Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs know...Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs （miRNAs） have been shown to regulate gene expression, which contributes to many physiological and pathophysiological processes in humans. Increasing evidence suggests that changes in miRNA expression profiles contribute to cellular senescence, aging and aging-related diseases. However, only a few miRNAs whose functions have been elucidated have been associated with aging and/or aging-related diseases. This article reviews the currently available findings regarding the roles of aging-related miRNAs, with a focus on cardiac and cardiovascular aging.展开更多
Objective To study the effects of obstructive sleep apneas on endothelial function and autonomic modulation. Methods From June 2009 to June 2011, male patients with obstructive sleep apnea hypopnea syndrome (OSAHS) we...Objective To study the effects of obstructive sleep apneas on endothelial function and autonomic modulation. Methods From June 2009 to June 2011, male patients with obstructive sleep apnea hypopnea syndrome (OSAHS) were consecutively enrolled in this study. Patients with an apnea/hypopnea index (AHI) of greater than 15 and without previous treatment for OSAHS were included as Group OSAHS and obese subjects with an AHI of less than 5 were included as non-OSAHS controls (Group Control). Electrocardiography and beat-to-beat blood pressure were continuously recorded from the radial artery by applanation tonometry which was synchronized with polysomnography recording. Endothelial function was measured by arterial augmentation index (AAI). Spectral analysis of heart rate variability (HRV) and blood pressure variability (BPV) were computed for cardiac parasympathetic modulation (high frequency power, HF); sympathetic modulation (low frequency power, LF), sympathovagal balance (LF/HF power of R-R variability, LF/HF) and BPV sympathetic modulation (BPV LF) in normalized units [total power of the components/(total power-very LF power)×100]. Results Finally, 27 moderate-severe OSAHS patients and 22 non-OSAHS obese controls were recruited in the Group OSAHS and Group Control, respectively. In Group OSAHS, the age was 43.3±9.3 year-old, body mass index (BMI) was 36.8±8.7 kg/m 2 ; in Group Control, the age was 42.9±8.6 year-old, BMI was 34.4±7.9 kg/m 2 ; there were no significant differences in age and BMI between the Group OSAHS and Group Control (all P>0.05). The baseline AAI (12.5%±2.2% vs. 8.2%±2.1%) and BPV LF (68.3%±13.5% vs. 61.1%±11.7%) of the Group OSAHS were significantly higher than those of the Group Control (all P<0.05). And after overnight sleep, systolic BP (143.7±14.2 vs. 132.8±13.3 mm Hg), diastolic BP (87.7±7.7 vs. 78.6±5.5 mm Hg), HRV LF (69.7%±14.4% vs. 64.3%±12.1%), HRV LF/HF (3.7±2.0 vs. 2.3±1.3) and BPV LF (77.8%±15.6% vs. 68.3%±13.5%) of the Group OSAHS were significantly increased (all P<0.001), while HRV HF was significantly decreased (21.1%±9.3% vs. 27.5%±10.3%, P<0.05) from baseline.Conclusions The baseline endothelial function and autonomic modulation are impaired in OSAHS patients, which happened prior to hypertension and other cardiovascular complications. And the load effects of overnight obstructive breathing events could induce blood pressure and sympathetic activity increasing in the morning in OSAHS patients without acute aggravation in endothelial dysfunction.展开更多
Objectives： Heart rate variability （HRV） can be a simple, non-invasive method of gauging cardiac autonomic nervous system fluctuations across periodised training workloads and taper in elite athlete populations. Th...Objectives： Heart rate variability （HRV） can be a simple, non-invasive method of gauging cardiac autonomic nervous system fluctuations across periodised training workloads and taper in elite athlete populations. The purpose of these three case studies was to examine daily cardiac autonomic variations in Paralympic athletes leading in to the Paralympic games. Methods： Three Paralympie gold medallist swimmers were monitored daily for their resting HRV over a 17-week monitoring period leading up to the Paralympic games. Specific time- and frequency-domain measures, along with non-linear indices of HRV were calculated for all analyses. All HRV data were analysed individually using daily values, weekly average values, and average values for rest and training phases. Results： A significant difference in HRV was seen for all variables between athlete 1 and athletes 2 and 3 （amputee disabilities） during the entire monitoring period. Conclusion： Despite minimal long-term changes, both swimming classification and disability type significantly influence HRV during athlete monitoring. An increased understanding of individual responses to training, travel, and other outside influences affecting Paralympic athletes could potentially lead to improved management and monitoring of training workloads for enhanced nerformance.展开更多
A revival of empiricist theories in cognitive psychology, neuropsychology, and philosophy has been led by figures such as Antonio Damasio （1994）, Lawrence Barsalou （1999）, George Lakoff （1987）, and Jesse Prinz ...A revival of empiricist theories in cognitive psychology, neuropsychology, and philosophy has been led by figures such as Antonio Damasio （1994）, Lawrence Barsalou （1999）, George Lakoff （1987）, and Jesse Prinz （2002; 2004）. Their work has served to connect familiar empiricist approaches to thought and reason with contemporary cognitive psychology and neuroscience. The work of Prinz is of special philosophical significance since it aims to bring together the work of neo-empirically minded theorists in the cognitive and neuro-sciences with main themes found in contemporary philosophical theories of intentionality and reference. In this paper, I examine Prinz＇s efforts to synthesize a neo-empiricist theory of concepts with contemporary semantic theories of reference and intentionality. In part one, I analyze Prinz＇s approach in some depth. In part two, I raise a question concerning the origins of intentionality. Specifically, I am interested in examining the minimum cognitive prerequisites for intentionality within Prinz＇s theory of perception-based representation. In part three, I raise a problem case for Prinz＇s account of the requirements for intentionality, and propose an adjustment in Prinz＇s account to meet the challenge of the objection.展开更多
OBJECTIVE: To investigate whether transdermal scopolamine increased cardiac vagal activity in patients during the acute phase of myocardial infarction. METHODS: 30 patients with a first acute myocardial infarction and...OBJECTIVE: To investigate whether transdermal scopolamine increased cardiac vagal activity in patients during the acute phase of myocardial infarction. METHODS: 30 patients with a first acute myocardial infarction and preserved sinus rhythm who were on no drug that could influence the sinus node were randomly assigned to either treatment group or placebo group. Measures of heart rate variability (HRV) in patients given drug or placebo were obtained by digital 24 hour Holter recording before and after treatment. Baroreflex sensitivity was performed using the phenylephrine method. RESULTS: No significant differences was found in the indices of the time domain and the frequency domain in both groups before treatment. Patients with transdermal scopolamine showed a significant increase in the standard deviation of normal RR intervals (SDNN), standard deviation of all five min mean normal RR intervals (SDANN), root mean square of differences of successive normal RR intervals (rMSSD), total power (TP, 0.000. - 0.40 Hz), low frequency peak (LF, 0.040 - 0.15 Hz), high frequency peak (HF, 0.15 - 0.40 Hz), and Baroreflex sensitivity after treatment (P展开更多
Integrative Body-Mind Training（IBMT） originates from ancient Eastern tradition.The method stresses no effort to control thoughts,but instead a state of restful alertness that allows a high degree of awareness of the...Integrative Body-Mind Training（IBMT） originates from ancient Eastern tradition.The method stresses no effort to control thoughts,but instead a state of restful alertness that allows a high degree of awareness of the body,breathing,and external instructions.A series of studies indicates that IBMT improves attention and self-regulation through interaction between the central（brain） and the autonomic（body） nervous systems.The present review mainly summarizes the recent results of IBMT studies and proposes how it changes the state of brain and body to lead to positive outcomes.Future directions in this field are also discussed.展开更多
Originating in China, tea and tea planting have spread throughout the world since the middle of the Tang dynasty. Now people from 160 countries in the world are accustomed to tea drinking. A brief history of tea＇s me...Originating in China, tea and tea planting have spread throughout the world since the middle of the Tang dynasty. Now people from 160 countries in the world are accustomed to tea drinking. A brief history of tea＇s medicinal role in China and its spread to the world are introduced. The effectiveness of tea active components and tea drinking on major human diseases, including cancer, metabolic syndrome, cardiovascular disease, and neurodegenerative diseases, is discussed. Also presented are some related issues, such as the bioavailability of tea active components, the new formulations of tea polyphenols, and the safety for consumers of dietary supplements containing tea polyphenols.展开更多
O-linked N-acetylglucosamine(O-GlcNAc)is a dynamic post-translational modification occurring on myriad proteins in the cell nucleus,cytoplasm,and mitochondria.The donor sugar for O-Glc NAcylation,uridine-diphosphate N...O-linked N-acetylglucosamine(O-GlcNAc)is a dynamic post-translational modification occurring on myriad proteins in the cell nucleus,cytoplasm,and mitochondria.The donor sugar for O-Glc NAcylation,uridine-diphosphate N-acetylglucosamine(UDP-Glc NAc),is synthesized from glucose through the hexosamine biosynthetic pathway(HBP).The recycling of O-GlcNAc on proteins is mediated by two enzymes in cells—O-GlcNAc transferase(OGT)and O-Glc NAcase(OGA),which catalyze the addition and removal of O-GlcNAc,respectively.O-GlcNAcylation is involved in a number of important cell processes including transcription,translation,metabolism,signal transduction,and apoptosis.Deregulation of O-GlcNAcylation has been reported to be associated with various human diseases such as cancer,diabetes,neurodegenerative diseases,and cardiovascular diseases.A better understanding of the roles of O-GlcNAcylation in physiopathological processes would help to uncover novel avenues for therapeutic intervention.The aim of this review is to discuss the recent updates on the mechanisms and impacts of O-GlcNAcylation on these diseases,and its potential as a new clinical target.展开更多
Objective： According to the theory of traditional Chinese medicine, the effect of cervical stimulation on autonomic nervous system activity in humans was investigated. Methods： Healthy young male volunteers were sel...Objective： According to the theory of traditional Chinese medicine, the effect of cervical stimulation on autonomic nervous system activity in humans was investigated. Methods： Healthy young male volunteers were selected as subjects of the trial. The upper cervical spine （C2-5） was stimulated bilaterally with spinal manipulation, and changes in heart rate and heart rate variability were calculated as measures of effects on autonomic nervous system tone. Results： Thirty healthy young male volunteers were tested. It was found that heart rate decreased （R-R interval prolonged） significantly. SDNN and total power spectrum increased significantly, indicating an increase in sympathetic tone. Conclusion： Cervical manipulation can regulate the autonomic nervous system tone in healthy young men, and it suggests a possibility of treating cardiovascular diseases such as arrhythmia with cervical manipulation.展开更多
Penetrating cerebral injuries caused by foreign bodies are rare in civilian neurosurgical trauma, al- though there are various reports of blast or gunshot injuries in warfare due to multiple foreign bodies like pellet...Penetrating cerebral injuries caused by foreign bodies are rare in civilian neurosurgical trauma, al- though there are various reports of blast or gunshot injuries in warfare due to multiple foreign bodies like pellets and nails. In our case, a 30-year-old man presented to neurosurgery clinic with signs and symptoms of right-sided weakness after suicide bomb attack. The skull X-ray showed a single intracranial nail. Small craniotomy was done and the nail was removed with caution to avoid injury to surrounding normal brain tissue. At 6 months＇ follow-up his right- sided power improved to against gravity.展开更多
文摘Aging is a multidimensional process that leads to an increased risk of developing severe diseases, such as cancer and cardiovascular, neurodegenerative, and immunological diseases. Recently, small non-coding RNAs known as microRNAs （miRNAs） have been shown to regulate gene expression, which contributes to many physiological and pathophysiological processes in humans. Increasing evidence suggests that changes in miRNA expression profiles contribute to cellular senescence, aging and aging-related diseases. However, only a few miRNAs whose functions have been elucidated have been associated with aging and/or aging-related diseases. This article reviews the currently available findings regarding the roles of aging-related miRNAs, with a focus on cardiac and cardiovascular aging.
基金Supported by a grant from National Natural Science Foundation of China (81070072)
文摘Objective To study the effects of obstructive sleep apneas on endothelial function and autonomic modulation. Methods From June 2009 to June 2011, male patients with obstructive sleep apnea hypopnea syndrome (OSAHS) were consecutively enrolled in this study. Patients with an apnea/hypopnea index (AHI) of greater than 15 and without previous treatment for OSAHS were included as Group OSAHS and obese subjects with an AHI of less than 5 were included as non-OSAHS controls (Group Control). Electrocardiography and beat-to-beat blood pressure were continuously recorded from the radial artery by applanation tonometry which was synchronized with polysomnography recording. Endothelial function was measured by arterial augmentation index (AAI). Spectral analysis of heart rate variability (HRV) and blood pressure variability (BPV) were computed for cardiac parasympathetic modulation (high frequency power, HF); sympathetic modulation (low frequency power, LF), sympathovagal balance (LF/HF power of R-R variability, LF/HF) and BPV sympathetic modulation (BPV LF) in normalized units [total power of the components/(total power-very LF power)×100]. Results Finally, 27 moderate-severe OSAHS patients and 22 non-OSAHS obese controls were recruited in the Group OSAHS and Group Control, respectively. In Group OSAHS, the age was 43.3±9.3 year-old, body mass index (BMI) was 36.8±8.7 kg/m 2 ; in Group Control, the age was 42.9±8.6 year-old, BMI was 34.4±7.9 kg/m 2 ; there were no significant differences in age and BMI between the Group OSAHS and Group Control (all P>0.05). The baseline AAI (12.5%±2.2% vs. 8.2%±2.1%) and BPV LF (68.3%±13.5% vs. 61.1%±11.7%) of the Group OSAHS were significantly higher than those of the Group Control (all P<0.05). And after overnight sleep, systolic BP (143.7±14.2 vs. 132.8±13.3 mm Hg), diastolic BP (87.7±7.7 vs. 78.6±5.5 mm Hg), HRV LF (69.7%±14.4% vs. 64.3%±12.1%), HRV LF/HF (3.7±2.0 vs. 2.3±1.3) and BPV LF (77.8%±15.6% vs. 68.3%±13.5%) of the Group OSAHS were significantly increased (all P<0.001), while HRV HF was significantly decreased (21.1%±9.3% vs. 27.5%±10.3%, P<0.05) from baseline.Conclusions The baseline endothelial function and autonomic modulation are impaired in OSAHS patients, which happened prior to hypertension and other cardiovascular complications. And the load effects of overnight obstructive breathing events could induce blood pressure and sympathetic activity increasing in the morning in OSAHS patients without acute aggravation in endothelial dysfunction.
文摘Objectives： Heart rate variability （HRV） can be a simple, non-invasive method of gauging cardiac autonomic nervous system fluctuations across periodised training workloads and taper in elite athlete populations. The purpose of these three case studies was to examine daily cardiac autonomic variations in Paralympic athletes leading in to the Paralympic games. Methods： Three Paralympie gold medallist swimmers were monitored daily for their resting HRV over a 17-week monitoring period leading up to the Paralympic games. Specific time- and frequency-domain measures, along with non-linear indices of HRV were calculated for all analyses. All HRV data were analysed individually using daily values, weekly average values, and average values for rest and training phases. Results： A significant difference in HRV was seen for all variables between athlete 1 and athletes 2 and 3 （amputee disabilities） during the entire monitoring period. Conclusion： Despite minimal long-term changes, both swimming classification and disability type significantly influence HRV during athlete monitoring. An increased understanding of individual responses to training, travel, and other outside influences affecting Paralympic athletes could potentially lead to improved management and monitoring of training workloads for enhanced nerformance.
文摘A revival of empiricist theories in cognitive psychology, neuropsychology, and philosophy has been led by figures such as Antonio Damasio （1994）, Lawrence Barsalou （1999）, George Lakoff （1987）, and Jesse Prinz （2002; 2004）. Their work has served to connect familiar empiricist approaches to thought and reason with contemporary cognitive psychology and neuroscience. The work of Prinz is of special philosophical significance since it aims to bring together the work of neo-empirically minded theorists in the cognitive and neuro-sciences with main themes found in contemporary philosophical theories of intentionality and reference. In this paper, I examine Prinz＇s efforts to synthesize a neo-empiricist theory of concepts with contemporary semantic theories of reference and intentionality. In part one, I analyze Prinz＇s approach in some depth. In part two, I raise a question concerning the origins of intentionality. Specifically, I am interested in examining the minimum cognitive prerequisites for intentionality within Prinz＇s theory of perception-based representation. In part three, I raise a problem case for Prinz＇s account of the requirements for intentionality, and propose an adjustment in Prinz＇s account to meet the challenge of the objection.
文摘OBJECTIVE: To investigate whether transdermal scopolamine increased cardiac vagal activity in patients during the acute phase of myocardial infarction. METHODS: 30 patients with a first acute myocardial infarction and preserved sinus rhythm who were on no drug that could influence the sinus node were randomly assigned to either treatment group or placebo group. Measures of heart rate variability (HRV) in patients given drug or placebo were obtained by digital 24 hour Holter recording before and after treatment. Baroreflex sensitivity was performed using the phenylephrine method. RESULTS: No significant differences was found in the indices of the time domain and the frequency domain in both groups before treatment. Patients with transdermal scopolamine showed a significant increase in the standard deviation of normal RR intervals (SDNN), standard deviation of all five min mean normal RR intervals (SDANN), root mean square of differences of successive normal RR intervals (rMSSD), total power (TP, 0.000. - 0.40 Hz), low frequency peak (LF, 0.040 - 0.15 Hz), high frequency peak (HF, 0.15 - 0.40 Hz), and Baroreflex sensitivity after treatment (P
基金supported by the National Natural Science Foundation of China (60971096)National Basic Research Development Program of China (973 Program,2012CB518200)
文摘Integrative Body-Mind Training（IBMT） originates from ancient Eastern tradition.The method stresses no effort to control thoughts,but instead a state of restful alertness that allows a high degree of awareness of the body,breathing,and external instructions.A series of studies indicates that IBMT improves attention and self-regulation through interaction between the central（brain） and the autonomic（body） nervous systems.The present review mainly summarizes the recent results of IBMT studies and proposes how it changes the state of brain and body to lead to positive outcomes.Future directions in this field are also discussed.
基金Project supported by the Consulting Project of the Chinese Academy of Engineering(No.2012-XY-17),China
文摘Originating in China, tea and tea planting have spread throughout the world since the middle of the Tang dynasty. Now people from 160 countries in the world are accustomed to tea drinking. A brief history of tea＇s medicinal role in China and its spread to the world are introduced. The effectiveness of tea active components and tea drinking on major human diseases, including cancer, metabolic syndrome, cardiovascular disease, and neurodegenerative diseases, is discussed. Also presented are some related issues, such as the bioavailability of tea active components, the new formulations of tea polyphenols, and the safety for consumers of dietary supplements containing tea polyphenols.
基金supported by the National Natural Science Foundation of China(Nos.91753125,31270865,31322019,and 31570804)the National Key Research and Development Program of China(No.2016YFA0100303)the Zhejiang Provincial Natural Science Foundation of China(No.LR15C050001)
文摘O-linked N-acetylglucosamine(O-GlcNAc)is a dynamic post-translational modification occurring on myriad proteins in the cell nucleus,cytoplasm,and mitochondria.The donor sugar for O-Glc NAcylation,uridine-diphosphate N-acetylglucosamine(UDP-Glc NAc),is synthesized from glucose through the hexosamine biosynthetic pathway(HBP).The recycling of O-GlcNAc on proteins is mediated by two enzymes in cells—O-GlcNAc transferase(OGT)and O-Glc NAcase(OGA),which catalyze the addition and removal of O-GlcNAc,respectively.O-GlcNAcylation is involved in a number of important cell processes including transcription,translation,metabolism,signal transduction,and apoptosis.Deregulation of O-GlcNAcylation has been reported to be associated with various human diseases such as cancer,diabetes,neurodegenerative diseases,and cardiovascular diseases.A better understanding of the roles of O-GlcNAcylation in physiopathological processes would help to uncover novel avenues for therapeutic intervention.The aim of this review is to discuss the recent updates on the mechanisms and impacts of O-GlcNAcylation on these diseases,and its potential as a new clinical target.
文摘Objective： According to the theory of traditional Chinese medicine, the effect of cervical stimulation on autonomic nervous system activity in humans was investigated. Methods： Healthy young male volunteers were selected as subjects of the trial. The upper cervical spine （C2-5） was stimulated bilaterally with spinal manipulation, and changes in heart rate and heart rate variability were calculated as measures of effects on autonomic nervous system tone. Results： Thirty healthy young male volunteers were tested. It was found that heart rate decreased （R-R interval prolonged） significantly. SDNN and total power spectrum increased significantly, indicating an increase in sympathetic tone. Conclusion： Cervical manipulation can regulate the autonomic nervous system tone in healthy young men, and it suggests a possibility of treating cardiovascular diseases such as arrhythmia with cervical manipulation.
文摘Penetrating cerebral injuries caused by foreign bodies are rare in civilian neurosurgical trauma, al- though there are various reports of blast or gunshot injuries in warfare due to multiple foreign bodies like pellets and nails. In our case, a 30-year-old man presented to neurosurgery clinic with signs and symptoms of right-sided weakness after suicide bomb attack. The skull X-ray showed a single intracranial nail. Small craniotomy was done and the nail was removed with caution to avoid injury to surrounding normal brain tissue. At 6 months＇ follow-up his right- sided power improved to against gravity.
