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微液滴微流控芯片:微液滴的形成、操纵和应用 被引量:7
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作者 宋文斌 董朝青 任吉存 《分析科学学报》 CAS CSCD 北大核心 2011年第1期106-112,共7页
微流控芯片中形成的微液滴粒径均一、可控,与传统的连续流体系相比,具有能实现试剂的快速混合、通量更高等优点。本文介绍了微流控芯片中由微通道控制的微液滴的形成、分裂、合并、混合、分选和捕获等微液滴操纵技术,以及微液滴技术在... 微流控芯片中形成的微液滴粒径均一、可控,与传统的连续流体系相比,具有能实现试剂的快速混合、通量更高等优点。本文介绍了微流控芯片中由微通道控制的微液滴的形成、分裂、合并、混合、分选和捕获等微液滴操纵技术,以及微液滴技术在纳米粒子、聚合物微粒的合成、纳米粒子自组装、蛋白质结晶研究和DNA、细胞分析等领域的研究进展。 展开更多
关键词 微液滴微流控芯片 形成 操纵 应用
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Numerical Study of the Evaporation Effects on the Microdroplet Dynamics in Digital Microfluidic Biochips
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作者 Ali Ahmadi Matt Dale Buat Mina Hoorfar 《Journal of Mechanics Engineering and Automation》 2011年第5期401-406,共6页
In this paper, an electrohydrodynamic approach is used to model and study dynamics of evaporating microdroplets in digital microfluidic systems. A numerical eleetrohydrodynamic approach is used to calculate the drivin... In this paper, an electrohydrodynamic approach is used to model and study dynamics of evaporating microdroplets in digital microfluidic systems. A numerical eleetrohydrodynamic approach is used to calculate the driving force and shear force (due to the walls). Effects of contact line pinning is considered by adding a three-phase contact line force, and also considering dynamic contact angle which modifies the mierodroplet boundary conditions. Since air is used as the filler fluid, the drag force is neglected. Although energy equation is not solved (constant temperature assumption), effects of the evaporation is considered from two aspects: It is shown that an additional force is needed to balance the dynamic equation of the mierodroplet motion. Also, at each time step the microdroplet interface has to be deformed due to the change in the microdroplet radius. Important findings of the proposed model includes the transient velocity and displacement of the microdroplet as well as the driving and opposing forces acting on the microdroplet as functions of time. It is shown that mass loss due to evaporation tends to accelerate the droplet; whereas the competitive effect of the reduced driving force decelerates the droplet at the end of motion. The modeling results indicate that evaporation plays a crucial role in microdroplet motion by changing the force balance and the microdroplet boundary condition. 展开更多
关键词 Digital microfluidic MICRODROPLET EVAPORATION electrohydrodynamic.
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