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健脾保肾利湿解毒汤结合肾脏替代疗法治疗急性肾衰竭少尿期临床观察 被引量:3
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作者 宗玮 王玲 +2 位作者 张嘉毅 李福鑫 颜玥 《中国中医急症》 2021年第11期2025-2027,共3页
目的观察健脾保肾利湿解毒汤结合肾脏替代疗法治疗急性肾衰竭少尿期的临床疗效及安全性。方法患者85例随机分为两组,对照组42例采取肾脏替代疗法治疗,观察组43例采取健脾保肾利湿解毒汤结合肾脏替代疗法治疗,比较两组患者临床疗效、治... 目的观察健脾保肾利湿解毒汤结合肾脏替代疗法治疗急性肾衰竭少尿期的临床疗效及安全性。方法患者85例随机分为两组,对照组42例采取肾脏替代疗法治疗,观察组43例采取健脾保肾利湿解毒汤结合肾脏替代疗法治疗,比较两组患者临床疗效、治疗前后肾功能、血液流变学及氧化指标变化,检测治疗前及治疗后7、14、28d两组患者血压及尿量症状积分。结果观察组临床疗效95.35%,高于对照组的80.95%(P<0.05)。治疗后两组肾功能指标[血肌酐(Scr)、尿素氮(BUN)、尿酸(UA)]水平较治疗前均下降(P<0.05),且观察组均低于对照组(P<0.05)。治疗后两组血浆黏度、全血黏度高切、中切及低切等血液流变学指标较治疗前均下降(P<0.05),且观察组均低于对照组(P<0.05)。治疗后两组MDA、XOR等指标较治疗前均下降(P<0.05),GSH-Px、SOD指标上升(P<0.05),且观察组均优于对照组(P<0.05)。治疗后两组患者血压及尿量症状积分较治疗前均下降(P<0.05),且观察组均低于对照组(P<0.05)。结论健脾保肾利湿解毒汤结合肾脏替代疗法治疗急性肾衰竭少尿期疗效显著,患者症状改善,肾功能改善,恢复良好,安全可靠。 展开更多
关键词 急性肾衰竭少尿 健脾保肾利湿解毒汤 肾脏替代疗法 肾功能
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TNF-α、TGF-β1在急性期肾功能衰竭患者血清中的表达意义
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作者 梁素忍 王青苗 +1 位作者 白燕 郭志玲 《药物与人》 2014年第4期49-50,共2页
目的:分析TNF-α、TGF-β1在急性期肾功能衰竭患者血清中的表达意义。方法:选取2010年4月—2013年5月间河科大一附院肾内科收治的急性期肾功能衰竭患者50例为研究对象进行分析,另选取同期在我院进行健康体检的受检人员50名为对照组,检... 目的:分析TNF-α、TGF-β1在急性期肾功能衰竭患者血清中的表达意义。方法:选取2010年4月—2013年5月间河科大一附院肾内科收治的急性期肾功能衰竭患者50例为研究对象进行分析,另选取同期在我院进行健康体检的受检人员50名为对照组,检测TNF-α、TGF-β1、BUN、Scr指标并对比分析相关性。结果:研究组患者TNF-α、TGF-β1、BUN、Scr指标均显著高于对照组,差异具有统计学意义(P〈0.05);血透治疗后患者TNF-α、TGF-β1、BUN、Scr指标均显著下降,差异具有统计学意义(P〈0.05);相关性分析结果显示TNF-α、TGF-β1与BUN、Scr呈正相关。结论:TNF-α、TGF-β1的高表达对指示患者肾脏损伤有积极作用,可用于指导急性期肾衰竭患者的临床治疗,改善预后。 展开更多
关键词 急性期肾衰竭 TNF-Α TGF-Β1 肾脏损伤 预后
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Postoperative mortality and morbidity in octogenarians and nonagenarians with hip fracture: an analysis of perioperative risk factors 被引量:10
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作者 MA Ren-shi GU Gui-shan HUANG Xu ZHU Dong ZHANG Yu LIMing YAO Hai-yu 《Chinese Journal of Traumatology》 CAS 2011年第6期323-328,共6页
Objective: To evaluate the role of high risk factors in octogenarians and nonagenarians with hip trauma, which may lead to excessive mortality and morbidity postoperatively. Methods: Fifty-four octogenarians and non... Objective: To evaluate the role of high risk factors in octogenarians and nonagenarians with hip trauma, which may lead to excessive mortality and morbidity postoperatively. Methods: Fifty-four octogenarians and nonagenarians patients were enrolled in the study, receiving surgical repair of hip fracture in our hospital from January 2006 to January 2010. High risk factors were recorded preoperatively in detail. Complications and survival state were followed up by telephone for 2 years postoperatively. All the data were analyzed by Chi-square test with SPSS 13.0. Results: Twenty-six males (48.1%), aged from 80 to 94 years with a mean age of 84.2 years, and twenty-eight females (51.9%), aged from 80 to 95 years with a mean age of 83.4 years, were presented in the cohort study. The hip traumas were caused by daily slight injuries (52 cases) and car accidents (2 cases), respectively. Twenty-eight patients (51.9%) with femoral neck fracture while 26 patients (48.1%) with intertrochanteric fracture were diagnosed through an anterior-posterior pelvic radiophotograph. In this series, 39 patients (72.2%) suffered from one or more comorbidities preoperatively. The morbidity was 48.1% and the major cause was urinary tract infection, while a significant difference was noted between females and males. The mortality was 20.4% with a predominant cause of acute renal failure. Conclusions: The gender should be considered as a critical high risk factor in octogenarians and nonagenarians with hip trauma postoperatively. Females are more likely to suffer complications postoperatively, which is especially obvious in senile patients over 80 years (P〈0.05). Urinary tract infection is the most frequent complication after hip surgery, followed by low limb embolism and malnutrition. The mortality is dramatically greater in patients over 80 years old than those below, and major causes are acute renal failure, multiple organ dysfunction syndrome and mental deterioration. Multidisciplinary consultations and mental assessment are encouraged in patients over 80 years old after hip trauma and surgery. Hip fractures in octogenarians and nonagenarians deserve special attention because of their advanced age and comorbidities. 展开更多
关键词 Hip fractures Mortality MORBIDITY RISKFACTORS Aged 80 and over
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