In order to estimate deformation and mechanical properties of material accurately,elastic and plastic deformation behavior of small punch test was discussed in this paper.A two-dimensional finite element model was est...In order to estimate deformation and mechanical properties of material accurately,elastic and plastic deformation behavior of small punch test was discussed in this paper.A two-dimensional finite element model was established based upon the Gurson-Tvergaard-Needleman(GTN)equation.According to the integration of load–displacement curves with different displacements,the evolution of elastic energy was obtained.The results show that the elastic energy increases quickly in the initial region and tends to be an approximate constant during the plastic bending phase.Meanwhile,an obvious change of the slope of load–displacement curve can be found in the elastic-plastic transition region.The macroscopic deformation and fracture feature were also discussed in order to verify the deformation analysis.Finally,the yield strength,tensile strength and elongation of AISI304 were obtained based on the analysis of deformation energy and percent fracture deflection.The results have a good agreement with that of conventional tensile tests,which may provide a theoretical basis of small punch analysis.展开更多
To characterize the elastic-plastic properties of thin film materials on elastic-plastic substrates,a simple theory model was proposed,which included three steps:dimensionless analysis,finite element modeling and data...To characterize the elastic-plastic properties of thin film materials on elastic-plastic substrates,a simple theory model was proposed,which included three steps:dimensionless analysis,finite element modeling and data fitting.The dimensionless analysis was applied to deriving two preliminary nondimensional relationships of the material properties,and finite element modeling and data fitting were carried out to establish their explicit forms.Numerical indentation tests were carried out to examine the effectiveness of the proposed model and the good agreement shows that the proposed theory model can be applied in practice.展开更多
OBJECTIVE: To investigate the effectiveness of Shoushen granule,Chinese herbal preparation,on carotid artery elasticity in patients with carotid atherosclerosis.METHODS: The total of 156 carotid atherosclerosis patien...OBJECTIVE: To investigate the effectiveness of Shoushen granule,Chinese herbal preparation,on carotid artery elasticity in patients with carotid atherosclerosis.METHODS: The total of 156 carotid atherosclerosis patients were randomly divided into the intervention group(83 cases,treated with Shoushen granule) and the control group(73 cases,treated with pravastatin). Brachial-ankle pulse wave velocity(ba PWV) and Ankle-Brachial Pressure Index(ABI)were measured by automated arteriosclerosis detector. The changes of common carotid artery intima-media thickness(IMT) and parameters of the carotid artery elasticity in patients,including stiffness parameter(β),pressure-strain elastic modulus(Ep),arterial compliance(Ac),augmentation index(AI),and pulse wave velocity β(PWVβ) were detected by Echo-Tracking(ET) technique before and after 24 week treatment. In the meantime,levels of blood lipid,and liver and renal function were measured respectively.RESULTS: After 24 weeks,ba PWV,IMT and parameters of the carotid artery elasticity(β,Ep,AI and PWVβ) were markedly decreased in intervention group compared with those of before treatment(P < 0.01),but the level of Ac was increased significantly(P < 0.01). And there were no significant differences compared with control group on the same period(P > 0.05).CONCLUSION: In this pilot study,it was demonstrated ET technology and automated arteriosclerosis detector could be used to evaluate carotid artery elasticity effectively,and the action of Shoushen granule on carotid atherosclerosis might be related to the regulation of carotid artery elasticity.展开更多
基金Project(2012AA040105)supported by National High-technology Research and Development of China
文摘In order to estimate deformation and mechanical properties of material accurately,elastic and plastic deformation behavior of small punch test was discussed in this paper.A two-dimensional finite element model was established based upon the Gurson-Tvergaard-Needleman(GTN)equation.According to the integration of load–displacement curves with different displacements,the evolution of elastic energy was obtained.The results show that the elastic energy increases quickly in the initial region and tends to be an approximate constant during the plastic bending phase.Meanwhile,an obvious change of the slope of load–displacement curve can be found in the elastic-plastic transition region.The macroscopic deformation and fracture feature were also discussed in order to verify the deformation analysis.Finally,the yield strength,tensile strength and elongation of AISI304 were obtained based on the analysis of deformation energy and percent fracture deflection.The results have a good agreement with that of conventional tensile tests,which may provide a theoretical basis of small punch analysis.
基金Projects(50531060,10525211,10828205)supported by the National Natural Science Foundation of ChinaProject(10525211)supported by National Science Found for Distinguished Young Scholars of ChinaProject(076044)supported by the Cultivation Fund of the Key Scientific and Technical Innovation Project,Ministry of Education of China
文摘To characterize the elastic-plastic properties of thin film materials on elastic-plastic substrates,a simple theory model was proposed,which included three steps:dimensionless analysis,finite element modeling and data fitting.The dimensionless analysis was applied to deriving two preliminary nondimensional relationships of the material properties,and finite element modeling and data fitting were carried out to establish their explicit forms.Numerical indentation tests were carried out to examine the effectiveness of the proposed model and the good agreement shows that the proposed theory model can be applied in practice.
基金Supported by the National Natural Science Foundation of China(the Role of TLR4/My D88/NF-κB Signal Transduction Pathway and Expression of mi RNA-146a in Atherosclerosis and the Intervention Mechanism of Shen Invigorating Compounds,No.81202731Study on the mechanism of two-ways regulation of angiogenesis using Guanxin 1 from the VEGF-Ang cascade signaling pathway,No.81202664)+2 种基金General Program of Shanghai Municipal Health Bureau Foundation(Evaluation of the Clinical Effect of the Shoushen Granule in Patients with Atherosclerosis based on Echo-Tracking Technique,No.20114047Study on Biomarkers of Atherosclerosis based on Telomere,No.2010225)Traditional Chinese Medicine Foundation of Shanghai Municipal Health Bureau(Anti atherosclerosis Study of the Traditional Chinese Medicine Shoushen Granule on the Basis of Telomere,No.2010L046A)
文摘OBJECTIVE: To investigate the effectiveness of Shoushen granule,Chinese herbal preparation,on carotid artery elasticity in patients with carotid atherosclerosis.METHODS: The total of 156 carotid atherosclerosis patients were randomly divided into the intervention group(83 cases,treated with Shoushen granule) and the control group(73 cases,treated with pravastatin). Brachial-ankle pulse wave velocity(ba PWV) and Ankle-Brachial Pressure Index(ABI)were measured by automated arteriosclerosis detector. The changes of common carotid artery intima-media thickness(IMT) and parameters of the carotid artery elasticity in patients,including stiffness parameter(β),pressure-strain elastic modulus(Ep),arterial compliance(Ac),augmentation index(AI),and pulse wave velocity β(PWVβ) were detected by Echo-Tracking(ET) technique before and after 24 week treatment. In the meantime,levels of blood lipid,and liver and renal function were measured respectively.RESULTS: After 24 weeks,ba PWV,IMT and parameters of the carotid artery elasticity(β,Ep,AI and PWVβ) were markedly decreased in intervention group compared with those of before treatment(P < 0.01),but the level of Ac was increased significantly(P < 0.01). And there were no significant differences compared with control group on the same period(P > 0.05).CONCLUSION: In this pilot study,it was demonstrated ET technology and automated arteriosclerosis detector could be used to evaluate carotid artery elasticity effectively,and the action of Shoushen granule on carotid atherosclerosis might be related to the regulation of carotid artery elasticity.