposition by adult male has been also studied for various levels of physical exertion. The dose conversion factor has been discussed as a function of fb.展开更多
Let T(R) be a two-order upper matrix algebra over the semilocal ring R which is determined by R=F×F where F is a field such that CharF=0. In this paper, we prove that any Jordan automorphism of T(R) can be decomp...Let T(R) be a two-order upper matrix algebra over the semilocal ring R which is determined by R=F×F where F is a field such that CharF=0. In this paper, we prove that any Jordan automorphism of T(R) can be decomposed into a product of involutive, inner and diagonal automorphisms.展开更多
The Global and Regional Assimilation and Prediction System (GRAPES), a limited-area regional model, was used to simulate the onset of South China Sea summer monsoon. In view of the relatively insufficient information ...The Global and Regional Assimilation and Prediction System (GRAPES), a limited-area regional model, was used to simulate the onset of South China Sea summer monsoon. In view of the relatively insufficient information about the initial field in simulation predictions, the Advanced Microwave Sounding Unit-B (AMSU-B) data from a NOAA satellite were introduced to improve the initial values. By directly using the 3-dimensional variational data assimilation system of GRAPES, two schemes for assimilation tests were designed. In the design, Test 1 (T1) assimilates both sounding and AMSU-B data, and Test 2 (T2) assimilates only the conventional sounding data, before applying the model in simulation forecasts. Comparative experiments showed that the model was very sensitive to initial fields and successful in reproducing the monsoon onset, allocation of high- and low-level wind fields during the pentad of onset, and the northward advancement of the monsoon and monsoon rain bands. The scheme, however, simulated rainfall and the location of the subtropical high with deviations from observations. The simulated location of the subtropical high was more westward and northward and the simulated rainfall for the South China Sea was larger and covered a broader area.展开更多
To better assimilate Advanced TIROS Operational Vertical Sounder(ATOVS) radiance data and provide more accurate initial fields for a numerical model,two bias correction schemes are employed to correct the ATOVS radian...To better assimilate Advanced TIROS Operational Vertical Sounder(ATOVS) radiance data and provide more accurate initial fields for a numerical model,two bias correction schemes are employed to correct the ATOVS radiance data.The difference in the two schemes lies in the predictors use in air-mass bias correction.The predictors used in SCHEME 1 are all obtained from model first-guess,while those in SCHEME 2 are from model first-guess and radiance observations.The results from the two schemes show that after bias correction,the observation residual became smaller and closer to a Gaussian distribution.For both land and ocean data sets,the results obtained from SCHEME 1 are similar to those from SCHEME 2,which indicates that the predictors could be used in bias correction of ATOVS data.展开更多
Snow data collection systems in the western United States were originally designed to forecast water supply and may be subject to several sources of bias. In addition to climate change and weather modification effects...Snow data collection systems in the western United States were originally designed to forecast water supply and may be subject to several sources of bias. In addition to climate change and weather modification effects, site-specific effects may be introduced from vegetation changes, site physical changes, measurement technique, and sensor changes. This paper examines changes in Utah's snowpack conditions over the past decade compared with all previous measurement years, focusing on the 15 snow courses with the longest observational record within the state of Utah. Although patterns in snowpack data consistent with those that would be expected due to temperature h as greater declines at lower elevations and latitudes--were not identified, snow water equivalent decreased at sites with significant increases in vegetation coverage. Additionally, we provide a list of 22 snow courses in Utah that are best-suited for long-term climate analysis.展开更多
Based on some former studies of Chinese rural society, this paper summerizes the achievements and limitations of general Chinese rural studies and then proposes a social operation model in rural areas which is dominat...Based on some former studies of Chinese rural society, this paper summerizes the achievements and limitations of general Chinese rural studies and then proposes a social operation model in rural areas which is dominated by the squires. It uses some specific historical data and discoveries of feild sduty to further examine the profound influence of the squires on rural politcal construction in three different aspects: the model of clan and religion, the role as inter-mediator and the growth of basic armed forces. The study found that this special social group played a center role in Chinese rural political system from ancient to modem times, particularly, the research considers the decline of the squire society since the establishment of the new government in 1949. In the end, this paper points out the cultural guiding significance of this social model in the study to the rural construction in contemporay China by predicting the possiblity of renaissance展开更多
This study delved into the formulaic patterns of liver cancer treatment outlined in“The Complete Book of Good Tumor Prescriptions”and explored the action mechanisms of core traditional Chinese medicine(TCM)combinati...This study delved into the formulaic patterns of liver cancer treatment outlined in“The Complete Book of Good Tumor Prescriptions”and explored the action mechanisms of core traditional Chinese medicine(TCM)combinations.Initially,liver cancer treatment formulas were extracted from the aforementioned book,and Excel 2017 was employed for calculating the frequency,properties,and meridians associated with the TCMs.IBM SPSS Modeler 18.0 was utilized for the analysis of TCM association rules,and Cytoscape 3.7.2 was employed for the visualization of these rules.Subsequently,network pharmacology was utilized to analyze the action mechanisms of core TCM combinations,leveraging TCMSP,TCMID,Genecards,DAVID,and other databases.The results revealed the inclusion of 131 prescriptions encompassing 303 TCMs.The core TCMs predominantly comprised those invigorating blood circulation and removing blood stasis,clearing heat,and tonifying deficiencies.The flavor of the TCMs was chiefly bitter or pungent,with a prevailing cold property entering the liver and spleen meridians.Association analysis indicated that the support of Angelicae sinensis radix-Trionycis carapax was the highest.Network pharmacology predictions indicated that Angelicae sinensis radix-Trionycis carapax possessed 20 target genes associated with anti-liver cancer properties,including IL-6,MAPK3,and SRC.Gene survival analysis demonstrated high expression of MAPK3 and SRC in liver cancer patients,correlating with a poor prognosis.KEGG analysis identified major anti-liver cancer pathways for Angelicae sinensis radix-Trionycis carapax,encompassing the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.In summary,this study elucidated that TCMs for liver cancer treatment primarily consisted of invigorating blood circulation and removing blood stasis,antipyretic,and tonifying medicines.The core TCM pair,Angelicae sinensis radix-Trionycis carapax,appeared pivotal in this context.The underlying mechanism might involve the modulation of key genes,such as MAPK3 and SRC,and the regulation of pathways,including the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.展开更多
The Majorana neutrino mass matrix combines information from the neutrino masses and the leptonic mixing in the flavor basis. Its invariance under some transformation matrices indicates the existence of certain residua...The Majorana neutrino mass matrix combines information from the neutrino masses and the leptonic mixing in the flavor basis. Its invariance under some transformation matrices indicates the existence of certain residual symmetry. We offer an intuitive display of the structure of the Majorana neutrino mass matrix, using the whole set of the oscillation data. The structure is revealed depending on the lightest neutrino mass. We find that there are three regions with distinct characteristics of structure. A group effect and the μ-T exchange symmetry are observed. Six types of texture non-zeros are shown. Implications for flavor models are discussed.展开更多
基金Supported by the National Natural Science Foundation of China(Nos.U1133001,41030855,and 41376027)the National High Technology Research and Development Program of China(863 Program)(No.2013AA09A502)the NSFC-Shandong Joint Fund for Marine Science Research Centers(No.U1406401)
文摘Energetic near-inertial internal waves (NlWs) were observed on the continental slope of the northern South China Sea in September 2008. Characteristics of the observed near-inertial waves were examined based on current data recorded by a moored acoustic Doppler current profiler. Results of a simple slab model indicated that the NIWs were generated by the surface winds of Typhoon Hagupit. Following Hagupit's passage, the wave field was dominated by baroclinic NIWs. The near-inertial currents were surface-intensified with a maximum of 0.52 m/s but still reached 0.1 m/s at the depth of 210 m. Moreover, the near-inertial currents were clockwise-polarized and slightly elliptical. A depth-leading phase of the near- inertial currents was evident, which indicated downward energy propagation. However, the rotary vertical wavenumber spectra suggested that upward energy propagation also existed, which was consistent previous theoretical study. The frequency of the NIWs, modified by the positive background vorticity, was 0.714 2 cycles per day, which was 0.02f0 higher than the local inertial frequency (f0). The near-inertial kinetic energy evolved exponentially and had an e-folding timescale of about 3 days. The vertical phase and group velocity were estimated to be 10 and 2.1 m/h, respectively, corresponding to a vertical wavelength of 340 m. The NlWs were dominated by the second mode with a variance contribution of 〉50%, followed by the third mode, while the first mode was insignificant.
文摘An experiment was conducted during Kharif seasons of 2009 and 2010 on sandy loam soil of West Bengal, India to evaluate the productivity and economic viability of maize + legume intercropping systems in additive as well as in replacement series with different row proportions. Maize (Zea rnays L.) cv. "Vijay" (composite), green gram (Vigna radiata L.) cv. "Samrat", black gram (Vigna mungo L.) cv. "Sarada", soybean (Glycine max L. Merril) cv. "PK 327" and peanut (Arachis hypogaea L.) cv. "JL 24", were tested in monoculture as well as in intercropping situations with 1:1 (additive series) and 1:2 ratios (replacement series). The result indicated that intercropped legumes improved the yield components of maize and offered some bonus yield. The highest maize grain yield (2,916.28 kg/ha) and maize equivalent yield (4,831.45 kg/ha) were recorded with maize + green gram (1:1) and maize + peanut (1:I), respectively. The values of all the competition functions were always greater than unity and maize + black gram (1:2) recorded the highest values of land equivalent ratio (1.433), area time equivalent ratio (1.374) and land equivalent coefficient (0.421). Maximum monetary advantage (Rs. 10,579.13) was found with maize + green gam (l:1). Maize + peanut (1:2) combination recorded the highest relative net return (2.01), net return (Rs. 28,523.08), benefit-cost ratio (2.76) ad per day return (Rs. 259.30).
文摘A numerical model is presented to investigate the performance of homogeneous charge compression ignition(HCCI) engines fueled with ethanol. Two approaches are studied. On one hand, two-step reaction mechanisms with Arrhenius reaction rates are implemented in combustion chemistry modeling. On the other hand, a reduced mechanism containing important reactions of ethanol involving heat release rate and reaction rates compatible with experimental data is employed. Since controls of combustion phenomenon and ignition timing are the main issues of these engines, the effects of inlet temperature and equivalence ratio as the controlling factors on the operating parameters such as ignition timing, burn duration, in-cylinder temperature and pressure of HCCI engines are explored. The results show that the maximum predicted pressures for thermodynamic model are about 71.3×10~5 Pa and 79.79×10~5 Pa, and for chemical kinetic model, they are about 71.48×10~5 Pa and 78.123×10~5 Pa, fairly comparable with corresponding experimental values of 72×10~5 Pa and 78.7×10~5 Pa. It is observed that increasing the initial temperature advances the ignition timing, decreases the burn duration and increases the peak temperature and pressure. Moreover, the maximum temperature and pressure are associated with richer mixtures.
基金the National Natural Science Foundation of China(No.12072290).
文摘The seismoacoustic analysis method has broad potential applications to source parameter estimation for near-surface explosion events such as industrial explosions and terrorist attacks.In this study,current models were improved by modifying the acoustic model and adopting the Bayesian Markov-chain-Monte-Carlo inversion method.The source parameters of near-surface small-yield chemical explosions were analyzed via the improved seismoacoustic analysis model and by the estimation accuracy of seismoacoustic joint inversion.Estimation and analysis results showed that the improved seismoacoustic analysis model considered ground shock coupling and the impact of explosion products ejecting from the surface so that the improved acoustic impulse relation was more consistent with the measured data than the Ford impulse relation.It is suitable for deep-burial,shallow-burial,and near-surface aerial explosions.Furthermore,trade-off relationships were declined through the application of the improved model to source parameter inversion for near-surface small-yield chemical explosions,and source parameter estimation accuracy was improved.
文摘Inhalation of 222Rn progeny in the domestic environment contributes the greatest fraction of the natural radiation exposure to the public. The ultrafine activity of these progeny amounts up to about l 0 percent of the total activity (attached and ultrafine), but is considered to yield about 50 percent of the total radiation dose. Therefore, measurements of ultrafine fraction are essential for the estimation of radiation dose. The current study presents measured data on the total equilibrium equivalent concentration (EEC) and ultrafine equilibrium equivalent concentration (EECUn), ultrafine fraction (fb), attached and unattached activity size distributions of radon progeny in the low ventilated rooms at Minia University, Minia city, Egypt. A screen diffusion battery was used for collection the ultrafine fraction and measuring the total activity concentration of radon progeny. The attached activity size distribution of 214pb is determined by using a low pressure cascade impactor. The EEC of radon progeny varied between 1.3 and 18.9 Bq/m3 with a mean value of 5.2 ± 0.48 Bq/m2. The mean activity thermodynamic diameter (AMTD) ofultrafine of radon progeny was determined to be 1.26 nm with relative mean geometric standard deviations (GSD) of 1.3. The ultrafine fraction of radon progeny, fb, has a range 0.01 to 0.21 with an average of 0.08 ± 0.03. A relative mean GSD of 2.7 was determined for attached 2Lapb at a mean active median aerodynamic diameter (AMD) of 350 nm. Based on the above experimental results, the deposition fractions have been evaluated in each air way generation through the human lung by applying a lung deposition model. The bronchial deposition efficiencies of particles in the size range of attached radon progeny were found to be lower than those of ultrafine progeny. The effect of radon progeny deposition by adult male has been also studied for various levels of physical exertion. The dose conversion factor has been discussed as a function of fb.
文摘Let T(R) be a two-order upper matrix algebra over the semilocal ring R which is determined by R=F×F where F is a field such that CharF=0. In this paper, we prove that any Jordan automorphism of T(R) can be decomposed into a product of involutive, inner and diagonal automorphisms.
基金National 863 Special Project (2006AA01A123)Research on Interpretation Techniques for High-Resolution Numerical Prediction of Hunan ProvinceResearch on Rainstorm Forecast System with GRAPES and Its Application and Accessment in Hunan and Key Project of Science in Hunan (2008FJ1006)
文摘The Global and Regional Assimilation and Prediction System (GRAPES), a limited-area regional model, was used to simulate the onset of South China Sea summer monsoon. In view of the relatively insufficient information about the initial field in simulation predictions, the Advanced Microwave Sounding Unit-B (AMSU-B) data from a NOAA satellite were introduced to improve the initial values. By directly using the 3-dimensional variational data assimilation system of GRAPES, two schemes for assimilation tests were designed. In the design, Test 1 (T1) assimilates both sounding and AMSU-B data, and Test 2 (T2) assimilates only the conventional sounding data, before applying the model in simulation forecasts. Comparative experiments showed that the model was very sensitive to initial fields and successful in reproducing the monsoon onset, allocation of high- and low-level wind fields during the pentad of onset, and the northward advancement of the monsoon and monsoon rain bands. The scheme, however, simulated rainfall and the location of the subtropical high with deviations from observations. The simulated location of the subtropical high was more westward and northward and the simulated rainfall for the South China Sea was larger and covered a broader area.
基金National Natural Science Foundation of China (40875021, 40930951)Knowledge Innovation Program of Chinese Academy of Sciences ( KZCX2-YW-Q03-3)
文摘To better assimilate Advanced TIROS Operational Vertical Sounder(ATOVS) radiance data and provide more accurate initial fields for a numerical model,two bias correction schemes are employed to correct the ATOVS radiance data.The difference in the two schemes lies in the predictors use in air-mass bias correction.The predictors used in SCHEME 1 are all obtained from model first-guess,while those in SCHEME 2 are from model first-guess and radiance observations.The results from the two schemes show that after bias correction,the observation residual became smaller and closer to a Gaussian distribution.For both land and ocean data sets,the results obtained from SCHEME 1 are similar to those from SCHEME 2,which indicates that the predictors could be used in bias correction of ATOVS data.
文摘Snow data collection systems in the western United States were originally designed to forecast water supply and may be subject to several sources of bias. In addition to climate change and weather modification effects, site-specific effects may be introduced from vegetation changes, site physical changes, measurement technique, and sensor changes. This paper examines changes in Utah's snowpack conditions over the past decade compared with all previous measurement years, focusing on the 15 snow courses with the longest observational record within the state of Utah. Although patterns in snowpack data consistent with those that would be expected due to temperature h as greater declines at lower elevations and latitudes--were not identified, snow water equivalent decreased at sites with significant increases in vegetation coverage. Additionally, we provide a list of 22 snow courses in Utah that are best-suited for long-term climate analysis.
文摘Based on some former studies of Chinese rural society, this paper summerizes the achievements and limitations of general Chinese rural studies and then proposes a social operation model in rural areas which is dominated by the squires. It uses some specific historical data and discoveries of feild sduty to further examine the profound influence of the squires on rural politcal construction in three different aspects: the model of clan and religion, the role as inter-mediator and the growth of basic armed forces. The study found that this special social group played a center role in Chinese rural political system from ancient to modem times, particularly, the research considers the decline of the squire society since the establishment of the new government in 1949. In the end, this paper points out the cultural guiding significance of this social model in the study to the rural construction in contemporay China by predicting the possiblity of renaissance
文摘This study delved into the formulaic patterns of liver cancer treatment outlined in“The Complete Book of Good Tumor Prescriptions”and explored the action mechanisms of core traditional Chinese medicine(TCM)combinations.Initially,liver cancer treatment formulas were extracted from the aforementioned book,and Excel 2017 was employed for calculating the frequency,properties,and meridians associated with the TCMs.IBM SPSS Modeler 18.0 was utilized for the analysis of TCM association rules,and Cytoscape 3.7.2 was employed for the visualization of these rules.Subsequently,network pharmacology was utilized to analyze the action mechanisms of core TCM combinations,leveraging TCMSP,TCMID,Genecards,DAVID,and other databases.The results revealed the inclusion of 131 prescriptions encompassing 303 TCMs.The core TCMs predominantly comprised those invigorating blood circulation and removing blood stasis,clearing heat,and tonifying deficiencies.The flavor of the TCMs was chiefly bitter or pungent,with a prevailing cold property entering the liver and spleen meridians.Association analysis indicated that the support of Angelicae sinensis radix-Trionycis carapax was the highest.Network pharmacology predictions indicated that Angelicae sinensis radix-Trionycis carapax possessed 20 target genes associated with anti-liver cancer properties,including IL-6,MAPK3,and SRC.Gene survival analysis demonstrated high expression of MAPK3 and SRC in liver cancer patients,correlating with a poor prognosis.KEGG analysis identified major anti-liver cancer pathways for Angelicae sinensis radix-Trionycis carapax,encompassing the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.In summary,this study elucidated that TCMs for liver cancer treatment primarily consisted of invigorating blood circulation and removing blood stasis,antipyretic,and tonifying medicines.The core TCM pair,Angelicae sinensis radix-Trionycis carapax,appeared pivotal in this context.The underlying mechanism might involve the modulation of key genes,such as MAPK3 and SRC,and the regulation of pathways,including the cancer pathway,TNF signaling pathway,and prolactin signaling pathway.
基金supported by the National Natural Science Foundation of China(Grant Nos.11035003 and 11120101004)
文摘The Majorana neutrino mass matrix combines information from the neutrino masses and the leptonic mixing in the flavor basis. Its invariance under some transformation matrices indicates the existence of certain residual symmetry. We offer an intuitive display of the structure of the Majorana neutrino mass matrix, using the whole set of the oscillation data. The structure is revealed depending on the lightest neutrino mass. We find that there are three regions with distinct characteristics of structure. A group effect and the μ-T exchange symmetry are observed. Six types of texture non-zeros are shown. Implications for flavor models are discussed.