To investigate the workpiece curvature influence on groove deformation,numerical studies with curvature varying from negative to positive were conducted on copper material.Groove deformations were analyzed,including g...To investigate the workpiece curvature influence on groove deformation,numerical studies with curvature varying from negative to positive were conducted on copper material.Groove deformations were analyzed,including groove geometry,effective stress distribution and plough force.The curled groove shape whose workpiece curvature was 0.133 mm-1 was validated by experiments.Moreover,a series of geometry models with various curvatures were introduced to analyze the change of groove deformation.The results show that positive curvatures influence groove deformation more intensively than negative or zero curvature.It is mainly due to the action of the tool forming face during plough process.展开更多
To identify the metabolite and CYP450 isoforms involved in rat liver microsomal metabolism of TM208. The present study investigated the metabolism of TM208 and the effects of selective CYP450 inhibitors on the metabol...To identify the metabolite and CYP450 isoforms involved in rat liver microsomal metabolism of TM208. The present study investigated the metabolism of TM208 and the effects of selective CYP450 inhibitors on the metabolism of TM208 in rat liver microsomes. Various specific inhibitors of CYP were used to identify the isoforms of CYP involved in the metabolism of TM208. The inhibitor of CYP2D and that of CYP2B had strong inhibitory effects on TM208 metabolism in a concentration-de- pendant manner, the inhibitor of CYP1A had a modest inhibitory effect, and the inhibitor of CYP3A seemed not to have an obvious inhibitory effect on TM208 metabolism. TM208 might mainly be metabolized by CYP2D and CYP2B in rat liver microsomes.展开更多
基金Project (U0834002) supported by the Key Program of NSFC-Guangdong Joint Funds of ChinaProject (51005079) supported by the National Natural Science Foundation of China+1 种基金Project (20100172120001) supported by Specialized Research Fund for the Doctoral Program of Higher Education, ChinaProject (10451064101005146) supported by the Natural Science Foundation of Guangdong Province,China
文摘To investigate the workpiece curvature influence on groove deformation,numerical studies with curvature varying from negative to positive were conducted on copper material.Groove deformations were analyzed,including groove geometry,effective stress distribution and plough force.The curled groove shape whose workpiece curvature was 0.133 mm-1 was validated by experiments.Moreover,a series of geometry models with various curvatures were introduced to analyze the change of groove deformation.The results show that positive curvatures influence groove deformation more intensively than negative or zero curvature.It is mainly due to the action of the tool forming face during plough process.
基金National Basic Research Program of China (863 Program,Grant No.2004AA2Z3783)National Natural Science Foundation of China (Grant No.20672009)
文摘To identify the metabolite and CYP450 isoforms involved in rat liver microsomal metabolism of TM208. The present study investigated the metabolism of TM208 and the effects of selective CYP450 inhibitors on the metabolism of TM208 in rat liver microsomes. Various specific inhibitors of CYP were used to identify the isoforms of CYP involved in the metabolism of TM208. The inhibitor of CYP2D and that of CYP2B had strong inhibitory effects on TM208 metabolism in a concentration-de- pendant manner, the inhibitor of CYP1A had a modest inhibitory effect, and the inhibitor of CYP3A seemed not to have an obvious inhibitory effect on TM208 metabolism. TM208 might mainly be metabolized by CYP2D and CYP2B in rat liver microsomes.
