AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of me...AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS.展开更多
Dynamic stiffness matrix method is applied to compute vibration of hull girder in this paper. This method can not only simplify the computational model, but also get much higher frequencies and responses accurately. T...Dynamic stiffness matrix method is applied to compute vibration of hull girder in this paper. This method can not only simplify the computational model, but also get much higher frequencies and responses accurately. The analytical expressions of dynamic stiffness matrix of a Timoshenko beam for transverse vibration are presented in this paper. All effects of rotatory inertia and shear deformation are taken into account in the formulation. The resulting dynamic stiffness matrix combined with the Wittrick-Williams algorithm is used to compute natural frequencies and mode shapes of the 299,500 DWT VLCC, and then the vibrational responses are solved by the mode superposition method. The computational results are compared with those obtained from other approximate methods and experiment, and it indicates that the method is accurate and efficient.展开更多
Bridge piers are impacted by autos sometimes. The pier usually has not been destroyed after once impact by auto. But there are few research on damage which will affect pier's capability, and most relative studies ...Bridge piers are impacted by autos sometimes. The pier usually has not been destroyed after once impact by auto. But there are few research on damage which will affect pier's capability, and most relative studies have focused the problems on piers impacted by vessels. The methods involve mainly sutra experience theory, numerical analysis, and experimental method. Owing to the complicacy of the bridge pier impacted by a vessel, there are few research derived with the sutra mechanics model and the piers impacted by autos. The dynamic response is studied here under the assumption of the rigid-plastic small-deformation for the pier impacted by auto. According to the Parkes beam model, the rigid-plastic theoretical solution is deduced. The final deformation is calculated by a practical example for the pier impacted by auto.展开更多
The semi-round rigid feet would cause position-posture deviation problem because the actual foothold position is hardly known due to the rolling effect of the semi-round rigid feet during the robot walking. The positi...The semi-round rigid feet would cause position-posture deviation problem because the actual foothold position is hardly known due to the rolling effect of the semi-round rigid feet during the robot walking. The position-posture deviation problem may harm to the stability and the harmony of the robot, or even makes the robot tip over and fail to walk forward. Focused on the position-posture deviation problem of multi-legged walking robots with semi-round rigid feet, a new method of position-posture closed-loop control is proposed to solve the position-posture deviation problem caused by semi-round rigid feet, based on the inverse velocity kinematics of the multi-legged walking robots. The position-posture closed-loop control is divided into two parts: the position closed-loop control and the posture closed-loop control. Thus, the position-posture control for the robot which is a tight coupling and nonlinear system is decoupled. Co-simulations of position-posture open-loop control and position-posture closed-loop control by MATLAB and ADAMS are implemented, respectively. The co-simulation results verify that the position-posture closed-loop control performs well in solving the position-posture deviation problem caused by semi-round rigid feet.展开更多
The dynamical Lie algebraic method is used for the description of statistical mechanics of rotationally inelastic molecule-surface scattering. It can give the time-evolution operators about the low power of and by s...The dynamical Lie algebraic method is used for the description of statistical mechanics of rotationally inelastic molecule-surface scattering. It can give the time-evolution operators about the low power of and by solving a set of coupled nonlinear differential equations. For considering the contribution of the high power of and , we use the Magnus formula. Thus, with the time-evolution operators we can get the statistical average values of the measurable quantities in terms of the density operator formalism in statistical mechanics. The method is applied to the scattering of (rigid rotor) by a flat, rigid surface to illustrate its general procedure. The results demonstrate that the method is useful for describing the statistical dynamics of gas-surface scattering.展开更多
By ANSYS, dynamic simulation analysis of rubber spring supporting equipment used in vibrating screen was made. The modal frequency, mode, and harmonic displacement under working frequency were obtained. Variation of r...By ANSYS, dynamic simulation analysis of rubber spring supporting equipment used in vibrating screen was made. The modal frequency, mode, and harmonic displacement under working frequency were obtained. Variation of rubber spring supporting equipment's dynamic performance was discussed first, which is under the condition of existing spring stiffness difference and exciting force bias. Also, the quantitative calculation formulas were given. The results indicate that the performance of vibrating screen is closely related with rubber spring supporting equipment's dynamic performance. Differences of springs' stiffness coefficients reduce the modal frequency reduced, decrease the dynamic stiffness, and increase vibration displacement. Exciting force bias induces a larger lateral displacement. When rubber springs' stiffness coefficients exist, differences and lateral force accounts for 5% in total exciting force; rubber spring supporting equipment's side swing is larger than 1 mm, exceeding the side swing limit.展开更多
Multi-pylon multi-span suspension bridge is a new type super flexible structure system, and the rigidity design of middle pylon is one of the main difficult technical issues. Due to the requirements of longitudinal ri...Multi-pylon multi-span suspension bridge is a new type super flexible structure system, and the rigidity design of middle pylon is one of the main difficult technical issues. Due to the requirements of longitudinal rigidity, the structural form and the corresponding foundation type of middle pylon are different from those of the ordinary steel pylon, and the complicated dynamic characteristics make the calculation quite difficult. In this article, exploration has been made in selection of similarity ratio and model materials, section simulation, restriction conditions simulation, fixing of mass blocks, fabrication scheme and testing method by taking into account different construction and working conditions such as restriction conditions and working environment of a three-pylon suspension bridge, to conduct the test experimental design of the dynamic behavior of the middle pylon, with the purpose to reveal its dynamic characteristics and make comparison and analysis with theoretical assumptions, to provide basis for anti-wind and anti-seismic design and reference for the design and research of three-pylon two-span suspension bridges in the future.展开更多
The paper presents the theoretical analysis of a variable stiffness beam. The bending stiffness EI varies continuously along the length of the beam. Dynamic equation yields differential equation with variable co- effi...The paper presents the theoretical analysis of a variable stiffness beam. The bending stiffness EI varies continuously along the length of the beam. Dynamic equation yields differential equation with variable co- efficients based on the model of the Euler-Bernoulli beam. Then differential equation with variable coefficients becomes that with constant coefficients by variable substitution. At last, the study obtains the solution of dy- namic equation. The cantilever beam is an object for analysis. When the flexural rigidity at free end is a constant and that at clamped end is varied, the dynamic characteristics are analyzed under several cases. The results dem- onstrate that the natural angular frequency reduces as the fiexural rigidity reduces. When the rigidity of clamped end is higher than that of free end, low-level mode contributes the larger displacement response to the total re- sponse. On the contrary, the contribution of low-level mode is lesser than that of hi^h-level mode.展开更多
A numerical model was developed by using the dual boundary element method to investigate the dynamic behavior of a moored floating structure with a pair of vertical and flexible skirts attached at its bottom in the li...A numerical model was developed by using the dual boundary element method to investigate the dynamic behavior of a moored floating structure with a pair of vertical and flexible skirts attached at its bottom in the linear wave field. Theoretical conception is based on potential theory with linear external forces. The motions of the structure were assumed to be small and linear. The flexible skirts mounted beneath the structure were assumed uniform flexural rigidity and the thickness of the skirts was negligible. Comparison between the present model and Gesraha's solution was made to verify the results for a moored floating structure with or without rigid skirts. The influence of the skirt rigidity on the moored floating structure, moored lines and waves is investigated in this study. The results show that, the natural frequencies of structure's oscillation, moored force, wave reflection and transmission tend to the region of short-period waves when the flexible rigidity gradually decreases. Positive correlation exists between the aft mooring force and the pitch motion of the floating structure.展开更多
Let R be a ring such that all left semicentral idempotents axe central and α a weakly rigid endomorphism of R. It is shown that the skew power series ring R[[x; α]] is right p.q.Baer if and only if R is right p.q.Ba...Let R be a ring such that all left semicentral idempotents axe central and α a weakly rigid endomorphism of R. It is shown that the skew power series ring R[[x; α]] is right p.q.Baer if and only if R is right p.q.Baer and any countable family of idempotents in R has a generalized join in I(R), where I(R) is the set of all idempotents of R.展开更多
The global adaptive set stabilization problem of the attitude of a rigid spacecraft is addressed in this paper. Two different cases are considered. First, by using adaptive backstepping method, the authors design a gl...The global adaptive set stabilization problem of the attitude of a rigid spacecraft is addressed in this paper. Two different cases are considered. First, by using adaptive backstepping method, the authors design a global adaptive control law for the attitude control system with unknown inertia matrix such that the attitude and the angular velocities can be globally asymptotically stabilized to a set consisting of two equilibria. And then, based on the obtained backstepping adaptive law, the authors consider the case that the angular velocities are not measurable. By introducing an auxiliary state, a semi-global adaptive set stabilization law without angular velocity measurements is also designed. It is rigorously proved that, for the two cases, both of the closed loop systems satisfy the set stability. The effectiveness of the proposed methods is verified by simulation results.展开更多
The modeling method and identified method adapted to multi-degree-of-freedom structures with strucrural nonlinearities are established.The component mode synthesis method is used to establish the nonlinear governing e...The modeling method and identified method adapted to multi-degree-of-freedom structures with strucrural nonlinearities are established.The component mode synthesis method is used to establish the nonlinear governing equations by extending the connected relationships.Based on the modeling method,the Hilbert transform method is applied to identify the nonlinear stiffness of multi-degree-of-freedom structures.Nonlinear analysis and identification of a typical folding wing configuration with three freeplay hinges are investigated.The nonlinear governing equation is established based on present methods and the computing results of different stiffness are checked by finite element programming.In order to illustrate the influence of the nonlinearities,the frequency response characteristics of the structure are analyzed and Hilbert transform is performed.The Hilbert transform identification method is utilized to identify the nonlinear stiffness of nonlinear hinges in the time domain and several parametric studies are performed.In addition,the comparison of response is made to illustrate the feasibility of the methods.The results show that the extending component mode synthesis method in the present work can be used to establish the governing equation with structural nonlinearities.Based on the modeling method,the Hilbert transform identified method can be extended to multi-degree-of-freedom structures accurately.展开更多
文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS.
文摘Dynamic stiffness matrix method is applied to compute vibration of hull girder in this paper. This method can not only simplify the computational model, but also get much higher frequencies and responses accurately. The analytical expressions of dynamic stiffness matrix of a Timoshenko beam for transverse vibration are presented in this paper. All effects of rotatory inertia and shear deformation are taken into account in the formulation. The resulting dynamic stiffness matrix combined with the Wittrick-Williams algorithm is used to compute natural frequencies and mode shapes of the 299,500 DWT VLCC, and then the vibrational responses are solved by the mode superposition method. The computational results are compared with those obtained from other approximate methods and experiment, and it indicates that the method is accurate and efficient.
文摘Bridge piers are impacted by autos sometimes. The pier usually has not been destroyed after once impact by auto. But there are few research on damage which will affect pier's capability, and most relative studies have focused the problems on piers impacted by vessels. The methods involve mainly sutra experience theory, numerical analysis, and experimental method. Owing to the complicacy of the bridge pier impacted by a vessel, there are few research derived with the sutra mechanics model and the piers impacted by autos. The dynamic response is studied here under the assumption of the rigid-plastic small-deformation for the pier impacted by auto. According to the Parkes beam model, the rigid-plastic theoretical solution is deduced. The final deformation is calculated by a practical example for the pier impacted by auto.
基金Project(51221004)supported by the Science Fund for Creative Research Groups of National Natural Science Foundation of ChinaProject supported by the Program for Zhejiang Leading Team of S&T Innovation,China
文摘The semi-round rigid feet would cause position-posture deviation problem because the actual foothold position is hardly known due to the rolling effect of the semi-round rigid feet during the robot walking. The position-posture deviation problem may harm to the stability and the harmony of the robot, or even makes the robot tip over and fail to walk forward. Focused on the position-posture deviation problem of multi-legged walking robots with semi-round rigid feet, a new method of position-posture closed-loop control is proposed to solve the position-posture deviation problem caused by semi-round rigid feet, based on the inverse velocity kinematics of the multi-legged walking robots. The position-posture closed-loop control is divided into two parts: the position closed-loop control and the posture closed-loop control. Thus, the position-posture control for the robot which is a tight coupling and nonlinear system is decoupled. Co-simulations of position-posture open-loop control and position-posture closed-loop control by MATLAB and ADAMS are implemented, respectively. The co-simulation results verify that the position-posture closed-loop control performs well in solving the position-posture deviation problem caused by semi-round rigid feet.
基金The project supported by Natural Science Foundation of Shandong Province of China+2 种基金National Natural Science Foundation of Chinathe Doctor Foundation of the Ministry of Education of China
文摘The dynamical Lie algebraic method is used for the description of statistical mechanics of rotationally inelastic molecule-surface scattering. It can give the time-evolution operators about the low power of and by solving a set of coupled nonlinear differential equations. For considering the contribution of the high power of and , we use the Magnus formula. Thus, with the time-evolution operators we can get the statistical average values of the measurable quantities in terms of the density operator formalism in statistical mechanics. The method is applied to the scattering of (rigid rotor) by a flat, rigid surface to illustrate its general procedure. The results demonstrate that the method is useful for describing the statistical dynamics of gas-surface scattering.
文摘By ANSYS, dynamic simulation analysis of rubber spring supporting equipment used in vibrating screen was made. The modal frequency, mode, and harmonic displacement under working frequency were obtained. Variation of rubber spring supporting equipment's dynamic performance was discussed first, which is under the condition of existing spring stiffness difference and exciting force bias. Also, the quantitative calculation formulas were given. The results indicate that the performance of vibrating screen is closely related with rubber spring supporting equipment's dynamic performance. Differences of springs' stiffness coefficients reduce the modal frequency reduced, decrease the dynamic stiffness, and increase vibration displacement. Exciting force bias induces a larger lateral displacement. When rubber springs' stiffness coefficients exist, differences and lateral force accounts for 5% in total exciting force; rubber spring supporting equipment's side swing is larger than 1 mm, exceeding the side swing limit.
文摘Multi-pylon multi-span suspension bridge is a new type super flexible structure system, and the rigidity design of middle pylon is one of the main difficult technical issues. Due to the requirements of longitudinal rigidity, the structural form and the corresponding foundation type of middle pylon are different from those of the ordinary steel pylon, and the complicated dynamic characteristics make the calculation quite difficult. In this article, exploration has been made in selection of similarity ratio and model materials, section simulation, restriction conditions simulation, fixing of mass blocks, fabrication scheme and testing method by taking into account different construction and working conditions such as restriction conditions and working environment of a three-pylon suspension bridge, to conduct the test experimental design of the dynamic behavior of the middle pylon, with the purpose to reveal its dynamic characteristics and make comparison and analysis with theoretical assumptions, to provide basis for anti-wind and anti-seismic design and reference for the design and research of three-pylon two-span suspension bridges in the future.
基金National Natural Science Foundation of China(No.51178175)
文摘The paper presents the theoretical analysis of a variable stiffness beam. The bending stiffness EI varies continuously along the length of the beam. Dynamic equation yields differential equation with variable co- efficients based on the model of the Euler-Bernoulli beam. Then differential equation with variable coefficients becomes that with constant coefficients by variable substitution. At last, the study obtains the solution of dy- namic equation. The cantilever beam is an object for analysis. When the flexural rigidity at free end is a constant and that at clamped end is varied, the dynamic characteristics are analyzed under several cases. The results dem- onstrate that the natural angular frequency reduces as the fiexural rigidity reduces. When the rigidity of clamped end is higher than that of free end, low-level mode contributes the larger displacement response to the total re- sponse. On the contrary, the contribution of low-level mode is lesser than that of hi^h-level mode.
文摘A numerical model was developed by using the dual boundary element method to investigate the dynamic behavior of a moored floating structure with a pair of vertical and flexible skirts attached at its bottom in the linear wave field. Theoretical conception is based on potential theory with linear external forces. The motions of the structure were assumed to be small and linear. The flexible skirts mounted beneath the structure were assumed uniform flexural rigidity and the thickness of the skirts was negligible. Comparison between the present model and Gesraha's solution was made to verify the results for a moored floating structure with or without rigid skirts. The influence of the skirt rigidity on the moored floating structure, moored lines and waves is investigated in this study. The results show that, the natural frequencies of structure's oscillation, moored force, wave reflection and transmission tend to the region of short-period waves when the flexible rigidity gradually decreases. Positive correlation exists between the aft mooring force and the pitch motion of the floating structure.
基金National Natural Science Foundation of China (10171082), TRAPOYT the Cultivation Fund of the Key Scientific and Technical Innovation Project, Ministry of Education of China
文摘Let R be a ring such that all left semicentral idempotents axe central and α a weakly rigid endomorphism of R. It is shown that the skew power series ring R[[x; α]] is right p.q.Baer if and only if R is right p.q.Baer and any countable family of idempotents in R has a generalized join in I(R), where I(R) is the set of all idempotents of R.
基金This research is supported by the National Nature Science Foundation of China under Grant Nos. 60504007 and 61074013, Open Foundation of Key Laboratory of Micro-Inertial Instruments and Navigation Technology, Ministry of Education under Grant No. 201004, Initial Research Fund of Highly Specialized Personnel from Jiangsu University under Grant No. 10JDGll2, and 973 Sub-project under Grant No. 2009CB724002.
文摘The global adaptive set stabilization problem of the attitude of a rigid spacecraft is addressed in this paper. Two different cases are considered. First, by using adaptive backstepping method, the authors design a global adaptive control law for the attitude control system with unknown inertia matrix such that the attitude and the angular velocities can be globally asymptotically stabilized to a set consisting of two equilibria. And then, based on the obtained backstepping adaptive law, the authors consider the case that the angular velocities are not measurable. By introducing an auxiliary state, a semi-global adaptive set stabilization law without angular velocity measurements is also designed. It is rigorously proved that, for the two cases, both of the closed loop systems satisfy the set stability. The effectiveness of the proposed methods is verified by simulation results.
基金supported by the National Natural Sciences Foundation of China(Grant Nos.91116005 and 10902006)
文摘The modeling method and identified method adapted to multi-degree-of-freedom structures with strucrural nonlinearities are established.The component mode synthesis method is used to establish the nonlinear governing equations by extending the connected relationships.Based on the modeling method,the Hilbert transform method is applied to identify the nonlinear stiffness of multi-degree-of-freedom structures.Nonlinear analysis and identification of a typical folding wing configuration with three freeplay hinges are investigated.The nonlinear governing equation is established based on present methods and the computing results of different stiffness are checked by finite element programming.In order to illustrate the influence of the nonlinearities,the frequency response characteristics of the structure are analyzed and Hilbert transform is performed.The Hilbert transform identification method is utilized to identify the nonlinear stiffness of nonlinear hinges in the time domain and several parametric studies are performed.In addition,the comparison of response is made to illustrate the feasibility of the methods.The results show that the extending component mode synthesis method in the present work can be used to establish the governing equation with structural nonlinearities.Based on the modeling method,the Hilbert transform identified method can be extended to multi-degree-of-freedom structures accurately.