白细胞介素-2联合平阳霉素治疗恶性胸水临床观察

目的 观察IL - 2联合平阳霉素胸腔内灌注的疗效。方法 将 4 5例恶性胸腔积液患者进行分组对照研究 ,IL - 2 +PYM组 ,IL - 2或 +组 ,其它药物组。结果 IL - 2 +PYM组有效率 91.3% ( 2 1/ 2 3) ,IL- 2或 +组有效率 71.4 % ,其它药物组有效率 53.3% ;全组疗效比较有显著差异 (P <0 .0 5) ,且毒副反应轻 ,患者均能耐受。结论 IL - 2联合平阳霉素治疗恶性胸腔积液是一个安全且有效率高的治疗方案 。

Observation of the curative effect between Nocardia rubra cell wall skeleton-injection combined with the intrapleural chemotherapy and following the intrapleural chemotherapy

Objective:To observe and compare the curative effect between the intrapleural-chemotherapy combined Nocardia rubra cell wall skeleton-injection and the Nocardia rubra cell wall skeleton-injection after control of the malignant pleural effusion by chemotherapy.Methods:Every time after elimination of pleural effusion,we injected DDP and Nocardia rubra cell wall skeleton at the same time into pleural cavity;or after we emplaced an improved central vena catheter into pleural cavity then took out closed-drainage or eliminated the pleural effusion every day,then injected 5-FU 0.5 qd intrapleural-space.After the malignant pleural effusion had being controlled,800μg Nocardia rubra cell wall skeleton was injected intrapleural-space. (We call it as"improved following-therapy").Results:Using the improved following-therapy,the control rate of malignant pleural effusion increased:CR+PR,79.07%>65.79%(P<0.05),and the incidence rate of the encapsulated pleural effusion that would impact on patient’s respiratory faction decreased.Conclusion:Giving chemotherapy after closed-drainage or immediately after taking out pleural effusion everyday,then giving biotherapy after pleural effusion had been controlled,the curative effect would be enhanced and the side-reaction would be reduced.