The Luo Rudy models of mammalian ventricular cell were chosen in studying cardiac electrophysiology. Rush and Larsen’s algorithm and adaptive time step methods were used to solve the ordinary differential equations (...The Luo Rudy models of mammalian ventricular cell were chosen in studying cardiac electrophysiology. Rush and Larsen’s algorithm and adaptive time step methods were used to solve the ordinary differential equations (ODE’s). The operator splitting (or time splitting) and adaptive time step methods were used to solve the partial differential equations (PDE’s) in cardiac tissue conduction models. The alternating direction implicit (ADI) method was used to integrate the PDE. Using these methods we accomplished the simulation programs of single cardiomyocyte model, one dimensional cable model(1 D) and two dimensional(2 D) tissue model. The methods of initiating spiral waves were studied with these software. The data getting from 2 D simulation can be used for further study on isopotential contour lines, spiral wave tip trajectories, and pseudo ECG. The software for computer simulation have been successfully used in simulation studying of electrophysiology properties of single cardiomyocyte, conduction in one dimensional cable model(1 D) and two dimensional(2 D) tissue model.展开更多
基金Project Supported by National Natural Science Foundation of China(No.3 0 10 0 0 67)
文摘The Luo Rudy models of mammalian ventricular cell were chosen in studying cardiac electrophysiology. Rush and Larsen’s algorithm and adaptive time step methods were used to solve the ordinary differential equations (ODE’s). The operator splitting (or time splitting) and adaptive time step methods were used to solve the partial differential equations (PDE’s) in cardiac tissue conduction models. The alternating direction implicit (ADI) method was used to integrate the PDE. Using these methods we accomplished the simulation programs of single cardiomyocyte model, one dimensional cable model(1 D) and two dimensional(2 D) tissue model. The methods of initiating spiral waves were studied with these software. The data getting from 2 D simulation can be used for further study on isopotential contour lines, spiral wave tip trajectories, and pseudo ECG. The software for computer simulation have been successfully used in simulation studying of electrophysiology properties of single cardiomyocyte, conduction in one dimensional cable model(1 D) and two dimensional(2 D) tissue model.
