This paper studies the numerical simulation for semiconductor devices and discusses the software design of the simulation system. Our focus is on the deep submicron device simulation for BJT, MOSFET, heterojunction bi...This paper studies the numerical simulation for semiconductor devices and discusses the software design of the simulation system. Our focus is on the deep submicron device simulation for BJT, MOSFET, heterojunction bipolar transistors (HBT), etc. So the object oriented technology for software design and its realization is used to make the system easy to implement, maintain and extend. Besides the discussion of simulation and software system design, this paper introduces a device simulator SMDS and its parallel extension under local network environment using CORBA technology.展开更多
Multi-function,multiband,cost-effective,miniaturized reconfigurable radio frequency(RF)components are highly demanded in modern and future wireless communication systems.This paper discusses the needs and implementati...Multi-function,multiband,cost-effective,miniaturized reconfigurable radio frequency(RF)components are highly demanded in modern and future wireless communication systems.This paper discusses the needs and implementation of multiband reconfigurable RF components with microfabrication techniques and advanced materials.RF applications of fabrication methods such as surface and bulk micromachining techniques are reviewed,especially on the development of RF microelectromechanical systems(MEMS)and other tunable components.Works on the application of ferroelectric and ferromagnetic materials are investigated,which enables RF components with continuous tunability,reduced size,and enhanced performance.Methods and strategies with nano-patterning to improve high frequency characteristics of ferromagnetic thin film(e.g.,ferromagnetic resonance frequency and losses)and their applications on the development of fully electrically tunable RF components are fully demonstrated.展开更多
A general theoretical model for microwave photonic filters based on multi-wavelength light source and dispersive media is summarized and presented, and is applied to the analysis of double-laser-based microwave photon...A general theoretical model for microwave photonic filters based on multi-wavelength light source and dispersive media is summarized and presented, and is applied to the analysis of double-laser-based microwave photonic notch filters’ performance. The different influences of the double-sideband(DSB) modulation and the single-sideband(SSB) modulation are demon- strated and explained theoretically. Furthermore, the impact of different factors, such as frequency spacing, 3dB bandwidth and the spectrum amplitude mismatch on the performance of the microwave photonic notch filters are also studied. The numerical simulation results are in good agreement with predictions, and could be beneficial for future optimization of microwave photonic filters.展开更多
Relatively to non-traditional and high-energy-beam micro-manufacturing technique, the micro-cutting technology has many merits. For instance, the machining range is bigger, the cost of equipments is much lower, and th...Relatively to non-traditional and high-energy-beam micro-manufacturing technique, the micro-cutting technology has many merits. For instance, the machining range is bigger, the cost of equipments is much lower, and the productivity and machining accuracy are higher. Therefore, the micro-cutting technology will take an important effect on the machining technique of complex shape microparts. In this paper, based on selfly-developed machine tool, the precision cutting technology of complex shape microparts made of metal material was studied by analyzing the modeling method on complex shape, the means of toolpaths layout and the optimal selection for cutting parameters. On the basis of above work, a typical duralumin specimen of high precision, low surface roughness and complex shape micropart was manufactured. This result will provide favorable technical support for farther research on the micro-cutting technology.展开更多
Changes in the regulatory requirements and the forthcoming Disinfectant/Disinfection By-Products (D/DBP) Rule will require that drinking water treatment facilities be operated to achieve maximum removals of particle...Changes in the regulatory requirements and the forthcoming Disinfectant/Disinfection By-Products (D/DBP) Rule will require that drinking water treatment facilities be operated to achieve maximum removals of particles and disinfectant tolerant microorganisms as well as natural organic matter (NOM). For drinking water production, the use of membrane filtration processes such as microfiltration and ultrafiltration (MF/UF) alone to satisfy the turbidity, particle and microorganism removal a requirement of the surface water treatment regulation (SWTR) is not enough. MF/UF treatment processes can achieve only nominal (10 percent) removal of disinfection by-products (DBP) precursors (James, et al., 1995). On the other hand, too fast fouling can make the filtration processes more difficult to carry on. To solve these problems, many authors have been interested in installing coagulation pretreatment before membrane filtration to improve membrane performance. However, previous studies reported conflicting results. Some supported the effectiveness of coagulation pretreatment, while others contended that coagulation aggravated membrane performance. This research aims to identify the effects of coagulation pretreatment on membrane filtration through a pilot study using PVDF membrane in combination with analyzing the rationale of coagulation. Another objective of this research was to evaluate the different impacts on membrane performance of using different membrane modules (the submerged module and pressured module). The results showed that coagulation pretreatment greatly improved the membrane performance, extending the filtration time as well as reducing the permeated organic level, and that the submerged module is much more efficient than the pressured module.展开更多
Objective:The aim of our study was to investigate the lymph node metastasis of mesorectum and ischiorectal foss in ultra-low rectal cancer and its influence on the surgical procedure selection.Methods:Large slices and...Objective:The aim of our study was to investigate the lymph node metastasis of mesorectum and ischiorectal foss in ultra-low rectal cancer and its influence on the surgical procedure selection.Methods:Large slices and tissue microarray technology were used to detect metastasis lymph nodes from 23 dissected specimens of ultra-low rectal cancer.Results:415 lymph nodes were detected in the 23 specimens.169 and 59 lymph nodes were metastasis and micrometastasis, respectively.Twelve specimens were diagnosed with lymph node metastasis, while other 4 specimens were with lymph node micro-metastasis.There were 29.0% (49/169) and 17.2% (29/169) metastatic lymph nodes located in the outer and anterior region of mesorectum.There were 2 cases with ischiorectal fossa lymph node metastasis and 1 case with micrometastasis.The 3 metastatic cases were only 13% (13/23) of all the 23 cases.Conclusion:There is regional lymph node metastasis existing in ultra-low rectal cancer.The metastatic incidences in distal mesorectum and ischiorectal fossa are relatively low.Considering Miles operation as the standard surgical procedure for ultra-low rectal cancer should be evaluated renewedly.展开更多
The catalytic activity of two common bacterial enzymes, lactate dehydrogenase (LDH) and cytochrome c oxidase (COX) from Escherichia coli was examined following bacterial exposure to microwave (MW) radiation unde...The catalytic activity of two common bacterial enzymes, lactate dehydrogenase (LDH) and cytochrome c oxidase (COX) from Escherichia coli was examined following bacterial exposure to microwave (MW) radiation under well-defined experimental conditions. The experiments were conducted in a specialized microwave processing apparatus, with an exposure frequency of 18 GHz, and a temperature profile that was restricted to below 40℃ to avoid thermal degradation of the bacteria. The absorbed power was calculated to be 1,500 kW/m3 and the electric field was determined to be 300 Wm. Both values were theoretically confirmed using Computer Simulation Technology (CST) Microwave Studio 3D Electromagnetic Stimulation Software. Results showed that the activity of both enzymes was increased following MW radiation compared to negative controls and thermally treated samples subjected to similar temperature profiles. It is suggested that the increase in COX and LDH enzyme activity could not be explained by conventional heating alone, but was rather a result of micro-thermal effects that incorporated 'undetectable' thermal mechanisms.展开更多
Efficiency and power loss in the microelectronic devices is a major issue in power electronics applications. The engineers are challenged every year to increase power density and at the same time reduce the amount of ...Efficiency and power loss in the microelectronic devices is a major issue in power electronics applications. The engineers are challenged every year to increase power density and at the same time reduce the amount of power dissipated in the applications to keep the maximum temperatures under specifications. This situation drives a constant demand for better efficiencies in smaller packages. Traditional approaches to improve efficiency in DC/DC synchronous buck converters include reducing conduction losses in the MOSFETs (metal oxide semiconductor field effect transistors) through lower RDS (ON) (resistance drain to source in the ON state) devices and lowering switching losses through low-frequency operation. However, the incremental improvements in RDS (ON) are at a point of diminishing returns and low RDS (ON) devices have large parasitic capacitances that do not facilitate the high-frequency operation required to improve power density. The drive for higher efficiency and increased power in smaller packages is being addressed by advancements in both silicon and packaging technologies. The NexFET power block combines these two technologies to achieve higher levels of performance, and in half the space versus discrete MOSFETs. This article explains these new technologies and highlights their performance advantage.展开更多
During the past six years comprehensive research programs have been conducted at the Beijing Polytechnic University to provide a better understanding of heat transfer characteristics of existing and condidate cool- in...During the past six years comprehensive research programs have been conducted at the Beijing Polytechnic University to provide a better understanding of heat transfer characteristics of existing and condidate cool- ing techniques for electronic and microelectronic devices.This paper provides a review and summary of the programs with emphasis on direct liquid cooling.Included in this review are the heat transfer investigations related to the following cooling modes:liquid free,mixed and forced convection,liquid jet impingement,flowing liquid film cooling,pool boiling,spray cooling,foreign gas jet impingement in liquid pool,and forced convection air-cooling.展开更多
Carcinoma-associated fibroblasts(CAFs) function as a double-edged sword in tumor progression. However,factors affecting the transition between tumor promotion and inhibition remain to be investigated. Here, we found t...Carcinoma-associated fibroblasts(CAFs) function as a double-edged sword in tumor progression. However,factors affecting the transition between tumor promotion and inhibition remain to be investigated. Here, we found that the transition was determined by stiffness heterogeneity of the tumor stroma in which tumor cells and CAFs were grown.When tumor cells were grown on a rigid plastic substrate,supernatants from CAFs inhibited the cytotoxic effects of 5-fluorouracil. In contrast, when tumor cells were grown on a soft substrate(5.3 kPa), supernatants from CAFs grown on a soft substrate increased the cytotoxicity of 5-fluorouracil. The diverse effects of CAFs were mediated by mechanotransduction factors, including stroma stiffness-induced cytokine expression in CAFs and signal transduction associated with stress fiber formation of CAFs. Moreover, we found that the cytokine expression in CAFs was regulated by nuclear Yesassociated protein, which changed according to cell stiffness,as characterized by atomic force microscopy. Overall, these findings suggested that modulating the mechanotransduction of the stroma together with CAFs might be important for increasing the efficacy of chemotherapy.展开更多
Thermal management is a key issue in the integrated circuit(IC)design.In this paper,the superposition strategy was experimentally validated using a modeling IC device,which was fabricated by laboratory-level microfabr...Thermal management is a key issue in the integrated circuit(IC)design.In this paper,the superposition strategy was experimentally validated using a modeling IC device,which was fabricated by laboratory-level microfabrication technique.Metal thin film resistors on the top of dielectric layer were used to analogize the multiple hot-spots in the modeling IC device.The measured temperature rise with multiple hot-spots agrees well with the predictions given by the superposition calculations.With the help of the superposition strategy,thermal management of IC device can be significantly simplified by decomposing the system into sub-systems and optimizing each part individually.The influence coefficients in the superposition strategy extracted from the experimental measurement offer the IC designers a useful engineering tool to facility the thermal optimization and evaluate the thermal performance of IC devices.展开更多
With the development of science and technology,ordered microstructures with special functions have aroused intense research interest.These functional microstructures have been widely used in fields of microelectronic ...With the development of science and technology,ordered microstructures with special functions have aroused intense research interest.These functional microstructures have been widely used in fields of microelectronic devices,micro-reactors,biochemical sensors and optical devices,etc.This paper summaries our work on preparation and application of microscopic patterned surfaces with ordered microstructures,and looks into the future development of this field.展开更多
文摘This paper studies the numerical simulation for semiconductor devices and discusses the software design of the simulation system. Our focus is on the deep submicron device simulation for BJT, MOSFET, heterojunction bipolar transistors (HBT), etc. So the object oriented technology for software design and its realization is used to make the system easy to implement, maintain and extend. Besides the discussion of simulation and software system design, this paper introduces a device simulator SMDS and its parallel extension under local network environment using CORBA technology.
基金Projects(1253929,1910853)supported by the National Natural Science Foundation of China。
文摘Multi-function,multiband,cost-effective,miniaturized reconfigurable radio frequency(RF)components are highly demanded in modern and future wireless communication systems.This paper discusses the needs and implementation of multiband reconfigurable RF components with microfabrication techniques and advanced materials.RF applications of fabrication methods such as surface and bulk micromachining techniques are reviewed,especially on the development of RF microelectromechanical systems(MEMS)and other tunable components.Works on the application of ferroelectric and ferromagnetic materials are investigated,which enables RF components with continuous tunability,reduced size,and enhanced performance.Methods and strategies with nano-patterning to improve high frequency characteristics of ferromagnetic thin film(e.g.,ferromagnetic resonance frequency and losses)and their applications on the development of fully electrically tunable RF components are fully demonstrated.
基金partically supported by the Science and Technology Department of Zhejiang Province (grant No. R104154)
文摘A general theoretical model for microwave photonic filters based on multi-wavelength light source and dispersive media is summarized and presented, and is applied to the analysis of double-laser-based microwave photonic notch filters’ performance. The different influences of the double-sideband(DSB) modulation and the single-sideband(SSB) modulation are demon- strated and explained theoretically. Furthermore, the impact of different factors, such as frequency spacing, 3dB bandwidth and the spectrum amplitude mismatch on the performance of the microwave photonic notch filters are also studied. The numerical simulation results are in good agreement with predictions, and could be beneficial for future optimization of microwave photonic filters.
基金Sponsored by China Postdoctoral Science Foundation (Grant No2004035530)
文摘Relatively to non-traditional and high-energy-beam micro-manufacturing technique, the micro-cutting technology has many merits. For instance, the machining range is bigger, the cost of equipments is much lower, and the productivity and machining accuracy are higher. Therefore, the micro-cutting technology will take an important effect on the machining technique of complex shape microparts. In this paper, based on selfly-developed machine tool, the precision cutting technology of complex shape microparts made of metal material was studied by analyzing the modeling method on complex shape, the means of toolpaths layout and the optimal selection for cutting parameters. On the basis of above work, a typical duralumin specimen of high precision, low surface roughness and complex shape micropart was manufactured. This result will provide favorable technical support for farther research on the micro-cutting technology.
文摘Changes in the regulatory requirements and the forthcoming Disinfectant/Disinfection By-Products (D/DBP) Rule will require that drinking water treatment facilities be operated to achieve maximum removals of particles and disinfectant tolerant microorganisms as well as natural organic matter (NOM). For drinking water production, the use of membrane filtration processes such as microfiltration and ultrafiltration (MF/UF) alone to satisfy the turbidity, particle and microorganism removal a requirement of the surface water treatment regulation (SWTR) is not enough. MF/UF treatment processes can achieve only nominal (10 percent) removal of disinfection by-products (DBP) precursors (James, et al., 1995). On the other hand, too fast fouling can make the filtration processes more difficult to carry on. To solve these problems, many authors have been interested in installing coagulation pretreatment before membrane filtration to improve membrane performance. However, previous studies reported conflicting results. Some supported the effectiveness of coagulation pretreatment, while others contended that coagulation aggravated membrane performance. This research aims to identify the effects of coagulation pretreatment on membrane filtration through a pilot study using PVDF membrane in combination with analyzing the rationale of coagulation. Another objective of this research was to evaluate the different impacts on membrane performance of using different membrane modules (the submerged module and pressured module). The results showed that coagulation pretreatment greatly improved the membrane performance, extending the filtration time as well as reducing the permeated organic level, and that the submerged module is much more efficient than the pressured module.
文摘Objective:The aim of our study was to investigate the lymph node metastasis of mesorectum and ischiorectal foss in ultra-low rectal cancer and its influence on the surgical procedure selection.Methods:Large slices and tissue microarray technology were used to detect metastasis lymph nodes from 23 dissected specimens of ultra-low rectal cancer.Results:415 lymph nodes were detected in the 23 specimens.169 and 59 lymph nodes were metastasis and micrometastasis, respectively.Twelve specimens were diagnosed with lymph node metastasis, while other 4 specimens were with lymph node micro-metastasis.There were 29.0% (49/169) and 17.2% (29/169) metastatic lymph nodes located in the outer and anterior region of mesorectum.There were 2 cases with ischiorectal fossa lymph node metastasis and 1 case with micrometastasis.The 3 metastatic cases were only 13% (13/23) of all the 23 cases.Conclusion:There is regional lymph node metastasis existing in ultra-low rectal cancer.The metastatic incidences in distal mesorectum and ischiorectal fossa are relatively low.Considering Miles operation as the standard surgical procedure for ultra-low rectal cancer should be evaluated renewedly.
文摘The catalytic activity of two common bacterial enzymes, lactate dehydrogenase (LDH) and cytochrome c oxidase (COX) from Escherichia coli was examined following bacterial exposure to microwave (MW) radiation under well-defined experimental conditions. The experiments were conducted in a specialized microwave processing apparatus, with an exposure frequency of 18 GHz, and a temperature profile that was restricted to below 40℃ to avoid thermal degradation of the bacteria. The absorbed power was calculated to be 1,500 kW/m3 and the electric field was determined to be 300 Wm. Both values were theoretically confirmed using Computer Simulation Technology (CST) Microwave Studio 3D Electromagnetic Stimulation Software. Results showed that the activity of both enzymes was increased following MW radiation compared to negative controls and thermally treated samples subjected to similar temperature profiles. It is suggested that the increase in COX and LDH enzyme activity could not be explained by conventional heating alone, but was rather a result of micro-thermal effects that incorporated 'undetectable' thermal mechanisms.
文摘Efficiency and power loss in the microelectronic devices is a major issue in power electronics applications. The engineers are challenged every year to increase power density and at the same time reduce the amount of power dissipated in the applications to keep the maximum temperatures under specifications. This situation drives a constant demand for better efficiencies in smaller packages. Traditional approaches to improve efficiency in DC/DC synchronous buck converters include reducing conduction losses in the MOSFETs (metal oxide semiconductor field effect transistors) through lower RDS (ON) (resistance drain to source in the ON state) devices and lowering switching losses through low-frequency operation. However, the incremental improvements in RDS (ON) are at a point of diminishing returns and low RDS (ON) devices have large parasitic capacitances that do not facilitate the high-frequency operation required to improve power density. The drive for higher efficiency and increased power in smaller packages is being addressed by advancements in both silicon and packaging technologies. The NexFET power block combines these two technologies to achieve higher levels of performance, and in half the space versus discrete MOSFETs. This article explains these new technologies and highlights their performance advantage.
文摘During the past six years comprehensive research programs have been conducted at the Beijing Polytechnic University to provide a better understanding of heat transfer characteristics of existing and condidate cool- ing techniques for electronic and microelectronic devices.This paper provides a review and summary of the programs with emphasis on direct liquid cooling.Included in this review are the heat transfer investigations related to the following cooling modes:liquid free,mixed and forced convection,liquid jet impingement,flowing liquid film cooling,pool boiling,spray cooling,foreign gas jet impingement in liquid pool,and forced convection air-cooling.
基金financially supported by the Postdoctoral Science Foundation Program of Chinese Academy of Medical Sciences & Peking Union Medical Collegethe National Natural Science Foundation of China (NSFC) (31470905)National Institutes of Health/National Cancer Institute (NIH/NCI) Grant R21, CA208196
文摘Carcinoma-associated fibroblasts(CAFs) function as a double-edged sword in tumor progression. However,factors affecting the transition between tumor promotion and inhibition remain to be investigated. Here, we found that the transition was determined by stiffness heterogeneity of the tumor stroma in which tumor cells and CAFs were grown.When tumor cells were grown on a rigid plastic substrate,supernatants from CAFs inhibited the cytotoxic effects of 5-fluorouracil. In contrast, when tumor cells were grown on a soft substrate(5.3 kPa), supernatants from CAFs grown on a soft substrate increased the cytotoxicity of 5-fluorouracil. The diverse effects of CAFs were mediated by mechanotransduction factors, including stroma stiffness-induced cytokine expression in CAFs and signal transduction associated with stress fiber formation of CAFs. Moreover, we found that the cytokine expression in CAFs was regulated by nuclear Yesassociated protein, which changed according to cell stiffness,as characterized by atomic force microscopy. Overall, these findings suggested that modulating the mechanotransduction of the stroma together with CAFs might be important for increasing the efficacy of chemotherapy.
基金supported by the National Science and Technology Major Project of China(Grant No.2009ZX02038-02)the Doctoral Fund of Ministry of Education of China(Grant No.20130001110006)
文摘Thermal management is a key issue in the integrated circuit(IC)design.In this paper,the superposition strategy was experimentally validated using a modeling IC device,which was fabricated by laboratory-level microfabrication technique.Metal thin film resistors on the top of dielectric layer were used to analogize the multiple hot-spots in the modeling IC device.The measured temperature rise with multiple hot-spots agrees well with the predictions given by the superposition calculations.With the help of the superposition strategy,thermal management of IC device can be significantly simplified by decomposing the system into sub-systems and optimizing each part individually.The influence coefficients in the superposition strategy extracted from the experimental measurement offer the IC designers a useful engineering tool to facility the thermal optimization and evaluate the thermal performance of IC devices.
基金supported by the National Natural Science Foundation of China (20921003,20534040 & 20874039)the National Basic Research Program of China (2007CB936402)
文摘With the development of science and technology,ordered microstructures with special functions have aroused intense research interest.These functional microstructures have been widely used in fields of microelectronic devices,micro-reactors,biochemical sensors and optical devices,etc.This paper summaries our work on preparation and application of microscopic patterned surfaces with ordered microstructures,and looks into the future development of this field.