Cardiac ankyrin repeat protein （CARP） not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated tha...Cardiac ankyrin repeat protein （CARP） not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now. In this review, we will discuss the continued progress in the research related to CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases.展开更多
microRNAs(miRNAs)are a class of small non-coding RNAs,which have been shown important to a wide range of biological process by post-transcriptionally regulating the expression of protein-coding genes.miRNAs have been ...microRNAs(miRNAs)are a class of small non-coding RNAs,which have been shown important to a wide range of biological process by post-transcriptionally regulating the expression of protein-coding genes.miRNAs have been demonstrated essential to normal cardiac development and function.Recently,numerous studies indicate miRNAs are involved in cardiac regeneration and cardiac disease,including cardiac hypertrophy,myocardial infarction and cardiac arrhythmia.These observations suggest miRNAs play important roles in cardiology.In this review,we summarize the recent progress of studying miRNAs in cardiac regeneration and cardiac disease.We also discuss the diagnostic and therapeutic potential of miRNAs in heart disease.展开更多
基金Project supported by the National Natural Science Foundation of China(No.31171392)
文摘Cardiac ankyrin repeat protein （CARP） not only serves as an important component of muscle sarcomere in the cytoplasm, but also acts as a transcription co-factor in the nucleus. Previous studies have demonstrated that CARP is up-regulated in some cardiovascular disorders and muscle diseases; however, its role in these diseases remains controversial now. In this review, we will discuss the continued progress in the research related to CARP, including its discovery, structure, and the role it plays in cardiac development and heart diseases.
基金supported by the March of Dimes Foundation(FY11-426)the National Institutes of Health(HL085635)
文摘microRNAs(miRNAs)are a class of small non-coding RNAs,which have been shown important to a wide range of biological process by post-transcriptionally regulating the expression of protein-coding genes.miRNAs have been demonstrated essential to normal cardiac development and function.Recently,numerous studies indicate miRNAs are involved in cardiac regeneration and cardiac disease,including cardiac hypertrophy,myocardial infarction and cardiac arrhythmia.These observations suggest miRNAs play important roles in cardiology.In this review,we summarize the recent progress of studying miRNAs in cardiac regeneration and cardiac disease.We also discuss the diagnostic and therapeutic potential of miRNAs in heart disease.
