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HIV/AIDS患者外周血总淋巴细胞数与CD4^+ T淋巴细胞数的相关性分析 被引量:3
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作者 常株洲 陈伟烈 +1 位作者 袁小珍 唐漾波 《国际医药卫生导报》 2007年第7期79-83,共5页
目的探讨HIV/AIDS患者外周血总淋巴细胞数(total lymphocyte count,TLC)与CD4阳性(CD4^+)T淋巴细胞数的相关性,了解用TLC预测CD4^+T淋巴细胞数的可行性。方法分析602例HIV/AIDS患者共计1883例次TLC和CD4^+T淋巴细胞数相关性... 目的探讨HIV/AIDS患者外周血总淋巴细胞数(total lymphocyte count,TLC)与CD4阳性(CD4^+)T淋巴细胞数的相关性,了解用TLC预测CD4^+T淋巴细胞数的可行性。方法分析602例HIV/AIDS患者共计1883例次TLC和CD4^+T淋巴细胞数相关性,根据灵敏度、特异度、阳性预测值和阴性预测值,估计预测CD4〈100个/μlCD4〈200个/μlCD4〈350个/μlTLC的临界值。相关分析和回归分析采用SPSS13.0统计软件。结果TLC与CD4^+T淋巴细胞数显著正相关(r=0.631,P〈0.001)。用TLC〈1200个/μl测CD4〈100个/μl敏度为70.3%,特异度为82.9%,阳性预测值为71%,阴性预测值为80.6%;TLC〈1500个/μl测CD4〈200个/μl敏度为71.1%,特异度为75.4%,阳性预测值为80.6%,阴性预测值为64.4%;用TLC〈1800个/μl测CD4〈350个/μl敏度为76.1%,特异度为75.9%,阳性预测值为92.7%,阴性预测值为45.1%。结论在无条件检测CD4^+T淋巴细胞计数的情况下,可用TLC预测CD4^+T淋巴细胞计数。分别以TLC〈1200个/μl〈1500个/μl〈1800个/μl测CD4〈100个/μl〈200个/μl〈350个/μl比较合适的。 展开更多
关键词 获得性免疫缺陷综合征 CD4^+T淋巴细胞 总淋巴细胞数
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110例HIV感染者/AIDS患者外周血总淋巴细胞数与CD4^+T淋巴细胞绝对计数的相关性分析 被引量:2
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作者 于卉 陶华林 《西南军医》 2017年第3期226-230,共5页
目的分析HIV感染者/艾滋病患者(HIV/AIDS)外周血总淋巴细胞数(TLC)和CD4^+T淋巴细胞绝对计数之间的相关性,探讨其在AIDS疾病分级、病程监测及临床诊疗中的意义。方法收集临床感染呼吸科HIV感染者/AIDS患者110例,应用Sysmex XT-2000i全... 目的分析HIV感染者/艾滋病患者(HIV/AIDS)外周血总淋巴细胞数(TLC)和CD4^+T淋巴细胞绝对计数之间的相关性,探讨其在AIDS疾病分级、病程监测及临床诊疗中的意义。方法收集临床感染呼吸科HIV感染者/AIDS患者110例,应用Sysmex XT-2000i全血细胞分析仪检测TLC,BD FACSCanto Ⅱ流式细胞仪进行CD4^+T淋巴细胞绝对计数,对各项结果进行统计学分析,计算TLC替代CD4^+T淋巴细胞绝对计数<100个/μL,<200个/μL及<350个/μL各临界值的敏感性、特异性、阳性预测值、阴性预测值和约登指数,并据此判断最佳临界值。结果 CD4^+T淋巴细胞绝对计数与TLC呈显著正相关(r=0.706,P<0.01),用TLC<800个/μL预测CD4<100个/μL敏感性为86.30%,特异性为100.00%,阳性预测值为100.00%,阴性预测值为78.72%,约登指数86.30%;TLC<1100个/μL预测CD4<200个/μL敏感性为89.53%,特异性为91.67%,阳性预测值为97.47%,阴性预测值为70.97%,约登指数81.20%;TLC<1200个/μL预测CD4<350个/μL敏感性为85.71%,特异性为91.66%,阳性预测值为98.82%,阴性预测值为44.00%,约登指数77.37%。结论 HIV/AIDS患者外周血总TLC与CD4^+T淋巴细胞绝对计数值呈正相关,在资源有限的国家和地区,用TLC预测CD4^+T淋巴细胞绝对计数具有一定的可行性,特殊情况下可作为替代指标用于监测HIV/AIDS患者疾病进展,指导临床诊疗。 展开更多
关键词 HIV/AIDS患者 CD4+T淋巴细胞绝对计 总淋巴细胞数 相关性
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93例AIDS患者并发贫血的临床分析 被引量:1
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作者 都泓莲 邹永胜 刘泽明 《检验医学与临床》 CAS 2015年第20期3031-3032,共2页
目的研究获得性免疫缺陷综合征(AIDS)患者并发贫血的情况,探讨影响贫血发生的相关因素。方法回顾分析93例AIDS患者的临床资料,了解贫血发生率及特点,对贫血与总淋巴细胞数(TLC)、血红蛋白(Hb)与清蛋白(ALB)之间的关系进行分析。结果 93... 目的研究获得性免疫缺陷综合征(AIDS)患者并发贫血的情况,探讨影响贫血发生的相关因素。方法回顾分析93例AIDS患者的临床资料,了解贫血发生率及特点,对贫血与总淋巴细胞数(TLC)、血红蛋白(Hb)与清蛋白(ALB)之间的关系进行分析。结果 93例AIDS患者中有61例并发贫血,贫血发生率为65.6%,轻、中、重度贫血分别占62.3%、26.2%、11.5%,大细胞、正细胞、小细胞性贫血各占8.2%、80.3%、11.5%。61例贫血患者中,27例(44.26%)为单纯贫血者,34例(55.74%)合并其他血细胞减少。贫血发生率随TLC减少逐渐增高,差异有统计学意义(P<0.05)。AIDS患者的Hb与ALB呈正相关(r=0.444,P<0.01)。结论 AIDS患者贫血的发生率较高,机会感染、免疫缺陷、营养状况与贫血发生相关。 展开更多
关键词 获得性免疫缺陷综合征 贫血 总淋巴细胞数 清蛋白
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Influence of Photoperiod over Morphometric and Hematological Parameters of Juvenile Piracanjubas (Brycon orbygnianus)
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作者 Monica Rodrigues Ferreira Machado] Eliane Aparecida de Andrade +5 位作者 Estefania de Souza Andrade Daniella Aparecida de Jesus Paula Julia Alvarenga Oliveira Adriano Carvalho Costa Ana Paula Peconick Luis David Solis Murgas 《Journal of Agricultural Science and Technology(B)》 2016年第5期350-359,共10页
The aim of this study was to evaluate morphometric and hematological parameters of juveniles Piracanjubas treated with two distinct photoperiod. Twenty nine fish with 100 g, in a factorial design were performed in 18 ... The aim of this study was to evaluate morphometric and hematological parameters of juveniles Piracanjubas treated with two distinct photoperiod. Twenty nine fish with 100 g, in a factorial design were performed in 18 h light:6 h dark (18L:6D) and 6L:lSD two different photoperiod, and morphometric and hematological parameters were evaluated at 45 d and 90 d after photoperiod treatment. Benzocaine 1% was used for euthanasia. Fish were weighed and measured, so as visceral fat, liver and gonads. Hematocrit, total count of white cells, lymphocytes and neutrophils were counted. Results showed that there was no significant relationship between bodyweight and standard length. Significant interaction (P = 0.00018) had been found between the fat index (FI) and gonado-somatic index (GSI) and the photoperiod and time. At 90 d, the fish kept in 18L:6D had a lower rate of fat than the fish kept in 6L:18D (P 〈 0.05). The GSI was higher in the group 6L.'18D compared with the 18L:6D (P 〈 0.005). There was no interaction between photoperiod and period of treatment for total leukocyte count, however with 90 d, the total leukocyte count was decreased (P 〈 0.05). Moreover, decrease of the hematocrit from 58.1% to 46.9% and an increase of lymphocytes from 31.5% to 43.5% had been found in fish kept in 18L:6D after 90 d (P 〈 0.05). Fish kept in 6L:ISD presented an increase in segmented neutrophils and lymphocytes (P 〈 0.05). It is concluded that photoperiod maintained at 6L: 18D for Piracanjubas permits a greater gonadal development and an amount of immune cells over the photoperiod maintained in 18L: 6D. 展开更多
关键词 Circadian rhythm fish maturity cellular immune response photoperiod.
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