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细胞因子的心理神经免疫学研究进展 被引量:1
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作者 高福 杨平 《医学综述》 2001年第9期515-517,共3页
关键词 细胞因子 心理神经疾病学 分子生物
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Electrophysiological evidence of P2X2 receptor expression in the neurons of intracardiac and paratracheal ganglia 被引量:1
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作者 马蓓 倪鑫 +1 位作者 韩红 BURNSTOCK Geoffrey 《Journal of Medical Colleges of PLA(China)》 CAS 2006年第3期137-142,共6页
Objective: To investigate the expression of P2X receptors on rat intracardiac and paratracheal ganglion neurons. Methods: For preparation of intracardiac neurons, hearts were excised, the atria were separated and th... Objective: To investigate the expression of P2X receptors on rat intracardiac and paratracheal ganglion neurons. Methods: For preparation of intracardiac neurons, hearts were excised, the atria were separated and the medial region containing intracardiac ganglia was isolated and cut into pieces. For preparation of paratracheal neurons, the tracheas were removed and the superficial membranous layer containing paratracheal ganglia was rapidly isolated. Intracardiac and paratracheal ganglion neurons were dissociated after digestion by collagenase and trypsin. Whole-cell patch clamp recording was used to identify the pharmacological properties of P2X receptors in cultured neurons. Results:Neurons from these two ganglia responded to ATP with a rapidly activating, sustained inward current, αβ-meATP failed to evoke any re- sponses in paratracheal ganglion neurons while a few of intracardiac ganglion neurons responded to αβ- meATP with a tiny sustained inward current. ADP and UTP had no effect on intracardiac neurons. Lowering pH potentiated ATP responses in neurons from these two ganglia whereas increasing pH inhibited ATP responses. Co-application of Zn^2+ potentiated ATP responses in intracardiac and paratracheal ganglion neurons. Conclusion: The receptor subtypes involved in intracardiac and paratracheal ganglia appear to be homomeric P2X2, while heteromeric P2X2/3 could not be completely excluded from intracardiac neurons. 展开更多
关键词 P2X receptor INTRACARDIAC paratracheal parasympathetic ganglion
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