Educational philosophy and enlightenment have been closely connected through the human pursuit to search for truth and improvement in history. In today＇s world, commercialism and technology have gained and accumulate...Educational philosophy and enlightenment have been closely connected through the human pursuit to search for truth and improvement in history. In today＇s world, commercialism and technology have gained and accumulated enormous power in its impact on human society and consciousness, and have posed serious challenges to the traditional pursuit of enlightenment and philosophical studies. This paper takes a retrospective look of Lao Zi＇s Dao De Jing （Tao Te Jing, 道德经）.1 The discussion provides Lao Zi＇s definition of enlightenment in comparison to the western philosophical tradition and examines his focal concepts of Dao （the Way,道） and Virtue （德）, their relationship as well as the connection with enlightenment and education. In addition, the paper analyzes the insights and meaning Lao Zi＇s thought has for the contemporary philosophers and practices and raises questions regarding the implementation of his philosophy in the classrooms today.展开更多
1.问:高中英语课本第一册LessonTen p.158,And it was one of thefew man-made objects on earththat could be seen by the astron-ants who landed on the moon.p.164此句的译文为:而且它是登上月球的宇航员能够着到的地球上为数不多...1.问:高中英语课本第一册LessonTen p.158,And it was one of thefew man-made objects on earththat could be seen by the astron-ants who landed on the moon.p.164此句的译文为:而且它是登上月球的宇航员能够着到的地球上为数不多的人工建筑物之一。“地球”是独一无二的东西,为什么其前无the? 答:费致德老先生在其《现代英语惯用法辞典》P.282说:1.展开更多
Autophagic and proteasomal proteolysis are two major pathways for degradation of cellular constituents. Current models suggest that autophagy is responsible for the nonselective bulk degradation of long-lived proteins...Autophagic and proteasomal proteolysis are two major pathways for degradation of cellular constituents. Current models suggest that autophagy is responsible for the nonselective bulk degradation of long-lived proteins and organelles while the proteasome specifically degrades short-lived proteins including misfolded proteins caused by the absence of Hsp90 function. Here, we show that the IκB kinase （IKK）, an essential activator of NF-κB, is selectively degraded by autophagy when Hsp90 is inhibited by geldanamycin （GA）, a specific Hsp90 inhibitor showing highly effective anti-tumor activity. We find that in this case inactivation of ubiquitination or proteasome fails to block IKK degradation. However, inhibition of autophagy by an autophagy inhibitor or knockout of Atg5, a key component of the autophagy pathway, significantly rescues IKK from GA-induced degradation. These findings provide the first evidence that an Hsp90 client may be degraded by a mechanism different from the proteasome pathway and establish a molecular link among Hsp90, NF-κB and autophagy展开更多
文摘Educational philosophy and enlightenment have been closely connected through the human pursuit to search for truth and improvement in history. In today＇s world, commercialism and technology have gained and accumulated enormous power in its impact on human society and consciousness, and have posed serious challenges to the traditional pursuit of enlightenment and philosophical studies. This paper takes a retrospective look of Lao Zi＇s Dao De Jing （Tao Te Jing, 道德经）.1 The discussion provides Lao Zi＇s definition of enlightenment in comparison to the western philosophical tradition and examines his focal concepts of Dao （the Way,道） and Virtue （德）, their relationship as well as the connection with enlightenment and education. In addition, the paper analyzes the insights and meaning Lao Zi＇s thought has for the contemporary philosophers and practices and raises questions regarding the implementation of his philosophy in the classrooms today.
文摘1.问:高中英语课本第一册LessonTen p.158,And it was one of thefew man-made objects on earththat could be seen by the astron-ants who landed on the moon.p.164此句的译文为:而且它是登上月球的宇航员能够着到的地球上为数不多的人工建筑物之一。“地球”是独一无二的东西,为什么其前无the? 答:费致德老先生在其《现代英语惯用法辞典》P.282说:1.
文摘Autophagic and proteasomal proteolysis are two major pathways for degradation of cellular constituents. Current models suggest that autophagy is responsible for the nonselective bulk degradation of long-lived proteins and organelles while the proteasome specifically degrades short-lived proteins including misfolded proteins caused by the absence of Hsp90 function. Here, we show that the IκB kinase （IKK）, an essential activator of NF-κB, is selectively degraded by autophagy when Hsp90 is inhibited by geldanamycin （GA）, a specific Hsp90 inhibitor showing highly effective anti-tumor activity. We find that in this case inactivation of ubiquitination or proteasome fails to block IKK degradation. However, inhibition of autophagy by an autophagy inhibitor or knockout of Atg5, a key component of the autophagy pathway, significantly rescues IKK from GA-induced degradation. These findings provide the first evidence that an Hsp90 client may be degraded by a mechanism different from the proteasome pathway and establish a molecular link among Hsp90, NF-κB and autophagy
