本文通过查阅中国知网(CNKI)、PubMed及相关参考书目,对目前心血管疾病常用中药注射液及其涉及中药有效组分的相关文献进行归纳及分析。文章所载中药注射液有川芎嗪注射液、丹参酮IIA磺酸钠注射液等5种中药注射液,其主要成分多数源自单...本文通过查阅中国知网(CNKI)、PubMed及相关参考书目,对目前心血管疾病常用中药注射液及其涉及中药有效组分的相关文献进行归纳及分析。文章所载中药注射液有川芎嗪注射液、丹参酮IIA磺酸钠注射液等5种中药注射液,其主要成分多数源自单味中药;中药中有效组分被提取作为中药注射液主要成分是趋势,占比80%;以上中药注射液不仅仅适用于某个中医证型,在相关心血管疾病中多有应用;涉及中药有丹参、川芎等,有效组分类型有皂苷和黄酮类等;多具有保护缺血再灌注损伤、抗炎、抗氧化、抗血栓形成等药理作用。本文为防治心血管疾病提供依据。China Knowledge Network (CNKI), PubMed and relevant bibliographies were consulted to summarize and analyze the current commonly-used traditional Chinese medicine injections (TCMIs) for cardiovascular diseases and their related literature involving the active components of traditional Chinese medicines. In this paper, there are 5 types of TCMIs, including ligustrazine injection, tanshinone IIA sodium sulfonate injection etc. The majority are derived from single-flavored Chinese medicines. It is a trend that the effective components of Chinese medicines are extracted to be the main ingredients of Chinese medicine injections, which accounts for 80% of the total. The above Chinese medicine injections are not only applicable to a certain TCM type, but also to the relevant cardiovascular diseases, in which they can be used in a variety of ways. Involving Chinese medicines such as Salvia miltiorrhiza and Rhizoma Ligustici Chuanxiong, etc., and the types of active components include saponins and flavonoids, etc. Most of them have the pharmacological effects of protection against ischemia-reperfusion injury, anti-inflammation, antioxidation and anti-thrombosis. This article can provide the basis of prevention and treatment of cardiovascular diseases.展开更多
近年来心血管疾病的残余风险促使人们探索更为有效的干预靶点。半胱氨酸天冬氨酸蛋白酶(cysteinyl aspartate specific proteinase,Caspase)家族是介导固有免疫、细胞程序性死亡的关键蛋白,通过细胞焦亡与细胞凋亡的多条通路参与心血管...近年来心血管疾病的残余风险促使人们探索更为有效的干预靶点。半胱氨酸天冬氨酸蛋白酶(cysteinyl aspartate specific proteinase,Caspase)家族是介导固有免疫、细胞程序性死亡的关键蛋白,通过细胞焦亡与细胞凋亡的多条通路参与心血管疾病的发生与发展。结合国内外文献,该文阐述Caspase-1/4/5/11介导的细胞焦亡与Caspase-3/7/8/9/10/12介导的细胞凋亡的科学内涵,并对Caspases家族与心血管疾病的关联及近5年中药复方针对Caspases干预心力衰竭、动脉粥样硬化性疾病、高血压相关代谢紊乱的相关研究进行述评,以期为心血管疾病的防治及中医药机制研究提供新视角。展开更多
高迁移率族蛋白B1(high mobility group box 1protein,HMGB1)是典型的核内非组蛋白,通过活化细胞的主动分泌和受损坏死细胞的被动释放2种方式进入胞外,介导炎性反应,是一种重要的炎性介质和促炎性细胞因子。HMGB1在动脉粥样硬化、心肌...高迁移率族蛋白B1(high mobility group box 1protein,HMGB1)是典型的核内非组蛋白,通过活化细胞的主动分泌和受损坏死细胞的被动释放2种方式进入胞外,介导炎性反应,是一种重要的炎性介质和促炎性细胞因子。HMGB1在动脉粥样硬化、心肌梗死、缺血再灌注损伤、心力衰竭等多种心血管疾病中表达上调,使其成为治疗心血管疾病的一个新靶点。中药具有低毒副作用、多靶点的特点,可对致病信号通路进行联合抑制。本文就HMGB1及其中药抑制剂治疗心血管疾病的研究进展进行概述。展开更多
文摘本文通过查阅中国知网(CNKI)、PubMed及相关参考书目,对目前心血管疾病常用中药注射液及其涉及中药有效组分的相关文献进行归纳及分析。文章所载中药注射液有川芎嗪注射液、丹参酮IIA磺酸钠注射液等5种中药注射液,其主要成分多数源自单味中药;中药中有效组分被提取作为中药注射液主要成分是趋势,占比80%;以上中药注射液不仅仅适用于某个中医证型,在相关心血管疾病中多有应用;涉及中药有丹参、川芎等,有效组分类型有皂苷和黄酮类等;多具有保护缺血再灌注损伤、抗炎、抗氧化、抗血栓形成等药理作用。本文为防治心血管疾病提供依据。China Knowledge Network (CNKI), PubMed and relevant bibliographies were consulted to summarize and analyze the current commonly-used traditional Chinese medicine injections (TCMIs) for cardiovascular diseases and their related literature involving the active components of traditional Chinese medicines. In this paper, there are 5 types of TCMIs, including ligustrazine injection, tanshinone IIA sodium sulfonate injection etc. The majority are derived from single-flavored Chinese medicines. It is a trend that the effective components of Chinese medicines are extracted to be the main ingredients of Chinese medicine injections, which accounts for 80% of the total. The above Chinese medicine injections are not only applicable to a certain TCM type, but also to the relevant cardiovascular diseases, in which they can be used in a variety of ways. Involving Chinese medicines such as Salvia miltiorrhiza and Rhizoma Ligustici Chuanxiong, etc., and the types of active components include saponins and flavonoids, etc. Most of them have the pharmacological effects of protection against ischemia-reperfusion injury, anti-inflammation, antioxidation and anti-thrombosis. This article can provide the basis of prevention and treatment of cardiovascular diseases.
文摘近年来心血管疾病的残余风险促使人们探索更为有效的干预靶点。半胱氨酸天冬氨酸蛋白酶(cysteinyl aspartate specific proteinase,Caspase)家族是介导固有免疫、细胞程序性死亡的关键蛋白,通过细胞焦亡与细胞凋亡的多条通路参与心血管疾病的发生与发展。结合国内外文献,该文阐述Caspase-1/4/5/11介导的细胞焦亡与Caspase-3/7/8/9/10/12介导的细胞凋亡的科学内涵,并对Caspases家族与心血管疾病的关联及近5年中药复方针对Caspases干预心力衰竭、动脉粥样硬化性疾病、高血压相关代谢紊乱的相关研究进行述评,以期为心血管疾病的防治及中医药机制研究提供新视角。
文摘高迁移率族蛋白B1(high mobility group box 1protein,HMGB1)是典型的核内非组蛋白,通过活化细胞的主动分泌和受损坏死细胞的被动释放2种方式进入胞外,介导炎性反应,是一种重要的炎性介质和促炎性细胞因子。HMGB1在动脉粥样硬化、心肌梗死、缺血再灌注损伤、心力衰竭等多种心血管疾病中表达上调,使其成为治疗心血管疾病的一个新靶点。中药具有低毒副作用、多靶点的特点,可对致病信号通路进行联合抑制。本文就HMGB1及其中药抑制剂治疗心血管疾病的研究进展进行概述。