目的探讨分析不同年龄阶段抗苗勒氏管激素(anti-mullerian hormone,AMH)与三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)、低密度脂蛋白(low density lipoprotein,LDL)等心血管风险因子相关...目的探讨分析不同年龄阶段抗苗勒氏管激素(anti-mullerian hormone,AMH)与三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)、低密度脂蛋白(low density lipoprotein,LDL)等心血管风险因子相关性。方法将我院2018年12月—2019年12月门诊计划生育专科体检的100例育龄期女性作为研究对象,将其分为25~35岁女性作为A组,将36~45岁女性作为B组,对其血清抗苗勒氏管激素进行测定,分析与其TG、HDL-C、LDL-C等心血管风险评估指标之间的相关性。结果A组女性抗苗勒氏管激素水平与血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、血清总胆固醇(TC)之间正线相关性(P<0.05),与高密度脂蛋白胆固醇(HDL-C)之间无明显相关性(P>0.05)。B组女性的抗苗勒氏管激素水平与TG、HDL-C、LDL-C、TC等风险因子之间并无明显相关性(P>0.05)。结论针对各年龄阶段育龄期女性血清抗苗勒氏管激素水平测定,对早期心血管疾病发生及评估具有一定的临床参考价值。展开更多
AIM:To clarify whether nonalcoholic fatty liver disease(NAFLD)increases the risk of cardiovascular disease.METHODS:We carried out a prospective observational study with a total of 1637 apparently healthy Japanese men ...AIM:To clarify whether nonalcoholic fatty liver disease(NAFLD)increases the risk of cardiovascular disease.METHODS:We carried out a prospective observational study with a total of 1637 apparently healthy Japanese men and women who were recruited from a health check-up program.NAFLD was diagnosed by abdominal ultrasonography.The metabolic syndrome(MS)was defined according to the modified National Cholesterol Education Program(NCEP)ATP Ⅲ criteria.Five years after the baseline evaluations,the incidence of cardiovascular disease was assessed by a self-administered questionnaire.RESULTS:Among 1221 participants available for outcome analyses,the incidence of cardiovascular disease was higher in 231 subjects with NAFLD at baseline(5 coronary heart disease,6 ischemic stroke,and 1 cerebral hemorrhage)than 990 subjects without NAFLD(3 coronary heart disease,6 ischemic stroke,and 1 cerebral hemorrhage).Multivariate analyses indicated that NAFLD was a predictor of cardiovascular disease independent of conventional risk factors(odds ratio 4.12,95% CI,1.58 to 10.75,P = 0.004).MS was alsoindependently associated with cardiovascular events.But simultaneous inclusion of NAFLD and MS in a multivariate model revealed that NAFLD but not MS retained a statistically significant correlation with cardiovascular disease.CONCLUSION:Although both of them were predictors of cardiovascular disease,NAFLD but not MS retained a statistically significant correlation with cardiovascular disease in a multivariate model.NAFLD is a strong predictor of cardiovascular disease and may play a central role in the cardiovascular risk of MS.展开更多
文摘目的探讨分析不同年龄阶段抗苗勒氏管激素(anti-mullerian hormone,AMH)与三酰甘油(triglyceride,TG)、高密度脂蛋白胆固醇(high density liptein cholesterol,HDL-C)、低密度脂蛋白(low density lipoprotein,LDL)等心血管风险因子相关性。方法将我院2018年12月—2019年12月门诊计划生育专科体检的100例育龄期女性作为研究对象,将其分为25~35岁女性作为A组,将36~45岁女性作为B组,对其血清抗苗勒氏管激素进行测定,分析与其TG、HDL-C、LDL-C等心血管风险评估指标之间的相关性。结果A组女性抗苗勒氏管激素水平与血清甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、血清总胆固醇(TC)之间正线相关性(P<0.05),与高密度脂蛋白胆固醇(HDL-C)之间无明显相关性(P>0.05)。B组女性的抗苗勒氏管激素水平与TG、HDL-C、LDL-C、TC等风险因子之间并无明显相关性(P>0.05)。结论针对各年龄阶段育龄期女性血清抗苗勒氏管激素水平测定,对早期心血管疾病发生及评估具有一定的临床参考价值。
基金Supported by a grant from the Gifu Medical Association
文摘AIM:To clarify whether nonalcoholic fatty liver disease(NAFLD)increases the risk of cardiovascular disease.METHODS:We carried out a prospective observational study with a total of 1637 apparently healthy Japanese men and women who were recruited from a health check-up program.NAFLD was diagnosed by abdominal ultrasonography.The metabolic syndrome(MS)was defined according to the modified National Cholesterol Education Program(NCEP)ATP Ⅲ criteria.Five years after the baseline evaluations,the incidence of cardiovascular disease was assessed by a self-administered questionnaire.RESULTS:Among 1221 participants available for outcome analyses,the incidence of cardiovascular disease was higher in 231 subjects with NAFLD at baseline(5 coronary heart disease,6 ischemic stroke,and 1 cerebral hemorrhage)than 990 subjects without NAFLD(3 coronary heart disease,6 ischemic stroke,and 1 cerebral hemorrhage).Multivariate analyses indicated that NAFLD was a predictor of cardiovascular disease independent of conventional risk factors(odds ratio 4.12,95% CI,1.58 to 10.75,P = 0.004).MS was alsoindependently associated with cardiovascular events.But simultaneous inclusion of NAFLD and MS in a multivariate model revealed that NAFLD but not MS retained a statistically significant correlation with cardiovascular disease.CONCLUSION:Although both of them were predictors of cardiovascular disease,NAFLD but not MS retained a statistically significant correlation with cardiovascular disease in a multivariate model.NAFLD is a strong predictor of cardiovascular disease and may play a central role in the cardiovascular risk of MS.
