正交法筛选莪术油微球制备工艺

目的通过正交设计法筛选出制备符合肝动脉栓塞要求的莪术油明胶微球的最佳工艺。方法以微球粒径、分布、载药量、包封率等为指标,采用正交设计法优化微球的制备工艺。结果按优化工艺参数制备的微球外观形态良好,粒径符合肝动脉栓塞的要求,平均载药量为9.45%,包封率为32.34%,平均收率为85.19%,重现性良好。结论确立的莪术油微球的制备工艺切实可行。

包埋法制备替米考星淀粉微球工艺的优化

[目的]研究替米考星淀粉微球的制备工艺。[方法]以可溶性淀粉为原料,以N,N’-亚甲基双丙烯酰胺为交联剂,以过硫酸钾和亚硫酸氢钠为引发剂,采用包埋法制备替米考星淀粉微球。以载药量和包封率为指标,通过正交试验,采用综合平衡法对替米考星淀粉微球的制备工艺进行优化,在扫描电子显微镜下观察替米考星交联微球的形貌及表面形态。[结果]替米考星淀粉微球的最佳制备工艺如下:替米考星0.02 g,可溶性淀粉4 g,交联剂(N,N’-亚甲基双丙烯酰胺)0.95 g,乳化剂(m_(Span80):m_(Tween80)=2∶1)0.75 g,反应时间1.5 h,在优化工艺参数下制得的替米考星淀粉微球载药量为1.63%,包封率为81.4%;微球大小分布均匀,外观圆整,表面粗糙多孔。[结论]该制备工艺可行,扩大了替米考星的应用,为替米考星的剂型改进提供了参考。

Synthesis and Properties of Micron-size Magnetic Polymer Spheres with Epoxy Groups

Micron-size superparamagnetic poly(styrene-divinylbenzene-glycidyl methacrylate) (PSt-DVB-GMA) spheres were prepared via a modified suspension copolymerization method. Oleic acid coated magnetite (Fe3O4 nanoparticles made by co-precipitation were first mixed with monomers of St, DVB, GMA, and benzoyl peroxide (BPO) to form oil in water suspension with the presence of poly(viny) pyrrolidone) (PVP-K30) as a stabilizer. Then the temperature of mixture was increased at a controlled rate to obtain small and relatively uniform droplets. Finally, the copolymerization reaction was initiated by the decomposition of BPO. The morphology and properties of magnetic PSt-DVB-GMA microspheres were examined by SEM, TEM, VSM, XRD and FT-IR. The magnetic microspheres obtained have very small size (about 4-7μm) in diameter with narrow size distribution and super-paramagnetic characteristics. Powder X-ray diffraction measurements show the inverse cubic spinel structure for the magnetite dispersed in polymer microspheres. FT-IR spectroscopy indicates extensive oxirane groups existed on the surface of magnetic PSt-DVB-GMA microspheres.