The tumor suppressor p53 pathway, whose alterations are highly associated with all types of human cancers, plays an essential role in preventingtumor development and progression mostly through its downstream target ge...The tumor suppressor p53 pathway, whose alterations are highly associated with all types of human cancers, plays an essential role in preventingtumor development and progression mostly through its downstream target genes. Over the last decade, a growing list of p53 microRNA （miRNA） targets has been identified as additional downstream players of this pathway. Further studies ofthese miRNAs have revealed their more complicated regulations and functions in executing and/or regulating p53 activity. Here, we review the p53 miRNA targets identified thus far, and discuss how they fine-tune p53 stress responses, mediate the crosstalk between p53 and other signaling pathways, and expand the role of p53 in other human diseases in addition to cancers.展开更多
Sparse signal processing is a signal processing technique that takes advantage of signal’s sparsity,allowing signal to be recovered with a reduced number of samples.Compressive sensing,a new branch of the sparse sign...Sparse signal processing is a signal processing technique that takes advantage of signal’s sparsity,allowing signal to be recovered with a reduced number of samples.Compressive sensing,a new branch of the sparse signal processing,has become a rapidly growing research field.Sparse microwave imaging introduces the sparse signal processing theory to radar imaging to obtain new theories,new systems and new methodologies of microwave imaging.This paper first summarizes the latest application of sparse microwave imaging,including Synthetic Aperture Radar(SAR),tomographic SAR and inverse SAR.As sparse signal processing keeps evolving,an avalanche of results have been obtained.We also highlight its recent theoretical advances,including structured sparsity,off-grid,Bayesian approaches,and point out new research directions in sparse microwave imaging.展开更多
文摘The tumor suppressor p53 pathway, whose alterations are highly associated with all types of human cancers, plays an essential role in preventingtumor development and progression mostly through its downstream target genes. Over the last decade, a growing list of p53 microRNA （miRNA） targets has been identified as additional downstream players of this pathway. Further studies ofthese miRNAs have revealed their more complicated regulations and functions in executing and/or regulating p53 activity. Here, we review the p53 miRNA targets identified thus far, and discuss how they fine-tune p53 stress responses, mediate the crosstalk between p53 and other signaling pathways, and expand the role of p53 in other human diseases in addition to cancers.
基金supported by the National Basic Research Program of China("973" Project)(Grant No.2010CB731900)
文摘Sparse signal processing is a signal processing technique that takes advantage of signal’s sparsity,allowing signal to be recovered with a reduced number of samples.Compressive sensing,a new branch of the sparse signal processing,has become a rapidly growing research field.Sparse microwave imaging introduces the sparse signal processing theory to radar imaging to obtain new theories,new systems and new methodologies of microwave imaging.This paper first summarizes the latest application of sparse microwave imaging,including Synthetic Aperture Radar(SAR),tomographic SAR and inverse SAR.As sparse signal processing keeps evolving,an avalanche of results have been obtained.We also highlight its recent theoretical advances,including structured sparsity,off-grid,Bayesian approaches,and point out new research directions in sparse microwave imaging.
