The landfall process of typhoon Haitang which affected East China seriously was simulated by using the MM5 model and the track, intensity, precipitation and structure of typhoon were successfully reproduced. Then thro...The landfall process of typhoon Haitang which affected East China seriously was simulated by using the MM5 model and the track, intensity, precipitation and structure of typhoon were successfully reproduced. Then through the sensitive test, the effects of terrain were analyzed Results show that the irregular track during the period of typhoon passing through Taiwan and later landfalling at Fujian was in relation to the occurring and developing of orthographic impressed depression. The amount of rainfall was enhanced more than one time and the strength of typhoon was weakened 4 to 5 hPa. It is found that the effect of terrain on the structure of typhoon is limited at low level and is backward in space compared with the one at high level. In addition, the phenomenon that the equivalent temperature in the typhoon's moving direction inclines to the west on the eye of landfall may be concerned with the terrain.展开更多
Based on day-to-day minimal ground temperatures in 1961-2010 from 62 meteorological stations in Shanxi province,the variation characteristics of Shanxi's first frost were analyzed.The results show:Shanxi's average ...Based on day-to-day minimal ground temperatures in 1961-2010 from 62 meteorological stations in Shanxi province,the variation characteristics of Shanxi's first frost were analyzed.The results show:Shanxi's average first frost date was October 7,and the first frost date of the north was generally earlier than the south; the average first frost date had obvious negative correlations with altitude and latitude,and the correlation coefficients were respectively-0.85 and-0.82.M-K mutation test shows that the first frost date of most meteorological stations had mutations from 1961 to 2010,mainly in the years from 1981 to 2000,and the mutation year of the central area was generally later than the north and the south; the mutation year had negative correlations with altitude and latitude,and the correlation coefficients were respectively-0.45 and-0.51.The first frost dates of most stations had a delaying trend.Specifically,the large delaying scope region was located in the north and the mid-east,and the large advancing scope region was located in the south and the south central.The changing trend had negative correlations with altitude and latitude,and the correlation coefficients were respectively-0.30 and-0.37.Probabilities of the mild,the moderate and the severe first frost were 62%-82%,6%-26% and 4%-22%,respectively,and the maximum probabilities appeared in the south central & northeast,the central & north central and the west & north central.Correlation of altitude with first frost tends to be volatile upon frost grade and latitude has bigger impacts on first frost probabilities.展开更多
Using the model data for surface mass changes of the atmosphere, ocean, soil moisture and snow depth, the vertical crustal displacements of 25 ficual stations in China were calculated according to the loading theory. ...Using the model data for surface mass changes of the atmosphere, ocean, soil moisture and snow depth, the vertical crustal displacements of 25 ficual stations in China were calculated according to the loading theory. From the spectral analysis of the results, we can see that the periods of displacements are 12 months and the semi-periods are 6 months. The results also show that the maximum seasonal displacements can reach 20 mm and even larger. The covariance analyses and significance tests show that the coefficients of 96 percent of the stations are significant at the 0.1 significance level. The results show that one of the reasons of the vertical crustal displacements is the changing surface fluid loads.展开更多
In order to analyze the stability of the underground rock structures,knowing the sensitivity of geomechanical parameters is important.To investigate the priority of these geomechanical properties in the stability of c...In order to analyze the stability of the underground rock structures,knowing the sensitivity of geomechanical parameters is important.To investigate the priority of these geomechanical properties in the stability of cavern,a sensitivity analysis has been performed on a single cavern in various rock mass qualities according to RMR using Phase 2.The stability of cavern has been studied by investigating the side wall deformation.Results showed that most sensitive properties are coefficient of lateral stress and modulus of deformation.Also parameters of Hoek-Brown criterion and r c have no sensitivity when cavern is in a perfect elastic state.But in an elasto-plastic state,parameters of Hoek-Brown criterion and r c affect the deformability;such effect becomes more remarkable with increasing plastic area.Other parameters have different sensitivities concerning rock mass quality(RMR).Results have been used to propose the best set of parameters for study on prediction of sidewall displacement.展开更多
A parameter, known as the parameter of humidification vibration deformation, was proposed, describing quantitatively the impact of water content on vibration settlement deformation, and its relationship with humidific...A parameter, known as the parameter of humidification vibration deformation, was proposed, describing quantitatively the impact of water content on vibration settlement deformation, and its relationship with humidification water content, dynamic shear stress peak value, initial consolidation stress and vibration frequency was built. The result shows that 1) the parameter of humidification vibration deformation increases with the vibration shear stress peak value increasing. 2) The humidification water content has significant influence on the curve of the parameter of humidification vibration deformation and the peak vibration shear stress. When the humidification water content is low, the curve increases slowly. However, when the humidification water content is high, the curve increases rapidly. 3) Initial consolidation stress has significant influence on the humidification vibration deformation coefficient. When initial consolidation stress is not large enough to destroy the loess structure, with initial consolidation stress increasing, the humidification vibration deformation coefficient decreases. On the contrary, the humidification vibration deformation coefficient increases with initial consolidation stress increasing. 4) With the increase of vibration time, the parameter of humidification vibration settlement shows an increasing trend overall. The initial dynamic shear stress peak value and humidification water content all have significant effects on the curve of the parameter of humidification vibration settlement and vibration time. However, the humidification water content is even more significant.展开更多
Objective The aim of this study was to assess the value of palliative local treatment of incurable metastatic lesions in colorectal cancer(CRC) patients receiving chemotherapy plus bevacizumab.Methods Data of 105 pati...Objective The aim of this study was to assess the value of palliative local treatment of incurable metastatic lesions in colorectal cancer(CRC) patients receiving chemotherapy plus bevacizumab.Methods Data of 105 patients with histologically confirmed synchronous or metachronous metastatic CRC who received bevacizumab treatment from January 1, 2011 to January 31, 2017 were retrospectively reviewed. Sixteen(15%) patients who were treated with bevacizumab for less than 4 cycles were excluded, and finally, 89(85%) patients were enrolled. Among them, 33(37%) patients who received palliative local treatment were categorized into the palliative local treatment group, and the remaining 56(63%) patients were categorized into the chemotherapy plus bevacizumab group. The primary endpoint was overall survival(OS), which was calculated using Kaplan-Meier survival analyses. Factors possibly influencing survival were evaluated by univariate and multivariate analyses. Adverse events(AEs) were graded according to Common Terminology Criteria for Adverse Events, version 4.0. Grades 1–2 and 3–4 AEs of the two groups were compared and analyzed using the Fisher's exact test and χ~2 analysis.Results The median follow-up period was 20.4 months, ranging from 1 to 60 months. The median OS in the palliative local treatment group was 36.3 months(95% CI, 33.5–39.2), and that in the chemotherapy plus bevacizumab group was 20.5 months(95% CI, 17.6–23.4). Both the univariate(HR 0.13, 95% CI, 0.05–0.30, P < 0.001) and multivariate(HR 0.16, 95% CI, 0.07–0.39, P < 0.001) analyses showed that the addition of palliative local treatment could prolong survival compared with chemotherapy plus bevacizumab alone. There were no significant differences in the rates of common chemotherapy-or bevacizumab-related AEs between the two groups.Conclusion These findings suggest palliative local treatment is an effective and safe method for treating patients with incurable metastatic CRC receiving chemotherapy plus bevacizumab.展开更多
Cold orbital forging is an advanced spur bevel gear forming technology. Generally, the spur bevel gear in the cold orbital forging process is formed by two steps: the preforming step and the final step. Due to the gre...Cold orbital forging is an advanced spur bevel gear forming technology. Generally, the spur bevel gear in the cold orbital forging process is formed by two steps: the preforming step and the final step. Due to the great importance of the final step to gear forming and its complication with interactive factors, this work aims at examining the influence of key factors on the final step in cold orbital forging of a spur bevel gear. Using the finite element(FE) method and control variate method, the influence rules of four key factors, rotation velocity of the upper tool, n, feeding velocity of the lower tool, v, tilted angle of the upper tool, γ, friction factor between the tools and the billet, m, on the geometry and the deformation inhomogeneity of the cold orbital forged gear are thoroughly clarified. The research results show that the flash becomes more homogeneous with increasing v, increasing m, decreasing n or decreasing γ. And the deformation of the gear becomes more homogeneous with increasing v, decreasing n or decreasing γ. Finally, a corresponding experiment is conducted, which verifies the accuracy of FE simulation conclusions.展开更多
Our research addresses questions about how micro-climate affects activity abundance of a common and widespread harvestman in an alpine ecosystem. Activity patterns of the Harvestman Mitopus morio(Fabricius, 1779) were...Our research addresses questions about how micro-climate affects activity abundance of a common and widespread harvestman in an alpine ecosystem. Activity patterns of the Harvestman Mitopus morio(Fabricius, 1779) were studied along different alpine gradients in the central Norwegian Scandes. Within a nested design, we surveyed 18 alpine habitats with pitfall traps and microclimatological equipment along oceanic-continental, two elevational, and(fine-scaled) microtopographic gradients. Sites in the oceanic region of the Scandes showed generally higher abundance of M. morio than sites in the continental region. Furthermore, along the elevational gradient, middle-alpine sites showed higher abundances than low-alpine sites. These general patterns are best explained by higher humidity in the oceanic region and in the middlealpine belt. Focusing at a finer scale, i.e. one elevational level within each region, revealed partly opposing activity patterns within relatively short distances. While in the western middle-alpine belt these patterns were best explained by humidityrelated measures but now with higher activity abundance during drier conditions, in the drier eastern middle-alpine belt heat sums rather than humidity were found to be the best explanatoryvariables for the observed patterns. Hence, our results imply a pronounced different reaction of the two populations towards climatic variables that partly even contradict the previously described general pattern. Regardless whether these differences in activity abundance in M. morio are a form of phenotypic plasticity or adaptation, our findings stress the importance of detailed autecological knowledge combined with fine-scaled climatic measurements when aiming at predictions about possible future ecosystem structures and spatiotemporal phenomena. M. morio proves to be an ideal biogeographic model organism for understanding spatio-temporal responses of alpine ecosystems under modified climatic conditions.展开更多
As an important channel connecting the East and South China Seas, circulations in the Taiwan Strait are strongly influenced by the East Asian monsoon and the topography of the strait, especially the Taiwan Bank(TWB), ...As an important channel connecting the East and South China Seas, circulations in the Taiwan Strait are strongly influenced by the East Asian monsoon and the topography of the strait, especially the Taiwan Bank(TWB), which is a remarkable topographic feature located at the southern entrance to the strait. Based on a series of pressure gauges deployed roughly 40 km offshore along the western Strait, subtidal sea-level variability under the combined impact of winter monsoon and topography was studied. The analyses show significant along-strait coherences of subtidal sea levels and their coherences with the large-scale monsoon wind for periods from 2 to 14 days. It is suggested that these fluctuations are mainly forced waves driven by the large-scale winds. In addition to the normal cross-shore wind setup, a sea-level setup in the along-strait direction is confirmed, which is induced by the combined forcing of the fluctuating winter monsoon and the blocking of the TWB. A southward current surge driven by a northerly wind event will cause a rising sea level over the TWB inducing a southward alongshore slope anomaly to the north of the TWB and a reversed slope anomaly to the south The subtidal current through the channel to the west of the TWB is found to be influenced by the reversed slope anomalies generated via the along-shore setup.展开更多
文摘The landfall process of typhoon Haitang which affected East China seriously was simulated by using the MM5 model and the track, intensity, precipitation and structure of typhoon were successfully reproduced. Then through the sensitive test, the effects of terrain were analyzed Results show that the irregular track during the period of typhoon passing through Taiwan and later landfalling at Fujian was in relation to the occurring and developing of orthographic impressed depression. The amount of rainfall was enhanced more than one time and the strength of typhoon was weakened 4 to 5 hPa. It is found that the effect of terrain on the structure of typhoon is limited at low level and is backward in space compared with the one at high level. In addition, the phenomenon that the equivalent temperature in the typhoon's moving direction inclines to the west on the eye of landfall may be concerned with the terrain.
基金Supported by China National 973 Project(2012CB955903)Meteorological Key Technology Integration and Application Projects of China Meteorological Administration(CMAGJ2011M10)Natural Science Fund of Shanxi Province(2013011038)~~
文摘Based on day-to-day minimal ground temperatures in 1961-2010 from 62 meteorological stations in Shanxi province,the variation characteristics of Shanxi's first frost were analyzed.The results show:Shanxi's average first frost date was October 7,and the first frost date of the north was generally earlier than the south; the average first frost date had obvious negative correlations with altitude and latitude,and the correlation coefficients were respectively-0.85 and-0.82.M-K mutation test shows that the first frost date of most meteorological stations had mutations from 1961 to 2010,mainly in the years from 1981 to 2000,and the mutation year of the central area was generally later than the north and the south; the mutation year had negative correlations with altitude and latitude,and the correlation coefficients were respectively-0.45 and-0.51.The first frost dates of most stations had a delaying trend.Specifically,the large delaying scope region was located in the north and the mid-east,and the large advancing scope region was located in the south and the south central.The changing trend had negative correlations with altitude and latitude,and the correlation coefficients were respectively-0.30 and-0.37.Probabilities of the mild,the moderate and the severe first frost were 62%-82%,6%-26% and 4%-22%,respectively,and the maximum probabilities appeared in the south central & northeast,the central & north central and the west & north central.Correlation of altitude with first frost tends to be volatile upon frost grade and latitude has bigger impacts on first frost probabilities.
文摘Using the model data for surface mass changes of the atmosphere, ocean, soil moisture and snow depth, the vertical crustal displacements of 25 ficual stations in China were calculated according to the loading theory. From the spectral analysis of the results, we can see that the periods of displacements are 12 months and the semi-periods are 6 months. The results also show that the maximum seasonal displacements can reach 20 mm and even larger. The covariance analyses and significance tests show that the coefficients of 96 percent of the stations are significant at the 0.1 significance level. The results show that one of the reasons of the vertical crustal displacements is the changing surface fluid loads.
文摘In order to analyze the stability of the underground rock structures,knowing the sensitivity of geomechanical parameters is important.To investigate the priority of these geomechanical properties in the stability of cavern,a sensitivity analysis has been performed on a single cavern in various rock mass qualities according to RMR using Phase 2.The stability of cavern has been studied by investigating the side wall deformation.Results showed that most sensitive properties are coefficient of lateral stress and modulus of deformation.Also parameters of Hoek-Brown criterion and r c have no sensitivity when cavern is in a perfect elastic state.But in an elasto-plastic state,parameters of Hoek-Brown criterion and r c affect the deformability;such effect becomes more remarkable with increasing plastic area.Other parameters have different sensitivities concerning rock mass quality(RMR).Results have been used to propose the best set of parameters for study on prediction of sidewall displacement.
基金Foundation item: Project(51178392) supported by the National Natural Science Foundation of China
文摘A parameter, known as the parameter of humidification vibration deformation, was proposed, describing quantitatively the impact of water content on vibration settlement deformation, and its relationship with humidification water content, dynamic shear stress peak value, initial consolidation stress and vibration frequency was built. The result shows that 1) the parameter of humidification vibration deformation increases with the vibration shear stress peak value increasing. 2) The humidification water content has significant influence on the curve of the parameter of humidification vibration deformation and the peak vibration shear stress. When the humidification water content is low, the curve increases slowly. However, when the humidification water content is high, the curve increases rapidly. 3) Initial consolidation stress has significant influence on the humidification vibration deformation coefficient. When initial consolidation stress is not large enough to destroy the loess structure, with initial consolidation stress increasing, the humidification vibration deformation coefficient decreases. On the contrary, the humidification vibration deformation coefficient increases with initial consolidation stress increasing. 4) With the increase of vibration time, the parameter of humidification vibration settlement shows an increasing trend overall. The initial dynamic shear stress peak value and humidification water content all have significant effects on the curve of the parameter of humidification vibration settlement and vibration time. However, the humidification water content is even more significant.
文摘Objective The aim of this study was to assess the value of palliative local treatment of incurable metastatic lesions in colorectal cancer(CRC) patients receiving chemotherapy plus bevacizumab.Methods Data of 105 patients with histologically confirmed synchronous or metachronous metastatic CRC who received bevacizumab treatment from January 1, 2011 to January 31, 2017 were retrospectively reviewed. Sixteen(15%) patients who were treated with bevacizumab for less than 4 cycles were excluded, and finally, 89(85%) patients were enrolled. Among them, 33(37%) patients who received palliative local treatment were categorized into the palliative local treatment group, and the remaining 56(63%) patients were categorized into the chemotherapy plus bevacizumab group. The primary endpoint was overall survival(OS), which was calculated using Kaplan-Meier survival analyses. Factors possibly influencing survival were evaluated by univariate and multivariate analyses. Adverse events(AEs) were graded according to Common Terminology Criteria for Adverse Events, version 4.0. Grades 1–2 and 3–4 AEs of the two groups were compared and analyzed using the Fisher's exact test and χ~2 analysis.Results The median follow-up period was 20.4 months, ranging from 1 to 60 months. The median OS in the palliative local treatment group was 36.3 months(95% CI, 33.5–39.2), and that in the chemotherapy plus bevacizumab group was 20.5 months(95% CI, 17.6–23.4). Both the univariate(HR 0.13, 95% CI, 0.05–0.30, P < 0.001) and multivariate(HR 0.16, 95% CI, 0.07–0.39, P < 0.001) analyses showed that the addition of palliative local treatment could prolong survival compared with chemotherapy plus bevacizumab alone. There were no significant differences in the rates of common chemotherapy-or bevacizumab-related AEs between the two groups.Conclusion These findings suggest palliative local treatment is an effective and safe method for treating patients with incurable metastatic CRC receiving chemotherapy plus bevacizumab.
基金Project(51105287)supported by the National Natural Science Foundation of ChinaProject(IRT13087)supported by Innovative Research Team Development Program of Ministry of Education of China+2 种基金Project(2012-86)supported by High-End Talent Leading Program of Hubei Province,ChinaProject(2014CFB876)supported by Natural Science Foundation of Hubei ProvinceChina
文摘Cold orbital forging is an advanced spur bevel gear forming technology. Generally, the spur bevel gear in the cold orbital forging process is formed by two steps: the preforming step and the final step. Due to the great importance of the final step to gear forming and its complication with interactive factors, this work aims at examining the influence of key factors on the final step in cold orbital forging of a spur bevel gear. Using the finite element(FE) method and control variate method, the influence rules of four key factors, rotation velocity of the upper tool, n, feeding velocity of the lower tool, v, tilted angle of the upper tool, γ, friction factor between the tools and the billet, m, on the geometry and the deformation inhomogeneity of the cold orbital forged gear are thoroughly clarified. The research results show that the flash becomes more homogeneous with increasing v, increasing m, decreasing n or decreasing γ. And the deformation of the gear becomes more homogeneous with increasing v, decreasing n or decreasing γ. Finally, a corresponding experiment is conducted, which verifies the accuracy of FE simulation conclusions.
基金partly sponsored by Color Line Aksjeselskap, Oslo
文摘Our research addresses questions about how micro-climate affects activity abundance of a common and widespread harvestman in an alpine ecosystem. Activity patterns of the Harvestman Mitopus morio(Fabricius, 1779) were studied along different alpine gradients in the central Norwegian Scandes. Within a nested design, we surveyed 18 alpine habitats with pitfall traps and microclimatological equipment along oceanic-continental, two elevational, and(fine-scaled) microtopographic gradients. Sites in the oceanic region of the Scandes showed generally higher abundance of M. morio than sites in the continental region. Furthermore, along the elevational gradient, middle-alpine sites showed higher abundances than low-alpine sites. These general patterns are best explained by higher humidity in the oceanic region and in the middlealpine belt. Focusing at a finer scale, i.e. one elevational level within each region, revealed partly opposing activity patterns within relatively short distances. While in the western middle-alpine belt these patterns were best explained by humidityrelated measures but now with higher activity abundance during drier conditions, in the drier eastern middle-alpine belt heat sums rather than humidity were found to be the best explanatoryvariables for the observed patterns. Hence, our results imply a pronounced different reaction of the two populations towards climatic variables that partly even contradict the previously described general pattern. Regardless whether these differences in activity abundance in M. morio are a form of phenotypic plasticity or adaptation, our findings stress the importance of detailed autecological knowledge combined with fine-scaled climatic measurements when aiming at predictions about possible future ecosystem structures and spatiotemporal phenomena. M. morio proves to be an ideal biogeographic model organism for understanding spatio-temporal responses of alpine ecosystems under modified climatic conditions.
基金supported by National Natural Science Foundation of China(Grant Nos.41476005&U1305231)supported by Chinese Offshore Physical Oceanography and Marine Meteorology Investigation and Assessment Project(Grant No.908-ZC-I-01)
文摘As an important channel connecting the East and South China Seas, circulations in the Taiwan Strait are strongly influenced by the East Asian monsoon and the topography of the strait, especially the Taiwan Bank(TWB), which is a remarkable topographic feature located at the southern entrance to the strait. Based on a series of pressure gauges deployed roughly 40 km offshore along the western Strait, subtidal sea-level variability under the combined impact of winter monsoon and topography was studied. The analyses show significant along-strait coherences of subtidal sea levels and their coherences with the large-scale monsoon wind for periods from 2 to 14 days. It is suggested that these fluctuations are mainly forced waves driven by the large-scale winds. In addition to the normal cross-shore wind setup, a sea-level setup in the along-strait direction is confirmed, which is induced by the combined forcing of the fluctuating winter monsoon and the blocking of the TWB. A southward current surge driven by a northerly wind event will cause a rising sea level over the TWB inducing a southward alongshore slope anomaly to the north of the TWB and a reversed slope anomaly to the south The subtidal current through the channel to the west of the TWB is found to be influenced by the reversed slope anomalies generated via the along-shore setup.