To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control H...To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infection spontaneously. Acute-phase CD4 responses were efficient in self-limited infections but undetectable in the coinfected patient with HBV persistence. CD8 responses were multispecific irrespective of the outcome of infection, but the CD8 repertoire associated with HBV persistence lacked the most dominant specificities detectable in self-limited infections. In conclusion, insufficient CD4 help and defective CD8 repertoire may play a role at the early stages of infection in influencing HBV persistence.展开更多
【据Hepatology International 2021年7月报道】题:非侵入性肝纤维化评估预警慢性乙型肝炎患者慢加急性肝衰竭的发生(作者Yang F等)在我国慢加急性肝衰竭(ACLF)多由重症化慢性HBV感染者加重发展而来,早期预测重症化慢性HBV感染者病情进...【据Hepatology International 2021年7月报道】题:非侵入性肝纤维化评估预警慢性乙型肝炎患者慢加急性肝衰竭的发生(作者Yang F等)在我国慢加急性肝衰竭(ACLF)多由重症化慢性HBV感染者加重发展而来,早期预测重症化慢性HBV感染者病情进展是提高ACLF患者生存率的关键。既往研究发现肝损伤程度是决定重症化慢性HBV感染者病情进展的关键因素。重症化慢性HBV感染者肝损伤程度由急性及慢性肝损伤程度组成,因此,理论上在不同肝损伤程度的患者中决定向ACLF进展的肝纤维化程度应该不一样。展开更多
文摘To characterize acute-phase hepatitis B virus (HBV)-specific T cell responses associated with self-limited and persistent HBV infections, we compared a patient with acute HBV/HCV coinfection, who was able to control HCV but developed chronic hepatitis B, with patients who resolved acute HBV infection spontaneously. Acute-phase CD4 responses were efficient in self-limited infections but undetectable in the coinfected patient with HBV persistence. CD8 responses were multispecific irrespective of the outcome of infection, but the CD8 repertoire associated with HBV persistence lacked the most dominant specificities detectable in self-limited infections. In conclusion, insufficient CD4 help and defective CD8 repertoire may play a role at the early stages of infection in influencing HBV persistence.
文摘【据Hepatology International 2021年7月报道】题:非侵入性肝纤维化评估预警慢性乙型肝炎患者慢加急性肝衰竭的发生(作者Yang F等)在我国慢加急性肝衰竭(ACLF)多由重症化慢性HBV感染者加重发展而来,早期预测重症化慢性HBV感染者病情进展是提高ACLF患者生存率的关键。既往研究发现肝损伤程度是决定重症化慢性HBV感染者病情进展的关键因素。重症化慢性HBV感染者肝损伤程度由急性及慢性肝损伤程度组成,因此,理论上在不同肝损伤程度的患者中决定向ACLF进展的肝纤维化程度应该不一样。
