水泥微制粒工艺提高新疆某金矿堆浸速度试验

新疆某金矿石金品位0.900 g/t,金属矿物以黄铁矿、褐铁矿、黄钾铁钒为主,脉石矿物主要为石英。采用堆浸氰化浸出工艺提取金,入堆矿石粒度P80约4.5 mm,-0.074 mm含量11.07%,严重影响矿堆的渗透性,浸出速度慢,生产周期长。为克服降低矿石粒度对堆浸矿石渗透性的不利影响,采用水泥微制粒工艺进行试验。结果表明,在水泥用量4 kg/t、石灰用量3 kg/t、补加水至矿石水分5.5%的条件下,浸出液适宜的极限滴淋强度为15~20 L/(h·m2),在保证金浸出率67.00%以上的前提下,矿石渗透率显著增大,浸出速度明显提高,生产周期大大缩短,且水泥微制粒工艺成本低、操作方便,值得推广使用。

基于高压辊磨水泥微制粒的堆浸技术试验研究及工程实践

金川矿业公司矿石为低品位难选冶金矿石,矿石硬度大、难破碎,破碎机衬板磨蚀快,且矿石中金以微细粒为主,金浸出率低,平均为57%左右。针对生产中存在的问题,在小型试验研究的基础上,采用高压辊磨机+水泥微制粒技术,解决了矿石磨蚀性问题,且大幅度降低了产品粒度,提高了生产能力,由544万t/a提高到645万t/a;同时采用水泥微制粒工艺,解决了粒度变细带来的渗透性问题,金浸出率提高了10百分点,年新增效益约12107万元,为类似矿山生产工艺优化改进提供了有益借鉴。

IMPROVED PARTICLE SWARM OPTIMIZATION ALGORITHM FOR INTELLIGENTLY SETTING UAV ATTITUDE CONTROLLER PARAMETERS

An improved particle swarm optimization （PSO） algorithm is investigated in the optimization of the attitude controller parameters of unmanned aerial vehicle （UAV）. Considering the stagnation phenomenon in the later phase of the basic PSO algorithm caused by the diversity scarcity of particles, a modified PSO algorithm is presented. For the basic PSO algorithm, the velocity of each particle is adjusted according to the inertia motion, the swarm previous best position and its own previous best position. However, in the improved PSO algorithm, each particle only learns from another randomly selected particle with higher performance, besides keeping the inertia motion. The inertia weight of the improved PSO algorithm is a random number. The modification decreases the uncertain parameters of the algorithm, simplifies the learning mechanism of the particle, and enhances the diversity of the swarm. Furthermore, a UAV attitude control system is built, and the improved PSO algorithm is applied in the optimized tuning of four controller parameters. Simulation results show that the improved PSO algorithm has stronger global searching ability than the common PSO algorithms, and obtains better UAV attitude control parameters.

Preparation of Sustained-release Silybin Microspheres by Spherical Crystallization Technique

Aim To improve the dissolution rate and bioavailability of silybin. Methods Sustained-release silybin microspheres were prepared by the spherical crystallization technique with soliddispersing and release-retarding polymers. A differential scanning calorimeter and an X-ray diffractometer were used to investigate the dispersion state of silybin in the microspheres. The shape, surface morphology, and internal structure of the microspheres were observed using a scanning electron microscope. Characterization of the microspheres, such as average diameter, size distribution and bulk density of the microspheres was investigated. Results The particle size of the microspheres was determined mainly by the agitation speed. The dissolution rate of silybin from microspheres was enhanced by increasing the amount of the dispersing agents, and sustained by the retarding agents. The release rate of microspheres was controlled by adjusting the combination ratio of the dispersing agents to the retarding agents. The resuits of X-ray diffraction and differential scanning calorimetry analysis indicated that silybin was highly dispersed in the microspheres in amorphous state. The release profiles and content did not change after a three-month accelerated stability test at 40 ℃ and 75% relative humidity. Conclusion Sustained-release silybin microspheres with a solid dispersion structure were prepared successfully in one step by a spherical crystallization technique combined with solid dispersion technique. The preparation process is simple, reproducible and inexpensive. The method is efficient for designing sustained-release microspheres with water-insoluble drugs.

Effect of Quercetin on CYP1A2, CYP2E1, CYP3A2 Activities and its Inhibitory Mechanism Studies in Rat Liver Microsomes

Aim To assess the potential effect of quercetin （QU）, an natural plant estrogen, on CYP1A2, CYP2E1, and CYP3A2 activities in rat liver microsomes; and to identify the magnitude of inhibitory effect and the probable inhibitory mechanism of QU. Methods QU and specific substrate were concurrently incubated, with HPLC detection of the substrate metabolites for data analysis. The magnitude of inhibitory effect of QU on CYP3A2 was compared with those of ketoconazole （Ket） and erythromycin （Ery）. The mechanism of its inhibitory effect on CYP3A2 and CYP2E1 was derived from Lineweaver-Burk plots. Results HPLC methods were in good linear relationship with r〉0.999 1. Relative standard deviations for intra-day and inter-day were〈8.4%. Recovery of each analyte in the concentrations studied was between 91.1% and 107.6 %. QU （up to 8 μmol·L^-1） showed potent induction to CYP1A2 （338.1% of the negative control）while inhibited CYP2E1 （49.2% of the negative control） and CYP3A2 （60.3% of the negative control） activity. The magnitude of inhibitory effect for QU on CYP3A2 was between those for Ket and Ery （Ket〉QU〉Ery）. QU exhibited competitive inhibition of CYP3A2 dextromethorphan N-demethylation reaction and expressed noncompetitive inhibition of CYP2E1 chlorzoxazone-6-hydroxylation reaction. Conclusion HPLC assay has been validated with precision and accuracy. QU is an effective inhibitor of several CYP isoforms. It may cause relevant drug-drug interactions with CYP3A substrates. As a plant flavonoid, QU has potential not only in molecular advantage but also in CYP450 module capability for further application in cancer chemotherapy.

沸腾焙烧处理细粉锌精矿的工艺改进及应用

对提高沸腾焙烧处理细粉锌精矿能力等进行探讨,通过细粉锌精矿在圆筒干燥过程中实现结构较松散的微制粒,满足沸腾焙烧入炉锌精矿粒度要求、优化沸腾焙烧工艺操作控制等工艺改进,能够提高沸腾焙烧处理含铜、铟高有价金属及高铅、高硅等细粉锌精矿能力,确保沸腾焙烧炉高效稳定经济运行。

Preparation and Crystal Modification of Ibuprofen-Loaded Solid Lipid Microparticles

An emulsion-congealing technique is used to prepare solid lipid microparticles （SLM） containing ibuprofen with glyceryl behenate, tripalmitin and beewax as excipients. The difference of the solubility parameters between the excipients and ibuprofen are used to analyze their compatibility. Both the solubility parameter analysis and the experimental results show that glyceryl behenate is the best among the three excipients. The solid particles disperse well in aqueous phase when the drug loading reaches 10% （relative to lipid only）. Glycerides exhibit marked polymorphism and their rapid rates of crystallization accelerate the formation of metastable crystal modification. The metastable crystal modification characterizes high drug loading capacity but less stability. Increasing the content of lipophilic drug in a lipid matrix facilitates the transformation of excipients to more stable polymorphic forms.

Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System

The submicroparticles of β-sitosterol were produced by using an aerosol solvent extraction system （ASES） and characterized by scanning electronic microscope （SEM）, X-ray diffraction （XRD）, and Fourier transform infrared （FT-IR） analysis. The effects of operational parameters including pressure, temperature, solution concentration, and ratio of flow rate （CO2/solution, r） on particle size （PS）, yield, and morphology were investigated. The results showed that microparticles of β-sitosterol （less than 1000 nm size and larger than 70% yield） could be obtained at 10-15 MPa, 35 50℃, 15 mg·ml^-1, 10/1（r）; β-sitosterol particles were found to occur as three mophologies： flakes, rods, and spheres by varying ratio of flow rate or solution concentration. In contrast, the crystallinity of β-sitosterol decreased, whereas its molecular structure remained almost unchanged after being ASES-treated. Therefore, ASES was an effective method to produce submicroparticles of β-sitosterol.

Beginning of a New Revolution of Science ＆ Technology

Modern science and technology is being developed towards destroying human and human calls for a new era of science ＆ technology. Contemporary science is seeing a significant breakthrough and a new revolution of science and technology is beginning. The theoretical basis of the new revolution of science and technology is ＂state space-time＂, ＂the unity of physics and biology＂, ＂thinking motion and automatic organization of the universe＂ and ＂thinking＇s active control＂. The new revolution of science and technology takes material （microscopic particle） science, life （organic and inorganic life） science and thinking science as the fundamental sciences, takes life technology, new information technology, new material technology and new energy technology as the basis of the overall technological system, progresses in all aspects, including life technology, medicine, new material technology, new information technology, new energy technology, new robot technology, new manufacturing technology, laser technology, astronavigation technology, ocean technology, military technology, new educational technology, etc., and at the same time Qigong technology with thinking control as its core will emerge. In the era of life, thinking and Qigong technology, technology proceeds very rapidly, global society and economy develop at a high speed, and globalization is accelerated. Life, thinking and Qigong technologies feature improvement of human internal energy and quality, purify human soul, reduce material desire, and greatly reduce environmental disruption. The overall （thinking and Qigong） technology takes the establishment of the cosmic era of human as its ultimate goal.

Preparation of electrolytic copper powders with high current efficiency enhanced by super gravity field and its mechanism

Super gravity field was employed to enhance electrolytic reaction for the preparation of copper powders.The morphology, microstructure and size of copper powders were characterized by scanning electron microscopy,X-ray diffractometry and laser particle analysis.The results indicated that current efficiencies of electrolytic copper powders under super gravity field increased by more than 20% compared with that under normal gravity condition.Cell voltage under super gravity field was also much lower.The size of copper powders decreased with the increase of gravity coefficient(G).The increase of current efficiency can be contributed to the disturbance of electrode/electrolyte interface and enhanced mass transfer of Cu2+ in super gravity field.Meanwhile,the huge gravity acceleration would promote the detachment of copper powders from electrode surface during electrolytic process,which can prevent the growth of copper powders.

Preparation of Well-shaped Microcapsule Immobilizing Inorganic Nanoparticles

A facile and efficient method has been developed for microencapsulation of metal oxide nanoparticles in polyurea via interfacial polymerization of toluene-2,4-diisocyanate and H20 through the atomizing emulsification approach. The resultant microcapsules were well-shaped and uniform sphere with diameter ranging from 2 to 6 um. Thermogravimetry （TG） and differential scanning calorimetry （DSC） curves revealed that the microcapsules showed good thermal stability （no decomposition observed under 245℃）. Besides, the microencapsulated TiC2 has been used as an efficient catalyst for photocatalytic degradation of methyl orange. Furthermore, the photocatalysis of immobilized TiC2 could be enhanced by introducing UV absorbing agent to the wall of microcapsules.

Elucidate the impact of particulates on aqueous pollutant sonication

The potential inhibition of particulates on sonication of aqueous pollutants was investigated. Sonodegradation of bromobenzene, bromophenolate ion, and 2,4,5-trichlorobiphenyl were studied in the presence of various types of particulates suspended in water. Particulates of three different diameters (10 nm, 15 μm, and 35 μm) and two types (silica and polyaromatic resin) were investigated over a wide range of concentrations (0.05 g/L to 10 g/L). The results demonstrated that particulates inhibited sonication only when the target compound sorbed on the solid during sonication and could not partition into cavitation bubbles. The inhibition of the sorbed molecules was almost complete, and relatively independent of the particle concentration within certain ranges. However, the complexity of sonochemistry and particulate-solute matrices precludes a simple universal prediction of the inhibition extent.

Microparticle Formation and Crystallization Rate of HMX with Supercritical CO_2 Antisolvent Recrystallization

Microparticle formation and crystallization rate of 1,3,5,7-tetranitro-l,3,5,7-tetraazacyclooctane (HMX) in acetone solution using supercritical carbon dioxide antisolvent (GAS) recrystallization were studied. Scanning electronic microscopy, X-ray diffraction and infrared radiation were used to examine particle size, crystallinity and chemical structure. The results show that B-HMX microparticle in different average size (2-9.5um) and with narrow size distribution were obtained by controlling the expansibility, expansion speed, initial concentration and temperature during recrystallization of HMX. The formation of nuclei may be a main cause of consumption of solute when the solution is expanded rapidly enough and the equilibrium concentration is lower, in which almost monodisperse microparticle can be obtained.

A MODEL FOR THE RELEASE BEHAVIOR OF DRUGS FROM HYDROGEL NANOPARTICLE

A model to correlate and predict the release behavior of drugs from hydrogel nanoparticles is presented in this paper. The nanoparticle is considered as a combination of a shell of an elastic semipermeable membrane and a core of a fluid phase （After swelling equilibrium）. The fluid core consists of network building materials and other components that are able to partition in hydrogel nanoparticle phase and surrounding coexisting liquid phase, and is enveloped by the membrane shell. The excess Gibbs energies of the hydrogel nanoparticle phase and the surrounding coexisting fluid phase are expressed e.g. using UNIQUAC equation with ＂free-volume＂ contribution for non-ionic solution and VERS-model for ionic one. The elastic properties of polymer network could be described, for example, by the ＂phanWm network＂ theory.

Influence of Grinding Ball⁃Motion Behavior on Particle Crushing Performance and a Way of Micro⁃particle Preparation in a Flutter Ball Mill

Motion behavior of grinding balls plays a vital role in improving efficiency of particle crushing.A method of preparing micro-particles by changing ball-motion behavior in a flutter mill is proposed and multiple grinding experiments are conducted.Crushing performance parameters,such as breakage rate Si,production rates of fine particles Fi and Fi*,are studied in different motion conditions.From the results,a better crushing performance is attained in the coupled motion modes of rotating speed ratio of 85%,with a vibrating amplitude of 8 mm and a frequency of 12 Hz.In addition,the influence of ball-motion behavior on particle crushing performance is discussed.The ball-motion behaviors,such as the collision energy loss E,among grinding balls have some relationship with the particle crushing performance of Si.Therefore,this study not just provides an efficiency way of accumulating micro-particles,but also reveals how the ball-motion behavior influence particle crushing performance in the flutter mill.

Numerical simulation of powder effect on solidification in directed energy deposition additive manufacturing

An integrated simulation of powder effects on particle temperature and microstructural evolution in laser directed energy deposition additive manufacturing process was carried out.The spatial distribution of the flying powder particles was simulated by the discrete element method to calculate the energy for the flying powder particles under the laser−particle interaction with electromagnetic wave analysis.Combined with the phase field method,the influence of particle size on the microstructural evolution was studied.The microstructural evolution is validated through comparison with experimental observation.Results indicate that the narrow particle size distribution is beneficial to obtaining a more uniform temperature distribution on the deposited layers and forming smaller equiaxed grains near the side surfaces of the sample.Appropriate powder particle size is beneficial to the conversion of the electromagnetic energy into heat.Particles with small size are recommended to form equiaxed grains and to improve product quality.Appropriate powder flow rate improves the laser energy efficiency,and higher powder flow rate leads to more uniform equiaxed grains on both sides of the cross-section.

Micronization of Griseofulvin by Ress in Supercritical CO_2 with Cosolvent Acetone

Griseofulvin (GF) is an antifungal drug whose pharmaceutical activity can be improved by reducing particle size. In this study the rapid expansion of supercritical solution (RESS) was employed to micronize GF.Carbon dioxide with cosolvent acetone was chosen as a supercritical mixed solvent. The solubility of GF in super-critical CO2 with cosolvent acetone was measured using a dynamic apparatus at pressures between 12 and 32 MPa,temperatures at 313, 323 and 333 K and cosolvent concentration at 1.5, 3.0, 4.5 and 6.0% (by mole). The effect of pre-expansion pressure, extraction temperature, spraying distance, nozzle size and concentration of cosolvent on the precipitated particles was investigated. The results show that the mean particle size of griseofulvin precipitated by RESS was less than 1.2μm. An increase in pre-expansion pressure, extraction temperature, spraying distance and concentration of cosolvent resulted in a decrease in particle size under the operating condition studied. With the decrease of nozzle diameter the particle size reduces. The crystallinity and melting point of the original material and the processed particle by RESS were tested by X-ray diffraction (XRD) and differential scanning calorimetry (DSC).No evident modification in the crystal habit was found under the experimental conditions tested. The morphology of particles precipitated was analyzed bY scanning electron microscopy (SEM).

The preparation of high concentration alkaline silica sol with the method of vacuum distillation

High concentration alkaline silica sol has been prepared by the method of vacuum distillation, which shows that the stable and high concentration silica sol can be obtained under conditions as follows： 70℃, vacuum degree of 0.095Mpa and dispersant of SDS. The experimental results show that the sol particles size decreases with mass concentration first and then increase, sol viscosity increases with mass concentration during the concentrating process. The TEM method was used to study the dispersion behavior of sol particles, its result showed that sol particles dispersed more uniformly after concentrating process than before concentrating distinctly. It could be concluded that the disperse degree of alkaline silica sol could be increased by addition of right dispersant. The dispersion mechanism of dispersant in alkaline silica sol was also discussed.

A comparable study of microbial community in aerobic granular sludge and activated sludge for wastewater treatment

Effect of ammonia at different concentrations on aerobic granular sludge and activated sludge was investigated in this study. Meanwhile, bacterial diversity variation and ammonia oxidizing bacterium （AOB） quantification within both kinds of sludge were monitored by terminal restriction fragment length polymorphism （T-RFLP） and real-time PCR （RT-PCR） technique, respectively. The results showed that the COD removal of both kinds of sludge changed slightly when the ammonia removal efficiency decreased gradually with the ammonia concentration increased from 100 mg L^-1 to 500 mg L^-1 Furthermore, activated sludge demonstrated higher ammonia removal ability than that of aerobic granular sludge （10%- 16%）. As revealed by T-RFLP, activated sludge was of higher ammonia removal ability and more abounding bacterial diversity than that of aerobic granular sludge, suggesting that the bacterial diversity was probably relevant to the ammonia removal. The RT-PCR results indicated that the AOB population size of activated sludge and aerobic granular sludge were 2.80× 10^4-3.44× 10^4cells （g dried sludge）^-1 and 7.83×10^4-1.18×10^5cells （g dried sludge）^-1, respectively. There is no obvious positive correlation between the ammonia removal ability and number of AOB in both kinds of sludge.

Modulation of Soil Particle Size and Nutrient Availability in the Maize Rhizosheath

Root exudates,microorganism colonization and soil aggregates together form the rhizosheath,a special cylinder of micro-ecosystem adhering to the root surface.To study how the rhizosheath affects soil structure and nutrient distribution,we analyzed the impact of maize rhizosheath on soil particle size and nutrient availability in pot and field experiments.The results showed that there was a significant size decrease of soil particles in the rhizosheath.Meanwhile,the soil mineral nitrogen in the rhizosheath was significantly higher than that in the rhizosphere or bulk soil at tasseling and maturity stages of maize.The contents of Fe and Mn were also differentially altered in the rhizosheath.Rhizosheath development,indicated by a dry weight ratio of rhizosheath soil to the root,was relatively independent of root development during the whole experimental period.The formation of maize rhizosheath contributed to the modulation of soil particle size and nutrient availability.The subtle local changes of soil physical and chemical properties may have profound influence on soil formation,rhizospheric ecosystem initiation,and mineral nutrient mobilization over the long history of plant evolution and domestication.