超声引导经皮微波固化疗法（PMCT）是近年来一种新的肝癌治疗手段，主要适用于不适合手术治疗包括不能手术切除、手术切除困难或不能耐受手术的早期肝癌患者，肝内肿瘤不超过3个，肿瘤直径≤5cm，且无血管内或远处转移灶，肝功能为 Chil...超声引导经皮微波固化疗法（PMCT）是近年来一种新的肝癌治疗手段，主要适用于不适合手术治疗包括不能手术切除、手术切除困难或不能耐受手术的早期肝癌患者，肝内肿瘤不超过3个，肿瘤直径≤5cm，且无血管内或远处转移灶，肝功能为 Child A 级或 B 级。对于中晚期肝癌患者，微波也可作为一种有效减小肿瘤的手段，以达到减轻痛苦、延缓发展，延长生存时间的目的。近年来，微波固化已成为继手术、放化疗、生物治疗及射频消融后又一种有效治疗肝癌的治疗方法。近年来研究表明，微波固化以其创伤小、简便可靠、疗效显著等优势在肿瘤临床治疗中得到了普遍的推广。现就微波固化在肝癌治疗方面研究进展作一综述。展开更多
Microwave coagulation therapy (MCT) has recently been applied to treat hepatic tumors. However, the histological changes in the liver following MCT have not been fully elucidated. A type of cell death known as microwa...Microwave coagulation therapy (MCT) has recently been applied to treat hepatic tumors. However, the histological changes in the liver following MCT have not been fully elucidated. A type of cell death known as microwave fixation has been reported in areas adjacent to the microwave irradiator electrodes, and these areas are without acid phosphatase (AcP) activity. Diagnosis of microwave- fixed tissue by hematoxylin and eosin (HE) staining is very difficult because morphology is well maintained for months. In an effort to clarify the histological changes and the mechanisms of microwave fixation, we performed HE staining, enzyme histochemistry for AcP, and electron microscopy in both rat and human liver samples after MCT. Although the microwave- fixed tissues maintained their structure on HE staining, membranes of microwave- fixed cells were seriously damaged and there were no apparent organelle structures in these cells on electron microscopy. Erythrocytes were also damaged in these tissues on both light and electron microscopy. The cause of microwave fixation is thought to be injury of the membrane, which is similar to coagulative necrosis. In conclusion, microwave fixation can be considered a type of coagulative necrosis without enzyme digestion. Disruption of erythrocytes on HE staining is an interesting and important diagnostic clue in distinguishing nonviable fixed tissues from viable tissues following MCT.展开更多
文摘超声引导经皮微波固化疗法（PMCT）是近年来一种新的肝癌治疗手段，主要适用于不适合手术治疗包括不能手术切除、手术切除困难或不能耐受手术的早期肝癌患者，肝内肿瘤不超过3个，肿瘤直径≤5cm，且无血管内或远处转移灶，肝功能为 Child A 级或 B 级。对于中晚期肝癌患者，微波也可作为一种有效减小肿瘤的手段，以达到减轻痛苦、延缓发展，延长生存时间的目的。近年来，微波固化已成为继手术、放化疗、生物治疗及射频消融后又一种有效治疗肝癌的治疗方法。近年来研究表明，微波固化以其创伤小、简便可靠、疗效显著等优势在肿瘤临床治疗中得到了普遍的推广。现就微波固化在肝癌治疗方面研究进展作一综述。
文摘Microwave coagulation therapy (MCT) has recently been applied to treat hepatic tumors. However, the histological changes in the liver following MCT have not been fully elucidated. A type of cell death known as microwave fixation has been reported in areas adjacent to the microwave irradiator electrodes, and these areas are without acid phosphatase (AcP) activity. Diagnosis of microwave- fixed tissue by hematoxylin and eosin (HE) staining is very difficult because morphology is well maintained for months. In an effort to clarify the histological changes and the mechanisms of microwave fixation, we performed HE staining, enzyme histochemistry for AcP, and electron microscopy in both rat and human liver samples after MCT. Although the microwave- fixed tissues maintained their structure on HE staining, membranes of microwave- fixed cells were seriously damaged and there were no apparent organelle structures in these cells on electron microscopy. Erythrocytes were also damaged in these tissues on both light and electron microscopy. The cause of microwave fixation is thought to be injury of the membrane, which is similar to coagulative necrosis. In conclusion, microwave fixation can be considered a type of coagulative necrosis without enzyme digestion. Disruption of erythrocytes on HE staining is an interesting and important diagnostic clue in distinguishing nonviable fixed tissues from viable tissues following MCT.
