目的基于全球疾病负担(Global Burden of Disease,GBD)2019研究,对比全球以及美国、日本和印度,分析中国心血管病(cardiovascular disease,CVD)的疾病负担流行趋势和危险因素。方法通过全球健康交流数据库(Global Health Data Exchange,...目的基于全球疾病负担(Global Burden of Disease,GBD)2019研究,对比全球以及美国、日本和印度,分析中国心血管病(cardiovascular disease,CVD)的疾病负担流行趋势和危险因素。方法通过全球健康交流数据库(Global Health Data Exchange,GHDx)获取数据,分性别、年龄分析中国CVD患病、发病、死亡、伤残调整寿命年(disability adjusted life year,DALY)等疾病负担现状和主要危险因素;利用年龄标化率对比中、美、日、印在1990—2019年期间CVD疾病负担变化趋势。结果2019年,中国CVD患病人数为1.20亿,新发病例数1234.11万,死亡458.43万;患病率、发病率、死亡率和DALY率从1990年的4235.43/10万、447.81/10万、204.75/10万和5091.03/10万,分别升高至2019年的8460.08/10万、867.65/10万、322.30/10万和6463.47/10万。患病率、发病率、死亡率和DALY率均随年龄呈上升趋势,且男性CVD疾病负担高于女性。尽管消除人口老龄化因素影响,中国CVD标化死亡率由1990年的381.21/10万下降至2019年的276.93/10万,标化DALY率由7412.81/10万下降至4938.38/10万,但仍略高于全球,且明显高于美国和日本。此外,2019年中国CVD前4位危险因素依次为高血压、饮食因素、空气污染和烟草,这些因素导致的CVD疾病负担均高于全球平均水平。结论由于高血压、饮食因素、空气污染和烟草等原因,加上人口老龄化迅速,中国CVD疾病负担仍然十分严峻,需要引起相关部门重视。展开更多
Depression and cardiovascular disease （CVD） are both highly prevalent disorders, and some evidence shows that there is a ＇vicious cy- cle＇ linking major depression and CVD. There is also growing evidence that immu...Depression and cardiovascular disease （CVD） are both highly prevalent disorders, and some evidence shows that there is a ＇vicious cy- cle＇ linking major depression and CVD. There is also growing evidence that immune abnormalities underpin the common pathophysiology of both CVD and major depression. The abnormalities include the following： abnormal levels of inflammatory markers, such as interleukin-6 （IL-6）, interleukin-1β （IL-1β）, minor necrosis factor α （TNF-α） and interleukin-12 （IL-12）; increased acute phase proteins, such as C-reactive protein, fibrinogen and haptoglobin; and abnormal complement factors. The findings show that major depression and CVD patients have greater immune abnormalities, which may increase depressive symptoms and cardiovascular pathological changes, and that there may be a bidirectional relationship, therefore more prospective studies are needed to draw conclusions.展开更多
文摘目的基于全球疾病负担(Global Burden of Disease,GBD)2019研究,对比全球以及美国、日本和印度,分析中国心血管病(cardiovascular disease,CVD)的疾病负担流行趋势和危险因素。方法通过全球健康交流数据库(Global Health Data Exchange,GHDx)获取数据,分性别、年龄分析中国CVD患病、发病、死亡、伤残调整寿命年(disability adjusted life year,DALY)等疾病负担现状和主要危险因素;利用年龄标化率对比中、美、日、印在1990—2019年期间CVD疾病负担变化趋势。结果2019年,中国CVD患病人数为1.20亿,新发病例数1234.11万,死亡458.43万;患病率、发病率、死亡率和DALY率从1990年的4235.43/10万、447.81/10万、204.75/10万和5091.03/10万,分别升高至2019年的8460.08/10万、867.65/10万、322.30/10万和6463.47/10万。患病率、发病率、死亡率和DALY率均随年龄呈上升趋势,且男性CVD疾病负担高于女性。尽管消除人口老龄化因素影响,中国CVD标化死亡率由1990年的381.21/10万下降至2019年的276.93/10万,标化DALY率由7412.81/10万下降至4938.38/10万,但仍略高于全球,且明显高于美国和日本。此外,2019年中国CVD前4位危险因素依次为高血压、饮食因素、空气污染和烟草,这些因素导致的CVD疾病负担均高于全球平均水平。结论由于高血压、饮食因素、空气污染和烟草等原因,加上人口老龄化迅速,中国CVD疾病负担仍然十分严峻,需要引起相关部门重视。
文摘Depression and cardiovascular disease （CVD） are both highly prevalent disorders, and some evidence shows that there is a ＇vicious cy- cle＇ linking major depression and CVD. There is also growing evidence that immune abnormalities underpin the common pathophysiology of both CVD and major depression. The abnormalities include the following： abnormal levels of inflammatory markers, such as interleukin-6 （IL-6）, interleukin-1β （IL-1β）, minor necrosis factor α （TNF-α） and interleukin-12 （IL-12）; increased acute phase proteins, such as C-reactive protein, fibrinogen and haptoglobin; and abnormal complement factors. The findings show that major depression and CVD patients have greater immune abnormalities, which may increase depressive symptoms and cardiovascular pathological changes, and that there may be a bidirectional relationship, therefore more prospective studies are needed to draw conclusions.
