AIM: To assess the extent of micronutrient and oxidative stress in blood and to examine their linkages with viral loads in chronic hepatitis C patients.METHODS: Hepatitis C virus (HCV)-RNA levels were quantified in th...AIM: To assess the extent of micronutrient and oxidative stress in blood and to examine their linkages with viral loads in chronic hepatitis C patients.METHODS: Hepatitis C virus (HCV)-RNA levels were quantified in the serum from 37 previously untreated patients with chronic hepatitis C. The plasma and erythrocyte micronutrients (zinc, selenium, copper, and iron) were estimated, and malondialdehyde (MDA)contents were determined as a marker to detect oxidative stress. Antioxidant enzymes, superoxide dismutase (SOD),glutathione peroxidase (GPX) and glutathione reductase (GR) activities in blood were also measured. The control group contained 31 healthy volunteers.RESULTS: The contents of zinc (Zn), and selenium (Se)in plasma and erythrocytes were significantly lower in hepatitis C patients than in the controls. On the contrary,copper (Cu) levels were significantly higher. Furthermore,plasma and erythrocyte MDA levels, and the SOD and GR activities in erythrocytes significantly increased in hepatitis C patients compared to the controls. However, the plasma GPX activity in patients was markedly lower. Plasma Se (r= -0.730, P<0.05), Cu (r = 0.635), and GPX (r = -0.675)demonstrated correlations with HCV-RNA loads. Significant correlation coefficients were also observed between HCV-RNA levels and erythrocyte Zn (r = -0.403), Se (r = -0.544), Cu (r = 0.701) and MDA (r = 0.629) and GR (r = 0.441).CONCLUSION: The levels of Zn, Se, Cu, and oxidative stress (MDA), as well as related anti-oxidative enzymes (GR and GPX) in blood have important impact on the viral factors in chronic hepatitis C. The distribution of these parameters might be significant biomarkers for HCV.展开更多
Studied the content and distribution of 18 environmental hazardous trace elementsin the lignite, fatty coal, anthracite and its burnt products by combustion simulatingexpriment in the one-dismensinal boiler.The transf...Studied the content and distribution of 18 environmental hazardous trace elementsin the lignite, fatty coal, anthracite and its burnt products by combustion simulatingexpriment in the one-dismensinal boiler.The transformations and concentration of 18 traceelements during different coal combustion were discussed.The results show that there aresome content distribution of 18 hazardous trace elements in every burnt product, but thelaw of concentration and dispersion of every trace element during different coal combustionis very different.Experiment results indicate that the transformation and concentrationof trace elements during coal combustion are related to the element contents and occur-rencesof trace elements in raw coal, but are also affected by some man-made factorssuch as the combustion method of boiler, combustion temperature and atmosphere, thetype of precipitators and so on.展开更多
Copper is a trace element that is required by almost all forms of life.Acting as cofactors for various key metabolism enzymes,copper takes part in many vital biological processes.Previous studies have found the concen...Copper is a trace element that is required by almost all forms of life.Acting as cofactors for various key metabolism enzymes,copper takes part in many vital biological processes.Previous studies have found the concentration of copper is significantly higher in tumor cells than in normal cells.In addition,copper can promote angiogenesis by activating VEGF and FGF signaling.展开更多
It has been suggested that microcracks do play a key role in the triggering of the bone remodeling process.In order to evaluate the influence of microcracks on the poroelastic behaviors of an osteon,a finite element m...It has been suggested that microcracks do play a key role in the triggering of the bone remodeling process.In order to evaluate the influence of microcracks on the poroelastic behaviors of an osteon,a finite element model is established and investigated by using the Comsol Multiphysics software.The findings show that the presence of a microcrack in the osteon wall strongly modifies(enlarges)its local fluid pressure and velocity.Especially,the pressure and velocity amplitudes produced in the microcracked region are larger than those of the non-cracked region.Thus,this study can also be used for proposing a likely mechanism that bone can sense the changes of surrounding mechanical environments.展开更多
The paper examines the chemical composition of alluvial soils from the Zeya and Selemdzha River valleys, one of the branch rivers in the Amur River basin. It has been established that the compositions of these soils a...The paper examines the chemical composition of alluvial soils from the Zeya and Selemdzha River valleys, one of the branch rivers in the Amur River basin. It has been established that the compositions of these soils are characterized by a relative shortage of practically all analyzed macro-and microelements as compared with UCC(upper continental crust) and PAAS(postArhean Australian average shale) compositions. The chemical composition of alluvial soils approximates that of the soils in NE China and Korea due to similar climatic and geographic conditions. On the basis of relationships between major and trace elements and peculiarities of trace elements concentration it is shown that the alluvial soils in the middle reaches of the Zeya River were formed by the sources largely transformed by chemical weathering processes. By comparison, the soils in the Selemdzha River and lower reaches of the Zeya River(below the Selemdzha River mouth) are dominated by material to a large degree reworked by the physical processes rather than chemical ones. This inference conforms with specific geological settings of the water-collector.展开更多
基金Supported by the Kuang-Tien General Hospital, Taichung, Taiwan,China
文摘AIM: To assess the extent of micronutrient and oxidative stress in blood and to examine their linkages with viral loads in chronic hepatitis C patients.METHODS: Hepatitis C virus (HCV)-RNA levels were quantified in the serum from 37 previously untreated patients with chronic hepatitis C. The plasma and erythrocyte micronutrients (zinc, selenium, copper, and iron) were estimated, and malondialdehyde (MDA)contents were determined as a marker to detect oxidative stress. Antioxidant enzymes, superoxide dismutase (SOD),glutathione peroxidase (GPX) and glutathione reductase (GR) activities in blood were also measured. The control group contained 31 healthy volunteers.RESULTS: The contents of zinc (Zn), and selenium (Se)in plasma and erythrocytes were significantly lower in hepatitis C patients than in the controls. On the contrary,copper (Cu) levels were significantly higher. Furthermore,plasma and erythrocyte MDA levels, and the SOD and GR activities in erythrocytes significantly increased in hepatitis C patients compared to the controls. However, the plasma GPX activity in patients was markedly lower. Plasma Se (r= -0.730, P<0.05), Cu (r = 0.635), and GPX (r = -0.675)demonstrated correlations with HCV-RNA loads. Significant correlation coefficients were also observed between HCV-RNA levels and erythrocyte Zn (r = -0.403), Se (r = -0.544), Cu (r = 0.701) and MDA (r = 0.629) and GR (r = 0.441).CONCLUSION: The levels of Zn, Se, Cu, and oxidative stress (MDA), as well as related anti-oxidative enzymes (GR and GPX) in blood have important impact on the viral factors in chronic hepatitis C. The distribution of these parameters might be significant biomarkers for HCV.
基金Supported by the National Natural Science Key Foundation of China(40133010)Natural Science Foundation of China of Anhui University of Science and Technology for ph.D to Research(DG414)
文摘Studied the content and distribution of 18 environmental hazardous trace elementsin the lignite, fatty coal, anthracite and its burnt products by combustion simulatingexpriment in the one-dismensinal boiler.The transformations and concentration of 18 traceelements during different coal combustion were discussed.The results show that there aresome content distribution of 18 hazardous trace elements in every burnt product, but thelaw of concentration and dispersion of every trace element during different coal combustionis very different.Experiment results indicate that the transformation and concentrationof trace elements during coal combustion are related to the element contents and occur-rencesof trace elements in raw coal, but are also affected by some man-made factorssuch as the combustion method of boiler, combustion temperature and atmosphere, thetype of precipitators and so on.
文摘Copper is a trace element that is required by almost all forms of life.Acting as cofactors for various key metabolism enzymes,copper takes part in many vital biological processes.Previous studies have found the concentration of copper is significantly higher in tumor cells than in normal cells.In addition,copper can promote angiogenesis by activating VEGF and FGF signaling.
基金supported by the program for the OIT of Higher Learning Institutions of Shanxi,the National Natural Science Foundation of China(Grant Nos.11302143 and 11472185)the Natural Science Foundation of Shanxi(Grant No.2014021013)
文摘It has been suggested that microcracks do play a key role in the triggering of the bone remodeling process.In order to evaluate the influence of microcracks on the poroelastic behaviors of an osteon,a finite element model is established and investigated by using the Comsol Multiphysics software.The findings show that the presence of a microcrack in the osteon wall strongly modifies(enlarges)its local fluid pressure and velocity.Especially,the pressure and velocity amplitudes produced in the microcracked region are larger than those of the non-cracked region.Thus,this study can also be used for proposing a likely mechanism that bone can sense the changes of surrounding mechanical environments.
文摘The paper examines the chemical composition of alluvial soils from the Zeya and Selemdzha River valleys, one of the branch rivers in the Amur River basin. It has been established that the compositions of these soils are characterized by a relative shortage of practically all analyzed macro-and microelements as compared with UCC(upper continental crust) and PAAS(postArhean Australian average shale) compositions. The chemical composition of alluvial soils approximates that of the soils in NE China and Korea due to similar climatic and geographic conditions. On the basis of relationships between major and trace elements and peculiarities of trace elements concentration it is shown that the alluvial soils in the middle reaches of the Zeya River were formed by the sources largely transformed by chemical weathering processes. By comparison, the soils in the Selemdzha River and lower reaches of the Zeya River(below the Selemdzha River mouth) are dominated by material to a large degree reworked by the physical processes rather than chemical ones. This inference conforms with specific geological settings of the water-collector.
