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ROC曲线下评估NT-proBNP与心-肾综合征的关系
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作者 易小艳 匡金石 胡飞跃 《中国现代医生》 2016年第30期1-4,共4页
目的 采用ROC曲线评估NT-proBNP与心-肾综合征(CRS)的关系。方法 313例住院患者根据eGFR水平进行分组,采用化学发光法测N末端B型利钠肽原(NT-proBNP)、肌钙蛋白I(TnI),采用速率法测肌酸激酶同工酶(CK-MB)。结果 据eGFRCysc+Gr... 目的 采用ROC曲线评估NT-proBNP与心-肾综合征(CRS)的关系。方法 313例住院患者根据eGFR水平进行分组,采用化学发光法测N末端B型利钠肽原(NT-proBNP)、肌钙蛋白I(TnI),采用速率法测肌酸激酶同工酶(CK-MB)。结果 据eGFRCysc+Gre分成两组,ROC曲线分析结果为NT-proBNP预测肾功能不全(AUC=0.704,与Az=0.5的比较:Z=6.157,P〈0.001)具有统计学意义。NT-proBNP临界点为203.9 pg/mL,灵敏度=63.1%;特异度=71.7%;以此临界点比较CRS发生率分别为1.76%(3/170)和6.29%(9/143),两者比较差异有统计学意义(χ^2=4.32,P=0.038)。结论 NT-proBNP具有承担心肌损伤和肾功能不全预测的双重生物标志物。 展开更多
关键词 ROC曲线 NT-PROBNP 心-肾综合征 生化标志物 功能
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血清中HMGB1表达水平与慢性肾-心综合征病情严重程度及预后的关系分析 被引量:1
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作者 赵文娟 夏世国 《中国中西医结合肾病杂志》 2023年第6期527-529,共3页
目的:探讨血清中高迁移率族蛋白B1(HMGB1)表达水平与慢性肾-心综合征病情严重程度及预后的关系。方法:选取2018年03月—2020年05月收治的81例慢性肾-心综合征患者作为综合征组,选取同期64例单纯慢性肾病作为慢性肾病组和50例体检健康者... 目的:探讨血清中高迁移率族蛋白B1(HMGB1)表达水平与慢性肾-心综合征病情严重程度及预后的关系。方法:选取2018年03月—2020年05月收治的81例慢性肾-心综合征患者作为综合征组,选取同期64例单纯慢性肾病作为慢性肾病组和50例体检健康者作为对照组,比较三组血清中HMGB1表达水平,并分析其临床病理特征与预后的关系,采用多因素回归分析其预后的影响因素。结果:肾心综合征组血清HMGB1水平高于慢性肾病组和对照组(P<0.05);Ⅲ期组血清HMGB1水平低于Ⅳ~Ⅴ期组(P<0.05);生存组血清HMGB1水平低于死亡组(P<0.05);血清HMGB1预测慢性肾-心综合征预后的ROC曲线下面积为0.720,95%CI为0.585~0.854;多因素回归分析,吸烟、糖尿病、高脂血症、HMGB1水平均为影响慢性肾-心综合征患者预后的独立危险因素(P<0.05)。结论:慢性肾-心综合征患者血清HMGB1水平与病情严重程度相关,可作为评估慢性肾-心综合征患者预后的指标。 展开更多
关键词 慢性-综合征 高迁移率族蛋白B1 预后
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舒适护理在心-肾贫血综合征患者中的应用
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作者 应兰芳 梁丹 黄国莹 《当代护士(下旬刊)》 2010年第5期30-31,共2页
目的探讨舒适护理在心-肾贫血综合征患者中的应用效果。方法将2008年1月~2009年3月对本院35例心-肾贫血综合征患者开展的舒适护理与2007年1月~2007年12月对本院30例患者开展的一般护理进行对比,进行患者满意度调查比较。结果开展舒适... 目的探讨舒适护理在心-肾贫血综合征患者中的应用效果。方法将2008年1月~2009年3月对本院35例心-肾贫血综合征患者开展的舒适护理与2007年1月~2007年12月对本院30例患者开展的一般护理进行对比,进行患者满意度调查比较。结果开展舒适护理后,患者满意度有明显提高(p<0.05),差异有统计学意义。结论舒适护理在心-肾贫血综合征中应用效果较好。 展开更多
关键词 -贫血综合征 舒适护理
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心-肾贫血综合征患者的出院指导
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作者 应兰芳 梁慧心 吕慕虹 《国际医药卫生导报》 2010年第23期2949-2951,共3页
目的 通过出院指导,提高心-肾贫血综合征患者的自我护理能力.方法 对65例心-肾贫血综合征患者,在患者病情稍稳定后就进行出院指导,采用健康教育处方发放 发放小册子 图谱教育 知识讲解 护患交流等方式.把出院指导贯穿于整个住院过程,多... 目的 通过出院指导,提高心-肾贫血综合征患者的自我护理能力.方法 对65例心-肾贫血综合征患者,在患者病情稍稳定后就进行出院指导,采用健康教育处方发放 发放小册子 图谱教育 知识讲解 护患交流等方式.把出院指导贯穿于整个住院过程,多次评估,对没有掌握的内容反复讲解,让患者和家属有充分的时间消化,并耐心解答患者和家属的各种疑问,使其理解各项措施的意义.结果 指导前与出院指导后患者对健康知识的掌握程度比较,有显著的统计学意义.患者和家属能较好掌握指导的内容,做好自我护理.结论 把握指导时机,全面细致的指导是患者和家属提高自我护理能力的关键. 展开更多
关键词 -贫血综合征 出院指导
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NGAL和HO-1在瓣膜置换术致急性肾损伤中的临床意义及干预研究 被引量:4
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作者 王祺 罗万俊 周巧玲 《中南大学学报(医学版)》 CAS CSCD 北大核心 2014年第10期1001-1007,共7页
目的:分析风湿性心脏瓣膜病择期行瓣膜置换术的患者术后急性肾损伤(acute kidney injury,AKI)发生情况并术中行下肢缺血处理,探讨瓣膜置换术所致心-肾综合征(cardio-renal syndrome,CRS)的发病机制及其预防措施。方法:入选46例风湿性心... 目的:分析风湿性心脏瓣膜病择期行瓣膜置换术的患者术后急性肾损伤(acute kidney injury,AKI)发生情况并术中行下肢缺血处理,探讨瓣膜置换术所致心-肾综合征(cardio-renal syndrome,CRS)的发病机制及其预防措施。方法:入选46例风湿性心脏瓣膜病择期行瓣膜置换术的患者,随机分为对照组(Con)16例,远隔缺血时处理组(remote ischemic perconditioning,RIPer C)15例,远隔缺血后处理组(remote ischemic postconditioning,RIPost C)15例。比较3组患者术前、开放主动脉后6,12,24,48 h血肌酐、尿素氮、血红素氧合酶-1(heme oxygennase-1,HO-1)、血清铁及尿中性粒细胞明胶酶相关脂质运载蛋白(neutrophil gelatinase associated lipocalin,NGAL)水平变化。结果:与术前基础值相比,对照组、RIPer C组及RIPost C组患者术后血肌酐,尿素氮,尿NGAL,血清铁(6,12 h),血HO-1均显著升高(P<0.05)。与对照组相比,RIPer C组及RIPost C组开放主动脉后6,12,24,48 h,血HO-1均显著升高,其中RIPer C组12,24,48 h的血HO-1水平,RIPost C组24,48 h的血HO-1水平差异有统计学意义(P<0.05);与对照组相比,RIPer C组及RIPost C组开放主动脉后6,12,24,48 h血肌酐、尿素氮、尿NGAL、血清铁均降低,但各组间差异均无统计学意义(P>0.05)。结论:瓣膜置换术后尿NGAL、血清铁、血HO-1的异常改变有望作为术后AKI发生的早期预警指标;远隔缺血处理方法对瓣膜置换术所致CRS具有良好的预防及肾保护作用。 展开更多
关键词 心-肾综合征 急性损伤 脏手术 远隔缺血处理 中性粒细胞明胶酶相关脂质运载蛋白 血红素加氧酶-1 血清铁
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新冠疫情防控下隔离人员中1例心-肝-肾综合征报道 被引量:1
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作者 高田 殷杰 +9 位作者 王巍 潘玉霞 郑昌荣 王玲 赵伟 胡东东 丁维志 朱双双 陈祖乾 靳苏香 《中国临床研究》 CAS 2023年第1期130-133,共4页
新冠肺炎疫情防控下隔离点人员人口基数大、人口结构不同,涉及病种繁多、病情复杂,不乏重症抢救病例。老年心功能不全患者在各种诱因(感染、腹泻、情绪变化等)下可出现急性心功能衰竭(acute heart failure,AHF),是由多种可能的潜在心脏... 新冠肺炎疫情防控下隔离点人员人口基数大、人口结构不同,涉及病种繁多、病情复杂,不乏重症抢救病例。老年心功能不全患者在各种诱因(感染、腹泻、情绪变化等)下可出现急性心功能衰竭(acute heart failure,AHF),是由多种可能的潜在心脏病和诱发因素导致的心脏功能急性或亚急性恶化。充血是大多数AHF患者的主要临床特征,少部分表现为外周灌注不足或心源性休克[1]。腹腔脏器血管受到静脉充血和交感神经兴奋的刺激最终调节系统故障,导致肝肾功能衰竭的综合征称为心-肝-肾综合征(cardio-hepatorena syndrome)。该病起病急,进展快,可迅速引起多脏器功能衰竭、凝血紊乱,甚至危及患者生命[2-3]。南京医科大学第四附属医院在新冠疫情防控下隔离人员中出现1例老年危重心肝肾综合征病例,经多学科综合抢救治疗疫情得到及时控制,患者现已康复出院。现报道如下。本研究经医院伦理委员会审核标准(伦理批准号:20221110-k057)。 展开更多
关键词 新冠肺炎疫情防控 功能衰竭 急性 功能损伤 急性 --综合征
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钠葡萄糖共转运蛋白-2抑制剂心肾保护机制的研究进展
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作者 谢林峰 罗素新 黄毕 《中华心力衰竭和心肌病杂志(中英文)》 2024年第2期145-150,共6页
钠-葡萄糖共转运蛋白-2(SGLT-2)抑制剂最初是用于治疗2型糖尿病的降糖药物,但临床试验证实,SGLT-2抑制剂除降糖作用外,还具有额外的心肾获益,目前已被指南作为“四驾马车”之一推荐用于心衰患者及糖尿病合并慢性肾脏病患者。目前,SGLT-... 钠-葡萄糖共转运蛋白-2(SGLT-2)抑制剂最初是用于治疗2型糖尿病的降糖药物,但临床试验证实,SGLT-2抑制剂除降糖作用外,还具有额外的心肾获益,目前已被指南作为“四驾马车”之一推荐用于心衰患者及糖尿病合并慢性肾脏病患者。目前,SGLT-2抑制剂对于心肾保护的详细机制尚不十分明确,可能包括降压、改善内皮功能及心脏和肾脏血流动力学、减少炎症和氧化应激等机制。本文就SGLT-2抑制剂在心肾保护中的临床证据及可能机制作一综述。 展开更多
关键词 -葡萄糖共转运蛋白-2抑制剂 心-肾综合征 保护
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心-肾贫血综合征76例临床分析 被引量:3
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作者 张鹏鹏 《临床内科杂志》 CAS 2007年第3期198-199,共2页
目的了解心-肾贫血综合征(CRAS)的发病率及影响因素。方法以同时具备心功能NYHAII以上,血红蛋白(Hb)男性<120g/L,女性<110g/L,内生肌酐清除率(Ccr)每1.73m2<60ml/min为标准诊断心-肾贫血综合征76例,按原发病的不同将其分为心... 目的了解心-肾贫血综合征(CRAS)的发病率及影响因素。方法以同时具备心功能NYHAII以上,血红蛋白(Hb)男性<120g/L,女性<110g/L,内生肌酐清除率(Ccr)每1.73m2<60ml/min为标准诊断心-肾贫血综合征76例,按原发病的不同将其分为心脏病组(32例)和肾脏病组(44例)。结果226例各种心脏病患者中发现CRAS32例,发病率为14.15%;68例各种原因的肾脏病患者中发现CRAS44例,发病率为64.7%。心脏病组患者Hb为80.37g/L±18.11g/L,Ccr每1.73m2为21.65ml/min±21.84ml/min;肾脏病组Hb为65.20g/L±13.71g/L,Ccr每1.73m2为15.12ml/min±11.42ml/min。两组Hb及Ccr比较有显著性差异(P<0.05)。在47例符合CRAS的患者中23例使用促红细胞生成素(EPO)。每周2次皮下注射,治疗前Hb为62.14g/L±14.32g/L,心功能III级10例、IV级13例;治疗6个月后Hb为96.56g/L±12.45g/L,心功能II级9例、III级14例。结论心-肾贫血综合征主要发生在原发病为肾小球疾病和高血压心脏病的基础上,贫血和肾功能减退的程度以肾脏病组较心脏病组严重。EPO在纠正贫血、心力衰竭方面起关键性作用。 展开更多
关键词 -贫血综合征 内生肌酐清除率 贫血 力衰竭 促红细胞生成素
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心肾贫血综合征53例的临床分析 被引量:2
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作者 边可陶 王丽艳 邵学敏 《实用心脑肺血管病杂志》 2010年第1期42-44,共3页
目的探讨慢性充血性心力衰竭、慢性肾衰竭和贫血之间的关系。了解心肾贫血综合征(CRAS)的发病率及影响因素。方法选取同时具备慢性充血性心力衰竭、慢性肾衰竭和贫血的患者53例,原发于肾病的28例为肾病组,原发于心脏病的25例为心脏病组... 目的探讨慢性充血性心力衰竭、慢性肾衰竭和贫血之间的关系。了解心肾贫血综合征(CRAS)的发病率及影响因素。方法选取同时具备慢性充血性心力衰竭、慢性肾衰竭和贫血的患者53例,原发于肾病的28例为肾病组,原发于心脏病的25例为心脏病组,比较两组间血红蛋白(Hb)及肌酐清除率(Ccr)有无差异,以及比较不同级别的心功能与Ccr及Hb之间的关系。结果92例心力衰竭合并贫血的患者中发现CRAS53例,发病率为57.61﹪;其中原发于心脏病的CRAS(心脏病组)25例,原发于肾脏病的CRAS(肾脏病组)28例,心脏病组Hb为(95.97±15.97)g/L,Ccr为(19.65±8.57)ml·min-1·1.73m-2;肾脏病组Hb为(85.39±27.47)g/L,Ccr为(14.12±7.24)ml·min-1·1.73m-2,两组Hb及Ccr比较有显著性差异(P<0.05)。结论慢性心功能不全、慢性肾功能不全和贫血三者常常同时存在,三者之间相互关联,治疗时要在治疗原发病的同时注意三者兼顾,才能取得良好的效果。 展开更多
关键词 -贫血综合征 内生肌酐清除率 贫血 力衰竭 慢性功能不全
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Fluid overload as a major target in management of cardiorenal syndrome:Implications for the practice of peritoneal dialysis 被引量:16
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作者 Amir Kazory 《World Journal of Nephrology》 2017年第4期168-175,共8页
Congestion is an integral component of cardiorenal syn-drome and portends an adverse impact on the outcomes. Recent studies suggest that congestion has the ability ofmodulating the interactions between the kidney and ... Congestion is an integral component of cardiorenal syn-drome and portends an adverse impact on the outcomes. Recent studies suggest that congestion has the ability ofmodulating the interactions between the kidney and the heart in this setting. Peritoneal dialysis (PD) is a home-based therapeutic modality that is not only offered to patients with end-stage renal disease to provide solute clearance and ultrafltration, but it has also been used in patients with refractory heart failure and fuid overload to help optimize volume status. Several uncontrolled studies and case series have so far evaluated the role of PD in management of hypervolemia for patients with heart failure. They have generally reported favorable results in this setting. However, the data on the outcomes of patients with end-stage renal disease and concomitant heart failure is mixed, and the proposed theoretical advantages of PD might not translate into improvedclinical endpoints. Congestion is prevalent in this patient population and has a signifcant effect on their survival. As studies suggest that a significant subset of patients with end-stage renal disease who receive PD therapy are hypervolemic, suboptimal management of congestion could at least in part explain these conficting results. PD is a highly fexible therapeutic modality and the choice oftechniques, regimens, and solutions can affect its ability for optimization of fluid status. This article provides an overview of the currently available data on the role and clinical relevance of congestion in patients with cardiorenal syndrome and reviews potential options to enhance decongestion in these patients. 展开更多
关键词 Heart failure Peritoneal dialysis CONGESTION Cardiorenal syndrome
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Epidemiology, pathophysiology, clinical characteristics and management of childhood cardiorenal syndrome 被引量:2
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作者 Wasiu A Olowu 《World Journal of Nephrology》 2012年第1期16-24,共9页
Cardiorenal syndrome(CRS) is a new term recently introduced to describe the acute or chronic comorbid state of the heart and kidney that has been long known and frequently managed in very sick individuals. The tight a... Cardiorenal syndrome(CRS) is a new term recently introduced to describe the acute or chronic comorbid state of the heart and kidney that has been long known and frequently managed in very sick individuals. The tight and delicate coordination of physiological functions among organ systems in the human body makes dysfunction in one to lead to malfunction of one or more other organ systems. CRS is a universal very common morbidity in the critically ill, with a high mortality rate that has received very little research attention in children. Simultaneous management of heart and renal failures in CRS is quite challenging; the therapeutic choice made for one organ must not jeopardize the other. This paper reviews the epidemiology, pathophysiology, clinical characteristics and management of acute and chronic CRS in children. 展开更多
关键词 Acute kidney injury Congestive heart failure Chronic kidney disease Ultrafltration
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Hepatitis C comorbidities affecting the course and response to therapy 被引量:2
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作者 Abdel-Rahman El-Zayadi 《World Journal of Gastroenterology》 SCIE CAS CSCD 2009年第40期4993-4999,共7页
Several studies have demonstrated that the outcome of chronic hepatitis C (CHC) infection is profoundly influenced by a variety of comorbidities. Many of these comorbidities have a significant influence on the respons... Several studies have demonstrated that the outcome of chronic hepatitis C (CHC) infection is profoundly influenced by a variety of comorbidities. Many of these comorbidities have a significant influence on the response to antiviral therapy. These comorbidities negatively affect the course and outcome of liver disease, often reducing the chance of achieving a sustained virological response with PEGylated interferon and ribavirin treatments. Comorbidities affecting response to antiviral therapy reduce compliance and adherence to inadequate doses of therapy. The most important comorbidities affecting the course of CHC include hepatitis B virus coinfection, metabolic syndrome, and intestinal bacterial overgrowth. Comorbidities affecting the course and response to therapy include schistosomiasis, iron overload, alcohol abuse, and excessive smoking. Comorbidities affecting response to antiviral therapy include depression, anemia, cardiovascular disease, and renal failure. 展开更多
关键词 COMORBIDITIES Chronic hepatitis C Responseto therapy
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Acute myocardial infarction in patients of nephrotic syndrome: a case series
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作者 Liang XIE Yi TANG +6 位作者 Jing LIU Song-Qing HE Jian-Hua LI Ying ZHU Zheng-Bing LIU Zhen CHENG Jian-Bin GONG 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2017年第7期481-484,共4页
Thromboembolic complications have been frequently re- ported in patients with long-lasting nephrotic syndrome (NS). Although thrombotic complications in the venous system are common in patients with NS, arterial thr... Thromboembolic complications have been frequently re- ported in patients with long-lasting nephrotic syndrome (NS). Although thrombotic complications in the venous system are common in patients with NS, arterial thromboses associated with NS are much less common. However, coronary thromboses are extremely rarely observed. So, NS is a rare cause of acute coronary syndrome (ACS). As such, the incidence, pathogenesis, and treatment of these patients have yet to be clearly defined. In the current litera- ture, publications contain less than 15 patients, most of whom are young children. 展开更多
关键词 Acute myocardial infarction Membranous nephropathy Nephrotic syndrome
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Therapeutic efficacy observation on auricular point sticking therapy for cardiac syndrome X in women 被引量:4
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作者 Zhang Ya-mei Wang Jun 《Journal of Acupuncture and Tuina Science》 CSCD 2020年第3期203-206,共4页
Objective:To observe the clinical effect of auricular point sticking therapy for cardiac syndrome X(CSX)in women.Methods:A total of 64 patients were randomized into two groups by the random number table,with 32 cases ... Objective:To observe the clinical effect of auricular point sticking therapy for cardiac syndrome X(CSX)in women.Methods:A total of 64 patients were randomized into two groups by the random number table,with 32 cases in each group.Patients in the control group received conventional treatment for angina,while patients in the treatment group received auricular point sticking therapy on the basis of conventional treatment.After 8 weeks of treatment,the levels of serum estradiol(E2),nitric oxide(NO)and endothelium-1(ET-1)were compared to evaluate the therapeutic effect.Results:After 8 weeks of treatment,the total effective rate and markedly effective rate in the treatment group were significantly higher than those in the control group,and the between-group comparisons showed statistical significance(both P<0.05).After treatment,the scores of chest pain and tightness in the control group dropped significantly,and the intra-group comparisons showed statistical significance(both P<0.05);the scores of chest pain and tightness,palpitations,weakness and shortness of breath in the treatment group dropped significantly,and the intra-group comparisons showed statistical significance(all P<0.05);there were significant inter-group differences in the scores of chest pain and tightness.After treatment,the intra-group comparisons of E2,NO and ET-1 contents in the control group showed no statistical significance(all P>0.05),while the E2,NO and ET-1 contents in the treatment group changed significantly after treatment and were significantly different from those in the control group(all P<0.05).Conclusion:Auricular point sticking on the basis of conventional treatment was effective for CSX in women,and is worth clinical application. 展开更多
关键词 Acupoint Therapy Auricular Point Sticking Otopoint Heart (CO15) Otopoint Liver (CO12) Otopoint Kidney (CO10) Microvascular Angina Cardiac Syndrome X WOMEN
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