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结直肠癌的精准医学:大数据和微进展的时代 被引量:1
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作者 魏少忠 胡胜 《中华结直肠疾病电子杂志》 2016年第5期370-375,共6页
依据大数据为基础的结直肠癌精准医学是一个有吸引力的研究方向。虽然下一代测序(next generation sequencing,NGS)技术发展迅速,但科学和实践方面的挑战导致临床上进展微小。最大的挑战是驱动突变的识别,因为除了EGFR、MLH1、PIK3CA和K... 依据大数据为基础的结直肠癌精准医学是一个有吸引力的研究方向。虽然下一代测序(next generation sequencing,NGS)技术发展迅速,但科学和实践方面的挑战导致临床上进展微小。最大的挑战是驱动突变的识别,因为除了EGFR、MLH1、PIK3CA和KRAS基因异常,结直肠癌没有其他有效的致癌驱动突变存在。发展生物信息学工具,超深度测序和监测循环肿瘤DNA(circulating tumor DNA,ct DNA)方法,以帮助确定发生率微小的驱动突变,以及评估通路的激活,并进行联合治疗的方法,有助于在将来解决上述问题。大多数候选基因组改变的发生率微小,限制了精准医学的临床实践。解决策略是发展个体化的篮子试验或雨伞试验。 展开更多
关键词 结直肠肿瘤 数据库 核酸 精准医学 微进展
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中重度脑白质疏松与急性腔隙性脑梗死患者CMBs进展的相关性
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作者 杜洪彬 《中国医学创新》 CAS 2021年第21期160-163,共4页
目的:观察急性腔隙性脑梗死(LI)患者脑白质疏松(LA)程度及脑微出血(CMBs)进展情况,分析中重度LA与CMBs进展的相关性。方法:回顾性分析2018年1月-2019年6月本院收治的106例急性LI患者的资料,患者入院2 d内及随访12个月后均接受头颅磁共振... 目的:观察急性腔隙性脑梗死(LI)患者脑白质疏松(LA)程度及脑微出血(CMBs)进展情况,分析中重度LA与CMBs进展的相关性。方法:回顾性分析2018年1月-2019年6月本院收治的106例急性LI患者的资料,患者入院2 d内及随访12个月后均接受头颅磁共振(MRI)检查,根据头颅MRI影像学表现评定患者LA及CMBs进展。比较不同程度CMBs患者LA程度,分析CMBs进展与LA程度的关系。结果:106例急性LI患者,后期随访12个月发生进展性CMBs 41例,未发生进展性CMBs 65例。CMBs 1级23例,2级11例,3级7例。不同程度CMBs患者LA程度比较,差异有统计学意义(P<0.001)。0级组LA程度优于1、2、3级组,1级组优于2、3级组,差异均有统计学意义(P<0.05)。Spearman相关分析显示,中重度LA与急性LI患者CMBs程度呈正相关(P<0.001)。结论:急性LI患者CMBs进展发生率较高,CMBs级别越高患者LA程度越严重,中重度LA可能是急性LI患者脑出血进展的影响因子,可为早期预防治疗提供有效依据。 展开更多
关键词 脑白质疏松 急性腔隙性脑梗死 出血进展 相关性
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A State-of-the-Art Review of Mixing in Microfluidic Mixers 被引量:12
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作者 Elmabruk A. +3 位作者 Mansur 叶明星 王运东 戴猷元 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2008年第4期503-516,共14页
Microreaction technology is one of the most innovative and rapid developing fields in chemical engineering, synthesis and process technology. Many expectations toward enhanced product selectivity, yield and purity, im... Microreaction technology is one of the most innovative and rapid developing fields in chemical engineering, synthesis and process technology. Many expectations toward enhanced product selectivity, yield and purity, improved safety, and access to new products and processes are directed to the microreaction technology. Microfluidic mixer is the most important component in microfluidic devices. Based on various principles, active and passive micromixers have been designed and investigated. This review is focused on the recent developments in microfluidic mixers. An overview of the flow phenomena and mixing characteristics in active and passive micromixers is presented, including the types of physical phenomena and their utilization in micromixers. Due to the simple fabrication technology and the easy implementation in a complex microfluidic system, T-micromixer is highlighted as an example to illustrate the effect of design and operating parameters on mixing efficiency and fuid flow inside microfluidic mixers. 展开更多
关键词 MICROMIXING MICROFLUIDICS T-shaped micromixer microfabricafion techniques microreaction technologies microelectromechanical systems
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Research progress of micro(nano)plastics in marine survey in China
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作者 GAO Yan DAI Yuanyuan +3 位作者 SUN Xueliang LI Wangcan HE Qing LIU Zeping 《Marine Science Bulletin》 CAS 2020年第1期90-96,共7页
The extensive existence of microplastics in the marine environment and the various definite and indefinite harm to the living creatures have been paid much attention.In this paper,the definition,source and pollution o... The extensive existence of microplastics in the marine environment and the various definite and indefinite harm to the living creatures have been paid much attention.In this paper,the definition,source and pollution of micro(Nano)plastics in marine environment are reviewed.The related literatures are retrieved by using big data platform,the distribution characteristics of micro(Nano)plastics in the marine environment,control measures and so on,and the characteristics of key words making,resource distribution and contribution rate of research institutions are comprehensively analyzed.It provides the technical support for the scientific management of micro(Nano)plastics in the future. 展开更多
关键词 micro-nano plastics oceanographic survey research progress
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The Application of the Fixed-point Theory in Jacketed Solution of Singularly Perturbed Nonlinear Problem
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作者 CHENG Yan (Department of Basic Course, Artillery Academy of P.L.A., Hefei 230031, China) 《Chinese Quarterly Journal of Mathematics》 CSCD 2003年第1期103-107,共5页
In this paper,the fixed_point theorem is used to estimated an asymptotic solution of initial value problems for a class of third nonlinear differential equations which has double initial_layer properties. We obtain th... In this paper,the fixed_point theorem is used to estimated an asymptotic solution of initial value problems for a class of third nonlinear differential equations which has double initial_layer properties. We obtain the uniformly valid asymptotic expansion of any orders including boundary layers. 展开更多
关键词 fixed_point theorem asymptotic expansion jacketed solution singular perturbation
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CAUCHY PROBLEM FOR A NONLINEAR SINGULAR INTEGRAL-DIFFERENTIAL EVOLUTION SYSTEM
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作者 ZHANG LINGHAI(Inst.of Appl.Phys.and Comp.Math.,Beijing 100088) 《Applied Mathematics(A Journal of Chinese Universities)》 SCIE CSCD 1994年第1期45-53,共9页
We study the Cauchy problem for a nonlinear evolution system with singularintegral differential terms.By means of some a priori estimates of the solution and theLeray-Schauder's fixed point theorem, we prove the e... We study the Cauchy problem for a nonlinear evolution system with singularintegral differential terms.By means of some a priori estimates of the solution and theLeray-Schauder's fixed point theorem, we prove the existence and the uniqueness theoremsof the generalized global solution of the mentioned problem. 展开更多
关键词 Cauchy Problem Nonlinear Evolution System Singular integral-differentialTerm Integral Estimate.
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The development of foot microsurgery: the past and the future
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作者 蔡锦方 《Chinese Journal of Traumatology》 CAS 2003年第1期45-53,共9页
关键词 Foot Diseases Foot Injuries Forecasting History 20th Century Humans MICROSURGERY Reconstructive Surgical Procedures Surgical Flaps
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