Aims of this paper are to improve ADI differential quadrature method (ADI-DQM) based on Bernstein polynomials and add a new application to the differential quadrature method. By using the new methodology, the numeri...Aims of this paper are to improve ADI differential quadrature method (ADI-DQM) based on Bernstein polynomials and add a new application to the differential quadrature method. By using the new methodology, the numerical solutions of the governing equations of unsteady two-dimensional flow of a polytropic gas are investigated. The numerical results reveal that the new technique is very effective and gives high accuracy, good convergence and reasonable stability.展开更多
Background:There is equivocal evidence regarding differences in the clinical course and outcomes of Crohn’s disease(CD)among African Americans compared with Caucasian Americans.We sought to analyze whether African Am...Background:There is equivocal evidence regarding differences in the clinical course and outcomes of Crohn’s disease(CD)among African Americans compared with Caucasian Americans.We sought to analyze whether African Americans with CD are more likely to be hospitalized for CD-related complications when compared with Caucasian Americans with CD.Methods:We conducted a retrospective cohort study including 909 African Americans and Caucasian Americans with CD who were seen at our tertiary care Inflammatory Bowel Disease(IBD)referral center between 2000 and 2013.We calculated the rate of hospitalization for CD-related complications among African Americans and Caucasian Americans separately.Zero-inflated Poisson regression models with robust variance estimates were used to estimate crude and multivariable adjusted rate ratios(RR)for CD-related hospitalizations.Multivariable adjusted models included adjustment for age,sex,duration of CD,smoking and CD therapy.Results:The cumulative rate of CD-related hospital admissions was higher among African American patients compared with Caucasian American patients(395.6/1000 person-years in African Americans vs.230.4/1000 person-years in Caucasian Americans).Unadjusted and multivariable adjusted rate ratios for CD-related hospitalization comparing African Americans and Caucasian Americans were 1.59(95%confidence interval[95%CI]:1.10–2.29;P=0.01)and 1.44(95%CI:1.02–2.03;P=0.04),respectively.Conclusions:African Americans with CD followed at a tertiary IBD-referral center had a higher rate for CD-related hospitalizations compared with Caucasian Americans.Future studies should examine whether socioeconomic status and biologic markers of disease status could explain the higher risk observed among African Americans.展开更多
We show sharp bounds for probabilities of large deviations for sums of independent random variables satisfying Bernstein's condition. One such bound is very close to the tail of the standard Gaussian law in certai...We show sharp bounds for probabilities of large deviations for sums of independent random variables satisfying Bernstein's condition. One such bound is very close to the tail of the standard Gaussian law in certain case; other bounds improve the inequalities of Bennett and Hoeffding by adding missing factors in the spirit of Talagrand(1995). We also complete Talagrand's inequality by giving a lower bound of the same form, leading to an equality. As a consequence, we obtain large deviation expansions similar to those of Cram′er(1938),Bahadur-Rao(1960) and Sakhanenko(1991). We also show that our bound can be used to improve a recent inequality of Pinelis(2014).展开更多
Understanding and predicting species range-expansions and biological invasions is an important challenge in modem ecology because of rapidly changing environments. Recent studies have revealed that consistent within-s...Understanding and predicting species range-expansions and biological invasions is an important challenge in modem ecology because of rapidly changing environments. Recent studies have revealed that consistent within-species variation in behavior (i.e. animal personality) can be imperative for dispersal success, a key stage in the invasion process. Here we investigate the composition and correlation of two important personality traits associated with invasion success, activity and boldness, and how they are connected to sex and individual size in a newly colonised population of the Chinese mitten crab Eriocheir sinensis in Lake Vanem, Sweden. We found no effect of sex or size on behavioral expressions orE. sinensis but a clear positive correlation between boldness and activity. In addition, this study generates important baseline data for monitoring behavioral develop ment, and thereby changing ecological impact, of an invading population over time. This has implications for predicting ecological effects of invasive species as well as for managing ecological invasions.展开更多
Background and aims:With expanding available treatment options and evolving understanding of the risks and benefits of medical therapies for inflammatory bowel disease(IBD),there is the possibility of significant vari...Background and aims:With expanding available treatment options and evolving understanding of the risks and benefits of medical therapies for inflammatory bowel disease(IBD),there is the possibility of significant variations in treatment and outcomes.Little is known about the variation in treatment between IBD specialists and other gastroenterology(GI)physicians.Evaluating possible variations is an important first step to help address standardized care and optimize treatment.We studied the differences in use of biologics and immunomodulators in the management of IBD patients at a tertiary care hospital between IBD-trained physicians and other gastroenterologists.Methods:A total of 325 IBD patients were included in the analysis.Of these,216 patients received care with an IBD physician and 109 had other GI/non-IBD physicians as their main caregivers.Results:The unadjusted use of immunomodulators(35.6%vs 16.5%,p¼0.001),biologics(45.8%vs 22.9%,p¼0.001)and dual therapy(biologics and immunomodulator)(14.4%vs 3.7%,p¼0.001)was significantly higher in the IBD-physician group.These differences in therapy between the two groups remained after adjusting for patient and disease characteristics.Conclusion:There are significant variations in the treatment of patients with IBD by GI physicians.The use of biologics and immunomodulators is higher in GI physicians with dedicated IBD interest and training.展开更多
文摘Aims of this paper are to improve ADI differential quadrature method (ADI-DQM) based on Bernstein polynomials and add a new application to the differential quadrature method. By using the new methodology, the numerical solutions of the governing equations of unsteady two-dimensional flow of a polytropic gas are investigated. The numerical results reveal that the new technique is very effective and gives high accuracy, good convergence and reasonable stability.
文摘Background:There is equivocal evidence regarding differences in the clinical course and outcomes of Crohn’s disease(CD)among African Americans compared with Caucasian Americans.We sought to analyze whether African Americans with CD are more likely to be hospitalized for CD-related complications when compared with Caucasian Americans with CD.Methods:We conducted a retrospective cohort study including 909 African Americans and Caucasian Americans with CD who were seen at our tertiary care Inflammatory Bowel Disease(IBD)referral center between 2000 and 2013.We calculated the rate of hospitalization for CD-related complications among African Americans and Caucasian Americans separately.Zero-inflated Poisson regression models with robust variance estimates were used to estimate crude and multivariable adjusted rate ratios(RR)for CD-related hospitalizations.Multivariable adjusted models included adjustment for age,sex,duration of CD,smoking and CD therapy.Results:The cumulative rate of CD-related hospital admissions was higher among African American patients compared with Caucasian American patients(395.6/1000 person-years in African Americans vs.230.4/1000 person-years in Caucasian Americans).Unadjusted and multivariable adjusted rate ratios for CD-related hospitalization comparing African Americans and Caucasian Americans were 1.59(95%confidence interval[95%CI]:1.10–2.29;P=0.01)and 1.44(95%CI:1.02–2.03;P=0.04),respectively.Conclusions:African Americans with CD followed at a tertiary IBD-referral center had a higher rate for CD-related hospitalizations compared with Caucasian Americans.Future studies should examine whether socioeconomic status and biologic markers of disease status could explain the higher risk observed among African Americans.
基金supported by the Post-Graduate Study Abroad Program sponsored by China Scholarship CouncilNational Natural Science Foundation of China(Grant Nos.11171044 and11401590)
文摘We show sharp bounds for probabilities of large deviations for sums of independent random variables satisfying Bernstein's condition. One such bound is very close to the tail of the standard Gaussian law in certain case; other bounds improve the inequalities of Bennett and Hoeffding by adding missing factors in the spirit of Talagrand(1995). We also complete Talagrand's inequality by giving a lower bound of the same form, leading to an equality. As a consequence, we obtain large deviation expansions similar to those of Cram′er(1938),Bahadur-Rao(1960) and Sakhanenko(1991). We also show that our bound can be used to improve a recent inequality of Pinelis(2014).
文摘Understanding and predicting species range-expansions and biological invasions is an important challenge in modem ecology because of rapidly changing environments. Recent studies have revealed that consistent within-species variation in behavior (i.e. animal personality) can be imperative for dispersal success, a key stage in the invasion process. Here we investigate the composition and correlation of two important personality traits associated with invasion success, activity and boldness, and how they are connected to sex and individual size in a newly colonised population of the Chinese mitten crab Eriocheir sinensis in Lake Vanem, Sweden. We found no effect of sex or size on behavioral expressions orE. sinensis but a clear positive correlation between boldness and activity. In addition, this study generates important baseline data for monitoring behavioral develop ment, and thereby changing ecological impact, of an invading population over time. This has implications for predicting ecological effects of invasive species as well as for managing ecological invasions.
文摘Background and aims:With expanding available treatment options and evolving understanding of the risks and benefits of medical therapies for inflammatory bowel disease(IBD),there is the possibility of significant variations in treatment and outcomes.Little is known about the variation in treatment between IBD specialists and other gastroenterology(GI)physicians.Evaluating possible variations is an important first step to help address standardized care and optimize treatment.We studied the differences in use of biologics and immunomodulators in the management of IBD patients at a tertiary care hospital between IBD-trained physicians and other gastroenterologists.Methods:A total of 325 IBD patients were included in the analysis.Of these,216 patients received care with an IBD physician and 109 had other GI/non-IBD physicians as their main caregivers.Results:The unadjusted use of immunomodulators(35.6%vs 16.5%,p¼0.001),biologics(45.8%vs 22.9%,p¼0.001)and dual therapy(biologics and immunomodulator)(14.4%vs 3.7%,p¼0.001)was significantly higher in the IBD-physician group.These differences in therapy between the two groups remained after adjusting for patient and disease characteristics.Conclusion:There are significant variations in the treatment of patients with IBD by GI physicians.The use of biologics and immunomodulators is higher in GI physicians with dedicated IBD interest and training.