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微针长度与马钱子碱可溶性微针刺入性能及治疗效果的关联性研究 被引量:6
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作者 汪云霞 宋信莉 +7 位作者 王永林 刘文 张永萍 王群 陈欢欢 石佳楠 杨小双 杨胜磊 《中草药》 CAS CSCD 北大核心 2022年第11期3338-3347,共10页
目的制备不同微针长度(针长)马钱子碱(brucnine,Bru)可溶性微针(Bru-DMNs),探讨针长对微针刺入性能及治疗效果的影响。方法采用两步离心法制备不同针长(350、450、550、650、750、850μm)Bru-DMNs。通过铝箔及鼠皮穿刺实验考察各针长微... 目的制备不同微针长度(针长)马钱子碱(brucnine,Bru)可溶性微针(Bru-DMNs),探讨针长对微针刺入性能及治疗效果的影响。方法采用两步离心法制备不同针长(350、450、550、650、750、850μm)Bru-DMNs。通过铝箔及鼠皮穿刺实验考察各针长微针穿刺性能;在体溶解实验考察各针长微针溶解性能;皮肤HE染色观察各针长微针刺入皮肤的深度;皮肤屏障恢复实验评估各针长微针对皮肤角质层的影响;采用Franz扩散池考察各针长微针体外透皮性能;体内药效学评估各针长微针对类风湿性关节炎(rheumatoid arthritis,RA)的治疗作用。结果350、850μm针长微针穿刺效果较差,450、550、650、750μm针长微针穿刺性能较佳,能成功刺入皮肤形成微孔通道成功递送药物,刺入皮肤后可快速溶解,微针越长,溶解越快;针长越长,刺入皮肤越深,皮肤角质层孔道闭合越慢(4~6 h);450μm针长微针促渗效果较差,长度达到550μm时即有较好促渗效果;各针长微针均可不同程度缓解和治疗RA,长度达到550μm时即可达到理想疗效。结论当微针长度达到550μm时,各项性能良好,具有显著的促渗效果和治疗效果。 展开更多
关键词 马钱子碱 可溶性 微针长度 经皮给药 类风湿性关节炎 两步离心法 药效学 促渗
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Effect of pin penetration depth on double-sided friction stir welded joints of AA6061-T913 alloy 被引量:2
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作者 Iman HEJAZI Seyyed Ehsan MIRSALEHI 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2016年第3期676-683,共8页
Friction stir welding (FSW) of aluminum alloys is currently utilized in several modern industries. The joints must have sufficient elastic?plastic response and formability levels similar to that of the base metal. In ... Friction stir welding (FSW) of aluminum alloys is currently utilized in several modern industries. The joints must have sufficient elastic?plastic response and formability levels similar to that of the base metal. In this work, double-sided FSW of AA6061 sheet was compared with its conventional single-sided one. An adjustable tool with different pin lengths (50%?95% of the sheet thickness) was used to perform the double-sided welds. Macro- and micro-structures, strength, and hardness of the joints were investigated to determine the optimum pin penetration depth. The best results were obtained for a double-sided joint made by a pin length equal to 65% of the sheet thickness, which showed an increase of 41% in the ultimate tensile strength compared with the single-sided joint. 展开更多
关键词 AA6061 aluminium alloy friction stir welding double-sided joint pin length mechanical properties microstructure
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