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慢性粒细胞性白血病不同病期bcr-abl基因P_(53)基因突变研究
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作者 李红玲 王超美 《兰州大学学报(自然科学版)》 CAS CSCD 北大核心 2002年第1期96-99,共4页
探讨 bcr- abl融合基因、P53 基因对 CML不同病期演变的作用 .采取 CML2 6例不同分期共30份标本 ,应用逆转录—聚合酶链反应 (RT- PCR)技术检测 bcr- abl融合基因 ,应用多聚酶变 .结果显示 2 4例 CML慢性期中 2 2例 bcr- abl基因 (+ ) ,... 探讨 bcr- abl融合基因、P53 基因对 CML不同病期演变的作用 .采取 CML2 6例不同分期共30份标本 ,应用逆转录—聚合酶链反应 (RT- PCR)技术检测 bcr- abl融合基因 ,应用多聚酶变 .结果显示 2 4例 CML慢性期中 2 2例 bcr- abl基因 (+ ) ,6例急变期中 5例 bcr- abl基因 (+ ) ;CML慢性期未发现 P53 基因突变 (0 / 2 4 ) ,急变期发现 2例突变 (2 / 6 ) .2例 P53 基因突变中 ,1例 bcr- abl基因(+ ) ,1例 bcr- abl基因 (- ) .由此可得 P53 基因突变在 CML慢性期少见 ;P53 基因突变对部分 展开更多
关键词 慢性粒细胞性白血病 BCR-ABL基因 P53基因 基因突变 RT-PCR技术 多变期 急变机制
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Numerical Simulation of the Heavy Rainfall in the Yangtze-Huai River Basin during Summer 2003 Using the WRF Model 被引量:13
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作者 LIU Hong-Bo 《Atmospheric and Oceanic Science Letters》 2012年第1期20-25,共6页
In this study, a 47-day regional climate simulation of the heavy rainfall in the Yangtze-Huai River Basin during the summer of 2003 was conducted using the Weather Research and Forecast (WRY) model. The simulation r... In this study, a 47-day regional climate simulation of the heavy rainfall in the Yangtze-Huai River Basin during the summer of 2003 was conducted using the Weather Research and Forecast (WRY) model. The simulation reproduces reasonably well the evolution of the rainfall during the study period's three successive rainy phases, especially the frequent heavy rainfall events occurring in the Huai River Basin. The model captures the major rainfall peak observed by the monitoring stations in the morning. Another peak appears later than that shown by the observations. In addition, the simulation realistically captures not only the evolution of the low-level winds but also the characteristics of their diurnal variation. The strong southwesterly (low-level jet, LLJ) wind speed increases beginning in the early evening and reaches a peak in the morning; it then gradually decreases until the afternoon. The intense LLJ forms a strong convergent circulation pattern in the early morning along the Yangtze-Huai River Basin. This pattern partly explains the rainfall peak observed at this time. This study furnishes a basis for the further analysis of the mechanisms of evolution of the LLJ and for the further study of the interactions between the LLJ and rainfall. 展开更多
关键词 heavy rainfall Yangtze-Huai River Basin the Weather Research and Forecast model low-level jet
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