目的:目前关于急性心肌梗死合并恶性肿瘤患者的相关临床资料相对匮乏。本研究主要探讨急性ST段抬高型心肌梗死(STEMI)合并恶性肿瘤的患者的临床特征及预后,以期为这类患者的临床监测、治疗和预后提供临床依据。方法:本研究收集了2021年1...目的:目前关于急性心肌梗死合并恶性肿瘤患者的相关临床资料相对匮乏。本研究主要探讨急性ST段抬高型心肌梗死(STEMI)合并恶性肿瘤的患者的临床特征及预后,以期为这类患者的临床监测、治疗和预后提供临床依据。方法:本研究收集了2021年1月~2021年12月于青岛大学附属烟台毓璜顶医院心内科住院的确诊为急性STEMI的男性吸烟患者。根据合并恶性肿瘤与否,分为合并肿瘤组和未合并肿瘤组。记录并分析研究人群的基线临床资料、冠脉造影结果、肿瘤类型和冠心病二级预防药物等治疗情况。对研究人群随访1年,记录研究终点的发生情况(终点事件包括:全因死亡、再发急性心肌梗死、住院治疗的不稳定型心绞痛、住院治疗的心功能不全)。结果:本研究共收集265例STEMI的男性吸烟患者,其中30例(11.3%)合并恶性肿瘤病史,最终纳入合并肿瘤组30例和未合并肿瘤组65例。在本研究人群中,最常见的恶性肿瘤分别是结直肠癌(20.0%)、肺癌(16.7%)、胃癌(13.3%)和肾癌(10.0%)。与未合并肿瘤组相比,合并肿瘤患者年龄更大(72.60 ± 8.23岁vs 64.06 ± 10.46岁,P Objective: Currently, there is relatively limited clinical data on patients with acute myocardial infarction and malignant tumors. This study mainly explores the clinical characteristics and prognosis of patients with malignant tumors in acute ST segment elevation myocardial infarction (STEMI), in order to provide clinical basis for clinical monitoring, treatment, and prognosis of such patients. Methods: This study collected male smoking patients diagnosed with acute STEMI who were hospitalized in the cardiology department of the Affiliated Yantai Yuhuangding Hospital of Qingdao University from January 2021 to December 2021. According to whether malignant tumors are merged or not, they are divided into tumor group and no tumor group: Record and analyze baseline clinical data, coronary angiography results, tumor types, and treatment status of secondary preventive drugs for coronary heart disease in the study population;follow up the study population for 1 year and record the occurrence of study endpoints (endpoint events include all-cause mortality, recurrent acute myocardial infarction, unstable angina treated in hospital, and cardiac dysfunction treated in hospital). Results: A total of 265 male smokers with acute STEMI were included in this study, of which 30 (11.3%) were complicated with malignant tumors. Ultimately, 30 cases were included in the tumor group and 65 cases were included in the no tumor group. In this study population, the most common malignant tumors were colorectal cancer (20.0%), lung cancer (16.7%), gastric cancer (13.3%), and kidney cancer (10.0%). Compared with the no tumor group, patients with concomitant tumors were older (72.60 ± 8.23 years vs 64.06 ± 10.46 years, P < 0.001), had higher levels of B-type natriuretic peptide [156.01 (73.15, 329.56) vs 55.52 (27.83, 241.25), P = 0.019], and lower levels of hemoglobin (125.17 ± 19.50 vs 142.25 ± 24.34, P = 0.001). In addition, compared with patients without tumors, patients with tumors are more inclined to choose elective surgery at the timing of coronary intervention (60.0% vs 7.7%, P < 0.001). There was no statistically significant difference in the incidence of all-cause mortality, recurrent acute myocardial infarction, unstable angina requiring hospitalization, and heart failure between the 2 groups during a one-year follow-up. Conclusions: Male smokers with acute STEMI combined with malignant tumors have relatively advanced age, higher levels of B-type brain natriuretic peptide and lower levels of hemoglobin, and tend to choose elective surgery at the time of intervention. There is no significant difference in 1-year clinical prognosis between the 2 groups.展开更多
文摘目的:目前关于急性心肌梗死合并恶性肿瘤患者的相关临床资料相对匮乏。本研究主要探讨急性ST段抬高型心肌梗死(STEMI)合并恶性肿瘤的患者的临床特征及预后,以期为这类患者的临床监测、治疗和预后提供临床依据。方法:本研究收集了2021年1月~2021年12月于青岛大学附属烟台毓璜顶医院心内科住院的确诊为急性STEMI的男性吸烟患者。根据合并恶性肿瘤与否,分为合并肿瘤组和未合并肿瘤组。记录并分析研究人群的基线临床资料、冠脉造影结果、肿瘤类型和冠心病二级预防药物等治疗情况。对研究人群随访1年,记录研究终点的发生情况(终点事件包括:全因死亡、再发急性心肌梗死、住院治疗的不稳定型心绞痛、住院治疗的心功能不全)。结果:本研究共收集265例STEMI的男性吸烟患者,其中30例(11.3%)合并恶性肿瘤病史,最终纳入合并肿瘤组30例和未合并肿瘤组65例。在本研究人群中,最常见的恶性肿瘤分别是结直肠癌(20.0%)、肺癌(16.7%)、胃癌(13.3%)和肾癌(10.0%)。与未合并肿瘤组相比,合并肿瘤患者年龄更大(72.60 ± 8.23岁vs 64.06 ± 10.46岁,P Objective: Currently, there is relatively limited clinical data on patients with acute myocardial infarction and malignant tumors. This study mainly explores the clinical characteristics and prognosis of patients with malignant tumors in acute ST segment elevation myocardial infarction (STEMI), in order to provide clinical basis for clinical monitoring, treatment, and prognosis of such patients. Methods: This study collected male smoking patients diagnosed with acute STEMI who were hospitalized in the cardiology department of the Affiliated Yantai Yuhuangding Hospital of Qingdao University from January 2021 to December 2021. According to whether malignant tumors are merged or not, they are divided into tumor group and no tumor group: Record and analyze baseline clinical data, coronary angiography results, tumor types, and treatment status of secondary preventive drugs for coronary heart disease in the study population;follow up the study population for 1 year and record the occurrence of study endpoints (endpoint events include all-cause mortality, recurrent acute myocardial infarction, unstable angina treated in hospital, and cardiac dysfunction treated in hospital). Results: A total of 265 male smokers with acute STEMI were included in this study, of which 30 (11.3%) were complicated with malignant tumors. Ultimately, 30 cases were included in the tumor group and 65 cases were included in the no tumor group. In this study population, the most common malignant tumors were colorectal cancer (20.0%), lung cancer (16.7%), gastric cancer (13.3%), and kidney cancer (10.0%). Compared with the no tumor group, patients with concomitant tumors were older (72.60 ± 8.23 years vs 64.06 ± 10.46 years, P < 0.001), had higher levels of B-type natriuretic peptide [156.01 (73.15, 329.56) vs 55.52 (27.83, 241.25), P = 0.019], and lower levels of hemoglobin (125.17 ± 19.50 vs 142.25 ± 24.34, P = 0.001). In addition, compared with patients without tumors, patients with tumors are more inclined to choose elective surgery at the timing of coronary intervention (60.0% vs 7.7%, P < 0.001). There was no statistically significant difference in the incidence of all-cause mortality, recurrent acute myocardial infarction, unstable angina requiring hospitalization, and heart failure between the 2 groups during a one-year follow-up. Conclusions: Male smokers with acute STEMI combined with malignant tumors have relatively advanced age, higher levels of B-type brain natriuretic peptide and lower levels of hemoglobin, and tend to choose elective surgery at the time of intervention. There is no significant difference in 1-year clinical prognosis between the 2 groups.
