微信消息推送与广播节目的运用

相信很多人都有这样的感觉,从前每天打开微博看一看,现在变成打开微信看一看,从希望自己的微博有评论,到关注朋友圈子是否有更新。就像微信的广告上说的那样：＂微信是一种生活方式,超过三亿人使用的手机应用。＂不知不觉间,微信已经开始成为人们生活中必不可少的一部分。这是个媒体交融的时代,而广播单一的电波传播已经无法消化所有信息,于是微信成了争取共鸣、披露真实的发布平台,微信的另一个功能就能大显神通。

天下信息网微信可以点答啦

搜信息、找智慧,一切尽在天下信息网!即日起,天下信息网微信平台开通点答题服务啦!关注天下信息网微信公众账号,将您需要的经验比对、工作调研、理论研讨、政策咨询、民意收集、决策探讨、文字综合材料等各类信息需求发送给我们,我们会第一时间为您收集整理最实用、最有价值的信息。天下信息微天下!

首个州盟政务微博上线

四川凉山彝族自治州政务类微博平台——"五彩凉山信息微博发布厅"26日在腾讯微博正式上线。聚合了对外宣传凉山和网络问政双重功能的新型传播平台,也是全国30个少数民族自治州盟中第一个政务微博平台。"五彩凉山信息微博发布厅"由凉山州政府新闻办管理,主账号"微凉山"

重庆科协:科技馆微博:抢占科普宣传高地

近日,由重庆市委对外宣传办公室及重庆市人民政府新闻办公室联合发布的的"重庆微政务"微博群动态2012年第一期简报对上半年成员单位的微博进行了总结,重庆科技馆作为"重庆微政务"64个成员单位其中之一,其利用微博平台,进行"微博科普"的方式和取得的效果受到肯定。微博已成为重要的新兴舆论场。

微信阅读助推教师素养提升

微信阅读已成为广大语文教师获取信息的重要途径,但微信阅读具有碎片化、浅表化等弊端。如何正确使用微信阅读,让它为我所用,提升教师素养呢？

Prognositic value of anoikis and tumor immune microenvironment-related gene in the treatment of osteosarcoma

Objective:Osteosarcoma is a highly aggressive primary malignant bone tumor commonly seen in children and adolescents,with a poor prognosis.Anchorage-dependent cell death(anoikis)has been proven to be indispensable in tumor metastasis,regulating the migration and adhesion of tumor cells at the primary site.However,as a type of programmed cell death,anoikis is rarely studied in osteosarcoma,especially in the tumor immune microenvironment.This study aims to clarify prognostic value of anoikis and tumor immune microenvironment-related gene in the treatment of osteosarcoma.Methods:Anoikis-related genes(ANRGs)were obtained from GeneCards.Clinical information and ANRGs expression profiles of osteosarcoma patients were sourced from the therapeutically applicable research to generate effective therapies and Gene Expression Omnibus(GEO)databases.ANRGs highly associated with tumor immune microenvironment were identified by the estimate package and the weighted gene coexpression network analysis(WGCNA)algorithm.Machine learning algorithms were performed to construct long-term survival predictive strategy,each sample was divided into high-risk and low-risk subgroups,which was further verified in the GEO cohort.Finally,based on single-cell RNA-seq from the GEO database,analysis was done on the function of signature genes in the osteosarcoma tumor microenvironment.Results:A total of 51 hub ANRGs closely associated with the tumor microenvironment were identified,from which 3 genes(MERTK,BNIP3,S100A8)were selected to construct the prognostic model.Significant differences in immune cell activation and immune-related signaling pathways were observed between the high-risk and low-risk groups based on tumor microenvironment analysis(all P<0.05).Additionally,characteristic genes within the osteosarcoma microenvironment were identified in regulation of intercellular crosstalk through the GAS6-MERTK signaling pathway.Conclusion:The prognostic model based on ANRGs and tumor microenvironment demonstrate good predictive power and provide more personalized treatment options for patients with osteosarcoma.

滴滴打车携手阿里健康进军移动医疗

随着互联网创新思维深入各个行业,越来越多的上门服务随之出现,例如:上门洗车、上门送菜以及上门按摩等等,现在就连看病都推出了上门服务,令人不禁感叹没有做不到只有想不到。10月18、19日,阿里健康联合滴滴出行、名医主刀合作在北京、上海、杭州和南京四个城市推出'一键呼叫医生,随车上门咨询'的免费便民服务,而这次随滴滴专车上门的医生均是四大城市知名医院的专家医生微信资讯。

让媒体在融合中变革

＂强化互联网思维,坚持传统媒体和新兴媒体优势互补、一体发展＂＂着力打造一批形态多样、手段先进、具有竞争力的新型主流媒体＂……一年前,习近平总书记在中央全面深化改革领导小组第四次会议上,对主流媒体提出了新要求,也开启了中国＂媒体融合元年＂。

Preparation of Cetyl-Chitosan Nanoparticles as Carriers for Paracetamol

Cetyl-chitosan, prepared by reacting chitosan with chlorocetane under alkaline condition, is soluble and spontaneously forms nanoparticles about 100 nm in diameter. Infrared spectra (IR) revealed that there was a substitution reaction mainly on the amine groups of chitosan (CS). By using paracetamol (PCTM) as a model drug, the balanced release concentration of PCTM in phosphate buffer solution (pH=7.4) can be decreased with the increase of degree of substitution alkyl and can be reduced effectively even under a lower PCTM loading.

Registration Method for CT-MR Image Based on Mutual Information

Medical image registration is important in many medical applications. Registration method based on maximization of mutual information of voxel intensities is one of the most popular methods for 3-D multi-modality medical image registration. Generally, the optimization process is easily trapped in local maximum, resulting in wrong registration results. In order to find the correct optimum, a new multi-resolution approach for brain image registration based on normalized mutual information is proposed. In this method, to eliminate the effect of local optima, multi-scale wavelet transformation is adopted to extract the image edge features. Then the feature images are registered, and the result at this level is taken as the initial estimate for the registration of the original images. Three-dimensional volumes are used to test the algorithm. Experimental results show that the registration strategy proposed is a robust and efficient method which can reach sub-voxel accuracy and improve the optimization speed.

Anorectal functional outcome after repeated transanal endoscopic microsurgery

AIM： TO evaluate the status of anorectal function after repeated transanal endoscopic microsurgery （TEN）. METHODS： Twenty-one patients undergoing subtotal colectomy with ileorectal anastomosis were included. There were more than 5 large （〉 1 cm） polyps in the remaining rectum （range： 6-20 cm from the anal edge）. All patients, 19 with villous adenomas and 2 with low-grade adenocarcinomas, underwent TEM with submucosal endoscopic excision at least twice between 2005 and 2011. Anorectal manometry and a question- naire about incontinence were carried out at week 1 before operation, and at weeks 2 and 3 and 6 mo after the last operation. Anal resting pressure, maxi- mum squeeze pressure, maximum tolerable volume （MTV） and rectoanal inhibitory reflexes （RAIR） were recorded. The integrity and thickness of the internal anal sphincter （IAS） and external anal sphincter （EAS） were also evaluated by endoanal ultrasonography. We determined the physical and mental health status with SF-36 score to assess the effect of multiple TEM on patient quality of life （QoL）. RESULTS： All patients answered the questionnaire. Apart from negative RAIR in 4 patients, all of the anorectal manometric values in the 21 patients were normal before operation. Mean anal resting pressure decreased from 38±5 mmHg to 19±3 mmHg （38±5 mmHg vs 19±3 mmHg, P = 0.000） and MTV from 165± 19mLto60± 11mL（165± 19mLvs60± 11 mL, P = 0.000） at month 3 after surgery. Anal resting pressure and MTV were 37 ± 5 mmHg （38 ± 5 mmHg vs 37 ± 5 mmHg, P = 0.057） and 159 ± 19 mL （165 ± 19 mL vs 159 ± 19 mL, P = 0.071）, respectively, at month 6 after TEM. Maximal squeeze pressure de- creased from 171 ± 19 mmHg to 62 ± 12 mmHg （171 ± 19 mmHg vs 62 ± 12 mmHg, P = 0.000） at week 2 after operation, and returned to normal values by postoperative month 3 （171 ± 19 vs 166 ± 18, P = 0.051）. RAIR were absent in 4 patients preoperatively and in 12 （χ2 = 4.947, P = 0.026） patients at month 3 after surgery. PAIR was absent only in 5 patients at postoperative month 6 （χ2 = 0.141, P = 0.707）. Endo- sonography demonstrated that IAS disruption occurred in 8 patients, and 6 patients had temporary inconti- nence to flatus that was normalized by postoperative month 3. IAS thickness decreased from 1.9 ± 0.6 mm preoperatively to 1.3 ± 0.4 mm （1.9 ± 0.6 mm vs 1.3 ± 0.4 mm, P = 0.000） at postoperative month 3 and increased to 1.8 ± 0.5 mm （1.9 ± 0.6 mm vs 1.8 ± 0.5 mm, P = 0.239） at postoperative month 6. EAS thickness decreased from 3.7 ± 0.6 mm preoperatively to 3.5 ± 0.3 mm （3.7 ± 0.6 mm vs 3.5 ± 0.3 mm, P = 0.510） at month 3 and then increased to 3.6 ± 0.4 mm （3.7 ± 0.6 mm vs 3.6 ± 0.4 mm, P = 0.123） at month 6 after operation. Most patients had frequent stools per day and relatively high Wexner scores in a short time period. While actual fecal incontinence was exceptional, episodes of soiling were reported by 3 pa- tients. With regard to the QoL, the physical and mental health status scores （SF-36） were 56.1 and 46.2 （50 in the general population）, respectively.CONCLUSION： The anorectal function after repeated TEM is preserved. Multiple TEM procedures are useful for resection of multi-polyps in the remaining rectum.

Microscopic simulation of multi-lane traffic under dynamic tolling and information feedback

To investigate drivers' lane-changing behavior under different information feedback strategies,a microscopic traffic simulation based on the cellular automaton model was made on the typical freeway with a regular lane and a high-occupancy one. A new dynamic tolling scheme in terms of the real-time traffic condition on the high-occupancy lane was further designed to enhance the whole freeway's flow throughput. The results show that the mean velocity feedback strategy is generally more efficient than the travel time feedback strategy in correctly guiding drivers' lane choice behavior. Specifically,the toll level,lane-changing rate and freeway's throughput and congestion coefficient induced by the travel time feedback strategy oscillate with larger amplitude and longer period. In addition,the dynamic tolling scheme can make the high-occupancy lane less congested and maximize the freeway's throughput when the regular-lane inflow rate is larger than 0.45.

Detection and treatment of synchronous lesions in colorectal cancer: The clinical implication of perioperative colonoscopy

AIM： To evaluate the clinical significance of preand intra-operative colonoscopy for the detection of synchronous lesions in colon cancer.METHODS： Two hundred and sixty-five pre-operative and 51 intra-operative colonoscopic evaluations were performed in 316 colorectal cancer patients who underwent curative resection from January 2001 to June 2006. The incidence and characteristics of synchronous lesions and their influence on surgery were evaluated.RESULTS： Two hundred and eighty-two synchronous lesions were detected in 124 （39.2%） of 316 patients including all lesions regardless of their histologic type. True adenomatous polyps were found in 91 （28.8%） of 326 patients, and 27 （5.4% of all patients） patients had synchronous colon cancers. The preoperative identification of synchronous lesions altered the planned surgery in 37 （14.0%） of 265 patients. In 18 patients among the surgically removed cases, the lesions were removed by extending the resection range. Further segmental resection or polypectomy through enterotomy was necessary in 29 patients. Nineteen （37.2%） of 52 intraoperative colonoscopy cases had synchronous lesions. Additional surgical procedures including segmental bowel resection and polypectomy with enterotomy were necessary in 7 （23.7%） of 52 intraoperative colonoscopy cases to remove the lesions.CONCLUSION： Synchronous colorectal polyps or cancer are frequent and their preoperative detection is important for optimal surgical planning and treatment. Intraoperative colonoscopy is a useful option in cases where a preoperative colonoscopy is not feasible.

Pulsed digital micro-holography of femto-second order by double-wavelength recording

Double-wavelength recording used in a pulsed digital micro-holographic system to record ultra-fast processing of the order of femto-second is reported for the first time, where a BBO crystal is used to generate harmonic wave of the incident laser wave, and both of the basic and the frequency doubled waves are time-delayed and introduced to a Michelson＇s interferometer to record two sub-holograms with different spatial frequencies on a single frame of a CCD. In the experiment, an ultrafast dynamic process of air ionization induced by a single femto-second laser pulse is recorded with holography by this system, and both of intensity and phase difference images digitally reconstructed are obtained through Fourier transformation and digital faltering, which show clearly the dynamic process of formation and propagation of the plasma, with a time resolution of the order of femto-second.

Online prediction for contamination of chlortetracycline fermentation based on Dezert–Smarandache theory

Fermentative production of chlortetracycline is a complex fed-batch bioprocess. It generally takes over 90 h for cultivation and is often contaminated by undesired microorganisms. Once the fermentation system is contaminated to certain extent, the product quality and yield will be seriously affected, leading to a substantial economic loss. Using information fusion based on the Dezer–Smarandache theory, self-recursive wavelet neural network and unscented kalman filter, a novel method for online prediction of contamination is developed. All state variables of culture process involving easy-to-measure and difficult-to-measure variables commonly obtained with soft-sensors present their contamination symptoms. By extracting and fusing latent information from the changing trend of each variable, integral and accurate prediction results for contamination can be achieved. This makes preventive and corrective measures be taken promptly. The field experimental results show that the method can be used to detect the contamination in time, reducing production loss and enhancing economic efficiency.

Educational Press for Remote Experimentation Applied in the Spring to Study Hooke＇s Law

The aim of this study is to report the use of RE （remote experimentation） in an educational press. The authors developed this remote experiment with the objective to study the Hooke＇s law through the analysis of the coil spring. The remote experiment is available in a website, where the students can manipulate and observe the educational press and confirm Hooke＇s statements with the output information. In addition, the students will have the opportunity to read in the website about the educational press, the physical law, and the use of the press in industrial processes. This remote experimentation exerts a force in the mechanical spring creating a deformation. In the defined point, the microcomputer will collect the data from the sensors, and it will save this data in the database. After the process execution, a graph with the data will be plotted in the website. The tests confirm that the educational press has informational potential because it returned values consistent with Hooke＇s law and the experiment presented repetition in all tests realized.

Research on the Shrinking of 2-components Adhesive with Automatically Calculating Hologram

In this paper, used BSO(Bi12SiO（20）) crystal as a hologram recording material,TV-camera as a detector, and a holographic setup controlled by a computer, automatically calculating hologram of 3-interferograms method is theoretically and experimentally studied. This new holographic recording material and automatically calculating hologram make it possible to use real-time holography in an industry. As a practical example, the shrinking of 2-components adhesive in 4 h is measured.

Immunohistochemical localization of glutathione S-transferase-pi in human colorectal polyps

AIM:To investigate the distribution of the placental form of glutathione-S-transferase (GST) in colon polyps in order to evaluate the role of GST-pi in these tissues. METHODS: Sixteen polyp tissues removed at colonoscopy were examined. Tissues were investigated histologically and ultrastructurally. GST-pi expression was also analysed immunohistochemically, using peroxidase anti-peroxidase (PAP) method and immunogold labelling method, for light and electron microscope respectively. RESULTS: All polyp tissues examined were adenoma of low, mild and high-grade dysplasia as shown in the histopathological reports. Nevertheless, the examination of the above specimens with electron microscope revealed that 3 of 9 adenoma of mild dysplasia had ultrastuctural features similar to high-grade dysplasia adenoma. GST-pi was variably expressed in adenoma, with the lowest relative levels occurring in low-gradeadenoma and the highest levels found in high-grade adenoma. GST-pi was located mainly in undifferentiated epithelial cells. GST-pi positive particles were found in the cytoplasm and especially in the nucleus adjacent to the nuclear membrane of these cells. CONCLUSION:The overexpression of GST-pi in mildgrade adenomas with significant subcellular changes and in the majority of high-grade dysplasia adenoma suggests that this might be related to the carcinogenetic proceeding. Immunohistochemical localization of GST-pi in combination with ultrastructural changes indicate that GST-pi might be a sensitive agent for the detection of preneoplastic transformations in adenoma.

Charge Qubit Storage and Its Engineered Decoherence via Microwave Cavity

We study the entanglement of the superconducting charge qubit with the quantized electromagnetic field in a microwave cavity. It can be controlled dynamically by a classical external field threading the SQUID within the charge qubit. Utilizing the controllable quantum entanglement, we can demonstrate the dynamic process of the quantum storage of information carried by charge qubit. On the other hand, based on this engineered quantum entanglement, we can also demonstrate a progressive decoherence of charge cubit with quantum jump due to the coupling with the cavity field in quasi-classical state.

Discrimination for minimal hepatic encephalopathy based on Bayesian modeling of default mode network

In order to classify the minimal hepatic encephalopathy （MHE） patients from healthy controls, the independent component analysis （ICA） is used to generate the default mode network （DMN） from resting-state functional magnetic resonance imaging （fMRI）. Then a Bayesian voxel- wised method, graphical-model-based multivariate analysis （GAMMA）, is used to explore the associations between abnormal functional integration within DMN and clinical variable. Without any prior knowledge, five machine learning methods, namely, support vector machines （SVMs）, classification and regression trees （ CART ）, logistic regression, the Bayesian network, and C4.5, are applied to the classification. The functional integration patterns were alternative within DMN, which have the power to predict MHE with an accuracy of 98%. The GAMMA method generating functional integration patterns within DMN can become a simple, objective, and common imaging biomarker for detecting MIIE and can serve as a supplement to the existing diagnostic methods.