Introduction. VZV virus- related peripheral neuropathies usually occur after shingles in adults and more rarely after chickenpox in childhood. Case report. A 54- year- old patient presented with a right VIIth nerve pa...Introduction. VZV virus- related peripheral neuropathies usually occur after shingles in adults and more rarely after chickenpox in childhood. Case report. A 54- year- old patient presented with a right VIIth nerve palsy following a chickenpox rash and recovered after antiviral treatment CSF analysis revealed lymphocytic meningitis and the virus was identified by PCK. Conclusions. Although previous chickenpox was not found in the patient’ s past history, the probability of reinfection is likely. The virus can be assumed to affect the nervous system directly; the axonal or demyelinating mechanism of the neuropathy may be discussed.展开更多
目的：建立单纯庖疹病毒1型（herpes simplex virus type 1，HSV-I）感染造成的面神经麻痹动物模型，研究HSV-I与面神经麻痹之间的关系。方法：Balb／c小鼠66只，切断双侧面神经耳后支，右侧神经断端接种HSV-1，左侧接种胎牛血清作为对...目的：建立单纯庖疹病毒1型（herpes simplex virus type 1，HSV-I）感染造成的面神经麻痹动物模型，研究HSV-I与面神经麻痹之间的关系。方法：Balb／c小鼠66只，切断双侧面神经耳后支，右侧神经断端接种HSV-1，左侧接种胎牛血清作为对照。观察小鼠全身情况、双侧面肌运动的对称性；颞骨连续切片HE染色；颞外段面神经锇酸染色：双侧面神经、脑干、三叉神经节、脊髓行PCR检测HSV-1DNA片断。结果：28只小鼠（4242％）于接种后2-5d发生右侧面神经麻痹，病程持续3-6d后恢复。38只未发生面神经麻痹。与对侧比较，颞骨连续切片显示面神经麻痹鼠右侧神经肿胀、神经周围间隙变小、展开更多
文摘Introduction. VZV virus- related peripheral neuropathies usually occur after shingles in adults and more rarely after chickenpox in childhood. Case report. A 54- year- old patient presented with a right VIIth nerve palsy following a chickenpox rash and recovered after antiviral treatment CSF analysis revealed lymphocytic meningitis and the virus was identified by PCK. Conclusions. Although previous chickenpox was not found in the patient’ s past history, the probability of reinfection is likely. The virus can be assumed to affect the nervous system directly; the axonal or demyelinating mechanism of the neuropathy may be discussed.
文摘目的：建立单纯庖疹病毒1型（herpes simplex virus type 1，HSV-I）感染造成的面神经麻痹动物模型，研究HSV-I与面神经麻痹之间的关系。方法：Balb／c小鼠66只，切断双侧面神经耳后支，右侧神经断端接种HSV-1，左侧接种胎牛血清作为对照。观察小鼠全身情况、双侧面肌运动的对称性；颞骨连续切片HE染色；颞外段面神经锇酸染色：双侧面神经、脑干、三叉神经节、脊髓行PCR检测HSV-1DNA片断。结果：28只小鼠（4242％）于接种后2-5d发生右侧面神经麻痹，病程持续3-6d后恢复。38只未发生面神经麻痹。与对侧比较，颞骨连续切片显示面神经麻痹鼠右侧神经肿胀、神经周围间隙变小、
