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蚕砂光敏剂对瘤区微血管作用的电镜观察 被引量:3
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作者 徐敏源 陈彤 +1 位作者 钟济秀 李唯佳 《中华理疗杂志》 1995年第4期209-210,共2页
蚕砂光敏剂对瘤区微血管作用的电镜观察徐敏源,陈彤,钟济秀,李唯佳光敏剂在光动力学疗法中已应用于临床[1~5],但对其机制尚未完全清楚。目前使用的光敏剂主要是血叶啉衍生物(IIPD),蚕砂光敏剂是我国传统中药蚕砂中提取... 蚕砂光敏剂对瘤区微血管作用的电镜观察徐敏源,陈彤,钟济秀,李唯佳光敏剂在光动力学疗法中已应用于临床[1~5],但对其机制尚未完全清楚。目前使用的光敏剂主要是血叶啉衍生物(IIPD),蚕砂光敏剂是我国传统中药蚕砂中提取的一种以叶绿三酸为主要成分的新型光... 展开更多
关键词 肿瘤 光动力疗法 蚕砂 光敏剂 微血管作用
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32P玻璃微球间质治疗联合加热对肿瘤微血管作用的实验研究
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作者 汪永跃 王大章 +1 位作者 郑光勇 毛祖彝 《口腔医学研究》 CAS CSCD 2004年第3期226-226,共1页
关键词 32P玻璃微球间质 联合加热 微血管作用 恶性肿瘤 放疗
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疏肝益肾方对激素依赖型乳腺癌患者骨髓抑制作用和血清凋亡Apaf-1、Ki-67、P53的表达及微血管生成的影响 被引量:1
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作者 王晓玲 李江涛 +2 位作者 赵莉娜 王成 汪旻琦 《辽宁中医药大学学报》 CAS 2022年第3期128-132,共5页
目的探讨疏肝益肾方对激素依赖型乳腺癌患者骨髓抑制作用和血清凋亡蛋白酶活化因子-1(Apaf-1)、增殖细胞核抗原(Ki-67)、肿瘤抑制蛋白P53的表达及微血管生成的影响。方法选择2019年1月—2020年6月于秦皇岛市中医医院治疗的106例激素依... 目的探讨疏肝益肾方对激素依赖型乳腺癌患者骨髓抑制作用和血清凋亡蛋白酶活化因子-1(Apaf-1)、增殖细胞核抗原(Ki-67)、肿瘤抑制蛋白P53的表达及微血管生成的影响。方法选择2019年1月—2020年6月于秦皇岛市中医医院治疗的106例激素依赖型乳腺癌患者进行前瞻性研究,根据随机数字表法将纳入研究的病例分为中药联合组和对照组,两组患者行不同治疗方案。对照组服用来曲唑片进行治疗,中药联合组在此基础上服用疏肝益肾方,连续治疗4周。疗程结束后对比两组疗效,骨髓抑制情况及凋亡Apaf-1、Ki-67、P53、血管内皮细胞生长因子(VEGF)、基质金属蛋白酶-2(MMP-2)、基质金属蛋白酶-9(MMP-9)含量。结果中药联合组疗效分级情况明显优于对照组(P<0.05);治疗后,两组患者的白细胞计数(WBC)、血红蛋白(HB)、血小板计数(PLT)含量相较于治疗前均明显升高(P<0.05),且中药联合组明显高于对照组(P<0.05);治疗后,两组患者的Apaf-1含量相较于治疗前均明显升高(P<0.05),且中药联合组明显高于对照组(P<0.05);两组患者的Ki-67、P53含量相较于治疗前均明显降低(P<0.05),且中药联合组明显低于对照组(P<0.05);治疗后,两组患者的血清VEGF、MMP-2、MMP-9含量相较于治疗前均明显降低(P<0.05),且中药联合组明显低于对照组(P<0.05)。结论疏肝益肾方对激素依赖型乳腺癌患者疗效较好,可有效缓解骨髓抑制效应,提高血清Apaf-1含量,降低Ki-67、P53表达,同时抑制微血管生成。 展开更多
关键词 激素依赖型乳腺癌 疏肝益肾方 骨髓抑制 微血管生成作用
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Herbal cardiotonic pills prevent gut ischemia/reperfusion-induced hepatic microvascular dysfunction in rats fed ethanol chronically 被引量:13
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作者 Yoshinori Horie Shuka Mori +6 位作者 Masahiro Konishi Mikio Kajihara Takehiko Kaneko Yoshiyuki Yamagishi Shinzo Kato Hiromasa Ishii Toshifumi Hibi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第4期511-515,共5页
AIM: Cardiotonic Pill (CP), an oral herbal medicine that includes Danshen (Salviae Miltiorrhizae), Panax notoginseny and Dyroblanops aromatica gaettn, has been clinically used for vascular diseases such as occlusive v... AIM: Cardiotonic Pill (CP), an oral herbal medicine that includes Danshen (Salviae Miltiorrhizae), Panax notoginseny and Dyroblanops aromatica gaettn, has been clinically used for vascular diseases such as occlusive vasculitis, coronary diseases, atherosclerosis, and cerebral infarction. The main component, Salviae Miltiorrhizae, has been reported to prevent cerebral and intestinal reperfusion injury. However, little is known about the effect of CP on hepatic microcirculation. Thus, this study aimed to determine whether CP could affect hepatic microvascular dysfunction elicited by gut ischemia/ reperfusion (I/R) in rats fed ethanol chronically. METHODS: Male Wistar rats were pair-fed with a liquid diet containing ethanol or isocaloric control diet for 6 wk. After laparotomy, one lobe of the liver was examined through an inverted intravital microscope. The rats were exposed to 30 min of gut ischemia followed by 60 min of reperfusion. Rhodamine-6G-labeled leukocytes in the sinusoids were observed 90 min after the onset of superior mesenteric artery occlusion. Plasma tumor necrosis factor (TNF)-α and endotoxin levels were measured 1 h after the onset of reperfusion. Plasma alanine aminotransferase (ALT) activities were measured 6 h after the onset of reperfusion. In another set of experiments, CP (0.8 g/kg, intragastrically) was administered 1 and 24 h before the onset of ischemia. RESULTS: In control rats, gut I/R elicited increases in the number of stationary leukocytes, and plasma TNF-α and endotoxin levels and plasma ALT activities. These changes were mitigated by pretreatment with CP. In ethanol-fed rats, the gut I/R-induced increases in the number of stationary leukocytes, plasma endotoxin levels and ALT activities were enhanced. Pretreatment with CP attenuated the enhancement of gut I/R-induced responses by chronic ethanol consumption. CONCLUSION: These results suggest that CP prevents the gut I/R-induced hepatic microvascular dysfunction and hepatocellular injury. A reduction of inflammatory responses such as TNF-α production via reduction of blood endotoxin levels appears to be involved in the mechanisms. Chronic ethanol consumption enhances gut I/R-induced hepatic microvascular and hepatocellular injury. CP also attenuates an enhancement of gut I/R-induced responses by chronic ethanol consumption via the reduction of blood endotoxin levels. 展开更多
关键词 Intestinal reperfusion injury Hepatic microvascular dysfunction Cardiotonic Pill ETHANOL
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Hepato-cardiovascular response and its regulation 被引量:1
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作者 Xiang-NongLi IrvingSBenjamin BarryAlexander 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第5期676-680,共5页
AIM: To determine the possible existence of a hepato-cardiovascular response and its regulatory mechanism in normal rats. METHODS: Systemic hemodynamic changes following intraportal injection of latex microspheres wer... AIM: To determine the possible existence of a hepato-cardiovascular response and its regulatory mechanism in normal rats. METHODS: Systemic hemodynamic changes following intraportal injection of latex microspheres were studied in two modified rat models of hepatic circulation, in which the extrahepatic splanchnic circulation was excluded by evisceration and the liver was perfused by systemic blood via either the portal vein (model 1) or hepatic artery (model 2) in vivo. RESULTS: In model 1, intraportal injection of two sized microspheres (15-μm and 80-μm) induced a similar decrease in mean arterial pressure, while extrahepatic portal venous occlusion induced an immediate increase in mean arterial pressure. In model 2, microsphere injection again induced a significant reduction in mean arterial pressure, aortic blood flow and aortic resistance. There were no significant differences in these parameters between liver-innervated rats and liver-denervated rats. The degrees of microsphere-induced reduction in mean arterial pressure (-38.1±1.9% in liver-innervated rats and -35.4±2.1% in liver-denervated rats, respectively) were similar to those obtained by withdrawal of 2.0 mL of blood via the jugular vein (-33.3±2.1%) (P>0.05). Injection of 2.0 mL Haemaccel in microsphere-treated rats, to compensate for the reduced effective circulating blood volume, led to a hyperdynamic state which, as compared with basal values and unlike control rats, was characterised by increased aortic blood flow (+21.6±3.3%), decreased aortic resistance (-38.1±3.5%) and reduced mean arterial pressure (-9.7±2.8%). CONCLUSION: A hepato-cardiovascular response exists in normal rats. It acts through a humoral mechanism leading to systemic vasodilatation, and may be involved in the hemodynamic disturbances associated with acute and chronic liver diseases. 展开更多
关键词 Hepato-cardiovascular response HEMODYNAMICS
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Mechanical behavior of the erythrocyte in microvessel stenosis 被引量:2
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作者 ZHANG ZhiGuo ZHANG XiWen 《Science China(Life Sciences)》 SCIE CAS 2011年第5期450-458,共9页
The passage of red blood cells (RBCs) through capillaries is essential for human blood microcirculation. This study used a moving mesh technology that incorporated leader-follower pairs to simulate the fluid-structu... The passage of red blood cells (RBCs) through capillaries is essential for human blood microcirculation. This study used a moving mesh technology that incorporated leader-follower pairs to simulate the fluid-structure and structure-structure interac- tions between the RBC and a microvessel stenosis. The numerical model consisted of plasma, cytoplasm, the erythrocyte membrane, and the microvessel stenosis. Computational results showed that the rheology of the RBC is affected by the Reynolds number of the plasma flow as well as the surface-to-volume ratio of the erythroeyte. At a constant inlet flow rate, an increased plasma viscosity will improve the transit of the RBC through the microvessel stenosis. For the above reasons, we consider that the decreased hemorheology in microvessels in a pathological state may primarily be attributed to an increase in the number of white blood cells. This leads to the aggregation of RBCs and a change in the blood flow structure. The present fundamental study of hemorheology aimed at providing theoretical guidelines for clinical hemorheology. 展开更多
关键词 red blood cell moving mesh leader-follower pair RHEOLOGY fluid-structure interaction
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