The transjugular intrahepatic portosystemic stent-shunt (TIPS) has successfully been used in the management of refractory variceal bleeding and ascites in patients with portal hypertension. Major drawbacks are the ind...The transjugular intrahepatic portosystemic stent-shunt (TIPS) has successfully been used in the management of refractory variceal bleeding and ascites in patients with portal hypertension. Major drawbacks are the induction of hepatic encephalopathy and shunt dysfunction. We present a 59-year-old woman with alcoholic liver cirrhosis who received a TIPS because of recurrent bleeding from esophageal varices. Stent occlusion occurred 4 mo after placement of the TIPS. Laboratory testing revealed resistance to activated protein C (APC). Combination therapy with low-dose enoxaparin and clopidogrel could not prevent her recurrent stent occlusion. Finally, therapy with high-dose enoxaparin was sufficient to prevent further shunt complications up to now (follow-up period of 1 year). In conclusion, early occlusion of a TIPS warrants testing for thrombophilia. If risk factors are confirmed,anticoagulation should be intensified. There are currently no evidence-based recommendations regarding the best available anticoagulant therapy and surveillance protocol for patients with TIPS.展开更多
A series of independent faulted basins developed in the present middle reaches of the Yellow River during late Cenozoic, among which the Sanmen Lake Basin is located in the east edge of the Loess Plateau, a transition...A series of independent faulted basins developed in the present middle reaches of the Yellow River during late Cenozoic, among which the Sanmen Lake Basin is located in the east edge of the Loess Plateau, a transitional zone between the second and third macromorphological step of China. The thick strata of the Sanmen Group deposited in the large basin. The Sanmen Group is a perfect place for the study on paleoenvironmental change, tectono-climatic cycles as well as the formation and evolution of the Yellow River. In this paper, the paleoenvironmental changes, regional tectonic movement and the evolutionary process of the Sanmen Lake Basin during the past 5 Ma were reconstructed based on the analysis of paleomagnetic stratigraphy, pollen, TOC and carbonate content from the Huangdigou outcrop near the Sanmenxia Reservoir, Pinglu County, Shanxi Province. The sedimentary records from the outcrop indicate that the basin was first formated by fault activity at about 5.4 MaBP, and after the strong tectonic movement at 3.6 MaBP the lake enlarged and the rainfall of summer monsoon increased. There was no great climatic transition near 2.6 MaBP, corresponding to the bottom age of loess in the Loess Plateau. After Olduvai event (about 1.77 MaBP) the Picea and Abies were presented in the sediments, which indicates a colder climate. The tectonic movement at 1.2 MaBP caused the light angular discordance between the upper and lower Sanmen Group. The sedimentary records show a cold and wet climate during the prosperous periods of loess accumulation such as L15, L9, L6. The tectonic intensification periods of the Sanmen Basin correspond with the tectonic movements in the Qinghai-Xizang Plateau chronologically. The earliest age of the outflow from the Paleo-Sanmen Lake or the partly cutting off of the Sanmenxia Gorge was about 0.41- 0.35 MaBP. The age of cutting thoroughly the Sanmenxia Gorge by the Yellow River and the disappearance of the Paleo-Sanmen Lake was about 0.15 MaBP, which symbolized the formation of the present Yellow River and had an important influence on the environmental and morphological evolution in the middle and lower reaches of the Yellow River.展开更多
Our serial studies from {dy1970}s on chemical composition, structure determination and formation mechanism of gallstones were reviewed. The chemical component investigation of brown-pigment gallstone demonstrated that...Our serial studies from {dy1970}s on chemical composition, structure determination and formation mechanism of gallstones were reviewed. The chemical component investigation of brown-pigment gallstone demonstrated that it consists of macromolecules such as proteins, glycoproteins, polysaccharides, bilirubin polymers and pigment polymers, and biomolecules such as cholesterol, bile salts, calcium salts of carbonate, phosphate, fatty acids and bilirubinate as well as various metal ions. The binding of metal ions with bile salts and bilirubin plays important roles in gallstone formation, i.e., calcium bilirubinate complex is the major constitute of brown-pigment gallstones, and copper bilirubinate complex is critical in the black color appearance of black-pigment gallstone. The cross section of many gallstones exhibits a concentric ring structure composed of various small particles with a fractal character. This is nonlinear phenomenon in gallstone formation. Atypical model system of metal ions-deoxycholate (or cholate)-gel was chosen to mimic an in vitro pattern formation system. The experimental results suggested that a nonlinear scientific concept should be considered in understanding gallstone formation. Minor changes in the chemical composition and/or the microenvironment may lead to very different precipitate patterns with a variety of shapes, colors, appearances, and structures. A new model was suggested that periodical templets of periodical and fractal patterns were formed in the initial stage, then the spatio-temporal patterns grew gradually on it. Furthermore, the interaction between divalent metal ions and bile saltsin vitro was investigated, and the results indicated that non-stoichiometric M(DC)2-NaDC mixed complexes with mixed micelles structure can be formed in physiological condition.展开更多
After corrosion and pitting corrosion, the wire nanometer phases are observed using a transmission electron microscope (TEM) in C+Ti dual implanted H13 steel. The property of corrosion resistance dual-implanted (C+Ti)...After corrosion and pitting corrosion, the wire nanometer phases are observed using a transmission electron microscope (TEM) in C+Ti dual implanted H13 steel. The property of corrosion resistance dual-implanted (C+Ti) H13 steel is studied using multi-sweep cyclic voltammetry. TEM images of the cross section of an implanted sample reveal plenty of circular nanometer structures with diameters of 10–30 nm. The phases are densely embedded in the implanted layer. The embedded structure improves the surface corrosion resistance, as can be observed with a scanning electron microscope (SEM). The phases with the shape of a tiny wire in nanometer size are formed. The nanometer phases, consisting of TiC, FeTi and FeTi2, are formed in dual implanted layer. The corrosion current peak density decreases to 1/16–1/10 that of the unimplanted H13 steel. The formation conditions of the nanometer phases and their effects are investigated. The passivation layer consists of nanometer phases. The corrosion resistance of the dual implantation can be further enhanced with an increase in ion dose.展开更多
文摘The transjugular intrahepatic portosystemic stent-shunt (TIPS) has successfully been used in the management of refractory variceal bleeding and ascites in patients with portal hypertension. Major drawbacks are the induction of hepatic encephalopathy and shunt dysfunction. We present a 59-year-old woman with alcoholic liver cirrhosis who received a TIPS because of recurrent bleeding from esophageal varices. Stent occlusion occurred 4 mo after placement of the TIPS. Laboratory testing revealed resistance to activated protein C (APC). Combination therapy with low-dose enoxaparin and clopidogrel could not prevent her recurrent stent occlusion. Finally, therapy with high-dose enoxaparin was sufficient to prevent further shunt complications up to now (follow-up period of 1 year). In conclusion, early occlusion of a TIPS warrants testing for thrombophilia. If risk factors are confirmed,anticoagulation should be intensified. There are currently no evidence-based recommendations regarding the best available anticoagulant therapy and surveillance protocol for patients with TIPS.
基金This work was supported by the Fund for Key Projects of Chinese Academy of Sciences (Grant No. KZ951-A 1-402-04-02) the Fund for National Key Projects (Grant No. G1998040800).
文摘A series of independent faulted basins developed in the present middle reaches of the Yellow River during late Cenozoic, among which the Sanmen Lake Basin is located in the east edge of the Loess Plateau, a transitional zone between the second and third macromorphological step of China. The thick strata of the Sanmen Group deposited in the large basin. The Sanmen Group is a perfect place for the study on paleoenvironmental change, tectono-climatic cycles as well as the formation and evolution of the Yellow River. In this paper, the paleoenvironmental changes, regional tectonic movement and the evolutionary process of the Sanmen Lake Basin during the past 5 Ma were reconstructed based on the analysis of paleomagnetic stratigraphy, pollen, TOC and carbonate content from the Huangdigou outcrop near the Sanmenxia Reservoir, Pinglu County, Shanxi Province. The sedimentary records from the outcrop indicate that the basin was first formated by fault activity at about 5.4 MaBP, and after the strong tectonic movement at 3.6 MaBP the lake enlarged and the rainfall of summer monsoon increased. There was no great climatic transition near 2.6 MaBP, corresponding to the bottom age of loess in the Loess Plateau. After Olduvai event (about 1.77 MaBP) the Picea and Abies were presented in the sediments, which indicates a colder climate. The tectonic movement at 1.2 MaBP caused the light angular discordance between the upper and lower Sanmen Group. The sedimentary records show a cold and wet climate during the prosperous periods of loess accumulation such as L15, L9, L6. The tectonic intensification periods of the Sanmen Basin correspond with the tectonic movements in the Qinghai-Xizang Plateau chronologically. The earliest age of the outflow from the Paleo-Sanmen Lake or the partly cutting off of the Sanmenxia Gorge was about 0.41- 0.35 MaBP. The age of cutting thoroughly the Sanmenxia Gorge by the Yellow River and the disappearance of the Paleo-Sanmen Lake was about 0.15 MaBP, which symbolized the formation of the present Yellow River and had an important influence on the environmental and morphological evolution in the middle and lower reaches of the Yellow River.
基金the National Natural Science Foundation of China (Grant Nos. 29671002, 39730160 and 20023005) and the State Key Project for Fundamental Research of MOST (Grant No. G1998061370).
文摘Our serial studies from {dy1970}s on chemical composition, structure determination and formation mechanism of gallstones were reviewed. The chemical component investigation of brown-pigment gallstone demonstrated that it consists of macromolecules such as proteins, glycoproteins, polysaccharides, bilirubin polymers and pigment polymers, and biomolecules such as cholesterol, bile salts, calcium salts of carbonate, phosphate, fatty acids and bilirubinate as well as various metal ions. The binding of metal ions with bile salts and bilirubin plays important roles in gallstone formation, i.e., calcium bilirubinate complex is the major constitute of brown-pigment gallstones, and copper bilirubinate complex is critical in the black color appearance of black-pigment gallstone. The cross section of many gallstones exhibits a concentric ring structure composed of various small particles with a fractal character. This is nonlinear phenomenon in gallstone formation. Atypical model system of metal ions-deoxycholate (or cholate)-gel was chosen to mimic an in vitro pattern formation system. The experimental results suggested that a nonlinear scientific concept should be considered in understanding gallstone formation. Minor changes in the chemical composition and/or the microenvironment may lead to very different precipitate patterns with a variety of shapes, colors, appearances, and structures. A new model was suggested that periodical templets of periodical and fractal patterns were formed in the initial stage, then the spatio-temporal patterns grew gradually on it. Furthermore, the interaction between divalent metal ions and bile saltsin vitro was investigated, and the results indicated that non-stoichiometric M(DC)2-NaDC mixed complexes with mixed micelles structure can be formed in physiological condition.
基金This work was supported by the National Natural Science Foundation of China (Grant No. 59671051) "863"Project.
文摘After corrosion and pitting corrosion, the wire nanometer phases are observed using a transmission electron microscope (TEM) in C+Ti dual implanted H13 steel. The property of corrosion resistance dual-implanted (C+Ti) H13 steel is studied using multi-sweep cyclic voltammetry. TEM images of the cross section of an implanted sample reveal plenty of circular nanometer structures with diameters of 10–30 nm. The phases are densely embedded in the implanted layer. The embedded structure improves the surface corrosion resistance, as can be observed with a scanning electron microscope (SEM). The phases with the shape of a tiny wire in nanometer size are formed. The nanometer phases, consisting of TiC, FeTi and FeTi2, are formed in dual implanted layer. The corrosion current peak density decreases to 1/16–1/10 that of the unimplanted H13 steel. The formation conditions of the nanometer phases and their effects are investigated. The passivation layer consists of nanometer phases. The corrosion resistance of the dual implantation can be further enhanced with an increase in ion dose.
