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心康平原料药的鉴别和含量测定 被引量:22
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作者 李洪玲 杨广德 贺浪冲 《药物分析杂志》 CAS CSCD 北大核心 2001年第5期348-351,共4页
目的 :研究新的中药复方制剂心康平的质控指标。方法 :采用细胞膜色谱法对三七、丹参和当归进行有效成分的筛选 ,在此基础上对原料药中三七的 4种有效成分三七皂苷R1、人参皂苷Rg1、Re和Rb1进行薄层色谱鉴别 ,薄层展开条件为氯仿 -醋酸... 目的 :研究新的中药复方制剂心康平的质控指标。方法 :采用细胞膜色谱法对三七、丹参和当归进行有效成分的筛选 ,在此基础上对原料药中三七的 4种有效成分三七皂苷R1、人参皂苷Rg1、Re和Rb1进行薄层色谱鉴别 ,薄层展开条件为氯仿 -醋酸乙酯 -甲醇 -水 (15∶40∶2 2∶10 ) ;对丹参和当归中的丹参酮ⅡA 和藁本内酯用HPLC法同时进行了含量测定 ,色谱条件为KromasilODS柱 (15 0mm× 4 6mm ) ,甲醇 -水 (80∶2 0 )为流动相 ,流速 1mL·min-1,2 5 4nm下检测结果 :TLC鉴别方法专属性强。HPLC法测定丹参酮ⅡA 和藁本内酯的回收率分别为 98 9%和 10 0 9% ,RSD分别为 3 0 %和 2 5 %。结论 展开更多
关键词 心康平 原料药 鉴别 含量测定 细胞膜色谱法 丹参酮ⅡA 高级液相色谱法
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心康平原料药体内过程研究
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作者 李洪玲 王琪 贺浪冲 《现代中药研究与实践》 CAS 2004年第3期54-56,共3页
目的 了解心康平原料药中藁本内酯、隐丹参酮、丹参酮 及丹参酮 A 的体内过程。方法 利用反相高效液相色谱法测定兔血浆及主要脏器中藁本内酯、隐丹参酮、丹参酮 和丹参酮 A。结果 血浆中藁本内酯、隐丹参酮、丹参酮 及丹参酮 ... 目的 了解心康平原料药中藁本内酯、隐丹参酮、丹参酮 及丹参酮 A 的体内过程。方法 利用反相高效液相色谱法测定兔血浆及主要脏器中藁本内酯、隐丹参酮、丹参酮 和丹参酮 A。结果 血浆中藁本内酯、隐丹参酮、丹参酮 及丹参酮 A 均未测出 ,仅在胆汁和肝脏中测得这几种有效成分。讨论 药物口服后其主要有效部位在体内吸收很差 。 展开更多
关键词 心康平 原料药 药物代谢 高效液相色谱法 藁本内酯 隐丹参酮 丹参酮Ⅰ 丹参酮ⅡA
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Sport participation and vigilance in children:Influence of different sport expertise 被引量:2
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作者 Rafael Ballester Florentino Huertas +1 位作者 Enrique Molina Daniel Sanabria 《Journal of Sport and Health Science》 SCIE 2018年第4期497-504,共8页
Purpose: The present study aimed to investigate the relationship between different types of sport expertise (externally-paced vs. self-paced sports) and vigilance performance in children by evaluating the cardiovas... Purpose: The present study aimed to investigate the relationship between different types of sport expertise (externally-paced vs. self-paced sports) and vigilance performance in children by evaluating the cardiovascular fitness level of the participants. Methods: Three groups of children (11.0 ± 0.2 years) differentiated in terms of their regular sport participation (football players, n = 20; track and field athletes, n = 20; non-athletic controls, n = 20) took part in the study. In one session, participants performed the Leger Multi-stage fitness test to estimate their aerobic fitness level. In another session, participants completed the Psychomotor Vigilance Task (PVT) to evaluate their vigilance performance under 2 conditions of velocity demands (normal vs. speed). Results: The results revealed that both groups of sport practitioners had higher cardiovascular fitness than non-athlete controls. In contrast, no significant differences in the performance PVT were found between track and field athletes and controls. Crucially, football players showed better performance in the PVT than track and field athletes and controls. These between-group differences were not modulated by the speed demands of the task. Conclusion: The major novel finding of this research points to a positive relationship between sport participation and vigilance performance during childhood. We discuss our results in terms of the different hypotheses put forward in the literature to explain the relationship between regular exercise and cognitive fimctioning: the "cardiovascular fitness" and the "cognitive component skills" hypotheses.2018 Published by Elsevier B.V. on behalf of Shanghai University of Sport. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/). 展开更多
关键词 CHILDHOOD COGNITION Cognitive skills Physical activity Physical exercise Sustained attention
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