To investigate the prognostic value of the radiological response after transarterial chemoembolization (TACE) and inflammatory markers in patients affected by hepatocellular carcinoma (HCC) awaiting liver transplantat...To investigate the prognostic value of the radiological response after transarterial chemoembolization (TACE) and inflammatory markers in patients affected by hepatocellular carcinoma (HCC) awaiting liver transplantation (LT).METHODSWe retrospectively evaluated the preoperative predictors of HCC recurrence in 70 patients treated with conventional (n = 16) or doxorubicin-eluting bead TACE (n = 54) before LT. The patient and tumour characteristics, including the static and dynamic alpha-fetoprotein, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio (PLR) measurements, were recorded. Treatment response was classified according to the modified Response Evaluation Criteria in Solid Tumours (mRECIST) and the European Association for the Study of the Liver (EASL) criteria as complete response (CR), partial response (PR), stable disease or progressive disease. After examination of the explanted livers, histological necrosis was classified as complete (100% of the cumulative tumour area), partial (50%-99%) or minimal (< 50%) and was correlated with the preoperative radiological findings.RESULTSAccording to the pre-TACE radiological evaluation, 22/70 (31.4%) and 12/70 (17.1%) patients were beyond Milan and University of San Francisco (UCSF) criteria, respectively. After TACE procedures, the objective response (CR + PR) rates were 71.4% and 70.0% according to mRECIST and EASL criteria, respectively. The agreement between the two guidelines in defining the radiological response was rated as very good both for the overall and target lesion response (weighted k-value: 0.98 and 0.93, respectively). Complete and partial histological necrosis were achieved in 14/70 (20.0%) and 28/70 (40.0%) patients, respectively. Using histopathology as the reference standard, mRECIST criteria correctly classified necrosis in 72.9% (51/70) of patients and EASL criteria in 68.6% (48/70) of cases. The mRECIST non-response to TACE [Exp(b) = 9.2, p = 0.012], exceeding UCSF criteria before TACE [Exp(b) = 4.7, p = 0.033] and a preoperative PLR > 150 [Exp(b) = 5.9, p = 0.046] were independent predictors of tumour recurrence.CONCLUSIONThe radiological response and inflammatory markers are predictive of tumour recurrence and allow the proper selection of TACE-treated candidates for LT.展开更多
Focused on the seed region selection and homogeneity criterion in Seeded Region Growing (SRG), an unsupervised seed region selection and a polynomial fitting homogeneity criterion for SRG are proposed in this paper. F...Focused on the seed region selection and homogeneity criterion in Seeded Region Growing (SRG), an unsupervised seed region selection and a polynomial fitting homogeneity criterion for SRG are proposed in this paper. First of all, making use of Peer Group Filtering (PGF) techniques, an unsupervised seed region selection algorithm is presented to construct a seed region. Then based on the constructed seed region a polynomial fitting homogeneity criterion is applied to solve the concrete problem of doorplate segmentation appearing in the robot navigation along a corridor. At last, experiments are performed and the results demonstrate the effectiveness of the proposed algorithm.展开更多
The influence of active metal components of catalyst, additives and catalyst preparation method on the reactivity of catalyst for selective hydrodesulfurization (HDS) of FCC naphtha was investigated, and the RSDS-21 c...The influence of active metal components of catalyst, additives and catalyst preparation method on the reactivity of catalyst for selective hydrodesulfurization (HDS) of FCC naphtha was investigated, and the RSDS-21 catalyst with high HDS performance and the RSDS-22 catalyst with high selectivity were developed by RIPP. The composite loading of a new series of catalysts for selective HDS of FCC gasoline has demonstrated excellent desulfurization activity and selectivity and can under conventional hydrotreating conditions manufacture clean gasoline product meeting the national IV emission standard and the Euro V emission standard with less loss in antiknock index. The finalized new series of FCC catalysts upon being adopted for selective HDS of FCC naphtha have good adaptability to different feedstocks along with good stability.展开更多
In this paper, we propose a new criterion, named PICa, to simultaneously select explanatory variables in the mean model and variance model in heteroscedastic linear models based on the model structure. We show that th...In this paper, we propose a new criterion, named PICa, to simultaneously select explanatory variables in the mean model and variance model in heteroscedastic linear models based on the model structure. We show that the new criterion can select the true mean model and a correct variance model with probability tending to 1 under mild conditions. Simulation studies and a real example are presented to evaluate the new criterion, and it turns out that the proposed approach performs well.展开更多
Two new constructions of chosen-ciphertext secure fuzzy identity-based encryption (fuzzy-IBE) schemes without random oracle are proposed. The first scheme combines the modification of chosen-plaintext secure Sahai a...Two new constructions of chosen-ciphertext secure fuzzy identity-based encryption (fuzzy-IBE) schemes without random oracle are proposed. The first scheme combines the modification of chosen-plaintext secure Sahai and Waters' "large universe" construction and authenticated symmetric encryption, and uses con- sistency checking to handle with ill-formed ciphertexts to achieve chosen-ciphertext security in the selective ID model. The second scheme improves the efficiency of first scheme by eliminating consistency checking. This improved scheme is more efficient than existing chosen-ciphertext secure fuzzy-IBE scheme in the standard model.展开更多
We conducted sexual selection experiments to produce strains with high and low mating discrimination in females of laboratory strains of Hawaiian Drosophila, D.silvestris, then examined secondary sexual traits of thes...We conducted sexual selection experiments to produce strains with high and low mating discrimination in females of laboratory strains of Hawaiian Drosophila, D.silvestris, then examined secondary sexual traits of these two lines, and compared them with that of standard line. In order to do this, we screened out super-males which mated successfully with females and with high mating records;and poor males which usually could not mate successfully with females and had low mating records. In the meantime,choosy females were also screened out, which almost never responded to males' nuptial dance and were difficult to be mated; but indiscriminate females were on the contrary,which were very ready to accept male's nuptial dance and were very easy to be mated. As a result, by mating supermales with choosy females, we were able to produce the high-line strain; similarly, for the low line, we mated poor males with indiscriminate females and we had a strain that was significantly different from our standard strain within just two generations of selection, i.e., morphological trait differences were measured between the standard strain and the two selected lines, which indicated that mating discrimination has affected secondary sexual traits of the lowline strain significantly: Cilia number on the foretibia of low-line males is significantly different from that of the standard line, which perhaps was the indication of incipient speciation in Hawaiian Drosophila.展开更多
文摘To investigate the prognostic value of the radiological response after transarterial chemoembolization (TACE) and inflammatory markers in patients affected by hepatocellular carcinoma (HCC) awaiting liver transplantation (LT).METHODSWe retrospectively evaluated the preoperative predictors of HCC recurrence in 70 patients treated with conventional (n = 16) or doxorubicin-eluting bead TACE (n = 54) before LT. The patient and tumour characteristics, including the static and dynamic alpha-fetoprotein, neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio (PLR) measurements, were recorded. Treatment response was classified according to the modified Response Evaluation Criteria in Solid Tumours (mRECIST) and the European Association for the Study of the Liver (EASL) criteria as complete response (CR), partial response (PR), stable disease or progressive disease. After examination of the explanted livers, histological necrosis was classified as complete (100% of the cumulative tumour area), partial (50%-99%) or minimal (< 50%) and was correlated with the preoperative radiological findings.RESULTSAccording to the pre-TACE radiological evaluation, 22/70 (31.4%) and 12/70 (17.1%) patients were beyond Milan and University of San Francisco (UCSF) criteria, respectively. After TACE procedures, the objective response (CR + PR) rates were 71.4% and 70.0% according to mRECIST and EASL criteria, respectively. The agreement between the two guidelines in defining the radiological response was rated as very good both for the overall and target lesion response (weighted k-value: 0.98 and 0.93, respectively). Complete and partial histological necrosis were achieved in 14/70 (20.0%) and 28/70 (40.0%) patients, respectively. Using histopathology as the reference standard, mRECIST criteria correctly classified necrosis in 72.9% (51/70) of patients and EASL criteria in 68.6% (48/70) of cases. The mRECIST non-response to TACE [Exp(b) = 9.2, p = 0.012], exceeding UCSF criteria before TACE [Exp(b) = 4.7, p = 0.033] and a preoperative PLR > 150 [Exp(b) = 5.9, p = 0.046] were independent predictors of tumour recurrence.CONCLUSIONThe radiological response and inflammatory markers are predictive of tumour recurrence and allow the proper selection of TACE-treated candidates for LT.
基金Supported by the National Hi-Tech R&D Program of China (No.2002AA423160)the Na-tional Natural Science Foundation of China (No.60205004)the Henan Natural Science Foundation (No.0411013700).
文摘Focused on the seed region selection and homogeneity criterion in Seeded Region Growing (SRG), an unsupervised seed region selection and a polynomial fitting homogeneity criterion for SRG are proposed in this paper. First of all, making use of Peer Group Filtering (PGF) techniques, an unsupervised seed region selection algorithm is presented to construct a seed region. Then based on the constructed seed region a polynomial fitting homogeneity criterion is applied to solve the concrete problem of doorplate segmentation appearing in the robot navigation along a corridor. At last, experiments are performed and the results demonstrate the effectiveness of the proposed algorithm.
文摘The influence of active metal components of catalyst, additives and catalyst preparation method on the reactivity of catalyst for selective hydrodesulfurization (HDS) of FCC naphtha was investigated, and the RSDS-21 catalyst with high HDS performance and the RSDS-22 catalyst with high selectivity were developed by RIPP. The composite loading of a new series of catalysts for selective HDS of FCC gasoline has demonstrated excellent desulfurization activity and selectivity and can under conventional hydrotreating conditions manufacture clean gasoline product meeting the national IV emission standard and the Euro V emission standard with less loss in antiknock index. The finalized new series of FCC catalysts upon being adopted for selective HDS of FCC naphtha have good adaptability to different feedstocks along with good stability.
基金supported by National Natural Science Foundation of China (Grant No.10971007)Beijing Natural Science Fund (Grant No. 1072003)Science Fund of Beijing Education Committee
文摘In this paper, we propose a new criterion, named PICa, to simultaneously select explanatory variables in the mean model and variance model in heteroscedastic linear models based on the model structure. We show that the new criterion can select the true mean model and a correct variance model with probability tending to 1 under mild conditions. Simulation studies and a real example are presented to evaluate the new criterion, and it turns out that the proposed approach performs well.
基金the National High Technology Research and Development Program (863) of China(No. 2006AA12A106)
文摘Two new constructions of chosen-ciphertext secure fuzzy identity-based encryption (fuzzy-IBE) schemes without random oracle are proposed. The first scheme combines the modification of chosen-plaintext secure Sahai and Waters' "large universe" construction and authenticated symmetric encryption, and uses con- sistency checking to handle with ill-formed ciphertexts to achieve chosen-ciphertext security in the selective ID model. The second scheme improves the efficiency of first scheme by eliminating consistency checking. This improved scheme is more efficient than existing chosen-ciphertext secure fuzzy-IBE scheme in the standard model.
基金supported by the China Scholarship Council(CSC)(2010843314)
文摘We conducted sexual selection experiments to produce strains with high and low mating discrimination in females of laboratory strains of Hawaiian Drosophila, D.silvestris, then examined secondary sexual traits of these two lines, and compared them with that of standard line. In order to do this, we screened out super-males which mated successfully with females and with high mating records;and poor males which usually could not mate successfully with females and had low mating records. In the meantime,choosy females were also screened out, which almost never responded to males' nuptial dance and were difficult to be mated; but indiscriminate females were on the contrary,which were very ready to accept male's nuptial dance and were very easy to be mated. As a result, by mating supermales with choosy females, we were able to produce the high-line strain; similarly, for the low line, we mated poor males with indiscriminate females and we had a strain that was significantly different from our standard strain within just two generations of selection, i.e., morphological trait differences were measured between the standard strain and the two selected lines, which indicated that mating discrimination has affected secondary sexual traits of the lowline strain significantly: Cilia number on the foretibia of low-line males is significantly different from that of the standard line, which perhaps was the indication of incipient speciation in Hawaiian Drosophila.