脑电图反应性定量分析对脑梗死患者预后的预测价值

目的 探讨脑电图反应性定量(QEEG)分析对脑梗死患者预后的预测价值。方法 前瞻性选取2020年3月至2023年10月在湖州市第一人民医院就诊的脑梗死患者276例。根据治疗30 d后改良Rankin量表(mRS)评分将患者分为预后良好组和预后不良组。分析两组患者基线资料、实验室检查指标和QEEG参数。采用多因素Logistic回归分析影响预后的因素,绘制受试者工作特征(ROC)曲线分析QEEG参数对预后的预测价值。结果 随访期间,失访5例,最终纳入271例,其中预后良好组42例,预后不良组229例。两组美国国立卫生研究院卒中量表(NIHSS)、急性生理与慢性健康(APACHE Ⅱ)评分、格拉斯哥昏迷(GCS)评分、白细胞计数(WBC)、C反应蛋白(CRP)、D-二聚体水平、侧脑室受压、基底池受压、其他区域受累占比、DTABR、DAR及梗死体积差异均有统计学意义(均P<0.05);多因素Logistic回归分析显示:NIHSS评分、APACHE Ⅱ评分、GCS评分、白细胞计数、梗死体积、DTABR及DAR是脑梗死患者预后的影响因素(均P<0.05);ROC曲线显示DTABR、DAR预测脑梗死患者预后的去线下面积为0.893、0.834,高于其他指标。结论 DTABR及DAR是脑梗死患者预后的影响因素,且可预测脑梗死患者的预后。

眼底造影荧光强度的计算机定量分析

目的 :建立眼底血管荧光造影 (fundusfluoresceinangiography ,FFA)中荧光强度定量图像分析方法 ,以评价眼底病变的病变程度和预后。方法 :分析湿性增龄性黄斑变性 (age -relatedmaculardegeneration ,AMD)患者FFA图像脉络膜新生血管膜 (choroidalneovascularizition ,CNV)渗漏强度在造影各期的变化趋势 ,分析正常眼底后极部 6.2 0mm2 区域的FFA荧光强度在造影各期的变化趋势 ,二者进行比较 ,验证荧光强度定量分析方法的客观性、有效性和实用性。结果 :湿性AMD患者的FFA图像CNV荧光素渗漏强度造影各期均显著高于正常眼底后极部 6.2 0mm2 区(P <0 .0 5或P <0 .0 1) ,动静脉期至 72 0秒差别具有非常显著性意义 (P <0 .0 1)。 180秒～ 3 0 0秒差别最明显。结论 :对眼底疾病的病变程度和预后进行评估 ,荧光强度计算机定量图像分析方法是比较客观。

生物样品定量分析方法验证中试验样品再分析的意义和对策

目的介绍试验样品再分析(incurred sample reanalysis,ISR)的法规要求、意义和对策。方法综述国际上关于试验样品再分析的指导原则、研究论文和统计数据,通过实例来总结试验样品再分析失败的原因及预防措施。结果与结论试验样品再分析有助于改善生物分析方法的重现性,已经成为法规生物样品分析的一项重要内容。采取适当的对策,可以防止试验样品再分析失败造成的损失。

A GIS-based Study on Suitability Estimation of Tea Cultivation in Qimen County

On the basis of data from Soil Test and Formula Fertilization project in Qimen county,we employed Geographic Information System Software ArcGIS 9.2 and CLRMIS（Cultivated Land Resource Management Information System at County Scale） to establish region-specific estimation index system for tea cultivation in Qimen County by determining the estimation units,and carried out quantitative estimation analysis on tea cultivation there via comprehensive evaluation indices for natural elements of cultivated land.The results showed that the highly suitable,suitable,reluctantly suitable and unsuitable acreages are 5 665.8,8 327.1,8 415.9 and 11 979.9 hm2 respectively,accounting for 24.0%,35.3%,35.7% and 5.1% of the total acreage of cultivated land.These results would facilitate the production of high yield and quality tea in Qimen County.

Qualitative and Quantitative Analysis of Rhizoma of Polygonum cuspidatum

Aim To establish reliable methods for evaluating the quality of rhizoma of Polygonum cuspidatum( Huzhang in Chinese). Methods TLC and HPLC were employed for the chemical identification and content determination,respectively. Results A qualitative TLC method and a quantitative HPLC method with piceid as the reference substance were established, respectively. With piceid as the reference substance and ethyl acetate-methanol-formic acid-water ( 19:3:0.5:1) as the mobile phase, a TLC method for the identification of Huzhang from the commonly used crude drugs of the same family was also set up. Conclusion The established TLC method can reasonably appraise the quality of the drug and easily distinguish Huzhang from the other commonly used crude drugs of the same family. The HPLC method for determining piceid is simple, reproducible, accurate, and feasible.

Determination of Melamine by Infrared Spectroscopy Based on Nonlinear Modeling

[Objective] The aim was to develop a nonlinear model of quantitative analysis of melamine content by infrared spectroscopy and provide theoretical basis for the nondestructive detection of melamine. [Method] According to dynamics,mathematical modeling and optimization theory,linear and nonlinear models were respectively set up by taking an absorption peak of 1 550 cm-1 as characteristic absorption peak. [Result] The correlation coefficient of nonlinear model was 0.922 7 and the recovery was 96%,which showed that the nonlinear model was more accurate than linearity model with correlation coefficient of 0.904 9 and recovery of 557%. [Conclusion] It is feasible to determine melamine content by using the nonlinear model quantitatively.

Predicting pillar stability for underground mine using Fisher discriminant analysis and SVM methods

The purpose of this study is to apply some statistical and soft computing methods such as Fisher discriminant analysis （FDA） and support vector machines （SVMs） methodology to the determination of pillar stability for underground mines selected from various coal and stone mines by using some index and mechanical properties, including the width, the height, the ratio of the pillar width to its height, the uniaxial compressive strength of the rock and pillar stress. The study includes four main stages： sampling, testing, modeling and assessment of the model performances. During the modeling stage, two pillar stability prediction models were investigated with FDA and SVMs methodology based on the statistical learning theory. After using 40 sets of measured data in various mines in the world for training and testing, the model was applied to other 6 data for validating the trained proposed models. The prediction results of SVMs were compared with those of FDA as well as the measured field values. The general performance of models developed in this study is close; however, the SVMs exhibit the best performance considering the performance index with the correct classification rate Prs by re-substitution method and Pcv by cross validation method. The results show that the SVMs approach has the potential to be a reliable and practical tool for determination of pillar stability for underground mines.

丁醛二乙缩醛在PVB中间膜中的应用研究

说明丁醛二乙缩醛作为PVB中间膜添加剂的使用背景。简单介绍塑料香精及防伪标记物的选择。阐述丁醛二乙缩醛的基本物性数据,合成机理及具体方法,为了验证合成后PVB树脂配方可行性,对其数据进行分析对比。利用HS-GC/MS对PVB中间膜中丁醛二乙缩醛的定性及定量分析研究。根据上述研究给出丁醛二乙缩醛的合理添加量及香精、防伪标记物此类添加剂的选择条件。

A DSS DEVELOPMENT AND APPLICATION FOR SUSTAINABLE DEVELOPMENT

The characteristics of sustainable development problems in the developing countries is discussed.In order to develop and use decision support system (DSS) for supporting sustainable development problem decision making in the developing countries,this paper presents a strategy of constructing the DSS for sustainable development.A methodology of representing the model of sustainable development problems and developing a nonprocedural modeling language that is used to define sustainable development problems,a methodology of numeric and non numeric operation based theorem proving is given in this paper.

Sensitivity of the Number of Snow Cover Days to Surface Air Temperature over the Qinghai-Tibetan Plateau

Based on the number of snow cover days （NSCDs） and homogenized surface air temperature data for the period 1951-2004, this study performs the quantitative analysis on the sensitivity of NSCDs to surface air temperature over the Qinghai-Tibetan Plateau （QTP）. Results show that both the extreme sensitivity and sensitivity under current climate are higher in the edge than in the central area of the QTP. There exists a strong negative correlation between station＇s elevation and critical temperature, at which the sensitivity reaches extremum. The negative correlation between the elevation and the extreme sensitivity is not as strong as the former one. Currently, the climatological temperatures in quite a few stations do not reach the critical stage. The sensitivity at these stations will become greater under the current background of climate warming, which means NSCDs will be more sensitive to surface air temperature.

Soluble Expression and Rapid Quantification of GFP-hepA Fusion Protein in Recombinant Escherichia coli

To establish a rapid quantification method for heparinase I during its production in recombinant Escherichia coli, a translational fusion vector was constructed by fusing the N terminus of heparinase I to the C terminus of a green fluorescent protein mutant （GFPmutl）. As a result, not only was the functional recombinant expression of heparinase I in E. coli accomplished, but also a linear correlation was obtained between the GFP fluorescence intensity and heparinase I activity, allowing enzyme activity to be quantified rapidly during the fermentation.

Quantitative analysis of the performance of vector tracking algorithms

Vector tracking changes the classical structure of receivers. Combining signal tracking and navigation solution,vector tracking can realize powerful processing capabilities by the fusion technique of receiving channel and feedback correction. In this paper,we try to break through the complicated details of numerical analysis,consider the overall influencing factors of the residual in observed data,and use the intrinsic link between a conventional receiver and a vector receiver. A simple method for performance analysis of the vector tracking algorithm is proposed. Kalman filter has the same steady performance with the classic digital lock loop through the analysis of the relation between gain and band width. The theoretical analysis by the least squares model shows that the reduction of range error is the basis for the superior performance realized by vector tracking. Thus,the bounds of its performance enhancement under weak signal and highly dynamic conditions can be deduced. Simulation results verify the effectiveness of the analysis presented here.

Reasonable selection of yield criteria for quantitative analysis of unsaturated soil slope stability

The yield criterion parameters of the soil material change with different values of the cohesion and the angle of friction because of sustained rainfall infiltration. Based on the Mohr-Coulomb(M-C) and Drucker-Prager(D-P) yield criteria, some reasonable yield criteria selections were discussed for quantitative analysis of unsaturated soil slope stability. Moreover, a critical point was found at the effective angle of friction equaling to 16.5° by transformation of parameters related to unsaturated soil under sustained rainfall. When the effective angle of friction more than 16.5° through parameter transformation of different yield criteria under natural condition, the calculation result of the safety factor was such that: f(DP1) > f(M-C) > f(equivalent M-C) > f(DP2) > f(DP3). While the effective angle of friction less than 16.5°, through parameter transformation, the safety factors were in the following order: f(DP1) > f(M-C) > f(DP2) > f(equivalent M-C) > f(DP3). The calculated results from a case study showed that the equivalent M-C yield criterion should be the best at evaluating soil slope stability before rainfall; the DP2 yield criterion should be selected to calculate the soil slope stability at the effective angle of friction less than 16.5° under sustained rainfall. The yield criterion should be selected or adjusted reasonably to calculate the safety factor of unsaturated soil slopes before and during sustained rainfall.

Quantitative analysis of transforming growth factor beta 1 mRNA in patients with alcoholic liver disease

AIM: To investigate the expression of the transforming growth factor beta 1(TGF-beta 1) mRNA in different stages of alcoholic liver disease (ALD) and its clinical value. METHODS: One hundred and seven male alcoholics were grouped by clinical findings into four groups: alcohol abusers without liver impairment (n =22), alcoholic steatosis (n =30); alcoholic hepatitis (n=31); and alcoholic cirrhosis(n=24). Using peripheral blood mononuclear cells (PBMC) as samples the gene expression of TGF-beta 1 was examined quantitatively by reverse transcription polymerase chain reaction (RT-PCR) and dot blot. There are 34 healthy subjects served as control. RESULTS: The expression of TGF-beta 1 from all ALD patients was significantly greater than that in controls (1.320 +/- 1.162 vs 0.808 +/- 0.276, P【0.001). The differences of the expressions were significant between the patients from each groups (alcoholic steatosis, alcoholic hepatitis and alcoholic cirrhosis) and the controls (1.168 +/- 0.852, 1.462 +/- 1.657, 1.329 +/- 0.610 vs 0.808 +/- 0.276, P【0.050). No significant differences of TGF -beta 1 mRNA expression were observed between alcohol abusers without liver impairment and controls. The expressions in patients with alcoholic hepatitis and alcoholic cirrhosis were significantly greater than that in alcohol abusers respectively (1.462 +/- 1.657, 1.329 +/- 0.610 vs 0.841 +/- 0.706, P【0.050). No significant differences of TGF-beta 1 mRNA expression were observed between alcoholic fatty liver men and alcohol abusers. CONCLUSION: TGF-beta 1 expression level can be a risk factor for alcoholic liver disease and might be related to the inflammatory activity and fibrosis of the liver in patients.

Qualitative and Quantitative Analysis of Linoleic Acid in Polygonati Rhizoma

Objective To explore the major compound in Polygonati Rhizoma(Huang Jing,黄精)for quality control.Methods The major compound was isolated and analyzed by liquid chromatography-mass spectrometry(LC-MS),and subsequently further identified by nuclear magnetic resonance(NMR).Thin layer chromatography(TLC)was optimized based on the previous methods reported in the Chinese Pharmacopeia(2015 edition).Results The major compound was isolated from the natural material and identified as linoleic acid.A high performance liquid chromatography(HPLC)method with robust linearity(R2=0.9997),specificity,precision,stability,repeatability and recovery was developed for linoleic acid determination.TLC chromatogram was improved significantly after optimization for qualitative analysis.Conclusions The optimized TLC method is practical and can be adopted for quality control of Polygonati Rhizoma(Huang Jing,黄精).The levels of linoleic acid vary between species of Polygonati Rhizoma(Huang Jing,黄精),with Polygonatum cyrtonema Hua(Jiang Xing Huang Jing,姜型黄精)showing the highest contents.This study provides valuable information for quality control of Polygonati Rhizoma(Huang Jing,黄精).

Exploring Enterprise Performance Indicators Network： A Case Study of China Telecommunication Industry

Perforrmnce indicators play some important roles in enterprise operation. Both researchers and managers have recently pointed out that the identification of correlation between different performmance indicators may lead to a better understanding of business. However, it is becoming more and more difficult to measure and analyze these indicators since the fast growing number of performance indicators and the complex relationships between them The existing categories failed to reflect these changes in an adequate way, and the quantitative analysis methods for identifying the characters of those pefformance indicators are still worthy of investigation. The main objective of this paper is to propose a practical methodology for managing and analyzing performance indicators in enterprises, which focuses on building up a performance indicator system and discovering the characters of those performance indicators by applying complex network methods. The empirical results of a telecommunieation enterprise show that the proposed method can be effective in understanding the correlations between performance indicators.

Quantitative Analysis of Relationships Between Crack Characteristics and Properties of Soda-saline Soils in Songnen Plain, China

The Songnen Plain has a typical soda-saline soil, which often shrinks and cracks under natural conditions during water evaporation. This study aims to analyze the relationships between the crack characteristics and the soil properties of soda-saline soils quantitatively, and attempts to establish prediction models for the main soil properties of soda-saline soils based on the results. In order to achieve these objectives, a desiccation cracking test was conducted using 17 soil specimens with different salinity levels under controlled laboratory conditions. Correlation analysis was then performed between the crack characteristics and the soil properties. The results indicate that the crack characteristics can well represent the surface appearances of cracked soils, they also can well distinguish the salinity levels of soda-saline soils while the clay contents and mineralogical compositions of soils are stable. Among the crack characteristics, crack length has the best relationships with the salinity levels of soda-saline soils. Specifically, the crack length has high correlation(R2 > 0.87) with the electrical conductivity(EC), Na+, CO32– and the salinity, it also has reasonable relationship(R2 > 0.68) with HCO3–, this indicates crack length can be well used for the prediction of these properties of soda-saline soils.

Improved Quantum ＂ Ping-Pong＂ Protocol Based on Extended Three-Particle GHZ State

In order to transmit secure messages, a quantum secure direct communication protocol based on extended three-particle GHZ state was presented, in which the extended three-particle GHZ state was used to detect eavesdroppers. In the security analysis, the method of the entropy theory is introduced, and three detection strategies are compared quantitatively by using the constraint between the information eavesdroppers can obtain and the interference introduced. If the eavesdroppers intend to obtain all inforrmtion, the detection rate of the original ＂Ping-pong＂ protocol is 50% ; the second protocol used two particles of EPR pair as detection particles is also 50%; while the presented protocol is 58%. At last, the security of the proposed protocol is discussed. The analysis results indicate that the protocol in this paper is more secure than the other two.

Survivability modeling and analysis on 3D mobile ad-hoc networks

Most existing work on survivability in mobile ad-hoc networks(MANETs) focuses on two dimensional(2D) networks.However,many real applications run in three dimensional(3D) networks,e.g.,climate and ocean monitoring,and air defense systems.The impact on network survivability due to node behaviors was presented,and a quantitative analysis method on survivability was developed in 3D MANETs by modeling node behaviors and analyzing 3D network connectivity.Node behaviors were modeled by using a semi-Markov process.The node minimum degree of 3D MANETs was discussed.An effective approach to derive the survivability of k-connected networks was proposed through analyzing the connectivity of 3D MANETs caused by node misbehaviors,based on the model of node isolation.The quantitative analysis of node misbehaviors on the survivability in 3D MANETs is obtained through mathematical description,and the effectiveness and rationality of the proposed approach are verified through numerical analysis.The analytical results show that the effect from black and gray attack on network survivability is much severer than other misbehaviors.

Chaotic characteristics of electromagnetic emission signals during deformation and fracture of coal

Electromagnetic emission(EME) is a kind of physical phenomenon accompanying the process of deformation and fracture of loaded coal and rock and it is of importance in quantitatively analyzing its characteristics.This will reveal the process of deformation and fracture of coal and predicting dynamic disasters in coal mines.In this study,the G-P(Grassberger and Procaccia) algorithm,calculation steps of the(if only 1 dimension) correlation dimension of time series and the identification standards of chaotic signals are introduced.Furthermore,the correlation dimensions of EME and the acoustic emission(AE) signals of time series during deformation and fracture of coal bodies are calculated and analyzed.The results show that the time series of pulses number of EME and the time series of AE count rate are chaotic and that the saturation embedding dimensions of a K3 coal sample are,respectively,5 and 6.The results can be used to provide basic parameters for predicting of EME and AE time series.