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基于微流体数字化技术的微化学反应器 被引量:2
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作者 朱丽 侯丽雅 章维一 《中国机械工程》 EI CAS CSCD 北大核心 2007年第5期597-599,共3页
微流体数字化技术利用压电陶瓷驱动器产生的脉冲惯性力来驱动和扰动微流体,实现了微流体的均匀离散和微喷射,具有数字可控性。由此设计了一种数字化微化学反应器,对不同微管道内的流体利用数字化微喷射,实现试样与试剂微液滴间的混合反... 微流体数字化技术利用压电陶瓷驱动器产生的脉冲惯性力来驱动和扰动微流体,实现了微流体的均匀离散和微喷射,具有数字可控性。由此设计了一种数字化微化学反应器,对不同微管道内的流体利用数字化微喷射,实现试样与试剂微液滴间的混合反应。该微化学反应器由玻璃微管道拉制仪拉制的微管道进行粘接组合而成,内部无可动件,无需复杂的微加工技术,结构简单,制造成本低。进行了氢氧化钠溶液和酚酞溶液的混合反应实验,实验证明该化学反应器可以用于微化学反应。 展开更多
关键词 流体数字化 喷射 液滴 微化学反应器 混合
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用微芯片化学反应器实现酶催化化学发光测定葡萄糖的研究 被引量:4
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作者 徐溢 《高等学校化学学报》 SCIE EI CAS CSCD 北大核心 2003年第1期49-51,共3页
Glucose oxidization was catalyzed by glucose peroxidase, reactive products peroxides could have Chemiluminescence reaction with luminol. These were applied to detect glucose quantitatively in-situ or on-line by the mi... Glucose oxidization was catalyzed by glucose peroxidase, reactive products peroxides could have Chemiluminescence reaction with luminol. These were applied to detect glucose quantitatively in-situ or on-line by the microreactor with micromixer and FIA system. In this paper, the effects of many factors, such as the characters of microchip, modification of microchip glass surface, pH values of the detecting system, CL intensifying agent and so on, were studied in detail on the glucose detection. A new reliable and portable easily automatable system was set up for the glucose detection. 展开更多
关键词 酶催化 葡萄糖 葡萄糖氧化酶 过氧化物酶 芯片化学反应器 流动注射分析 化学发光
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声化学微反应器降解亚甲基蓝废水试验研究
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作者 程洋 王栋 +4 位作者 刘汇洋 刘佩佩 石赛 夏晓露 俞建峰 《化学工业与工程》 CAS CSCD 北大核心 2022年第6期93-100,共8页
为提高Fe2+活化过硫酸钠(SPS)降解亚甲基蓝(MB)的效率,设计了一种声化学微反应器。首先研究了静置系统、磁力搅拌系统、毛细管微反应器系统和声化学微反应器系统中MB和硫酸亚铁(FeSO_(4))混合液pH值、FeSO_(4)浓度、SPS浓度对MB降解率... 为提高Fe2+活化过硫酸钠(SPS)降解亚甲基蓝(MB)的效率,设计了一种声化学微反应器。首先研究了静置系统、磁力搅拌系统、毛细管微反应器系统和声化学微反应器系统中MB和硫酸亚铁(FeSO_(4))混合液pH值、FeSO_(4)浓度、SPS浓度对MB降解率的影响。其次,在声化学微反应器系统和毛细管微反应器系统中研究了流道结构和流速对MB降解率的影响。结果表明:在不同的MB和FeSO_(4)混合液pH值、FeSO_(4)浓度下,声化学微反应器系统中MB降解率均高于其他反应系统。随着SPS浓度的增加,MB降解率呈上升趋势,但在声化学微反应器系统中增加SPS浓度会影响MB降解。相比于直线形、三角波形和半圆波形流道结构,MB在矩形波形流道结构中降解效率更高。溶液在管道内停留时间相同时,增加流速更有利于氧化降解反应的进行。实验表明:当MB浓度为0.2 mmol·L^(-1),MB和FeSO_(4)混合液pH值为3、FeSO_(4)浓度为1.4 mmol·L^(-1)、SPS浓度为1.8 mmol·L^(-1),流道结构为矩形波形,流速为13.16 cm·s^(-1)时,声化学微反应系统中MB降解率达到85.45%。 展开更多
关键词 化学反应器 降解 亚铁离子 过硫酸钠 亚甲基蓝
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Development and characterization of a microfluidic glucose sensing system based on an enzymatic microreactor and chemiluminescence detection 被引量:2
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作者 MOON B.-U. de VRIES M.G. +1 位作者 WESTERINK B.H.C. VERPOORTE E. 《Science China Chemistry》 SCIE EI CAS 2012年第4期515-523,共9页
Chemiluminescence detection was developed as an alternative to amperometric detection for glucose analysis in a portable, microfluidicsbased continuous glucose monitoring system. Amperometric detection allows easy det... Chemiluminescence detection was developed as an alternative to amperometric detection for glucose analysis in a portable, microfluidicsbased continuous glucose monitoring system. Amperometric detection allows easy determination of hydrogen peroxide, a product of the glucose oxidasecatalyzed reaction of glucose with oxygen, by oxidation at a microelectrode. However, (micro)electrodes in direct contact with physiological sample are subject to electrode fouling, which leads to signal drift, decreased reproducibility and shortened detector lifetimes. Moreover, there are a few species present in the body (e.g. ascorbic acid, uric acid) which can undergo oxidation at the same applied potential as hydrogen peroxide. These species can thus inter- fere with the glucose measurement, reducing detection specificity. The rationale for exploring chemiluminescence as opposed to amperometric detection is thus to attempt to improve the lifetime and reproducibility of glucose analysis for monitoring purposes, while reducing interference caused by other chemicals in the body. The study reported here represents a first step in this direction, namely the realization of a microfluidic device with integrated silicon photodiode for chemiluminescence detection of glucose. This microflow device uses a chaotic mixing approach to perform enzymatic conversion of glucose, followed by reaction of the hydrogen peroxide produced with luminol to produce light at 425 nm. The chemil reaction is catalyzed by horseradish peroxidase in the presence of iodophenol. The performance of the fabricated chip was characterized to establish optimal reaction conditions with respect to sample and reagent flow rates, pH, and concentrations. A linear calibra- tion curve was obtained for current response as a function of glucose concentration in the clinically relevant range between 2 and 10 mM, with a sensitivity of 39 pA/mM (R = 0.9963, one device, n = 3) and a limit of detection of 230 ktM (S/N - 3). 展开更多
关键词 microfluidic chip glucose sensing system enzymatic microreactor chemiluminescence chaotic mixing
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