The last decade has witnessed a growing appreciation of the fundamental role played by an early assembly of a diverse and balanced gut microbiota and its subsequent maintenance for future health of the host. Gut micro...The last decade has witnessed a growing appreciation of the fundamental role played by an early assembly of a diverse and balanced gut microbiota and its subsequent maintenance for future health of the host. Gut microbiota is currently viewed as a key regulator of a fluent bidirectional dialogue between the gut and the brain(gut-brain axis). A number of preclinical studies have suggested that the microbiota and its genome(microbiome) may play a key role in neurodevelopmental and neurodegenerative disorders. Furthermore, alterations in the gut microbiota composition in humans have also been linked to a variety of neuropsychiatric conditions, including depression, autism and Parkinson's disease. However, it is not yet clear whether these changes in the microbiome are causally related to such diseases or are secondary effects thereof. In this respect, recent studies in animals have indicated that gut microbiota transplantation can transfer a behavioral phenotype, suggesting that the gut microbiota may be a modifiable factor modulating the development or pathogenesis of neuropsychiatric conditions. Further studies are warranted to establish whether or not the findings of preclinical animal experiments can be generalized to humans. Moreover, although different communication routes between the microbiota and brain have been identified, further studies must elucidate all the underlying mechanisms involved. Such research is expected to contribute to the design of strategies to modulate the gut microbiota and its functions with a view to improving mental health, and thus provide opportunities to improve the management of psychiatric diseases. Here, we review the evidence supporting a role of the gut microbiota in neuropsychiatric disorders and the state of the art regarding the mechanisms underlying its contribution to mental illness and health. We also consider the stages of life where the gut microbiota is more susceptible to the effects of environmental stressors, and the possible microbiota-targeted intervention strategies that could improve health status and prevent psychiatric disorders in the near future.展开更多
About 50% of patients with hepatitis C virus(HCV)infection complain of neuropsychiatric symptoms,"brain fog",weakness,fatigue,and exhibit some degree of quality of life impairment,irrespective of the severit...About 50% of patients with hepatitis C virus(HCV)infection complain of neuropsychiatric symptoms,"brain fog",weakness,fatigue,and exhibit some degree of quality of life impairment,irrespective of the severity of liver disease.Since the first observation of HCV-related cognitive deficits,10 studies have been published that have evaluated neuropsychiatric performance in patients with HCV infection and different degrees of hepatic impairment.Unfortunately,these have often included patients with cirrhosis,patients who had acquired the infection through previous intravenous drug misuse,who had a history of relatively recent treatment with interferon,or were on psychoactive medication.In addition,different neuropsychological batteries and tests that explored different cognitive domains were used,which makes the results of the studies difficult to compare.Finally,limited information is available on the pathogenesis of HCV-related cognitive impairment.Cerebral and/or systemic inflammation may be important players but their potential role has not been substantiated by experimental data.The present review outlines the available evidence of the presence of cognitive impairment in patients with HCV infection,with a focus on the potential relationship with cerebral and/or systemic inflammation.展开更多
The pathogenesis of Functional Dyspepsia （FD） remains unclear, appears diverse and is thus inadequately understood. Akin to other functional gastrointestinal disorders, research has demonstrated an association betwe...The pathogenesis of Functional Dyspepsia （FD） remains unclear, appears diverse and is thus inadequately understood. Akin to other functional gastrointestinal disorders, research has demonstrated an association between this common diagnosis and psychosocial factors and psychiatric morbidity. Conceptualising the relevance of these factors within the syndrome of FD requires application of the biopsychosocial model of disease. Using this paradigm, dysregulation of the reciprocal communication between the brain and the gut is central to symptom generation, interpretation and exacerbation. Appreciation and understanding of the neurobiological correlates of various psychological states is also relevant. The view that psychosocial factors exert their influence in FD predominantly through motivation of health care seeking also persists. This appears too one-dimensional an assertion in light of the evidence available supporting a more intdnsic aetiological link. Evolving understanding of pathogenic mechanisms and the heterogeneous nature of the syndrome will facilitate effective management. Co-morbid psychiatric illness warrants treatment with conventional therapies. Acknowledging the relevance of psychosocial variables in FD, the degree of which is subject to vadation, has implications for assessment and management. Available evidence suggests psychological therapies may benefit FD patients particularly those with chronic symptoms. The rationale for use of psychotropic medications in FD is apparent but the evidence base to support the use of antidepressant pharmacotherapy is to date limited.展开更多
Objective： To investigate the expression of P2X receptors on rat intracardiac and paratracheal ganglion neurons. Methods： For preparation of intracardiac neurons, hearts were excised, the atria were separated and th...Objective： To investigate the expression of P2X receptors on rat intracardiac and paratracheal ganglion neurons. Methods： For preparation of intracardiac neurons, hearts were excised, the atria were separated and the medial region containing intracardiac ganglia was isolated and cut into pieces. For preparation of paratracheal neurons, the tracheas were removed and the superficial membranous layer containing paratracheal ganglia was rapidly isolated. Intracardiac and paratracheal ganglion neurons were dissociated after digestion by collagenase and trypsin. Whole-cell patch clamp recording was used to identify the pharmacological properties of P2X receptors in cultured neurons. Results：Neurons from these two ganglia responded to ATP with a rapidly activating, sustained inward current, αβ-meATP failed to evoke any re- sponses in paratracheal ganglion neurons while a few of intracardiac ganglion neurons responded to αβ- meATP with a tiny sustained inward current. ADP and UTP had no effect on intracardiac neurons. Lowering pH potentiated ATP responses in neurons from these two ganglia whereas increasing pH inhibited ATP responses. Co-application of Zn^2＋ potentiated ATP responses in intracardiac and paratracheal ganglion neurons. Conclusion： The receptor subtypes involved in intracardiac and paratracheal ganglia appear to be homomeric P2X2, while heteromeric P2X2/3 could not be completely excluded from intracardiac neurons.展开更多
A revival of empiricist theories in cognitive psychology, neuropsychology, and philosophy has been led by figures such as Antonio Damasio （1994）, Lawrence Barsalou （1999）, George Lakoff （1987）, and Jesse Prinz ...A revival of empiricist theories in cognitive psychology, neuropsychology, and philosophy has been led by figures such as Antonio Damasio （1994）, Lawrence Barsalou （1999）, George Lakoff （1987）, and Jesse Prinz （2002; 2004）. Their work has served to connect familiar empiricist approaches to thought and reason with contemporary cognitive psychology and neuroscience. The work of Prinz is of special philosophical significance since it aims to bring together the work of neo-empirically minded theorists in the cognitive and neuro-sciences with main themes found in contemporary philosophical theories of intentionality and reference. In this paper, I examine Prinz＇s efforts to synthesize a neo-empiricist theory of concepts with contemporary semantic theories of reference and intentionality. In part one, I analyze Prinz＇s approach in some depth. In part two, I raise a question concerning the origins of intentionality. Specifically, I am interested in examining the minimum cognitive prerequisites for intentionality within Prinz＇s theory of perception-based representation. In part three, I raise a problem case for Prinz＇s account of the requirements for intentionality, and propose an adjustment in Prinz＇s account to meet the challenge of the objection.展开更多
This paper will add to an evolving new paradigm for financial decision-making by exploring the important roles that intuition, heuristics, and impulses play as a bridge between how the conscious and unconscious can wo...This paper will add to an evolving new paradigm for financial decision-making by exploring the important roles that intuition, heuristics, and impulses play as a bridge between how the conscious and unconscious can work together more effectively in making better decisions. Historically, the roles of financial/accounting theory and cognitive psychology have been extensively studied and documented in attempting to explain individual financial decision-making. More recently, neuroscience has made substantial contributions to learning how prospective financial decisions and outcomes affect brain activity and observed decision-making behavior. The evidence from neuroscience indicates that up to 90% of our decisions are initiated at the unconscious level, which is only beginning to be investigated in a systematic manner. Integrating these findings from multiple disciplines, including recent contributions from neuroscience, has many implications, not only with respect to personal and corporate financial decisions and how markets work, but also as an essential component in the tool box of the general decision maker.展开更多
There has been a paradigm shift in medicine away from tradition, anecdote and theoretical reasoning from the basic sciences towards evidence-based medicine(EBM). In palliative care however, statistically significant b...There has been a paradigm shift in medicine away from tradition, anecdote and theoretical reasoning from the basic sciences towards evidence-based medicine(EBM). In palliative care however, statistically significant benefits may be marginal and may not be related to clinical meaningfulness. The typical treatment vs. placebo comparison necessitated by ‘gold standard' randomised controlled trials(RCTs) is not necessarily applicable. The complex multimorbidity of end of life care involves considerations of the patient's physical, psychological, social and spiritual needs. In addition, the field of palliative care covers a heterogeneous group of chronic and incurable diseases no longer limited to cancer. Adequate sample sizes can be difficult to achieve, reducing the power of studies and high attrition rates can result in inadequate follow up periods. This review uses examples of the management of cancer-related fatigue and death rattle(noisy breathing) to demonstrate the current state of EBM in palliative care. The future of EBM in palliative care needs to be as diverse as the patients who ultimately derive benefit. Non-RCT methodologies of equivalent quality, validity and size conducted by collaborative research networks using a ‘mixed methods approach' are likely to pose the correct clinical questions and derive evidencebased yet clinically relevant outcomes.展开更多
The issue of students＇ mental health has become a common concern for the students, parents, universities and even the society. Using literature to analyze the causes and types of students＇ psychological barriers and...The issue of students＇ mental health has become a common concern for the students, parents, universities and even the society. Using literature to analyze the causes and types of students＇ psychological barriers and to explain the impacts of sports on the mental health of students, the writer considers that sports can not only improve the body＇ s healthy state of college students, but also improve their mental health and play a very significant role in treating students＇ mental illness.展开更多
Objective：To observe the effect of electroacupuncture （EA） for Alzheimer’s disease （AD）. Methods：A total of 30 eligible cases were treated by needling Shenting （GV 24）, Baihui （GV 20）, Dazhui （GV 14）, Fen...Objective：To observe the effect of electroacupuncture （EA） for Alzheimer’s disease （AD）. Methods：A total of 30 eligible cases were treated by needling Shenting （GV 24）, Baihui （GV 20）, Dazhui （GV 14）, Fengfu （GV 16）, Mingmen （GV 1） and Yongquan （KI 1）. Upon arrival of qi, the G6805-II electric stimulator was connected to Shenting （GV 24） and Baihui （GV 20） （one pair）, to Dazhui （GV 14） and Fengfu （GV 16） （one pair） and to bilateral Yongquan （KI 1） （one pair） for 25 min, using continuous wave at the frequency of 2-100 Hz and voltage of 2-4 V. With a tolerable intensity, the EA was conducted once a day for 10 d （one treatment course）. There was a 3-day interval between two courses. After three courses, the therapeutic efficacies were evaluated using the mini-mental state examination （MMSE）, revised Hasegawa dementia scale （HDS-R）, activities of daily living （ADL） and neurological function defect scale （NFDS）. Results：After EA treatment, the MMSE and HDS-R scores were significantly increased （P〈0.01） and the ADL and NFDS scores were significantly decreased （P〈0.01）. Conclusion：EA is effective for AD and can improve the overall intelligence and repair neurologic deficits in AD patients.展开更多
Objective： To observe the influence of acupuncture-moxibustion treatment on patients with mild cognition disorder. Methods： Sixty patients with mild cognition disorder were randomly divided into a treatment group an...Objective： To observe the influence of acupuncture-moxibustion treatment on patients with mild cognition disorder. Methods： Sixty patients with mild cognition disorder were randomly divided into a treatment group and a control group, with 30 cases in each group. Acupuncture-moxibustion treatment was used in the treatment group, while Western medicine was taken by the patients in the control group. The differences of intra-group and inter-group comparisons were assessed by 3 measurement scales including Mini-mental State Examination （MMSE）, Activity of Daily Living （ADL） and Montreal Cognitive Assessment （MoCA）. Results： After treatment, the MMSE, MoCA and ADL scores of both groups were higher than those before treatment （P〈0.05）. The MMSE, MoCA and ADL scores of the treatment group have more noticeable improvement than those of the control group （P〈0.05）. Conclusion： Acupuncture-moxibustion treatment can effectively improve cognitive function of the patients with mild cognitive impairment.展开更多
Objective:To observe the clinical efficacy of Jin's three-needle therapy on post-stroke cognitive impairment(PSCI)and the effect on neuroelectrophysiology(event-related potentials).Methods:A total of 60 PSCI patie...Objective:To observe the clinical efficacy of Jin's three-needle therapy on post-stroke cognitive impairment(PSCI)and the effect on neuroelectrophysiology(event-related potentials).Methods:A total of 60 PSCI patients were selected and divided into a treatment group and a control group according to the method of random number table,with 30 cases in each group.The patients in the control group received routine treatment while the patients in the treatment group received additional Jin's three-needle therapy.The treatment for both groups lasted four weeks.Mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)scores as well as amplitude and latency of potential 300(P300)were adopted to compare the between-group results before and after treatment.Results:Before treatment,there were no significant differences(all P>0.05)in MMSE and MoCA scores,P300 latency and P300 amplitude between the two groups.After 4 weeks of treatment,the MMSE and MoCA scores and P300 amplitudes were improved in both groups,and the P300 latencies became shorter.The results showed significant intra-group and between-group differences(all P<0.05).Conclusion:Based on the routine treatment,Jin's three-needle therapy is effective for PSCI.The mechanism is probably through its regulation on the patients'neuroelectrophysiology.展开更多
基金Supported by Spanish Ministry of Economy and Competitiveness(MINECO),No.AGL2014-52101-PA Sara Borrell postdoctoral fellowship from the Instituto de Salud Carlos Ⅲ at the Spanish Ministry of Health(Spain),No.CD14/00237(Cenit MC)
文摘The last decade has witnessed a growing appreciation of the fundamental role played by an early assembly of a diverse and balanced gut microbiota and its subsequent maintenance for future health of the host. Gut microbiota is currently viewed as a key regulator of a fluent bidirectional dialogue between the gut and the brain(gut-brain axis). A number of preclinical studies have suggested that the microbiota and its genome(microbiome) may play a key role in neurodevelopmental and neurodegenerative disorders. Furthermore, alterations in the gut microbiota composition in humans have also been linked to a variety of neuropsychiatric conditions, including depression, autism and Parkinson's disease. However, it is not yet clear whether these changes in the microbiome are causally related to such diseases or are secondary effects thereof. In this respect, recent studies in animals have indicated that gut microbiota transplantation can transfer a behavioral phenotype, suggesting that the gut microbiota may be a modifiable factor modulating the development or pathogenesis of neuropsychiatric conditions. Further studies are warranted to establish whether or not the findings of preclinical animal experiments can be generalized to humans. Moreover, although different communication routes between the microbiota and brain have been identified, further studies must elucidate all the underlying mechanisms involved. Such research is expected to contribute to the design of strategies to modulate the gut microbiota and its functions with a view to improving mental health, and thus provide opportunities to improve the management of psychiatric diseases. Here, we review the evidence supporting a role of the gut microbiota in neuropsychiatric disorders and the state of the art regarding the mechanisms underlying its contribution to mental illness and health. We also consider the stages of life where the gut microbiota is more susceptible to the effects of environmental stressors, and the possible microbiota-targeted intervention strategies that could improve health status and prevent psychiatric disorders in the near future.
文摘About 50% of patients with hepatitis C virus(HCV)infection complain of neuropsychiatric symptoms,"brain fog",weakness,fatigue,and exhibit some degree of quality of life impairment,irrespective of the severity of liver disease.Since the first observation of HCV-related cognitive deficits,10 studies have been published that have evaluated neuropsychiatric performance in patients with HCV infection and different degrees of hepatic impairment.Unfortunately,these have often included patients with cirrhosis,patients who had acquired the infection through previous intravenous drug misuse,who had a history of relatively recent treatment with interferon,or were on psychoactive medication.In addition,different neuropsychological batteries and tests that explored different cognitive domains were used,which makes the results of the studies difficult to compare.Finally,limited information is available on the pathogenesis of HCV-related cognitive impairment.Cerebral and/or systemic inflammation may be important players but their potential role has not been substantiated by experimental data.The present review outlines the available evidence of the presence of cognitive impairment in patients with HCV infection,with a focus on the potential relationship with cerebral and/or systemic inflammation.
文摘The pathogenesis of Functional Dyspepsia （FD） remains unclear, appears diverse and is thus inadequately understood. Akin to other functional gastrointestinal disorders, research has demonstrated an association between this common diagnosis and psychosocial factors and psychiatric morbidity. Conceptualising the relevance of these factors within the syndrome of FD requires application of the biopsychosocial model of disease. Using this paradigm, dysregulation of the reciprocal communication between the brain and the gut is central to symptom generation, interpretation and exacerbation. Appreciation and understanding of the neurobiological correlates of various psychological states is also relevant. The view that psychosocial factors exert their influence in FD predominantly through motivation of health care seeking also persists. This appears too one-dimensional an assertion in light of the evidence available supporting a more intdnsic aetiological link. Evolving understanding of pathogenic mechanisms and the heterogeneous nature of the syndrome will facilitate effective management. Co-morbid psychiatric illness warrants treatment with conventional therapies. Acknowledging the relevance of psychosocial variables in FD, the degree of which is subject to vadation, has implications for assessment and management. Available evidence suggests psychological therapies may benefit FD patients particularly those with chronic symptoms. The rationale for use of psychotropic medications in FD is apparent but the evidence base to support the use of antidepressant pharmacotherapy is to date limited.
基金Supported by the National Natural Foundation of China (No. 30570597)
文摘Objective： To investigate the expression of P2X receptors on rat intracardiac and paratracheal ganglion neurons. Methods： For preparation of intracardiac neurons, hearts were excised, the atria were separated and the medial region containing intracardiac ganglia was isolated and cut into pieces. For preparation of paratracheal neurons, the tracheas were removed and the superficial membranous layer containing paratracheal ganglia was rapidly isolated. Intracardiac and paratracheal ganglion neurons were dissociated after digestion by collagenase and trypsin. Whole-cell patch clamp recording was used to identify the pharmacological properties of P2X receptors in cultured neurons. Results：Neurons from these two ganglia responded to ATP with a rapidly activating, sustained inward current, αβ-meATP failed to evoke any re- sponses in paratracheal ganglion neurons while a few of intracardiac ganglion neurons responded to αβ- meATP with a tiny sustained inward current. ADP and UTP had no effect on intracardiac neurons. Lowering pH potentiated ATP responses in neurons from these two ganglia whereas increasing pH inhibited ATP responses. Co-application of Zn^2＋ potentiated ATP responses in intracardiac and paratracheal ganglion neurons. Conclusion： The receptor subtypes involved in intracardiac and paratracheal ganglia appear to be homomeric P2X2, while heteromeric P2X2/3 could not be completely excluded from intracardiac neurons.
文摘A revival of empiricist theories in cognitive psychology, neuropsychology, and philosophy has been led by figures such as Antonio Damasio （1994）, Lawrence Barsalou （1999）, George Lakoff （1987）, and Jesse Prinz （2002; 2004）. Their work has served to connect familiar empiricist approaches to thought and reason with contemporary cognitive psychology and neuroscience. The work of Prinz is of special philosophical significance since it aims to bring together the work of neo-empirically minded theorists in the cognitive and neuro-sciences with main themes found in contemporary philosophical theories of intentionality and reference. In this paper, I examine Prinz＇s efforts to synthesize a neo-empiricist theory of concepts with contemporary semantic theories of reference and intentionality. In part one, I analyze Prinz＇s approach in some depth. In part two, I raise a question concerning the origins of intentionality. Specifically, I am interested in examining the minimum cognitive prerequisites for intentionality within Prinz＇s theory of perception-based representation. In part three, I raise a problem case for Prinz＇s account of the requirements for intentionality, and propose an adjustment in Prinz＇s account to meet the challenge of the objection.
文摘This paper will add to an evolving new paradigm for financial decision-making by exploring the important roles that intuition, heuristics, and impulses play as a bridge between how the conscious and unconscious can work together more effectively in making better decisions. Historically, the roles of financial/accounting theory and cognitive psychology have been extensively studied and documented in attempting to explain individual financial decision-making. More recently, neuroscience has made substantial contributions to learning how prospective financial decisions and outcomes affect brain activity and observed decision-making behavior. The evidence from neuroscience indicates that up to 90% of our decisions are initiated at the unconscious level, which is only beginning to be investigated in a systematic manner. Integrating these findings from multiple disciplines, including recent contributions from neuroscience, has many implications, not only with respect to personal and corporate financial decisions and how markets work, but also as an essential component in the tool box of the general decision maker.
文摘There has been a paradigm shift in medicine away from tradition, anecdote and theoretical reasoning from the basic sciences towards evidence-based medicine(EBM). In palliative care however, statistically significant benefits may be marginal and may not be related to clinical meaningfulness. The typical treatment vs. placebo comparison necessitated by ‘gold standard' randomised controlled trials(RCTs) is not necessarily applicable. The complex multimorbidity of end of life care involves considerations of the patient's physical, psychological, social and spiritual needs. In addition, the field of palliative care covers a heterogeneous group of chronic and incurable diseases no longer limited to cancer. Adequate sample sizes can be difficult to achieve, reducing the power of studies and high attrition rates can result in inadequate follow up periods. This review uses examples of the management of cancer-related fatigue and death rattle(noisy breathing) to demonstrate the current state of EBM in palliative care. The future of EBM in palliative care needs to be as diverse as the patients who ultimately derive benefit. Non-RCT methodologies of equivalent quality, validity and size conducted by collaborative research networks using a ‘mixed methods approach' are likely to pose the correct clinical questions and derive evidencebased yet clinically relevant outcomes.
文摘The issue of students＇ mental health has become a common concern for the students, parents, universities and even the society. Using literature to analyze the causes and types of students＇ psychological barriers and to explain the impacts of sports on the mental health of students, the writer considers that sports can not only improve the body＇ s healthy state of college students, but also improve their mental health and play a very significant role in treating students＇ mental illness.
基金supported by the Scientific Research Project of Leshan Vocational&Technical College,Sichuan Province,No.KY2014012~~
文摘Objective：To observe the effect of electroacupuncture （EA） for Alzheimer’s disease （AD）. Methods：A total of 30 eligible cases were treated by needling Shenting （GV 24）, Baihui （GV 20）, Dazhui （GV 14）, Fengfu （GV 16）, Mingmen （GV 1） and Yongquan （KI 1）. Upon arrival of qi, the G6805-II electric stimulator was connected to Shenting （GV 24） and Baihui （GV 20） （one pair）, to Dazhui （GV 14） and Fengfu （GV 16） （one pair） and to bilateral Yongquan （KI 1） （one pair） for 25 min, using continuous wave at the frequency of 2-100 Hz and voltage of 2-4 V. With a tolerable intensity, the EA was conducted once a day for 10 d （one treatment course）. There was a 3-day interval between two courses. After three courses, the therapeutic efficacies were evaluated using the mini-mental state examination （MMSE）, revised Hasegawa dementia scale （HDS-R）, activities of daily living （ADL） and neurological function defect scale （NFDS）. Results：After EA treatment, the MMSE and HDS-R scores were significantly increased （P〈0.01） and the ADL and NFDS scores were significantly decreased （P〈0.01）. Conclusion：EA is effective for AD and can improve the overall intelligence and repair neurologic deficits in AD patients.
基金supported by National Natural Science Foundation of China(30973801)
文摘Objective： To observe the influence of acupuncture-moxibustion treatment on patients with mild cognition disorder. Methods： Sixty patients with mild cognition disorder were randomly divided into a treatment group and a control group, with 30 cases in each group. Acupuncture-moxibustion treatment was used in the treatment group, while Western medicine was taken by the patients in the control group. The differences of intra-group and inter-group comparisons were assessed by 3 measurement scales including Mini-mental State Examination （MMSE）, Activity of Daily Living （ADL） and Montreal Cognitive Assessment （MoCA）. Results： After treatment, the MMSE, MoCA and ADL scores of both groups were higher than those before treatment （P〈0.05）. The MMSE, MoCA and ADL scores of the treatment group have more noticeable improvement than those of the control group （P〈0.05）. Conclusion： Acupuncture-moxibustion treatment can effectively improve cognitive function of the patients with mild cognitive impairment.
文摘Objective:To observe the clinical efficacy of Jin's three-needle therapy on post-stroke cognitive impairment(PSCI)and the effect on neuroelectrophysiology(event-related potentials).Methods:A total of 60 PSCI patients were selected and divided into a treatment group and a control group according to the method of random number table,with 30 cases in each group.The patients in the control group received routine treatment while the patients in the treatment group received additional Jin's three-needle therapy.The treatment for both groups lasted four weeks.Mini-mental state examination(MMSE)and Montreal cognitive assessment(MoCA)scores as well as amplitude and latency of potential 300(P300)were adopted to compare the between-group results before and after treatment.Results:Before treatment,there were no significant differences(all P>0.05)in MMSE and MoCA scores,P300 latency and P300 amplitude between the two groups.After 4 weeks of treatment,the MMSE and MoCA scores and P300 amplitudes were improved in both groups,and the P300 latencies became shorter.The results showed significant intra-group and between-group differences(all P<0.05).Conclusion:Based on the routine treatment,Jin's three-needle therapy is effective for PSCI.The mechanism is probably through its regulation on the patients'neuroelectrophysiology.
