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白细胞介素-6与急性心肌梗死后心功能不全的相关性研究
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作者 郑波涛 来春林 《中国药物与临床》 CAS 2013年第S1期18-19,共2页
近年来有关冠状动脉粥样斑块的发生、发展机制和预防措施的研究日益受到重视,越来越多证据支持炎症在冠心病的发生发展中起重要作用。炎症细胞因子的代表白细胞介素6(IL-6)在冠心病中的作用日益受到重视。本课题采用放射免疫分析方法检... 近年来有关冠状动脉粥样斑块的发生、发展机制和预防措施的研究日益受到重视,越来越多证据支持炎症在冠心病的发生发展中起重要作用。炎症细胞因子的代表白细胞介素6(IL-6)在冠心病中的作用日益受到重视。本课题采用放射免疫分析方法检测急性心肌梗死(AMI)组入院后第1、3。 展开更多
关键词 急性心肌 心功能不全 白细胞介素 炎症细胞因子 不稳定型心绞痛 下壁 心肌梗死组 典型性心绞痛 重度心力衰竭 胸痛持续时间
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腔隙性梗死后的认知障碍和神经代谢产物变化的关系
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作者 Van Zandvoort M.J.E. Van Der Grond J. +2 位作者 Kappelle L.J. DeHaan E.H.F. 赵正卿 《世界核心医学期刊文摘(神经病学分册)》 2005年第8期43-44,共2页
In contrast to earlier observations, recent studies have demonstrated that sup ratentorial lacunar infarcts in the white matter may cause mild neuropsychologic al impairments. The origin of these cognitive disturbance... In contrast to earlier observations, recent studies have demonstrated that sup ratentorial lacunar infarcts in the white matter may cause mild neuropsychologic al impairments. The origin of these cognitive disturbances is yet unknown. In th e current study proton magnetic resonance spectroscopy ( 1HMRS) was used to eluc idate the hypothesized relation between a lacunar infarct, metabolic alterations , and neuropsychological function. Patients with a single supratentorial lacunar infarct(n=26) were compared with patients with a mild myocardial infarct (n=12) and healthy controls (n=12) on a comprehensive neuropsychological examination, and on the N-acetyl-aspartate/creatine, choline/creatine and lactate/creatine ratios. The volume of interest of the MRI/MRS examination was locatedin normal- appearing white matter of the centrum semiovale ata distance from the infarct, i n both the ipsilateral and contralateral hemisphere. On neuropsychological exami nation patients with a lacunar infarct performed worse than both patients with a myocardial infarct and healthy controls. The N-acetyl-aspartate/creatine rati o was decreased in patients with a lacunar infarct compared with the other two g roups. More important,this decrease in neurometabolites was significantly correl ated to the level of cognitive functioning for the ipsilateral hemisphere and, a lthough to a lesser extent, for the contralateral hemisphere.We conclude that a single symptomatic lacunar infarct in the white matter is associated with (distant) disturbances in neuro metabolites and that this decrease is related to a reduced cognitive capacity. 展开更多
关键词 腔隙性 认知障碍 神经心理 代谢产物 大脑半球 磁共振质子波谱 心肌梗死组 乳酸盐 半卵圆中心 肌酸
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Mn-SOD在心肌缺血预适应中的作用
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作者 张松 李玉辉 +2 位作者 葛均波 张卉 翟昌林 《上海医学》 CAS CSCD 北大核心 2007年第S1期81-81,共1页
目的通过建立心肌梗死和心肌缺血预适应(ischemic predonditioning,IP)动物模型,检测血清中Mn-SOD含量的变化,对IP机制进行研究,为临床提供指导作用。方法采用Wistar大鼠为实验动物.通过开胸结扎冠状动脉的方法建立心肌梗死和IP动物实... 目的通过建立心肌梗死和心肌缺血预适应(ischemic predonditioning,IP)动物模型,检测血清中Mn-SOD含量的变化,对IP机制进行研究,为临床提供指导作用。方法采用Wistar大鼠为实验动物.通过开胸结扎冠状动脉的方法建立心肌梗死和IP动物实验模型,通过过氧化物还原酶法测定血清中的Mn-SOD含量的变化,通过TTC染色的方法测定心肌梗死的面积。实验共分6组:A组(对照组); B组(心肌梗死组);C1组(缺血预适应1个循环组):C2组(缺血预适应2个循环组);C3组(缺血预适应3个循环组);C4组(缺血预适应4个循环组)。结果B组心肌梗死面积最大,平均达21.86%,而在心肌缺血预适应后,梗死面积明显下降,C3组心肌梗死面积最小,为16.69%,两组间差异有统计学意义(P<0.05);C3和C4组差异无统计学意义(P>0.05):后5组心肌梗死后血清Mn-SOD含量明显升高达(82.20±18.08)mg/mL,与对照组相比差异有统计学意义(P<0.05)。IP后血清Mn-SOD含量亦有明显的升高,从C1组到C3组,随着循环次数的增加血清Mn-SOD含量依次增加,C3组达到(169.69±23.35)mg/mL,与对照组相比差异有统计学意义(P<0.05):C4组血清Mn-SOD的含量稍有下降,与C3组相比差异无统计学意义(P>0.05),与C2组相比差异有统计学意义(P<0.05)。结论IP后心肌梗死面积明显减少,对缺血心肌有明显的保护作用。IP后血清Mn-SOD含量有明显升高,参与IP的形成过程。Mn-SOD含量并不是无限性增加,可能与其耗竭或产生不足有关。 展开更多
关键词 心肌缺血预适应 MN-SOD 心肌面积 开胸结扎 心肌梗死组 动物实验模型 缺血心肌 大鼠 过氧化物还原酶
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间歇运动调控miR-155/SIRT1/FoxO3a通路抑制心梗大鼠肾脏细胞凋亡
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作者 林琴琴 耿元文 +2 位作者 王湘怡 李若明 田振军 《解剖学杂志》 CAS 2021年第S01期45-45,共1页
探讨间歇运动调控心肌梗死(MI)大鼠肾脏miR-155/SIRT1/FoxO3a通路抑制肾脏细胞凋亡的作用。本实验用SD大鼠,左冠脉前降支结扎制备心梗模型,术后随机分为假手术组(sham)、心肌梗死组(MI)和心梗+间歇运动组(ME)。术后1周,ME组采用大鼠跑... 探讨间歇运动调控心肌梗死(MI)大鼠肾脏miR-155/SIRT1/FoxO3a通路抑制肾脏细胞凋亡的作用。本实验用SD大鼠,左冠脉前降支结扎制备心梗模型,术后随机分为假手术组(sham)、心肌梗死组(MI)和心梗+间歇运动组(ME)。术后1周,ME组采用大鼠跑台进行4周间歇训练干预。训练结束后次日取材,测定各组大鼠心电图变化,RT-qPCR检测肾脏SIRT1及肾脏和血液miR-155表达,Western blotting检测肾脏SIRT1、FoxO3a、caspase-3、cleaved-caspase-3、Bax和Bcl-2蛋白表达。 展开更多
关键词 SIRT1 间歇运动 大鼠心电图 间歇训练 心肌梗死组 细胞凋亡 大鼠 肾脏
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组织因子途径抑制物在冠心病不同阶段的表达
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作者 彭娟 樊冰 《上海医学》 CAS CSCD 北大核心 2007年第S1期73-74,共2页
目的研究组织因子途径抑制物(TFPI)在冠心病不同阶段的表达。方法入选者140例,分为正常对照组13例、稳定性心绞痛组30例、不稳定性心绞痛组34例、急性心肌梗死组55例和陈旧性心肌梗死组8例。用酶联免疫吸附法(ELISA)检测外周血的TFPI浓... 目的研究组织因子途径抑制物(TFPI)在冠心病不同阶段的表达。方法入选者140例,分为正常对照组13例、稳定性心绞痛组30例、不稳定性心绞痛组34例、急性心肌梗死组55例和陈旧性心肌梗死组8例。用酶联免疫吸附法(ELISA)检测外周血的TFPI浓度。56例行冠脉造影检查的患者比较外周血和冠状动脉窦血的TFPI浓度,40例行冠状动脉支架植入术的患者比较冠状动脉窦血在术后即刻和术前的TFPI浓度。复查冠状动脉造影的患者分为有支架内再狭窄组17例和对照组11例,比较他们外周血的TFPI浓度。结果正常对照组、稳定性心绞痛组、不稳定性心绞痛组、急性心肌梗死组和陈旧性心肌梗死组的外周血TFPI水平分别为(0.613±0.407)、(0.499±0.227)、(0.446±0.253)、(0.39±0.142)和(0.378±0.140)μg/L,组间差异无统计学意义(P>0.05),但急性冠脉综合征组[ (0.404±0.178)μg/L]低于对照组[(0.517±0.256)μg/L](P<0.05)。急性心肌梗死组[(0.389±0.142)μg/L]低于对照组[(0.517±0.256)μg/L](P<0.01)。冠状动脉窦血浆TFPI水平[(0.368±0.143)μg/L]比外周血[(0.451±0.235)μg/L]低(P<0.01)。冠状动脉支架植入之后即刻的TFPI水平[(0.389±0.170)μg/L]和术前[(0.382±0.140)μg/L]差异无统计学意义(P>0.05)。冠状动脉植入支架后有支架内再狭窄的患者外周血TFPI水平[(0.385±0.189)μg/L]比对照组[(0.530±0.333)μg/L]差异无统计学意义(P>0.05)。结论TFPI的降低提示体内对TF介导的凝血途径阻断不足,机体处于高凝状态,血栓形成的危险增加。在急性冠脉综合征的患者TFPI水平降低。冠状动脉局部的TFPI比全身血循环中的更低.冠状动脉局部的TFPI变化对临床治疗过程采用局部干预有指导意义。冠状动脉支架内再狭窄的患者外周血TFPI水平比无支架内再狭窄的低,有可能作为判断再狭窄的血液学诊断指标之一。 展开更多
关键词 支架内再狭窄 稳定性心绞痛 急性冠脉综合征 冠脉造影检查 凝血途径 心肌梗死组 支架植入 诊断指标 高凝状态 临床治疗过程
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高血压系列问答(6) 如何正确评价和合理使用血管紧张素转换酶抑制剂? 被引量:5
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作者 胡大一 《中国临床医生杂志》 2004年第7期60-60,共1页
关键词 噻嗪类利尿剂 慢性心力衰竭 心肌梗死组 降血压药物 赖诺普利 联合用药 强适应证 吲达帕胺 次要终点 终点事件
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血BNP检测对ACS危险分层和预后判断的意义
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作者 钱琦 杜蕾 蒋金法 《上海医学》 CSCD 北大核心 2007年第S1期18-19,共2页
目的通过检测ACS和稳定型心绞痛(SA)患者及ACS各亚组患者入院时的血浆BNP、cTnI、hsCRP和白细胞(WBC)的浓度,评价BNP单独或和cTnI、hsCRP、WBC联合检测对ACS的危险分层和预后判断的意义。方法选择ACS患者67例为试验组,SA20例为对照组, ... 目的通过检测ACS和稳定型心绞痛(SA)患者及ACS各亚组患者入院时的血浆BNP、cTnI、hsCRP和白细胞(WBC)的浓度,评价BNP单独或和cTnI、hsCRP、WBC联合检测对ACS的危险分层和预后判断的意义。方法选择ACS患者67例为试验组,SA20例为对照组, ACS组分为③个亚组:ST抬高心肌梗死(STEMI)组27例、非ST抬高心肌梗死组(NSTEMI)20例、不稳定型心绞痛(UA)20例。入院后24 h、5 d分别床旁测定血浆BNP、cTNI浓度,同时测hsCRP和WBC浓度,并查心电图、心超,行CAG术,记录患者病变的部位范围及各参数的值;并通过随诊访问患者或其家属了解30 d内、3个月内心血管事件(梗死后心绞痛、非致命性心肌梗死、心力衰竭、心律失常、靶血管血运重建及心脏性死亡)发生情况来判断预后。结果①ACS组和SA组之间的BNPI (559.59±735.) 16pg/ml比(23.28±11.69)pg/ml]的差异有统计学意义(P<0.05)。BNP水平在STEMI组明显高于NSTEMI组和UA组[(1050.59±932.31) pg/ml比(357.65±263.48)、(98.69±96.99)pg/ml, P<0.051;②前壁AMI患者B N P浓度高于其他壁AMI患者(806.3548±973.22604比347.1028±326.99646,P<0.01)。BNP与左室射血分数(LVEF)呈负相关(r=-0.759,p<0.05)。③冠脉3支病变组血浆B N P浓度明显高于1支病变组[(972.54±224.05)pg/ml比(249.29±192.1)pg/ml,P <0.01]。血清BNP与hsCRP(r=0.459,P<0.001)及cTNI(r=0.548,P<0.001)之间有良好的相关性。④BNP对30 d死亡率预测的ROC曲线下面积(AUC)为0.887(95%CI为0.805-0.969: P<0.05),当BNP>100 pg/ml时的敏感性为75%,特异为97%,正确性为81%。BNP预测3个月心血管事件的ROC曲线下面积(AUC)为0.787 (95%CI为0.672-0.902;P<0.05),敏感性84%,特异性69%,正确性64%。⑤ACS组与SA组比较: cTnI[(16.06±13.15)ng/ml比(0.05±0)ng/mL]、hsCRP[(40.86±42.22)mg/L比(4.61±4.12)mg/L)、WBC[(9.04±3.39)×109个/L比(5.63±0.97)×109个/L],差异均有统计学意义。⑥BNP阳性、cTnI阳性、hsCRP阳性、WBC阳性及四者均阳性时其心血管事件发生率分别为56.5%、55.0%、51.0%、75.0%和80.0%。结论血BNP水平与ACS疾病严重程度有关,BNP水平高多见于前壁心梗、血管病变数量多和心衰程度严重者,并与心血管事件呈正相关,故BNP是ACS危险分层和预后的独立预测因子:同时联合检测cTNI、hs CRP、WBC后评估ACS风险和预后的作用更大。从而有利于判断临床预后与拟订合适的治疗方案。 展开更多
关键词 危险分层 ACS BNP 心血管事件 心肌梗死组 靶血管血运重建 不稳定型心绞痛 致命性心肌 心脏性 心衰程度
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Baoyuan decoction alleviates myocardial infarction through the regulation of metabolic dysfunction and the mitochondria-dependent caspase-9/3 pathway 被引量:2
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作者 Zhiyong Du Zeliu Shu +7 位作者 Chun Li Xiaomin Song Xiaoli Ma Lixi Liao Jun Li Pengfei Tu Kewu Zeng Yong Jiang 《Acupuncture and Herbal Medicine》 2021年第1期49-58,共10页
Objective:Baoyuan decoction(BYD)is a traditional Chinese formula with myocardial protection efficacy validated by modern pharmacological tests.The present study aimed to investigate the effect and mechanism of BYD on ... Objective:Baoyuan decoction(BYD)is a traditional Chinese formula with myocardial protection efficacy validated by modern pharmacological tests.The present study aimed to investigate the effect and mechanism of BYD on alleviating myocardial infarction(MI).Methods:Nuclear magnetic resonance-based serum and urinary metabolomics were employed to explore the metabolic regulation effects of BYD in rats with MI induced by left anterior descending ligation.Oxygen-glucose deprivation/recovery(OGD/R)model in H9c2 cells and multiple molecular biology approaches were used to clarify the underlying action mechanisms of BYD.Results:BYD treatment recovered the serum and urinary metabolite profiles of the MI rats toward normal metabolic status and significantly improved mitochondrial energy metabolism and apoptosis pathways perturbed by MI.Analysis of the molecular mechanism of BYD indicated that it suppressed OGD/R-induced H9c2 cell apoptosis in a concentration-dependent manner by inhibiting the mitochondria-dependent caspase-9/3-poly ADP-ribose polymerase pathway.Conclusions:Our results demonstrate that BYD protects against myocardial apoptosis via the mitochondrial metabolic and apoptosis pathways.They also provide novel insights into the clinical application of BYD for the treatment of ischemic heart diseases. 展开更多
关键词 Baoyuan decoction Caspase-9/3 pathway Mechanisms Metabolomics Mitochondrial energy metabolism Myocardial infarction
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Effects of Panax Notoginseng Saponins on Homing of C-kit^+ Bone Mesenchymal Stem Cells to the Infarction Heart in Rats 被引量:19
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作者 张金生 何庆勇 +1 位作者 黄涛 张宝霞 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2011年第3期203-208,共6页
Objective:To investigate the effects of panax notoginseng saponins(PNS) on homing of C-kit+ bone mesenchymal stem cells(BMSCs) to the infarction heart.Methods:The acute myocardial infraction(AMI) model was established... Objective:To investigate the effects of panax notoginseng saponins(PNS) on homing of C-kit+ bone mesenchymal stem cells(BMSCs) to the infarction heart.Methods:The acute myocardial infraction(AMI) model was established in 140 Wistar rats,105 model rats survived after operation,and the model rats were randomly divided into five groups,21 rats in each group:Western medicine group mobilized by subcutaneous injection of human granuloctye colony stimulating factor(G-CSF) 50 μg·kg-1·d-1;sham operation group and a model group treated by subcutaneous injection of normal saline 50 μg·kg-1·d-1;Chinese medicine group mobilized by intraperitoneal injection of Xuesaitong(血塞通)(ingredients of PNS) 150 mg·kg-1·d-1;integrative medicine group mobilized by subcutaneous injection of G-CSF 50 μg·kg-1·d-1 and intraperitoneal injection of Xuesaitong 150 mg·kg-1·d-1.Except for the sham-operated group,each group was divided into three sub-groups by three time points of 1 d,7 d and 14 d.G-CSF was injected once a day for 7 d.Xuesaitong was injected once a day until the rats were killed.The flow cytometry was used for detection of C-kit + cells in the peripheral blood in different time points,and immunohistochemical method was used for detection of the changes of C-kit + cell and Ki-67+ cell numbers in the marginal zone of AMI.Results:Twenty-four hours after the operation,C-kit + cells had a slight increase in the model group compared with the sham operation group(P>0.05).The peripheral blood C-kit+ cells in the integrative group increased significantly compared with the other groups on 7 d and 14 d(all P<0.05).Meanwhile the expression of C-kit + cells and Ki-67+ cells in the marginal zone of AMI in the integrative group increased significantly compared with the Chinese medicine group,the western medicine group and the model group on 1 d,7 d and 14 d(all P<0.05),and the cells in the integrative group decreased significantly on 14 d compared with that on 7 d(P<0.05).Conclusion:PNS can cooperate with G-CSF to mobilize C-kit+ BMSCs from the marrow into the peripheral blood and promote them "homing" to the infarction heart. 展开更多
关键词 Panax notoginseng saponins(PNS) bone mesenchymal stem cells (BMSCs) HOMING experimental research
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